CN1096784A - 含取代4(5)-氨基-1,8-二氨杂萘的治疗剂 - Google Patents

含取代4(5)-氨基-1,8-二氨杂萘的治疗剂 Download PDF

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Publication number
CN1096784A
CN1096784A CN93109454A CN93109454A CN1096784A CN 1096784 A CN1096784 A CN 1096784A CN 93109454 A CN93109454 A CN 93109454A CN 93109454 A CN93109454 A CN 93109454A CN 1096784 A CN1096784 A CN 1096784A
Authority
CN
China
Prior art keywords
formula
alkyl
compound
methyl
ethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN93109454A
Other languages
English (en)
Chinese (zh)
Inventor
B·J·阿米
J·G·包文
M·J·克罗斯利
I·M·亨尼波尔
B·W·莱斯利
T·K·米勒
M·施包维奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boots Co PLC
Original Assignee
Boots Co PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB919127252A priority Critical patent/GB9127252D0/en
Priority to US08/244,369 priority patent/US5464781A/en
Priority to CZ941535A priority patent/CZ153594A3/cs
Priority to AT93900052T priority patent/ATE171452T1/de
Priority to EP93900052A priority patent/EP0618916B1/en
Priority to PCT/EP1992/002901 priority patent/WO1993013097A1/en
Priority to DE69227125T priority patent/DE69227125T2/de
Priority to NZ246156A priority patent/NZ246156A/en
Priority to AU31587/93A priority patent/AU656832B2/en
Priority to CA002125858A priority patent/CA2125858A1/en
Priority to JP5511397A priority patent/JP2527917B2/ja
Priority to HU9401877A priority patent/HUT66971A/hu
Priority to SK750-94A priority patent/SK75094A3/sk
Priority to IN758MA1992 priority patent/IN174405B/en
Priority to IL104169A priority patent/IL104169A0/xx
Priority to SI19929200408A priority patent/SI9200408A/sl
Priority to MX9207494A priority patent/MX9207494A/es
Priority to HR921455A priority patent/HRP921455A2/hr
Application filed by Boots Co PLC filed Critical Boots Co PLC
Priority to CN93109454A priority patent/CN1096784A/zh
Priority to BG98813A priority patent/BG98813A/bg
Priority to FI943019A priority patent/FI943019A7/fi
Priority to NO942376A priority patent/NO942376L/no
Publication of CN1096784A publication Critical patent/CN1096784A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN93109454A 1991-12-23 1993-06-22 含取代4(5)-氨基-1,8-二氨杂萘的治疗剂 Pending CN1096784A (zh)

Priority Applications (22)

Application Number Priority Date Filing Date Title
GB919127252A GB9127252D0 (en) 1991-12-23 1991-12-23 Therapeutic agents
US08/244,369 US5464781A (en) 1991-12-23 1992-10-12 Amino naphthyridine compounds as anti-rhoumatic agents
SK750-94A SK75094A3 (en) 1991-12-23 1992-12-12 Naphthyridine derivatives
EP93900052A EP0618916B1 (en) 1991-12-23 1992-12-12 Anti-rheumatic naphthyridine derivatives
PCT/EP1992/002901 WO1993013097A1 (en) 1991-12-23 1992-12-12 Anti-rheumatic naphthyridine derivatives
DE69227125T DE69227125T2 (de) 1991-12-23 1992-12-12 Antirheumatische naphthyridinderivate.
NZ246156A NZ246156A (en) 1991-12-23 1992-12-12 4-anilino-1,8-naphthyridine derivatives and pharmaceutical compositions
AU31587/93A AU656832B2 (en) 1991-12-23 1992-12-12 Anti-rheumatic naphthyridine derivatives
CA002125858A CA2125858A1 (en) 1991-12-23 1992-12-12 Therapeutic agents
AT93900052T ATE171452T1 (de) 1991-12-23 1992-12-12 Antirheumatische naphthyridinderivate.
HU9401877A HUT66971A (en) 1991-12-23 1992-12-12 4-amino-naphthyridine derivatives pharmaceutical compositions containing the same and process for the production of thereof
CZ941535A CZ153594A3 (en) 1991-12-23 1992-12-12 Therapeutically active substances
JP5511397A JP2527917B2 (ja) 1991-12-23 1992-12-12 治療薬
IN758MA1992 IN174405B (enExample) 1991-12-23 1992-12-17
IL104169A IL104169A0 (en) 1991-12-23 1992-12-18 Therapeutic agents
SI19929200408A SI9200408A (en) 1991-12-23 1992-12-22 Substituted 4(5)-amino-1,8-naphtyridine derivatives
MX9207494A MX9207494A (es) 1991-12-23 1992-12-22 4(5)-amino-1,8-naftiridinas substituidas, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
HR921455A HRP921455A2 (en) 1991-12-23 1992-12-22 Substituted 4(5)-amino-1,8-naphthyridines
CN93109454A CN1096784A (zh) 1991-12-23 1993-06-22 含取代4(5)-氨基-1,8-二氨杂萘的治疗剂
BG98813A BG98813A (bg) 1991-12-23 1994-05-31 Терапевтични средства
FI943019A FI943019A7 (fi) 1991-12-23 1994-06-22 Terapeuttisia aineita
NO942376A NO942376L (no) 1991-12-23 1994-06-22 Terapeutiske midler

