CN109464342B - A kind of anti-aging Essence and preparation method thereof - Google Patents
A kind of anti-aging Essence and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of anti-aging Essences, include the following components'mass percentage: active peptide 0.01-2%, polyalcohol 3-15%, moisturizer 0.01-10%, plant antiseptic agent 0.5-1.2%, skin conditioning agent 0.1-10%, chelating agent 0.02-0.1%, anti-inflammatory renovation agent 0.1-2% and balance deionized water.The present invention also provides the preparation method of above-mentioned anti-aging Essence and its preparing the application in skin nursing products.Anti-aging Essence of the invention, can be used for daily skin care, has moisturizing, anti-inflammatory releive, desalinates wrinkle, bright color effect, simultaneously, using natural plant preservative, solves deactivation prob when active peptide and traditional chemical preservative compatibility, guarantee the stability of product function.
Description
Technical field
The invention belongs to cosmetic technical fields, and in particular to it is a kind of have effects that desalinate wrinkle anti-aging Essence and
Preparation method.
Background technique
Skin aging refers to that skin function Aging damages, and makes skin to the protective capacities of body, and regulating power etc. declines,
Thus skin does not adapt to the variation of internal and external environment, the change of the appearances integral status such as color, color, form, texture occurs.Skin
Skin aging is the external manifestation of human senility, is due to endogenous and the coefficient result of composite factors such as exogenous, wherein
Intrinsic aging refers to the natural aging that skin increases with the age, shows as whiteness of skin, occur fine wrinkles, flexibility decrease,
Cutis laxa etc.；It is extrinsic aging main the reason is that light aging caused by solarization, show as wrinkle, cutis laxa, it is coarse,
The dermatodyschroia of Beige color, telangiectasis, pigmented spots are formed.
Polypeptide is a-amino acid with the compound that peptide bond links together and is formed, it is also the centre of protein hydrolysis
Product.The compound as made of two amino acid molecular dehydrating condensations is called dipeptides, similarly analogizes also tripeptides, tetrapeptide, pentapeptide
Deng.Usually the compound as made of three or three or more amino acid molecular dehydrating condensations, which can become, is polypeptide.
The effect of biologically active polypeptide is: 1. on epidermis level, influencing the activity and growth factor of keratinocyte, stimulates
Keratinocyte migration and epithelialization, stimulation epidermal cell breaks up and correction, strongly facilitates epidermis reparation and healing；2. in corium water
On flat, fibroblasts are stimulated, enhancing extracellular matrix is shunk and construction, provides skin Nutrients uptake skin wound healing
And functional regeneration；3. enhancing in skin integral level to environmental assaults, ultraviolet light, pollutant, stimulant, sensitizer and inflammation
Property cell resistance, consolidate, enhancing skin tensor muscle, enhance skin elasticity, stimulation scar tissue fade, reduce cicatrization,
Delay skin aging.
Biologically active polypeptide is the optimum activity ingredient of skin nursing, can control or regulate skin aging process, protection
Damaged skin, delay skin aging maintain the normal physiological activity and metabolism of body to the structure and function for keeping normal skin
It is of great significance, therefore, more and more effective biologically active peptides are used in skin nursing products.
CN107411997A discloses a kind of anti-aging face cream composition, comprising by nonapeptide -1, -1 copper of tripeptides, acetyl group eight
The anti-apolexis composition that peptide -3 and palmityl tripeptides -5 form, the invention have good anti-aging effects.But in the invention
Traditional preservatives are added to, deactivation prob when active peptide and traditional preservatives compatibility is easily caused, to affect product function
The stability of energy.
CN103505377A discloses a kind of peptide composition for having skin activity, can be one or more class meat poisonings and makees
With polypeptide and one or more compatibilities for improving skin quality polypeptide, wherein the polypeptide with the effect of class meat poisoning can be a kind of or more
Kind be selected from following polypeptide: Ac-EEMQRR-NH2, AcEEMQRRAD-NH2, β-Ala-Pro-Dab-NHBzl, GPRPA-NH2,
There is Tyr-D-Ala-Gly-Phe-Leu the polypeptide for promoting skin protein to generate improvement skin quality to be also possible to one or more
Selected from following polypeptide: Pal-KTTKS, Pal-GHK, Pal-KVK, Pal-GQPR, Pal-VGVAPG, the present invention can achieve in short term
Interior wrinkle reduction and long-term the effect of improving skin quality.
