CN110945006A - 用于制备胆汁酸衍生物的方法和中间体 - Google Patents

用于制备胆汁酸衍生物的方法和中间体 Download PDF

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Publication number
CN110945006A
CN110945006A CN201880047896.5A CN201880047896A CN110945006A CN 110945006 A CN110945006 A CN 110945006A CN 201880047896 A CN201880047896 A CN 201880047896A CN 110945006 A CN110945006 A CN 110945006A
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CN
China
Prior art keywords
compound
formula
acid
reacting
disease
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Pending
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CN201880047896.5A
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English (en)
Chinese (zh)
Inventor
R·佩里恰里
A·焦伊洛
加布里埃尔·加尔文
罗纳德·D·路易斯
马修·亚尼克
金明九
弗雷德·罗纳德·莱乌辛克
巴尔特吉安·科宁
托马斯·亨塞尔
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Alpha Sigma Ag
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Intercept Pharmaceuticals Inc
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Publication of CN110945006A publication Critical patent/CN110945006A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
CN201880047896.5A 2017-06-23 2018-06-22 用于制备胆汁酸衍生物的方法和中间体 Pending CN110945006A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762523937P 2017-06-23 2017-06-23
US62/523,937 2017-06-23
PCT/US2018/039148 WO2018237350A1 (en) 2017-06-23 2018-06-22 METHODS AND INTERMEDIATES FOR PREPARING BILARY ACID DERIVATIVES

Publications (1)

Publication Number Publication Date
CN110945006A true CN110945006A (zh) 2020-03-31

Family

ID=64691408

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Application Number Title Priority Date Filing Date
CN201880047896.5A Pending CN110945006A (zh) 2017-06-23 2018-06-22 用于制备胆汁酸衍生物的方法和中间体

Country Status (10)

Country Link
US (2) US11066437B2 (https=)
EP (1) EP3642217A4 (https=)
JP (1) JP7224307B2 (https=)
KR (2) KR20250109791A (https=)
CN (1) CN110945006A (https=)
AU (1) AU2018288883B2 (https=)
BR (1) BR112019027458A2 (https=)
CA (1) CA3067219A1 (https=)
IL (3) IL271343B2 (https=)
WO (1) WO2018237350A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112795615A (zh) * 2021-02-03 2021-05-14 湖南醇康医药科技有限公司 一种诱变菌种以及微生物发酵制备熊去氧胆酸的方法
CN114045239A (zh) * 2021-11-08 2022-02-15 浙江树人学院（浙江树人大学） 具有二甲基乙酰胺降解能力的泛养副球菌ybh-7及应用

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SMT201800657T1 (it) 2013-03-13 2019-01-11 Sage Therapeutics Inc Steroidi neuroattivi e loro metodi di utilizzo
WO2015195967A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
MX382122B (es) 2015-07-06 2025-03-13 Sage Therapeutics Inc Oxiesteroles y metodos de uso de los mismos.
PL3319611T3 (pl) 2015-07-06 2021-07-12 Sage Therapeutics, Inc. Oksysterole i sposoby ich stosowania
AU2016289965B2 (en) 2015-07-06 2021-09-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
MA42339A1 (fr) * 2015-10-07 2019-01-31 Intercept Pharmaceuticals Inc Modulateurs du récepteur farnésoïde x
EP3436022B1 (en) 2016-04-01 2022-03-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
WO2018009867A1 (en) 2016-07-07 2018-01-11 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
PT3519422T (pt) 2016-09-30 2022-12-05 Sage Therapeutics Inc Oxisteróis substituídos em c7 e métodos como moduladores nmda
DK4105223T3 (da) 2016-10-18 2025-07-07 Sage Therapeutics Inc Oxysteroler og fremgangsmåder til anvendelse deraf
CA3041088C (en) 2016-10-18 2024-05-21 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
JP2022552655A (ja) 2019-10-07 2022-12-19 キャリーオペ，インク． Ｇｐｒ１１９アゴニスト
WO2021155167A1 (en) * 2020-01-31 2021-08-05 The Johns Hopkins University Bile acid-gcpii inhibitor conjugates to treat inflammatory diseases
IL295825A (en) 2020-02-28 2022-10-01 Kallyope Inc gpr40 agonists
US12215127B2 (en) 2020-04-17 2025-02-04 Cornell University Compositions and methods for profiling of gut microbiota-associated bile salt hydrolase (BSH) activity
WO2021236617A1 (en) 2020-05-19 2021-11-25 Kallyope, Inc. Ampk activators
CA3183575A1 (en) 2020-06-26 2021-12-30 Iyassu Sebhat Ampk activators
WO2023288123A1 (en) * 2021-07-16 2023-01-19 Interecept Pharmaceuticals, Inc. Methods and intermediates for the preparation of 3.alpha.,7.alpha.,11.beta.-trihydroxy-6.alpha.-ethyl-5.beta.-cholan-24-oic acid
WO2023205447A2 (en) * 2022-04-21 2023-10-26 Intercept Pharmaceuticals, Inc. Uses of farnesoid x receptor agonists
WO2024163640A2 (en) * 2023-02-01 2024-08-08 Intercept Pharmaceuticals, Inc. Methods and intermediates for the preparation of bile acid derivatives

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US3277121A (en) * 1964-05-04 1966-10-04 Canada Packers Ltd Conversion of delta11-steroids to 11-oxygenated steroids
DE3040634A1 (de) * 1980-10-29 1982-05-27 Hoechst Ag, 6000 Frankfurt Verfahren zur herstellung von 3 (alpha) -hydroxy-5- (beta) -pregnan-11,20-dion
WO2014184271A1 (en) * 2013-05-14 2014-11-20 Tes Pharma Srl. 11-hydroxyl-derivatives of bile acids and amino acid conjugates thereof as farnesoid x receptor modulators
WO2017062763A1 (en) * 2015-10-07 2017-04-13 Intercept Pharmaceuticals, Inc. Farnesoid x receptor modulators

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JPS58155098A (ja) * 1982-03-09 1983-09-14 Yakult Honsha Co Ltd 微生物によるウルソデオキシコ−ル酸の製造法
DK0464153T3 (da) * 1989-02-07 1995-04-24 Upjohn Co Dehalogenering af organiske forbindelser under anvendelse af tin eller bly
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US10604544B2 (en) 2015-08-07 2020-03-31 Intercept Pharmaceuticals, Inc. Methods for preparation of bile acids and derivatives thereof
CN107973834A (zh) 2016-10-22 2018-05-01 合帕吉恩治疗公司 作为fxr/tgr5调节剂的胆酸衍生物
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US2554882A (en) * 1943-02-04 1951-05-29 Reichstein Tadeus 3-hydroxy-11-ketoetiocholanic acid and its esters
US3277121A (en) * 1964-05-04 1966-10-04 Canada Packers Ltd Conversion of delta11-steroids to 11-oxygenated steroids
DE3040634A1 (de) * 1980-10-29 1982-05-27 Hoechst Ag, 6000 Frankfurt Verfahren zur herstellung von 3 (alpha) -hydroxy-5- (beta) -pregnan-11,20-dion
WO2014184271A1 (en) * 2013-05-14 2014-11-20 Tes Pharma Srl. 11-hydroxyl-derivatives of bile acids and amino acid conjugates thereof as farnesoid x receptor modulators
WO2017062763A1 (en) * 2015-10-07 2017-04-13 Intercept Pharmaceuticals, Inc. Farnesoid x receptor modulators

Non-Patent Citations (3)

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LEWIS HASTINGS SARETT: "PARTIAL SYNTHESIS OF PREGNENE-4-TRIOL-17(β),20(β),21-DIONE-3,11 AND PREGNENE-4-DIOL-17(β),21-TRIONE-3,11,20 MONOACETATE", 《JOURNAL OF BIOLOGICAL CHEMISTRY》 *
VON A. LARDON, T. REIEHSTEIN: "Über Gallensäuren und verwandte Stoffe. 35. Mitteilung1). 3α-Acetoxy-nor-, bisnor- und -ätio-cholen-(9)-säure-methylester", 《HELVETICA CHIMICA ACTA》 *
VON G. H. OTT, T. REICHSTEIN: "Über Gallensäuren und verwandte Stoffe. 27. Mitteilung. α-Oxyde der beiden 3-Oxy- und der 3-Keto-cholen-(11)-säure", 《HELVETICA CHIMICA ACTA》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112795615A (zh) * 2021-02-03 2021-05-14 湖南醇康医药科技有限公司 一种诱变菌种以及微生物发酵制备熊去氧胆酸的方法
CN114045239A (zh) * 2021-11-08 2022-02-15 浙江树人学院（浙江树人大学） 具有二甲基乙酰胺降解能力的泛养副球菌ybh-7及应用
CN114045239B (zh) * 2021-11-08 2023-09-29 浙江树人学院（浙江树人大学） 具有二甲基乙酰胺降解能力的泛养副球菌ybh-7及应用

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US20220127302A1 (en) 2022-04-28
BR112019027458A2 (pt) 2020-07-07
CA3067219A1 (en) 2018-12-27
JP7224307B2 (ja) 2023-02-17
US20180371009A1 (en) 2018-12-27
JP2020525426A (ja) 2020-08-27
KR102831293B1 (ko) 2025-07-08
IL304455A (en) 2023-09-01
IL271343B1 (en) 2023-08-01
KR20250109791A (ko) 2025-07-17
IL271343B2 (en) 2023-12-01
AU2018288883B2 (en) 2022-06-02
KR20200020877A (ko) 2020-02-26
WO2018237350A1 (en) 2018-12-27
EP3642217A1 (en) 2020-04-29
EP3642217A4 (en) 2021-06-16
IL304455B1 (en) 2026-03-01
US11066437B2 (en) 2021-07-20
IL326587A (en) 2026-04-01
AU2018288883A1 (en) 2020-01-16
IL271343A (en) 2020-01-30

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