DE69721292D1 - Enzymatisches verfahren zur herstellung von ascorbinsäure,2-keto-l-gulonsäure und 2-keto-l-gulonsäure-estern - Google Patents

Enzymatisches verfahren zur herstellung von ascorbinsäure,2-keto-l-gulonsäure und 2-keto-l-gulonsäure-estern

Info

Publication number
DE69721292D1
DE69721292D1 DE69721292T DE69721292T DE69721292D1 DE 69721292 D1 DE69721292 D1 DE 69721292D1 DE 69721292 T DE69721292 T DE 69721292T DE 69721292 T DE69721292 T DE 69721292T DE 69721292 D1 DE69721292 D1 DE 69721292D1
Authority
DE
Germany
Prior art keywords
keto
gulonic acid
acid
gulonic
enzymatic process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69721292T
Other languages
English (en)
Other versions
DE69721292T2 (de
Inventor
Clark Hubbs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eastman Chemical Co
Original Assignee
Eastman Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eastman Chemical Co filed Critical Eastman Chemical Co
Application granted granted Critical
Publication of DE69721292D1 publication Critical patent/DE69721292D1/de
Publication of DE69721292T2 publication Critical patent/DE69721292T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C12P7/60—2-Ketogulonic acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/836—Bacillus licheniformis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/847—Erwinia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/913—Aspergillus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/921—Candida
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/933—Penicillium

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
DE69721292T 1996-05-17 1997-05-16 Enzymatisches verfahren zur herstellung von ascorbinsäure,2-keto-l-gulonsäure und 2-keto-l-gulonsäure-estern Expired - Fee Related DE69721292T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1787996P 1996-05-17 1996-05-17
US08/845,295 US5817490A (en) 1996-05-17 1997-04-25 Enzymatic process for the manufacture of ascorbic acid 2-keto-L-gulonic acid and esters of 2-keto-L-gulonic acid
PCT/US1997/008668 WO1997043433A1 (en) 1996-05-17 1997-05-16 Enzymatic process for the manufacture of ascorbic acid, 2-keto-l-gulonic acid and esters of 2-keto-l-gulonic acid

Publications (2)

Publication Number Publication Date
DE69721292D1 true DE69721292D1 (de) 2003-05-28
DE69721292T2 DE69721292T2 (de) 2003-11-13

Family

ID=26690448

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69721292T Expired - Fee Related DE69721292T2 (de) 1996-05-17 1997-05-16 Enzymatisches verfahren zur herstellung von ascorbinsäure,2-keto-l-gulonsäure und 2-keto-l-gulonsäure-estern

Country Status (10)

Country Link
US (4) US5817490A (de)
EP (1) EP0938582B1 (de)
JP (1) JP3759621B2 (de)
CN (3) CN1182250C (de)
AT (1) ATE238429T1 (de)
AU (1) AU3075697A (de)
BR (1) BR9709099A (de)
DE (1) DE69721292T2 (de)
MY (1) MY134224A (de)
WO (1) WO1997043433A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817490A (en) * 1996-05-17 1998-10-06 Eastman Chemical Company Enzymatic process for the manufacture of ascorbic acid 2-keto-L-gulonic acid and esters of 2-keto-L-gulonic acid
CA2296020A1 (en) * 1999-01-18 2000-07-18 F. Hoffmann-La Roche Ag Manufacture of l-ascorbic acid and d-erythorbic acid
EP1026257B1 (de) * 1999-01-18 2006-04-12 DSM IP Assets B.V. Herstellung von L-Ascorbinsäure und D-Erythorbinsäure
DE19938980A1 (de) 1999-08-19 2001-02-22 Basf Ag Verfahren zur Herstellung von 2-Keto-L-gulonsäureestern
BR0113034B1 (pt) * 2000-08-04 2014-09-16 Genencor Int Método para aumento da produção biossintética de ácido 2-ceto-L-gulônico (2-KLG) de uma célula hospedeira
US6720168B2 (en) 2000-08-04 2004-04-13 Genencor International, Inc. 2,5-DKG permeases
AU781277B2 (en) * 2000-08-23 2005-05-12 Dsm Ip Assets B.V. Microbial production of L-ascorbic acid and D-erythorbic acid
EP1182262A1 (de) * 2000-08-23 2002-02-27 Roche Vitamins AG Mikrobielle Herstellung von L-Ascorbinsäure und D-Erythorbinsäure
US6642035B2 (en) * 2001-01-26 2003-11-04 The Scripps Research Institute Synthesis of B-keto esters
US7229811B2 (en) * 2001-08-03 2007-06-12 Genencor International, Inc. 2,5-diketo-D-gluconic acid (2,5-DKG) permeases
US20070298474A1 (en) * 2001-08-03 2007-12-27 Manoj Kumar Enhanced 2-Keto-L-Gulonic acid production
US7465563B2 (en) 2001-11-09 2008-12-16 Dsm Ip Assets B.V. Enzymatic process for the manufacture of L-ascorbic acid and D-erythorbic acid
ATE322499T1 (de) * 2002-11-11 2006-04-15 Verfahren zur herstellung von 2-keto-l-gulonsäure-c-4 c-10 /sb -alkylestern
BRPI0608223A2 (pt) * 2005-02-11 2009-11-24 Dsm Ip Assets Bv gene sms 05
AT502990A1 (de) * 2005-12-27 2007-07-15 Dsm Fine Chem Austria Gmbh Neues polypeptid mit esteraseaktivität, und rekombinante esterase sowie deren verwendung
MX2008012009A (es) * 2006-03-20 2008-10-03 Duramed Pharmaceuticals Inc Anillos intravaginales comprimidos y flexibles, metodos de elaboracion y utilizacion de los mismos y apaato de elaboracion de los mismos.
JP5438259B2 (ja) * 2006-04-13 2014-03-12 Ｂｉｏ−ｅｎｅｒｇｙ株式会社 カンジダ・アンタークティカ由来リパーゼｂを細胞表層に提示する酵母
US8765425B2 (en) 2011-03-23 2014-07-01 Butamax Advanced Biofuels Llc In situ expression of lipase for enzymatic production of alcohol esters during fermentation
US8759044B2 (en) 2011-03-23 2014-06-24 Butamax Advanced Biofuels Llc In situ expression of lipase for enzymatic production of alcohol esters during fermentation
CN103459607A (zh) * 2011-03-30 2013-12-18 诺维信公司 酯化反应法
CN103344719B (zh) * 2013-06-27 2015-04-15 东北制药集团股份有限公司 一种可同时检测古龙酸、古龙酸甲酯、甲醇和乙醇的高效液相方法
CN111377543A (zh) * 2018-12-27 2020-07-07 南京百斯杰生物工程有限公司 脂肪酶在降低黄水酸度中的应用
KR102357426B1 (ko) * 2019-12-10 2022-01-28 건국대학교 산학협력단 신규 에스터 가수분해효소를 이용한 베타 아미노산의 효소적 생산방법