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919127252A GB9127252D0 (en) 1991-12-23 1991-12-23 Therapeutic agents
CN93109454A CN1096784A (zh) 1991-12-23 1993-06-22 含取代4(5)-氨基-1,8-二氨杂萘的治疗剂

Publications (1)

Publication Number Publication Date
CN1096784A true CN1096784A (zh) 1994-12-28

Family

ID=36822317

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93109454A Pending CN1096784A (zh) 1991-12-23 1993-06-22 含取代4(5)-氨基-1,8-二氨杂萘的治疗剂

Country Status (22)

Country Link
US (1) US5464781A (enExample)
EP (1) EP0618916B1 (enExample)
JP (1) JP2527917B2 (enExample)
CN (1) CN1096784A (enExample)
AT (1) ATE171452T1 (enExample)
AU (1) AU656832B2 (enExample)
BG (1) BG98813A (enExample)
CA (1) CA2125858A1 (enExample)
CZ (1) CZ153594A3 (enExample)
DE (1) DE69227125T2 (enExample)
FI (1) FI943019A7 (enExample)
GB (1) GB9127252D0 (enExample)
HR (1) HRP921455A2 (enExample)
HU (1) HUT66971A (enExample)
IL (1) IL104169A0 (enExample)
IN (1) IN174405B (enExample)
MX (1) MX9207494A (enExample)
NO (1) NO942376L (enExample)
NZ (1) NZ246156A (enExample)
SI (1) SI9200408A (enExample)
SK (1) SK75094A3 (enExample)
WO (1) WO1993013097A1 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9312891D0 (en) * 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
GB9318931D0 (en) * 1993-09-14 1993-10-27 Boots Co Plc Therapeutic agents
GB9420168D0 (en) * 1994-10-06 1994-11-23 Boots Co Plc Therapeutic agents
AR004010A1 (es) 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
WO1998013350A1 (en) 1996-09-25 1998-04-02 Zeneca Limited Qinoline derivatives inhibiting the effect of growth factors such as vegf
GB9800569D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
US6166069A (en) * 1998-05-12 2000-12-26 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
JP2003504363A (ja) 1999-07-09 2003-02-04 グラクソ グループ リミテッド プロテインチロシンキナーゼ阻害剤としてのアニリノキナゾリン類
US6933299B1 (en) 1999-07-09 2005-08-23 Smithkline Beecham Corporation Anilinoquinazolines as protein tyrosine kinase inhibitors
AU779695B2 (en) 2000-04-07 2005-02-10 Astrazeneca Ab Quinazoline compounds
US6534656B2 (en) * 2001-05-31 2003-03-18 North Carolina State University Short synthesis of pyridine-based pharmaceutical intermediates
JP2003329989A (ja) * 2002-03-06 2003-11-19 Nippon Telegr & Teleph Corp <Ntt> 光送信装置
GB0230018D0 (en) 2002-12-23 2003-01-29 Syngenta Ltd Fungicides
CN1984660B (zh) 2003-07-03 2010-12-15 美瑞德生物工程公司 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
KR100807920B1 (ko) 2003-12-23 2008-02-27 화이자 인코포레이티드 신규한 퀴놀린 유도체
EP1833482A4 (en) 2005-01-03 2011-02-16 Myriad Genetics Inc COMPOUNDS AND ITS THERAPEUTIC USE
US8258145B2 (en) * 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
EP2345652A1 (en) 2005-12-21 2011-07-20 Abbott Laboratories Antiviral compounds
RU2467007C2 (ru) 2005-12-21 2012-11-20 Эбботт Лэборетриз Производные [1,8]нафтиридина, полезные в качестве ингибиторов репликации вируса hcv
ES2395386T3 (es) * 2005-12-21 2013-02-12 Abbott Laboratories Compuestos antivirales
RU2441869C2 (ru) * 2005-12-21 2012-02-10 Эбботт Лэборетриз Противовирусные соединения
TWI392676B (zh) * 2005-12-21 2013-04-11 Abbott Lab 抗病毒化合物、其製備方法及用途
CA2672737A1 (en) 2006-12-20 2008-11-06 Abbott Laboratories Anti-viral compounds
KR20110025856A (ko) * 2008-07-03 2011-03-11 메르크 파텐트 게엠베하 오로라 키나아제 억제제로서 나프티리디니논
US8415333B2 (en) 2009-02-24 2013-04-09 Respiratorious Ab Bronchodilating diazaheteroaryls
WO2011063398A1 (en) * 2009-11-23 2011-05-26 Cylene Pharamaceuticals, Inc. Polymorphs and salts of a kinase inhibitor
NZ603332A (en) 2010-04-02 2014-11-28 Senomyx Inc Sweet flavor modifier

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4466965A (en) * 1982-07-26 1984-08-21 American Hospital Supply Corporation Phthalazine compounds, compositions and use
NZ213986A (en) * 1984-10-30 1989-07-27 Usv Pharma Corp Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such
EP0222839A4 (en) * 1985-05-17 1988-11-09 Univ Australian ANTI-MALARIA COMPOUNDS.
JPS6368568A (ja) * 1986-09-10 1988-03-28 Otsuka Pharmaceut Factory Inc ｐ−アミノフエノ−ル誘導体
DE3644825A1 (de) * 1986-12-31 1988-07-14 Basf Ag Substituierte 1,8-naphthyridin-derivate und diese enthaltende fungizide
EP0302303A3 (en) * 1987-07-22 1989-05-24 Schering Corporation Bicyclic compounds, their use as pharmaceuticals, their preparation, and intermediates useful in their preparation
GB8804443D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
US4978661A (en) * 1988-09-29 1990-12-18 Innocenzo Caruso Use of 6-halo-4-quinolone compounds and pharmaceutical compositions thereof for the preparation of a medicament for the therapeutical application in rheumatoid arthritis
GR900100380A (el) * 1989-05-20 1991-10-10 Fisons Plc Μέ?οδος παρασκευής αντι-φλεγμονωδών παραγώγων αμινοφενόλης.
AU634561B2 (en) * 1989-07-27 1993-02-25 Eli Lilly And Company Naphthyridine derivatives
JP2988739B2 (ja) * 1990-04-16 1999-12-13 協和醗酵工業株式会社 １，８−ナフチリジン−２−オン誘導体
JP3157077B2 (ja) * 1994-02-16 2001-04-16 内山工業株式会社 ベアリングシール

Also Published As

Publication number Publication date
AU3158793A (en) 1993-07-28
HUT66971A (en) 1995-01-30
JPH07502280A (ja) 1995-03-09
NZ246156A (en) 1996-01-26
DE69227125T2 (de) 1999-02-18
FI943019A0 (fi) 1994-06-22
HRP921455A2 (en) 1994-12-31
SK75094A3 (en) 1995-04-12
JP2527917B2 (ja) 1996-08-28
NO942376D0 (enExample) 1994-06-22
FI943019A7 (fi) 1994-06-22
MX9207494A (es) 1993-07-01
ATE171452T1 (de) 1998-10-15
AU656832B2 (en) 1995-02-16
BG98813A (bg) 1995-05-31
HU9401877D0 (en) 1994-09-28
EP0618916B1 (en) 1998-09-23
IN174405B (enExample) 1994-11-26
WO1993013097A1 (en) 1993-07-08
EP0618916A1 (en) 1994-10-12
DE69227125D1 (de) 1998-10-29
NO942376L (no) 1994-06-22
GB9127252D0 (en) 1992-02-19
SI9200408A (en) 1993-09-30
CZ153594A3 (en) 1995-02-15
US5464781A (en) 1995-11-07
CA2125858A1 (en) 1993-07-08
IL104169A0 (en) 1993-05-13

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication