ATE171452T1 - Antirheumatische naphthyridinderivate. - Google Patents

Antirheumatische naphthyridinderivate.

Info

Publication number
ATE171452T1
ATE171452T1 AT93900052T AT93900052T ATE171452T1 AT E171452 T1 ATE171452 T1 AT E171452T1 AT 93900052 T AT93900052 T AT 93900052T AT 93900052 T AT93900052 T AT 93900052T AT E171452 T1 ATE171452 T1 AT E171452T1
Authority
AT
Austria
Prior art keywords
alkyl
represents hydrogen
halo
alkoxy
pct
Prior art date
Application number
AT93900052T
Other languages
English (en)
Inventor
Bernard John Armitage
John Gareth Bowen
Malcolm John Crossley
Ian Michael Hunneyball
Bruce William Leslie
Thomas Kerr Miller
Michael Spowage
Original Assignee
Knoll Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Ag filed Critical Knoll Ag
Application granted granted Critical
Publication of ATE171452T1 publication Critical patent/ATE171452T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT93900052T 1991-12-23 1992-12-12 Antirheumatische naphthyridinderivate. ATE171452T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919127252A GB9127252D0 (en) 1991-12-23 1991-12-23 Therapeutic agents
CN93109454A CN1096784A (zh) 1991-12-23 1993-06-22 含取代4(5)-氨基-1,8-二氨杂萘的治疗剂

Publications (1)

Publication Number Publication Date
ATE171452T1 true ATE171452T1 (de) 1998-10-15

Family

ID=36822317

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93900052T ATE171452T1 (de) 1991-12-23 1992-12-12 Antirheumatische naphthyridinderivate.

Country Status (22)

Country Link
US (1) US5464781A (de)
EP (1) EP0618916B1 (de)
JP (1) JP2527917B2 (de)
CN (1) CN1096784A (de)
AT (1) ATE171452T1 (de)
AU (1) AU656832B2 (de)
BG (1) BG98813A (de)
CA (1) CA2125858A1 (de)
CZ (1) CZ153594A3 (de)
DE (1) DE69227125T2 (de)
FI (1) FI943019A (de)
GB (1) GB9127252D0 (de)
HR (1) HRP921455A2 (de)
HU (1) HUT66971A (de)
IL (1) IL104169A0 (de)
IN (1) IN174405B (de)
MX (1) MX9207494A (de)
NO (1) NO942376L (de)
NZ (1) NZ246156A (de)
SI (1) SI9200408A (de)
SK (1) SK75094A3 (de)
WO (1) WO1993013097A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9312891D0 (en) * 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
GB9318931D0 (en) * 1993-09-14 1993-10-27 Boots Co Plc Therapeutic agents
GB9420168D0 (en) * 1994-10-06 1994-11-23 Boots Co Plc Therapeutic agents
AR004010A1 (es) 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
IL128994A (en) * 1996-09-25 2004-12-15 Zeneca Ltd History of quinoline and naphthyridine and their salts, processes for their preparation, pharmaceutical preparations containing them and their use as medicines
RS49779B (sr) 1998-01-12 2008-06-05 Glaxo Group Limited, Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
US6166069A (en) * 1998-05-12 2000-12-26 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
WO2001004111A1 (en) 1999-07-09 2001-01-18 Glaxo Group Limited Anilinoquinazolines as protein tyrosine kinase inhibitors
US6933299B1 (en) 1999-07-09 2005-08-23 Smithkline Beecham Corporation Anilinoquinazolines as protein tyrosine kinase inhibitors
ES2267748T3 (es) 2000-04-07 2007-03-16 Astrazeneca Ab Compuestos de quinazolina.
US6534656B2 (en) * 2001-05-31 2003-03-18 North Carolina State University Short synthesis of pyridine-based pharmaceutical intermediates
JP2003329989A (ja) * 2002-03-06 2003-11-19 Nippon Telegr & Teleph Corp <Ntt> 光送信装置
GB0230018D0 (en) 2002-12-23 2003-01-29 Syngenta Ltd Fungicides
WO2005003100A2 (en) 2003-07-03 2005-01-13 Myriad Genetics, Inc. 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
SG141459A1 (en) 2003-12-23 2008-04-28 Pfizer Novel quinoline derivatives
CA2592900A1 (en) 2005-01-03 2006-07-13 Myriad Genetics Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
US8258145B2 (en) * 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
TWI392677B (zh) * 2005-12-21 2013-04-11 Abbott Lab 抗病毒化合物、其製備方法及用途
EP1979349B1 (de) * 2005-12-21 2010-07-28 Abbott Laboratories Antivirale verbindungen
EP2345652A1 (de) 2005-12-21 2011-07-20 Abbott Laboratories Antivirale Verbindungen
AU2006330924B2 (en) * 2005-12-21 2012-03-15 Abbvie Inc. Anti-viral compounds
ES2395386T3 (es) 2005-12-21 2013-02-12 Abbott Laboratories Compuestos antivirales
EP2094276A4 (de) 2006-12-20 2011-01-05 Abbott Lab Antivirale verbindungen
EA201100126A1 (ru) * 2008-07-03 2011-08-30 Мерк Патент Гмбх Нафтиридиноны в качестве ингибиторов протеинкиназ
US8415333B2 (en) 2009-02-24 2013-04-09 Respiratorious Ab Bronchodilating diazaheteroaryls
WO2011063398A1 (en) * 2009-11-23 2011-05-26 Cylene Pharamaceuticals, Inc. Polymorphs and salts of a kinase inhibitor
RU2605549C2 (ru) 2010-04-02 2016-12-20 Синомикс, Инк. Производные 3-карбокси-4-аминохинолина, полезные как модификаторы сладкого вкуса