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES135896A1 (es) * 1933-10-25 1934-12-16 Hoffmann La Roche PROCEDIMIENTO PARA LA FABRICACIoN DEL áCIDO 2-CETO-1-GULoNICO
GB466548A (en) * 1935-11-26 1937-05-31 Tadeus Reichstein Process for the manufacture of laevo-ascorbic acid (vitamin-c)
US4760025A (en) * 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
US4595659A (en) * 1983-10-20 1986-06-17 Kraft, Inc. Fermentation production of ascorbic acid from L-galactonic substrate
US5008193A (en) * 1984-06-14 1991-04-16 Genentech, Inc. Ascorbic acid intermediates and process enzymes
US5001059A (en) * 1985-07-01 1991-03-19 Bio-Technical Resources, Inc. L-ascorbic acid production in microorganisms
CN86105960A (zh) * 1985-08-09 1987-05-13 鲁布里佐尔公司 在基本无水条件下从2-酮-l-古洛糖酸制备l-抗坏血酸
EP0401704B1 (de) * 1989-06-03 1995-02-15 Mitsubishi Rayon Co., Ltd Verfahren zur Herstellung von organischen Estern
JPH04141093A (ja) * 1990-10-03 1992-05-14 Mitsubishi Rayon Co Ltd 有機酸エステルの製造法
JPH04335893A (ja) * 1991-05-07 1992-11-24 Mitsubishi Rayon Co Ltd 固定化酵素を用いるエステル合成方法
DE69221024T2 (de) * 1991-05-18 1997-12-18 Mitsubishi Rayon Co Verfahren zur Herstellung von Ascorbinsäure-Estern oder Erythorbinsäure-Estern
JPH061783A (ja) * 1992-06-17 1994-01-11 Mitsubishi Rayon Co Ltd 有機酸エステルの製造法
US5817490A (en) * 1996-05-17 1998-10-06 Eastman Chemical Company Enzymatic process for the manufacture of ascorbic acid 2-keto-L-gulonic acid and esters of 2-keto-L-gulonic acid

Also Published As

Publication number Publication date
AU3075697A (en) 1997-12-05
CN1225686A (zh) 1999-08-11
US6022719A (en) 2000-02-08
BR9709099A (pt) 1999-08-03
CN1182250C (zh) 2004-12-29
CN1181206C (zh) 2004-12-22
DE69721292T2 (de) 2003-11-13
CN1113100C (zh) 2003-07-02
WO1997043433A1 (en) 1997-11-20
MY134224A (en) 2007-11-30
JP2001505042A (ja) 2001-04-17
JP3759621B2 (ja) 2006-03-29
EP0938582A1 (de) 1999-09-01
CN1412316A (zh) 2003-04-23
EP0938582B1 (de) 2003-04-23
CN1412315A (zh) 2003-04-23
US6271006B1 (en) 2001-08-07
ATE238429T1 (de) 2003-05-15
US6136575A (en) 2000-10-24
US5817490A (en) 1998-10-06

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee