CN111712249A - 分离的赤红球菌细胞壁骨架在制备治疗宫颈糜烂的药物中的用途 - Google Patents
分离的赤红球菌细胞壁骨架在制备治疗宫颈糜烂的药物中的用途 Download PDFInfo
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- CN111712249A CN111712249A CN201980010820.XA CN201980010820A CN111712249A CN 111712249 A CN111712249 A CN 111712249A CN 201980010820 A CN201980010820 A CN 201980010820A CN 111712249 A CN111712249 A CN 111712249A
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- rhodococcus ruber
- cell wall
- wall skeleton
- isolated
- cervical erosion
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Abstract
分离的赤红球菌细胞壁骨架或包含其的组合物在制备治疗人宫颈糜烂的药物中的用途。该赤红球菌骨架从2019年03月22日保藏在北京市朝阳区北辰西路1号院3号的中国微生物菌种保藏管理委员会普通微生物中心，保藏编号为CGMCC 17431的赤红球菌中分离获得。
Description
PCT国内申请，说明书已公开。
Claims (15)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019100360014 | 2019-01-15 | ||
| CN201910036001 | 2019-01-15 | ||
| CN201911022193 | 2019-10-25 | ||
| CN201911022193X | 2019-10-25 | ||
| PCT/CN2019/128656 WO2020147547A1 (zh) | 2019-01-15 | 2019-12-26 | 分离的赤红球菌细胞壁骨架在制备治疗宫颈糜烂的药物中的用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111712249A true CN111712249A (zh) | 2020-09-25 |
Family
ID=71613086
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980010257.6A Active CN111727235B (zh) | 2019-01-15 | 2019-12-13 | 赤红球菌产品及其制药用途 |
| CN201980010253.8A Active CN111801105B (zh) | 2019-01-15 | 2019-12-16 | 赤红球菌产品在治疗复发性阿弗他溃疡中的用途 |
| CN201980010519.9A Pending CN111801106A (zh) | 2019-01-15 | 2019-12-20 | 赤红球菌产品在治疗温血动物的皮肤损伤或溃疡中的用途 |
| CN201980010480.0A Active CN111787931B (zh) | 2019-01-15 | 2019-12-24 | 分离的赤红球菌细胞壁骨架在制备治疗人乳头瘤病毒感染的药物中的用途 |
| CN201980010554.0A Active CN111727048B (zh) | 2019-01-15 | 2019-12-25 | 分离的赤红球菌细胞壁骨架在制备治疗单纯疱疹和/或带状疱疹的药物中的用途 |
| CN201980010541.3A Pending CN111867606A (zh) | 2019-01-15 | 2019-12-25 | 分离的赤红球菌细胞壁骨架在制备治疗人宫颈癌前病变的药物中的用途 |
| CN201980010820.XA Pending CN111712249A (zh) | 2019-01-15 | 2019-12-26 | 分离的赤红球菌细胞壁骨架在制备治疗宫颈糜烂的药物中的用途 |
| CN201980010311.7A Pending CN111727236A (zh) | 2019-01-15 | 2019-12-30 | 赤红球菌产品在治疗白色念珠菌感染引起的疾病中的用途 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109576180A (zh) * | 2018-12-17 | 2019-04-05 | 北京利昂盛生物技术有限公司 | 一株赤红球菌及其作为免疫佐剂在制备疫苗中的应用 |