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4466965A (en) * 1982-07-26 1984-08-21 American Hospital Supply Corporation Phthalazine compounds, compositions and use
NZ213986A (en) * 1984-10-30 1989-07-27 Usv Pharma Corp Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such
WO1986006718A1 (en) * 1985-05-17 1986-11-20 The Australian National University Antimalarial compounds
JPS6368568A (ja) * 1986-09-10 1988-03-28 Otsuka Pharmaceut Factory Inc ｐ−アミノフエノ−ル誘導体
DE3644825A1 (de) * 1986-12-31 1988-07-14 Basf Ag Substituierte 1,8-naphthyridin-derivate und diese enthaltende fungizide
AU632461B2 (en) * 1987-07-22 1993-01-07 Schering Corporation Bicyclic compounds, their use as pharmaceuticals, their preparation, and intermediates useful in their preparation
GB8804443D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
US4978661A (en) * 1988-09-29 1990-12-18 Innocenzo Caruso Use of 6-halo-4-quinolone compounds and pharmaceutical compositions thereof for the preparation of a medicament for the therapeutical application in rheumatoid arthritis
GR900100380A (el) * 1989-05-20 1991-10-10 Fisons Plc Μέ?οδος παρασκευής αντι-φλεγμονωδών παραγώγων αμινοφενόλης.
AU634561B2 (en) * 1989-07-27 1993-02-25 Eli Lilly And Company Naphthyridine derivatives
JP2988739B2 (ja) * 1990-04-16 1999-12-13 協和醗酵工業株式会社 １，８−ナフチリジン−２−オン誘導体
JP3157077B2 (ja) * 1994-02-16 2001-04-16 内山工業株式会社 ベアリングシール

Also Published As

Publication number Publication date
CA2125858A1 (en) 1993-07-08
NO942376D0 (de) 1994-06-22
WO1993013097A1 (en) 1993-07-08
IL104169A0 (en) 1993-05-13
EP0618916A1 (de) 1994-10-12
GB9127252D0 (en) 1992-02-19
SK75094A3 (en) 1995-04-12
NZ246156A (en) 1996-01-26
IN174405B (de) 1994-11-26
CN1096784A (zh) 1994-12-28
DE69227125T2 (de) 1999-02-18
US5464781A (en) 1995-11-07
FI943019A0 (fi) 1994-06-22
BG98813A (bg) 1995-05-31
JPH07502280A (ja) 1995-03-09
NO942376L (no) 1994-06-22
JP2527917B2 (ja) 1996-08-28
AU656832B2 (en) 1995-02-16
HUT66971A (en) 1995-01-30
MX9207494A (es) 1993-07-01
CZ153594A3 (en) 1995-02-15
DE69227125D1 (de) 1998-10-29
HRP921455A2 (en) 1994-12-31
EP0618916B1 (de) 1998-09-23
AU3158793A (en) 1993-07-28
SI9200408A (en) 1993-09-30
FI943019A (fi) 1994-06-22
HU9401877D0 (en) 1994-09-28

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee