CN1113100C - 用于制备抗坏血酸、2－酮－l－古洛糖酸及2－酮－l－古洛糖酸酯的酶促方法 - Google Patents

用于制备抗坏血酸、2－酮－l－古洛糖酸及2－酮－l－古洛糖酸酯的酶促方法 Download PDF

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Publication number
CN1113100C
CN1113100C CN97196510A CN97196510A CN1113100C CN 1113100 C CN1113100 C CN 1113100C CN 97196510 A CN97196510 A CN 97196510A CN 97196510 A CN97196510 A CN 97196510A CN 1113100 C CN1113100 C CN 1113100C
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klg
lipase
ala
leu
val
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CN97196510A
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CN1225686A (zh
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J·C·胡布斯
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Eastman Chemical Co
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Eastman Chemical Co
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C12P7/60—2-Ketogulonic acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/836—Bacillus licheniformis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/847—Erwinia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/913—Aspergillus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/921—Candida
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/933—Penicillium

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
CN97196510A 1996-05-17 1997-05-16 用于制备抗坏血酸、2－酮－l－古洛糖酸及2－酮－l－古洛糖酸酯的酶促方法 Expired - Fee Related CN1113100C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1787996P 1996-05-17 1996-05-17
US60/017,879 1996-05-17
US08/845,295 US5817490A (en) 1996-05-17 1997-04-25 Enzymatic process for the manufacture of ascorbic acid 2-keto-L-gulonic acid and esters of 2-keto-L-gulonic acid
US08/845,295 1997-04-25

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CNB021199698A Division CN1182250C (zh) 1996-05-17 1997-05-16 用于制备抗坏血酸、2-酮-l-古洛糖酸及2-酮-l-古洛糖酸酯的酶促方法
CNB021199671A Division CN1181206C (zh) 1996-05-17 1997-05-16 用于制备抗坏血酸、2-酮-l-古洛糖酸及2-酮-l-古洛糖酸酯的酶促方法

Publications (2)

Publication Number Publication Date
CN1225686A CN1225686A (zh) 1999-08-11
CN1113100C true CN1113100C (zh) 2003-07-02

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Family Applications (3)

Application Number Title Priority Date Filing Date
CN97196510A Expired - Fee Related CN1113100C (zh) 1996-05-17 1997-05-16 用于制备抗坏血酸、2－酮－l－古洛糖酸及2－酮－l－古洛糖酸酯的酶促方法
CNB021199671A Expired - Fee Related CN1181206C (zh) 1996-05-17 1997-05-16 用于制备抗坏血酸、2-酮-l-古洛糖酸及2-酮-l-古洛糖酸酯的酶促方法
CNB021199698A Expired - Fee Related CN1182250C (zh) 1996-05-17 1997-05-16 用于制备抗坏血酸、2-酮-l-古洛糖酸及2-酮-l-古洛糖酸酯的酶促方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
CNB021199671A Expired - Fee Related CN1181206C (zh) 1996-05-17 1997-05-16 用于制备抗坏血酸、2-酮-l-古洛糖酸及2-酮-l-古洛糖酸酯的酶促方法
CNB021199698A Expired - Fee Related CN1182250C (zh) 1996-05-17 1997-05-16 用于制备抗坏血酸、2-酮-l-古洛糖酸及2-酮-l-古洛糖酸酯的酶促方法

Country Status (10)

Country Link
US (4) US5817490A (enExample)
EP (1) EP0938582B1 (enExample)
JP (1) JP3759621B2 (enExample)
CN (3) CN1113100C (enExample)
AT (1) ATE238429T1 (enExample)
AU (1) AU3075697A (enExample)
BR (1) BR9709099A (enExample)
DE (1) DE69721292T2 (enExample)
MY (1) MY134224A (enExample)
WO (1) WO1997043433A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817490A (en) * 1996-05-17 1998-10-06 Eastman Chemical Company Enzymatic process for the manufacture of ascorbic acid 2-keto-L-gulonic acid and esters of 2-keto-L-gulonic acid
EP1026257B1 (en) * 1999-01-18 2006-04-12 DSM IP Assets B.V. Manufacture of L-ascorbic acid and D-erythorbic acid
ATE323172T1 (de) * 1999-01-18 2006-04-15 Dsm Ip Assets Bv Herstellung von l-ascorbinsäure und d- erythorbinsäure
DE19938980A1 (de) 1999-08-19 2001-02-22 Basf Ag Verfahren zur Herstellung von 2-Keto-L-gulonsäureestern
US6720168B2 (en) 2000-08-04 2004-04-13 Genencor International, Inc. 2,5-DKG permeases
MXPA03001030A (es) * 2000-08-04 2003-11-25 Microgenomics Inc Permeasas del acido 2,5-diceto-d-gluconico.
AU781277B2 (en) * 2000-08-23 2005-05-12 Dsm Ip Assets B.V. Microbial production of L-ascorbic acid and D-erythorbic acid
EP1182262A1 (en) * 2000-08-23 2002-02-27 Roche Vitamins AG Microbial production of l-ascorbic acid and d-erythorbic acid
US6642035B2 (en) * 2001-01-26 2003-11-04 The Scripps Research Institute Synthesis of B-keto esters
US7229811B2 (en) * 2001-08-03 2007-06-12 Genencor International, Inc. 2,5-diketo-D-gluconic acid (2,5-DKG) permeases
US20070298474A1 (en) * 2001-08-03 2007-12-27 Manoj Kumar Enhanced 2-Keto-L-Gulonic acid production
CN1318600C (zh) * 2001-11-09 2007-05-30 Dsmip资产有限公司 生产l－抗坏血酸和d－异抗坏血酸的酶方法
CN1711276A (zh) 2002-11-11 2005-12-21 巴斯福股份公司 制备2－酮基－l－古洛糖酸c4－c10－烷基酯的方法
BRPI0608223A2 (pt) * 2005-02-11 2009-11-24 Dsm Ip Assets Bv gene sms 05
AT502990A1 (de) * 2005-12-27 2007-07-15 Dsm Fine Chem Austria Gmbh Neues polypeptid mit esteraseaktivität, und rekombinante esterase sowie deren verwendung
EP2001350A4 (en) * 2006-03-20 2013-04-17 Teva Womens Health Inc FLEXIBLE COMPRESSED INTRAVAGINAL RINGS, METHOD FOR THEIR PRODUCTION AND USE AND DEVICE FOR THEIR PRODUCTION
JP5438259B2 (ja) * 2006-04-13 2014-03-12 Ｂｉｏ−ｅｎｅｒｇｙ株式会社 カンジダ・アンタークティカ由来リパーゼｂを細胞表層に提示する酵母
US8759044B2 (en) 2011-03-23 2014-06-24 Butamax Advanced Biofuels Llc In situ expression of lipase for enzymatic production of alcohol esters during fermentation
US8765425B2 (en) 2011-03-23 2014-07-01 Butamax Advanced Biofuels Llc In situ expression of lipase for enzymatic production of alcohol esters during fermentation
EP2691532A1 (en) * 2011-03-30 2014-02-05 Novozymes A/S Esterification process
CN103344719B (zh) * 2013-06-27 2015-04-15 东北制药集团股份有限公司 一种可同时检测古龙酸、古龙酸甲酯、甲醇和乙醇的高效液相方法
CN111377543A (zh) * 2018-12-27 2020-07-07 南京百斯杰生物工程有限公司 脂肪酶在降低黄水酸度中的应用
KR102357426B1 (ko) * 2019-12-10 2022-01-28 건국대학교 산학협력단 신규 에스터 가수분해효소를 이용한 베타 아미노산의 효소적 생산방법
CN119876086A (zh) * 2025-01-08 2025-04-25 浙江工业大学 一种脂肪酶突变体及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0207763A2 (en) * 1985-07-01 1987-01-07 Bio-Technical Resources, Inc. L-Ascorbic acid production in microorganisms
EP0292303A1 (en) * 1987-05-21 1988-11-23 Genentech, Inc. Ascorbic acid intermediates and process enzymes

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ES135896A1 (es) * 1933-10-25 1934-12-16 Hoffmann La Roche PROCEDIMIENTO PARA LA FABRICACIoN DEL áCIDO 2-CETO-1-GULoNICO
GB466548A (en) * 1935-11-26 1937-05-31 Tadeus Reichstein Process for the manufacture of laevo-ascorbic acid (vitamin-c)
US4760025A (en) * 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
US4595659A (en) * 1983-10-20 1986-06-17 Kraft, Inc. Fermentation production of ascorbic acid from L-galactonic substrate
CN86105960A (zh) * 1985-08-09 1987-05-13 鲁布里佐尔公司 在基本无水条件下从2-酮-l-古洛糖酸制备l-抗坏血酸
DE69016838T2 (de) * 1989-06-03 1995-07-20 Mitsubishi Rayon Co Verfahren zur Herstellung von organischen Estern.
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JPH061783A (ja) * 1992-06-17 1994-01-11 Mitsubishi Rayon Co Ltd 有機酸エステルの製造法
US5817490A (en) * 1996-05-17 1998-10-06 Eastman Chemical Company Enzymatic process for the manufacture of ascorbic acid 2-keto-L-gulonic acid and esters of 2-keto-L-gulonic acid

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
EP0207763A2 (en) * 1985-07-01 1987-01-07 Bio-Technical Resources, Inc. L-Ascorbic acid production in microorganisms
EP0292303A1 (en) * 1987-05-21 1988-11-23 Genentech, Inc. Ascorbic acid intermediates and process enzymes

Also Published As

Publication number Publication date
ATE238429T1 (de) 2003-05-15
CN1412315A (zh) 2003-04-23
JP3759621B2 (ja) 2006-03-29
EP0938582B1 (en) 2003-04-23
WO1997043433A1 (en) 1997-11-20
US6136575A (en) 2000-10-24
US6271006B1 (en) 2001-08-07
MY134224A (en) 2007-11-30
EP0938582A1 (en) 1999-09-01
AU3075697A (en) 1997-12-05
DE69721292D1 (de) 2003-05-28
CN1412316A (zh) 2003-04-23
JP2001505042A (ja) 2001-04-17
BR9709099A (pt) 1999-08-03
CN1181206C (zh) 2004-12-22
CN1182250C (zh) 2004-12-29
US5817490A (en) 1998-10-06
DE69721292T2 (de) 2003-11-13
US6022719A (en) 2000-02-08
CN1225686A (zh) 1999-08-11

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