But be added to chemical preservative in CN107411997A and CN103505377A, such preservative with work
Property peptide compatibility during, easily cause active peptide inactivation, to influence the stability of product efficacy.Meanwhile chemical preservative, such as
Benzyl alcohol easily causes skin allergy.Therefore, it is very urgent to seek safer, milder, more effective skin care item.
Summary of the invention
It is compound by various active peptide in order to solve the above-mentioned technical problems, the present invention provides a kind of anti-aging Essence
Superposition promotes product anti-aging function, meanwhile, solve deactivation prob when active peptide and traditional chemical preservative compatibility,
Guarantee the stability of product function；The present invention also provides the preparation method of above-mentioned anti-aging Essence, the preparation method techniques
Simply, at low cost, the popularization and application for anti-aging Essence provide technical support.
To achieve the goals above, the invention adopts the following technical scheme:
A kind of anti-aging Essence, includes the following components'mass percentage:
Active peptide 0.01-2%；
Polyalcohol 3-15%；
Moisturizer 0.01-10%；
Plant antiseptic agent 0.5-1.2%；
Skin conditioning agent 0.1-10%；
Chelating agent 0.02-0.1%；
Anti-inflammatory renovation agent 0.1-2% and
Balance deionized water.
Preferably, the active peptide is dipeptides diaminobutyryl benzyl amide diacetin, Argireline, three
Peptide -1, -1 ketone of tripeptides, -1 ketone of palmityl tripeptides, palmityl tetrapeptide -7, Matrixyl -4, palmityl tripeptides -1, palmityl three
At least one of peptide -5, Matrixyl -18, palmityl tripeptides -29, palmityl hexapeptide -3 and carnosine；Further preferably
For dipeptides diaminobutyryl benzyl amide diacetin, Argireline, palmityl tetrapeptide -7, palmityl tripeptides -1 and carnosine
At least one of.
Preferably, the polyalcohol is butanediol, glycerol, propylene glycol, dipropylene glycol, 1,2- hexylene glycol, 1,2- penta 2
At least one of pure and mild 1,3- propylene glycol；It is further preferably at least one of butanediol, glycerol and dipropylene glycol.
Preferably, the moisturizer is that glycerin polyether -26, diglycerol, Natrulon H-10, Sodium Hyaluronate, β-Portugal are poly-
At least one of sugar, spirulina maxim extract, acetyl chitosamine and dried tremella extract；It is further preferably hyaluronic acid
At least one of sodium, beta glucan, acetyl chitosamine and dried tremella extract.
Preferably, the anti-inflammatory renovation agent is hydrolytic collagen, Euglena gracilis polysaccharide, boswellia serrata resin extract, product
Avenge careless extract, gorgonian extract, dipotassium glycyrrhizinate, Chinese herbaceous peony root extract, hydroxy phenylpropionyl amine benzoic acid, allantoin, mind
Through at least one of amide 1, Cer NS, Cer NP, ceramide 4 and Cer AP；Further preferably hydrolyze
At least one of collagen, Euglena gracilis polysaccharide, boswellia serrata resin extract and Gotu Kola P.E.
Preferably, the chelating agent is disodium ethylene diamine tetraacetate and/or phytic acid.
Preferably, the skin conditioning agent is hydroxyethyl piperazine ethane sulfonic acid, hydroxypropyl cyclodextrin, natto gum, ripple
Irish moss, adenosine, cyclodextrin, silk amino acid, natto gum, hydrolytic collagen, HERBA DENDROBII stem extraction, Angelica roots,
At least one of Herba Verbenae, Radix Notoginseng root extract, tomonea extract and Chinese herbaceous peony root extract, further preferably
At least one of Chondrus crispus, silk amino acid, natto gum and hydrolytic collagen.
Preferably, the plant antiseptic agent is pepper extract and/or forsythia suspense extraction.
Above technical scheme can be realized technical effect of the present invention, but in some preferred embodiments,
Technical effect achieved is better than other schemes.
In some preferred embodiments, the active peptide includes acetyl hexapeptide -8 and dipeptides diaminobutyryl benzyl amide
Diacetin, wherein the mass ratio of the acetyl hexapeptide -8 and dipeptides diaminobutyryl benzyl amide diacetin is 1:1.
In some preferred embodiments, the active peptide includes carnosine, acetyl hexapeptide -8 and dipeptides diaminobutyryl benzyl
Base amide diacetin, wherein the quality of the carnosine, acetyl hexapeptide -8 and dipeptides diaminobutyryl benzyl amide diacetin
Than for 10:0.5:0.5.
In some preferred embodiments, the active peptide includes acetyl hexapeptide -8, dipeptides diaminobutyryl benzyl amide
Diacetin, palmityl tripeptides -1 and palmityl tetrapeptide -7, wherein the acetyl hexapeptide -8, dipeptides diaminobutyryl benzyl acyl
The mass ratio of amine diacetin, palmityl tripeptides -1 and palmityl tetrapeptide -7 is 10:10:1:1.
In some preferred embodiments, the moisturizer includes Sodium Hyaluronate, beta glucan and dried tremella extract,
In, the mass ratio of the Sodium Hyaluronate, beta glucan and dried tremella extract is 1:1:1.
In some preferred embodiments, the polyalcohol includes butanediol and glycerol, wherein the butanediol and glycerol
Mass ratio be 1:2.
In some preferred embodiments, the preservative includes pepper extract and forsythia suspense extraction, wherein the flower
The mass ratio of green pepper extract and forsythia suspense extraction is 1:2.
In some preferred embodiments, the anti-inflammatory renovation agent includes hydrolytic collagen, Euglena gracilis polysaccharide, boswellia serrata
Resin extract and Gotu Kola P.E, wherein the hydrolytic collagen, Euglena gracilis polysaccharide, boswellia serrata resin extract and
The mass ratio of Gotu Kola P.E is 1:1:1:1.
In some preferred embodiments, the skin conditioning agent includes natto gum, Chondrus crispus and silk amino acid,
Wherein, the mass ratio of the natto gum, Chondrus crispus and silk amino acid is 1:8:10.
The present invention also provides above-mentioned anti-aging Essences to prepare the application in skin nursing products.
The present invention also provides the preparation methods of above-mentioned anti-aging Essence, include the following steps,
(1) active peptide is added to the polyalcohol of (1-3)/4 formula ratio, deionized water is added after impregnating 10-20min, is stirred
Dissolution, obtains polypeptide liquid；
(2) polyalcohol of (1-3)/4 formula ratio, moisturizer and chelating agent are mixed, are heated to 80-85 DEG C, stirring and dissolving,
Obtain A phase；
(3) plant antiseptic agent is mixed with deionized water, is heated to 50-60 DEG C, dissolution obtains B phase；
(4) the A phase for obtaining step (2) after being cooled to 45 DEG C, sequentially adds the polypeptide liquid of step (1) acquisition, anti-inflammatory repairs
Multiple agent, skin conditioning agent and B phase, stirring are cooled to 35-40 DEG C to get the anti-aging Essence.
The invention has the benefit that
(1) anti-aging Essence of the invention, quality is unique, and skin sense water moistens, is salubrious not sticky, can be used for daily skin
Nursing has moisturizing, anti-inflammatory releive, desalinates wrinkle, bright color effect.
(2) present invention passes through the complex superposition of various active peptide, improves product anti-aging function, meanwhile, using day
Right plant antiseptic agent solves deactivation prob when active peptide and traditional chemical preservative compatibility, guarantees the stabilization of product function
Property.
(3) compared with existing Essence, the good penetrability of anti-aging Essence of the present invention is easier to absorb, while product is steady
It is qualitative good.
(4) the preparation method simple process and low cost of this product, the popularization and application for anti-aging Essence provide technology
It supports.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below to technical solution of the present invention
It is further described.
When embodiment provides numberical range, it should be appreciated that except non-present invention is otherwise noted, two ends of each numberical range
Any one numerical value can be selected between point and two endpoints.Unless otherwise defined, all technologies used herein and section
Technics has and the normally understood identical meaning of general technical staff of the technical field of the invention.
Unless otherwise specified, raw material of the present invention is ordinary commercial products.
Embodiment 1
A kind of anti-aging Essence, includes the following components'mass percentage: active peptide 0.01%, polyalcohol 3%, moisturizing
Agent 0.01%, plant antiseptic agent 0.5%, skin conditioning agent 0.1%, chelating agent 0.02%, anti-inflammatory renovation agent 0.1% and surplus are gone
Ionized water；
The active peptide includes carnosine, acetyl hexapeptide -8 and dipeptides diaminobutyryl benzyl amide diacetin, wherein institute
The mass ratio for stating carnosine, acetyl hexapeptide -8 and dipeptides diaminobutyryl benzyl amide diacetin is 10:0.5:0.5；
The polyalcohol includes butanediol and glycerol, wherein the mass ratio of the butanediol and glycerol is 1:2；
The moisturizer includes Sodium Hyaluronate, beta glucan and dried tremella extract, wherein the Sodium Hyaluronate, β-
The mass ratio of glucan and dried tremella extract is 1:1:1；
The plant antiseptic agent includes pepper extract and forsythia suspense extraction, wherein the pepper extract and Fructus Forsythiae mention
The mass ratio for taking object is 1:2.
The skin conditioning agent includes natto gum, Chondrus crispus and silk amino acid, wherein the natto gum, ripple
The mass ratio of Irish moss and silk amino acid is 1:8:10.
The chelating agent is disodium ethylene diamine tetraacetate.
The anti-inflammatory renovation agent includes that hydrolytic collagen, Euglena gracilis polysaccharide, boswellia serrata resin extract and centella mention
Take object, wherein the hydrolytic collagen, Euglena gracilis polysaccharide, boswellia serrata resin extract and Gotu Kola P.E mass ratio
For 1:1:1:1.
Preparation method:
(1) active peptide is added to the polyalcohol of 1/4 formula ratio, deionized water is added after impregnating 10min, stirring and dissolving obtains
Polypeptide liquid；
(2) polyalcohol of 3/4 formula ratio, moisturizer and chelating agent are mixed, is heated to 80 DEG C, stirring and dissolving, obtains A
Phase；
(3) plant antiseptic agent is mixed with deionized water, is heated to 50 DEG C, dissolution obtains B phase；
(4) the A phase for obtaining step (2) after being cooled to 45 DEG C, sequentially adds the polypeptide liquid of step (1) acquisition, anti-inflammatory repairs
Multiple agent, skin conditioning agent and B phase, stirring are cooled to 35 DEG C to get the anti-aging Essence.
Embodiment 2
A kind of anti-aging Essence, includes the following components'mass percentage:
Peptide 2 %, polyalcohol 15%, moisturizer 10%, plant antiseptic agent 1.2%, skin conditioning agent 10%, chelating agent
0.1%, anti-inflammatory renovation agent 2% and balance deionized water；
The active peptide includes acetyl hexapeptide -8 and dipeptides diaminobutyryl benzyl amide diacetin, wherein the second
The mass ratio of acyl hexapeptide -8 and dipeptides diaminobutyryl benzyl amide diacetin is 1:1；
The polyalcohol includes butanediol and glycerol, wherein the mass ratio of the butanediol and glycerol is 1:2；
The moisturizer includes Sodium Hyaluronate, beta glucan and dried tremella extract, wherein the Sodium Hyaluronate, β-
The mass ratio of glucan and dried tremella extract is 1:1:1；
The plant antiseptic agent includes pepper extract and forsythia suspense extraction, wherein the pepper extract and Fructus Forsythiae mention
The mass ratio for taking object is 1:2；
The skin conditioning agent includes natto gum, Chondrus crispus and silk amino acid, wherein the natto gum, ripple
The mass ratio of Irish moss and silk amino acid is 1:8:10；
The chelating agent is disodium ethylene diamine tetraacetate；
The anti-inflammatory renovation agent includes that hydrolytic collagen, Euglena gracilis polysaccharide, boswellia serrata resin extract and centella mention
Take object, wherein the hydrolytic collagen, Euglena gracilis polysaccharide, boswellia serrata resin extract and Gotu Kola P.E mass ratio
For 1:1:1:1.
Preparation method:
(1) active peptide is added to the polyalcohol of 3/4 formula ratio, deionized water is added after impregnating 20min, stirring and dissolving obtains
Polypeptide liquid；
(2) polyalcohol of 1/4 formula ratio, moisturizer and chelating agent are mixed, is heated to 85 DEG C, stirring and dissolving, obtains A
Phase；
(3) plant antiseptic agent is mixed with deionized water, is heated to 60 DEG C, dissolution obtains B phase；
(4) the A phase for obtaining step (2) after being cooled to 45 DEG C, sequentially adds the polypeptide liquid of step (1) acquisition, anti-inflammatory repairs
Multiple agent, skin conditioning agent and B phase, stirring are cooled to 40 DEG C to get the anti-aging Essence.
A kind of anti-aging Essence of embodiment 3, includes the following components'mass percentage:
Active peptide 1.5%, polyalcohol 5.5%, moisturizer 2.5%, plant antiseptic agent 0.8%, skin conditioning agent 2%, chela
Mixture 0.05%, anti-inflammatory renovation agent 0.8% and balance deionized water；
The active peptide includes acetyl hexapeptide -8, dipeptides diaminobutyryl benzyl amide diacetin by, palmityl tripeptides -
1 and palmityl tetrapeptide -7, wherein the acetyl hexapeptide -8, dipeptides diaminobutyryl benzyl amide diacetin press, palmityl three
The mass ratio of peptide -1 and palmityl tetrapeptide -7 is 10:10:1:1.
The polyalcohol includes butanediol and glycerol, wherein the mass ratio of the butanediol and glycerol is 1:2；
The moisturizer includes Sodium Hyaluronate, beta glucan and dried tremella extract, wherein the Sodium Hyaluronate, β-
The mass ratio of glucan and dried tremella extract is 1:1:1；
The plant antiseptic agent includes pepper extract and forsythia suspense extraction, wherein the pepper extract and Fructus Forsythiae mention
The mass ratio for taking object is 1:2；
The skin conditioning agent includes natto gum, Chondrus crispus and silk amino acid, wherein the natto gum, ripple
The mass ratio of Irish moss and silk amino acid is 1:8:10；
The chelating agent is phytic acid；
The anti-inflammatory renovation agent includes that hydrolytic collagen, Euglena gracilis polysaccharide, boswellia serrata resin extract and centella mention
Take object, wherein the hydrolytic collagen, Euglena gracilis polysaccharide, boswellia serrata resin extract and Gotu Kola P.E mass ratio
For 1:1:1:1.
Preparation method:
(1) active peptide is added to the polyalcohol of 3/4 formula ratio, deionized water is added after impregnating 20min, stirring and dissolving obtains
Polypeptide liquid；
(2) polyalcohol of 1/4 formula ratio, moisturizer and chelating agent are mixed, is heated to 85 DEG C, stirring and dissolving, obtains A
Phase；
(3) plant antiseptic agent is mixed with deionized water, is heated to 60 DEG C, dissolution obtains B phase；
(4) the A phase for obtaining step (2) after being cooled to 45 DEG C, sequentially adds the polypeptide liquid of step (1) acquisition, anti-inflammatory repairs
Multiple agent, skin conditioning agent and B phase, stirring are cooled to 40 DEG C to get the anti-aging Essence.
Comparative example 1
Difference from example 1 is that being free of acetyl hexapeptide -8 in the active peptide, wherein the carnosine and two
The mass ratio of peptide diaminobutyryl benzyl amide diacetin is 10:1；
The preparation method is the same as that of Example 1.
Comparative example 2
Difference from example 1 is that the plant antiseptic agent is pepper extract；The skin conditioning agent is silkworm
Silk amino acid；The anti-inflammatory renovation agent is Gotu Kola P.E.
The preparation method is the same as that of Example 1.
Comparative example 3
Difference from example 1 is that the plant antiseptic agent is forsythia suspense extraction；The skin conditioning agent is silkworm
Silk amino acid；The anti-inflammatory renovation agent is Gotu Kola P.E.
The preparation method is the same as that of Example 1.
Comparative example 4
Difference from example 1 is that the preservative is Phenoxyethanol；The skin conditioning agent is silk amino
Acid；The anti-inflammatory renovation agent is Gotu Kola P.E.
The preparation method is the same as that of Example 1.
Comparative example 5
The difference is that, the active peptide is acetyl hexapeptide -8 with embodiment 2.
Preparation method is the same as embodiment 2.
Comparative example 6
The difference is that, the active peptide is dipeptides diaminobutyryl benzyl amide diacetin with embodiment 2.
