CN110088079A - 用于早期沙卡布曲中间体的新方法 - Google Patents

用于早期沙卡布曲中间体的新方法 Download PDF

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Publication number
CN110088079A
CN110088079A CN201780078296.0A CN201780078296A CN110088079A CN 110088079 A CN110088079 A CN 110088079A CN 201780078296 A CN201780078296 A CN 201780078296A CN 110088079 A CN110088079 A CN 110088079A
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compound
formula
salt
group
alkyl
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Chinese (zh)
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F·K·克伦贝克-莱尼克
T·卡普菲尔
K·劳门
T·鲁赫
T·施拉玛
J·库
Y·李
W·彭
Y·杨
H·金
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201780078296.0A 2016-12-23 2017-12-20 用于早期沙卡布曲中间体的新方法 Pending CN110088079A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2016111674 2016-12-23
CNPCT/CN2016/111674 2016-12-23
PCT/IB2017/058203 WO2018116203A1 (en) 2016-12-23 2017-12-20 New process for early sacubitril intermediates

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CN110088079A true CN110088079A (zh) 2019-08-02

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US (1) US10774036B2 (https=)
EP (1) EP3558930B1 (https=)
JP (1) JP7138106B2 (https=)
CN (1) CN110088079A (https=)
ES (1) ES2883363T3 (https=)
WO (1) WO2018116203A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111205204A (zh) * 2020-01-16 2020-05-29 南京红杉生物科技有限公司 沙库必曲中间体及其合成方法、应用
CN114524741A (zh) * 2022-02-15 2022-05-24 上海龙翔生物医药开发有限公司 一种抗肿瘤药物美法仑的合成工艺
CN116606224A (zh) * 2023-04-18 2023-08-18 重庆普佑生物医药有限公司 一种沙库比曲中间体的酶催化制备方法

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CN110964759B (zh) * 2018-09-28 2021-04-09 北京瑞莱博基医药科技有限公司 一种抗心衰药物中间体的新合成工艺
CN111748590B (zh) * 2019-03-29 2024-05-28 弈柯莱(台州)药业有限公司 转氨酶在制备Sacubitril中间体中的应用
EP4630568A1 (en) * 2022-12-09 2025-10-15 KRKA, D.D., Novo Mesto Process for the preparation of sitagliptin
CN118931983A (zh) * 2024-07-24 2024-11-12 苏州弗莱明生物技术有限公司 一种沙库巴曲中间体及其制备方法

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Cited By (3)

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Publication number Priority date Publication date Assignee Title
CN111205204A (zh) * 2020-01-16 2020-05-29 南京红杉生物科技有限公司 沙库必曲中间体及其合成方法、应用
CN114524741A (zh) * 2022-02-15 2022-05-24 上海龙翔生物医药开发有限公司 一种抗肿瘤药物美法仑的合成工艺
CN116606224A (zh) * 2023-04-18 2023-08-18 重庆普佑生物医药有限公司 一种沙库比曲中间体的酶催化制备方法

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ES2883363T3 (es) 2021-12-07
EP3558930B1 (en) 2021-05-26
WO2018116203A1 (en) 2018-06-28
US10774036B2 (en) 2020-09-15
JP2020502244A (ja) 2020-01-23
JP7138106B2 (ja) 2022-09-15
EP3558930A1 (en) 2019-10-30
US20190359554A1 (en) 2019-11-28

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