| CN111787931A (zh) * | 2019-01-15 | 2020-10-16 | 辽宁格瑞仕特生物制药有限公司 | 分离的赤红球菌细胞壁骨架在制备治疗人乳头瘤病毒感染的药物中的用途 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020182180A1 (zh) * | 2019-03-14 | 2020-09-17 | 辽宁格瑞仕特生物制药有限公司 | 赤红球菌产品在治疗外阴白色病变中的用途 |
| JP2022531109A (ja) * | 2019-04-24 | 2022-07-06 | ▲遼▼▲寧▼格瑞仕特生物制▲藥▼有限公司 | 熱損傷の治療におけるロドコッカスルーバー製品の使用 |
| CN110101721A (zh) * | 2019-05-21 | 2019-08-09 | 福建省微生物研究所 | 一种赤红球菌提取物的用途 |
| JP2023510232A (ja) * | 2020-01-21 | 2023-03-13 | ▲遼▼▲寧▼格瑞仕特生物制▲藥▼有限公司 | ロドコッカス・ルーバーの細胞壁骨格の再生医学における用途 |
| WO2022199453A1 (zh) * | 2021-03-24 | 2022-09-29 | 辽宁格瑞仕特生物制药有限公司 | 赤红球菌产品在治疗放射病中的用途 |
| CN115025128A (zh) * | 2022-06-24 | 2022-09-09 | 辽宁格瑞仕特生物制药有限公司 | 红色诺卡氏菌细胞壁骨架在治疗宫颈病变中的应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1735431A (zh) * | 2002-09-06 | 2006-02-15 | 伦敦大学 | 作为免疫调节物的全细菌细胞 |
| US9717687B2 (en) * | 2012-08-28 | 2017-08-01 | National University Corporation Hokkaido University | Lipid membrane structure including bacterial cell component having dispersibility in non-polar solvent, and method for producing same |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63126493A (ja) * | 1986-11-17 | 1988-05-30 | Nippon Oil & Fats Co Ltd | 抗ウイルス剤 |
| WO2000009659A1 (de) * | 1998-08-13 | 2000-02-24 | Lonza Ag | Verfahren zur herstellung von indanderivaten |
| ES2280325T3 (es) * | 2001-06-22 | 2007-09-16 | Institut Francais Du Petrole | Conjunto de genes del citocromo p-450 de rhodococcus ruber y uso del mismo en la escision de combustible de tipo eter. |
| DE10149715B4 (de) * | 2001-10-09 | 2013-04-18 | Evonik Degussa Gmbh | Esterase EstA aus Rhodococcus ruber |
| CN1291725C (zh) * | 2002-03-08 | 2006-12-27 | 沈阳胜宝康生物制药有限公司 | 用于治疗宫颈糜烂的红色诺卡氏菌细胞壁骨架制剂及其制法 |
| CN1214798C (zh) * | 2002-06-21 | 2005-08-17 | 沈阳胜宝康生物制药有限公司 | 用于治疗单纯疱疹和带状疱疹的诺卡软膏 |
| US20050250175A1 (en) * | 2002-08-02 | 2005-11-10 | Takehiko Nomura | Bacterial cell wall skeleton component preparaion |
| PT1534330E (pt) * | 2002-09-06 | 2014-06-23 | Ucl Business Plc | Células bacterianas inteiras como moduladores imunitários |
| CN1223673C (zh) | 2003-01-23 | 2005-10-19 | 中国科学院微生物研究所 | 一种产生生物乳化剂和降解多环芳烃的赤红球菌Em及用途 |
| GB2422544B (en) * | 2003-11-14 | 2008-05-14 | Ucl Biomedica Plc | Immune modulator |
| WO2005102369A1 (ja) * | 2004-04-22 | 2005-11-03 | Dainippon Sumitomo Pharma Co., Ltd. | 細菌細胞壁骨格成分を含有する製剤 |
| CN1879661B (zh) * | 2005-06-16 | 2012-06-20 | 辽宁纳可佳生物制药有限公司 | 红色诺卡氏菌细胞壁骨架在制备抗真菌感染的药物中的用途 |
| GB0526032D0 (en) * | 2005-12-21 | 2006-02-01 | Bioeos Ltd | Use |
| CN100519737C (zh) | 2006-04-29 | 2009-07-29 | 浙江工业大学 | 赤红球菌zjb-064及其应用 |
| CN101073583A (zh) * | 2006-05-19 | 2007-11-21 | 沈阳胜宝康生物制药有限公司 | 红色诺卡氏菌细胞壁骨架在制备药物中的用途 |
| CN101209267B (zh) * | 2006-12-29 | 2012-10-03 | 辽宁纳可佳生物制药有限公司 | 红色诺卡氏菌细胞壁骨架在制备治疗皮肤损伤和疮疡的药物中的用途 |
| JP5019519B2 (ja) * | 2007-03-20 | 2012-09-05 | 独立行政法人産業技術総合研究所 | ロドコッカス属細菌由来の抗菌活性物質及びそれを用いた微生物防除法 |
| GB0716778D0 (en) * | 2007-08-29 | 2007-10-10 | Bioeos Ltd | Use |
| CN101250490A (zh) | 2008-03-28 | 2008-08-27 | 天津科技大学 | 活酵母细胞衍生物的生产方法 |
| CN101580808B (zh) | 2008-05-15 | 2011-11-16 | 汕头大学 | 一株赤红球菌及其在降解烃类化合物中的应用 |
| CN101323865B (zh) | 2008-08-07 | 2012-07-18 | 山东省科学院能源研究所 | 微生物油脂分离提取方法 |
| CN101619299B (zh) | 2009-07-08 | 2012-07-04 | 天津科技大学 | 一种赤红球菌以及利用该菌制备5-氰基戊酰胺的方法 |
| CN101892283A (zh) * | 2010-06-03 | 2010-11-24 | 华东理工大学 | 红球菌Rhodococcus ruber 4.1187催化制备光学纯(S)-(+)-2-苯基丙酸 |
| CN102250796B (zh) | 2011-06-21 | 2013-11-06 | 中国农业科学院农业环境与可持续发展研究所 | 一种赤红球菌和微生物菌剂及它们的应用 |
| CN102604875B (zh) | 2012-03-26 | 2014-12-10 | 江西师范大学 | 赤红球菌及其在降解苯酚污染物中的应用 |
| CN102895264B (zh) * | 2012-11-15 | 2014-05-14 | 福建广生堂药业股份有限公司 | 红色诺卡氏菌细胞壁骨架口含片及其制备方法 |
| CN103160491B (zh) | 2013-04-15 | 2014-12-10 | 江西师范大学 | 赤红球菌sd3的诱变菌m1的固定化细胞及其在降解苯酚污染物中的应用 |
| CN103509833B (zh) | 2013-08-15 | 2016-04-06 | 天津科技大学 | 一种利用赤红球菌制备2,6-二氟苯甲酰胺的方法 |
| CN103627653B (zh) | 2013-10-17 | 2016-01-20 | 浙江省环境保护科学设计研究院 | 一种赤红球菌菌株及其在含有机污染物的废水处理中的应用 |
| CN104830738B (zh) | 2015-05-22 | 2017-09-15 | 厦门大学 | 一种赤红球菌及其在制备十溴联苯醚降解剂中的应用 |
| CN106591168B (zh) | 2016-02-02 | 2019-08-16 | 江苏南资环保科技有限公司 | 一种烟嘧磺隆降解赤红球菌ymhl-1及其应用 |
| CA3015688A1 (en) * | 2016-02-25 | 2017-08-31 | Thomas Julius Borody | Compositions and methods of treatment of chronic infectious diseases |
| CN106591172B (zh) | 2016-04-01 | 2019-11-29 | 江苏南资环保科技有限公司 | 一种赤红球菌pta-2及其固定化和应用 |
| CN105820982B (zh) | 2016-04-29 | 2019-06-28 | 河北省科学院生物研究所 | 一种赤红球菌xs-2、其生物菌剂及制备方法和应用 |
| CN106434466B (zh) | 2016-10-14 | 2019-10-18 | 天津科技大学 | 一种产生天然红色素的赤红球菌及其制备方法与应用 |
| CN107151635B (zh) | 2017-04-28 | 2020-02-18 | 中国农业科学院研究生院 | 一种能够降解邻苯二甲酸酯的赤红球菌及其应用 |
| CN108815197A (zh) * | 2017-05-03 | 2018-11-16 | 辽宁格瑞仕特生物制药有限公司 | 红色诺卡氏菌细胞壁骨架作为cd4+t细胞增殖促进剂的用途 |
| CN108938674A (zh) * | 2017-05-27 | 2018-12-07 | 福建省山河药业有限公司 | 红色诺卡氏菌细胞壁骨架在制备治疗皮肤病变药物中的用途 |
| CN108130288B (zh) | 2017-12-15 | 2020-10-09 | 浙江工业大学 | 赤红球菌及其降解有机污染物的应用 |
| CN108862590B (zh) | 2018-08-03 | 2021-01-12 | 中国石油大学(北京) | 一种降解丙烯腈废水cod的方法 |
| CN109576180B (zh) | 2018-12-17 | 2021-11-26 | 北京利昂盛生物技术有限公司 | 一株赤红球菌及其作为免疫佐剂在制备疫苗中的应用 |
| CN109666609B (zh) * | 2019-01-14 | 2020-04-17 | 付家栋 | 一种赤红球菌发酵方法及其作为佐剂在动物疫苗中的应用 |
| EP3913045A4 (en) * | 2019-01-15 | 2022-12-28 | Liaoning Greatest Bio-Pharmaceutical Co., Ltd. | PRODUCT DERIVED FROM RHODOCOCCUS RUBER, AND PHARMACEUTICAL USE THEREOF |
| WO2020182180A1 (zh) * | 2019-03-14 | 2020-09-17 | 辽宁格瑞仕特生物制药有限公司 | 赤红球菌产品在治疗外阴白色病变中的用途 |
| JP2022531109A (ja) * | 2019-04-24 | 2022-07-06 | ▲遼▼▲寧▼格瑞仕特生物制▲藥▼有限公司 | 熱損傷の治療におけるロドコッカスルーバー製品の使用 |
| CN110184215B (zh) * | 2019-05-21 | 2021-08-13 | 福建省微生物研究所 | 一种赤红球菌菌株、菌制剂及其菌体细胞与提取物的应用 |
| JP2023510232A (ja) * | 2020-01-21 | 2023-03-13 | ▲遼▼▲寧▼格瑞仕特生物制▲藥▼有限公司 | ロドコッカス・ルーバーの細胞壁骨格の再生医学における用途 |
| WO2022199453A1 (zh) * | 2021-03-24 | 2022-09-29 | 辽宁格瑞仕特生物制药有限公司 | 赤红球菌产品在治疗放射病中的用途 |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1735431A (zh) * | 2002-09-06 | 2006-02-15 | 伦敦大学 | 作为免疫调节物的全细菌细胞 |
| US9717687B2 (en) * | 2012-08-28 | 2017-08-01 | National University Corporation Hokkaido University | Lipid membrane structure including bacterial cell component having dispersibility in non-polar solvent, and method for producing same |
Non-Patent Citations (2)
| Title |
|---|
| HUI LI等: "In Vitro and in Vivo Anticancer Activity of Sophorolipids to Human Cervical Cancer" * |
| 朱关平等: "分枝杆菌和珊瑚红球菌细胞壁成分的免疫特性" * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109576180A (zh) * | 2018-12-17 | 2019-04-05 | 北京利昂盛生物技术有限公司 | 一株赤红球菌及其作为免疫佐剂在制备疫苗中的应用 |
| CN109576180B (zh) * | 2018-12-17 | 2021-11-26 | 北京利昂盛生物技术有限公司 | 一株赤红球菌及其作为免疫佐剂在制备疫苗中的应用 |
| CN111787931A (zh) * | 2019-01-15 | 2020-10-16 | 辽宁格瑞仕特生物制药有限公司 | 分离的赤红球菌细胞壁骨架在制备治疗人乳头瘤病毒感染的药物中的用途 |
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