CN109475640B - 核酸被运载物的混合载运体 - Google Patents

核酸被运载物的混合载运体 Download PDF

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Publication number
CN109475640B
CN109475640B CN201780036069.1A CN201780036069A CN109475640B CN 109475640 B CN109475640 B CN 109475640B CN 201780036069 A CN201780036069 A CN 201780036069A CN 109475640 B CN109475640 B CN 109475640B
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cys
nucleic acid
rna
orn
lys
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CN109475640A (zh
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帕特里克·鲍姆霍夫
卡罗琳·蒂勒
乔安娜·雷杰曼
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Kurewag Europe
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Kurewag Europe
Curevac AG
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    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/14—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic the nitrogen atom of the amino group being further bound to hydrocarbon groups substituted by amino groups
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CN201780036069.1A 2016-06-09 2017-06-09 核酸被运载物的混合载运体 Expired - Fee Related CN109475640B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2016063226 2016-06-09
EPPCT/EP2016/063226 2016-06-09
PCT/EP2017/064059 WO2017212009A1 (en) 2016-06-09 2017-06-09 Hybrid carriers for nucleic acid cargo

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CN109475640A CN109475640A (zh) 2019-03-15
CN109475640B true CN109475640B (zh) 2023-03-10

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US (2) US11478552B2 (https=)
EP (1) EP3468613A1 (https=)
JP (1) JP7145579B2 (https=)
KR (1) KR20190029576A (https=)
CN (1) CN109475640B (https=)
AU (1) AU2017277731B2 (https=)
BR (1) BR112018075479A2 (https=)
CA (1) CA3023174A1 (https=)
MX (1) MX2018013919A (https=)
RU (1) RU2751001C2 (https=)
SG (1) SG11201809912UA (https=)
WO (1) WO2017212009A1 (https=)

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WO2012116714A1 (en) 2011-03-02 2012-09-07 Curevac Gmbh Vaccination in elderly patients
WO2013120499A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen
RU2658490C2 (ru) 2012-03-27 2018-06-21 Кьюрвак Аг Искусственные молекулы нуклеиновых кислот для улучшенной экспрессии белков или пептидов
RU2718988C2 (ru) 2013-02-22 2020-04-15 Куревак Аг Комбинация противораковой рнк-вакцины и ингибитора пути pd-1 и ее применение
AU2014310935B2 (en) 2013-08-21 2019-11-21 CureVac SE Combination vaccine
BR112016003361A2 (pt) 2013-08-21 2017-11-21 Curevac Ag vacina do vírus sincicial respiratório (rsv)
ES2806575T3 (es) 2013-11-01 2021-02-18 Curevac Ag ARN modificado con propiedades inmunoestimuladoras disminuidas
WO2015135558A1 (en) 2014-03-12 2015-09-17 Curevac Gmbh Combination of vaccination and ox40 agonists
DE202015010000U1 (de) 2014-12-12 2023-07-03 CureVac SE Artifizielle Nukleinsäuremoleküle für eine verbesserte Proteinexpression
DK3294885T3 (da) 2015-05-08 2020-08-10 Curevac Real Estate Gmbh Fremgangsmåde til at fremstille rna
PL4108769T3 (pl) 2015-05-29 2024-02-05 CureVac Manufacturing GmbH Sposób wytwarzania i oczyszczania rna obejmujący co najmniej jeden etap filtracji o przepływie stycznym
US11225682B2 (en) 2015-10-12 2022-01-18 Curevac Ag Automated method for isolation, selection and/or detection of microorganisms or cells comprised in a solution
US11413346B2 (en) 2015-11-09 2022-08-16 Curevac Ag Rotavirus vaccines
EP3701963A1 (en) 2015-12-22 2020-09-02 CureVac AG Method for producing rna molecule compositions
EP3394280A1 (en) 2015-12-23 2018-10-31 CureVac AG Method of rna in vitro transcription using a buffer containing a dicarboxylic acid or tricarboxylic acid or a salt thereof
US11723967B2 (en) 2016-02-17 2023-08-15 CureVac SE Zika virus vaccine
EP3423595A1 (en) 2016-03-03 2019-01-09 CureVac AG Rna analysis by total hydrolysis
WO2017186928A1 (en) 2016-04-29 2017-11-02 Curevac Ag Rna encoding an antibody
EP3452101A2 (en) 2016-05-04 2019-03-13 CureVac AG Rna encoding a therapeutic protein
EP4631970A3 (en) 2016-05-04 2026-01-07 CureVac SE Nucleic acid molecules and uses thereof
EP4233898A3 (en) 2016-05-04 2023-11-01 CureVac SE Influenza mrna vaccines
WO2017212009A1 (en) 2016-06-09 2017-12-14 Curevac Ag Hybrid carriers for nucleic acid cargo
US11279923B2 (en) 2016-11-28 2022-03-22 Curevac Ag Method for purifying RNA
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