Preparation method is the same as embodiment 2.
Comparative example 7
The difference is that, the moisturizer includes Sodium Hyaluronate and dried tremella extract with embodiment 2, wherein institute
The mass ratio for stating Sodium Hyaluronate and dried tremella extract is 1:1；
Preparation method is the same as embodiment 2.
Comparative example 8
Anti-aging face cream prepared by CN107411997A embodiment 1.
Comparative example 9
Essence prepared by CN103505377A embodiment 1.
The test of 1 bacteriostasis property of experimental example
The anti-aging Essence for taking 0.5g embodiment 1-3, comparative example 2-4 to prepare, face cream and comparative example prepared by comparative example 8
The Essences of 9 preparations, are added after the 55wt% ethanol solution of 10ml and obtain sample liquid after stirring and dissolving, save with spare.
Try bacterial suspension preparation: by bacillus subtilis, Escherichia coli, staphylococcus aureus, Candida albicans,
Pseudomonas aeruginosa and black-koji mould are inoculated in Tube propagation base, and aseptic process is added after cultivating 48 hours at 37 DEG C in insulating box
Distilled water, concussion obtain experimental bacteria suspension.The SOB culture medium for taking 15ml to melt, is placed in sterilizing plates, then distinguishes
1ml experimental strain is added dropwise, and it is made to pave plate bottom.After culture medium solidification, 4 Oxford cups are stood up on each plate,
It is then respectively adding 0.1ml plant-based bacteriostat solution, measures the size of antibacterial circle diameter after cultivating 24 hours at 37 DEG C respectively
(unit: mm).
Experimental result:
1 bacteriostasis property of table tests table
2 stability test of experimental example
Product prepared by embodiment 1-3, comparative example 2-4 and comparative example 8-9 is respectively put into 40 DEG C, room temperature and -15 DEG C
In environment, stability test is carried out, every 1 week controlled observation 1 time, is observed continuously 1 month, then, monthly observation is primary.It is qualified
Standard is that the abnormal conditions that precipitating, peculiar smell, discoloration etc. have significant change are not precipitated in product.
Experimental result:
2 stability test result of table
As shown in Table 2, anti-aging Essence performance of the invention is stablized.
3 replenishing water and preserving moisture effect assessment of experimental example
The women subject for selecting 60 stemness or combination is divided into 6 groups, and every group of 10 people first clean skin,
Product prepared by embodiment 1-3, comparative example 7-9 is coated after 2 hours again, measurement skin is wet respectively at 1h, 8h, 12h and for 24 hours
Degree.Using humidity of skin tester CM825 type (German CK Products) at 25 DEG C of temperature and 50% relative humidity into
Row measurement.
Experimental result:
Table is tested in 3 moisturizing of table
| Group | 1h | 8h | 12h | 24h |
| Embodiment 1 | 85% | 76% | 59% | 40% |
| Embodiment 2 | 83% | 72% | 55% | 33% |
| Embodiment 3 | 84% | 74% | 56% | 35% |
| Comparative example 7 | 58% | 48% | 25% | 9% |
| Comparative example 8 | 63% | 54% | 27% | 13% |
| Comparative example 9 | 61% | 52% | 30% | 15% |
As shown in Table 3, the moistening effect of embodiment 1-3 is obviously got well than comparative example, anti-aging essence prepared by the present invention
For magnificent liquid after science combination compounding, the characteristic of each component plays complementary, coordinative role, generates synergistic effect, has good moisturizing
Effect.
The test of 4 anti-aging of experimental example
Test equipment: the skin elasticity Cotometer of German Courage+Khazaka company (German CK company) manufacture
MPA580 host, used probe are Reviscometer RV600 elastic fibrous tissue test probes.
Subject: 30-60 years old normal female subject.
Grouping: subject is divided into 10 groups by each age group, every group of 10 people, wherein the average age of example 1 group is 35
Year, the average age that 2 groups of embodiment are 45 years old, and the average age that 3 groups of embodiment is 55 years old；The average age of comparative example 1-4 group
It is 35 years old, the average age of comparative example 5-6 group is 45 years old, and the average age that 9 groups of comparative example is 55 years old.
The anti-aging Essence that embodiment 1-3 group is prepared using embodiment 1-3 respectively, comparative example 1-4 group use comparative example
The anti-aging Essence that the anti-aging Essence of 1-4 preparation, comparative example 5-6 group are prepared using comparative example 5-6 respectively, comparative example 9
The Essence of preparation accelerates processing 8h using preceding above-mentioned Essence is placed at 40 DEG C.
Tester region: place between the eyebrows middle up 2cm forehead region, lower lip middle 2cm chin area, nose down
With cheek region left and right at pupil intersection.
Testing procedure: the blank value (R of 30min after the region clean of test section is first measured2, R5, R7, wherein R2=Ua/Uf, R5
=Ur/Ue, R7=Ur/Uf)。
Uf-- skin maximum tension amount；
Ue-- after constant negative pressure is added on skin, the amount of tension of skin, positioning elastic part amount of tension at 0.1 second；
Ur-- after cancelling negative pressure, skin will restore to the original state rapidly state, equally be divided into elastic portion score value Ur, that is, cancel negative pressure
After 0.1 second, the recovery value and visco-elastic portions value or plastic value of skin；
Ua-- from cancellation negative pressure to the recovery value of skin when follow-on test skin surface adds negative pressure again next time；
Then sample is spread evenly across face, adheres to trying out daily sooner or later, other cosmetics, continuous use must not be used
4 weeks, the 1st week, 2 weeks, 3 weeks, the R of the skin of 4 weeks test areas were tested respectively2, R5, R7.The test of the same subject is by same
A survey crew completes.Pass through the R of the skin before and after test use2, R5, R7Value changes to assess the skin anti-aging function of product
Effect.
Experimental result:
4 Antisenility Experiment result of table
Note: R2, R5, R7Closer to 1, skin elasticity is better.
As shown in Table 4, after testing 4 weeks, the R of the anti-aging Essence of 1-3 of the embodiment of the present invention2, R5, R7Value is all larger than
0.900, much higher than the value of comparative example, show that anti-aging Essence of the invention has the function for obviously increasing skin elasticity anti-aging
Effect.The present invention passes through the complex superposition of various active peptide, improves product anti-aging function, meanwhile, quality is unique, skin sense water
It is profit, salubrious not sticky, it can be used for daily skin care, there is moisturizing, anti-inflammatory releive, desalinate wrinkle, bright color effect；This
Invention uses natural plant preservative, solves deactivation prob when active peptide and traditional chemical preservative compatibility, guarantees product
The stability of function.In addition, anti-aging Essence of the invention using skin elasticity after 3 weeks be improved significantly, show this hair
The good penetrability of bright anti-aging Essence, is more easily absorbed by the skin.
Claims (4)
1. a kind of anti-aging Essence, which is characterized in that include the following components'mass percentage:
Active peptide 0.01-2%；
Polyalcohol 3-15%；
Moisturizer 0.01-10%；
Plant antiseptic agent 0.5-1.2%；
Skin conditioning agent 0.1-10%；
Chelating agent 0.02-0.1%；
Anti-inflammatory renovation agent 0.1-2% and
Balance deionized water；
The plant antiseptic agent is pepper extract and forsythia suspense extraction；The mass ratio of the pepper extract and forsythia suspense extraction
It is 1: 2；
The active peptide is dipeptides diaminobutyryl benzyl amide diacetin, Argireline, tripeptides -1, tripeptides -1
Copper, palmityl tetrapeptide -7, Matrixyl -4, palmityl tripeptides -1, palmityl tripeptides -5, Matrixyl -18, palmityl three
At least one of peptide -29, palmityl hexapeptide -3 and carnosine；
The polyalcohol is butanediol, glycerol, propylene glycol, dipropylene glycol, 1,2- hexylene glycol and 1, in 2- pentanediol at least
It is a kind of；
The moisturizer is glycerin polyether -26, diglycerol, Natrulon H-10, Sodium Hyaluronate, beta glucan, spirulina maxim
At least one of extract, acetyl chitosamine and dried tremella extract；
The anti-inflammatory renovation agent be hydrolytic collagen, Euglena gracilis polysaccharide, boswellia serrata resin extract, Gotu Kola P.E,
Gorgonian extract, dipotassium glycyrrhizinate, Chinese herbaceous peony root extract, hydroxy phenylpropionyl amine benzoic acid, allantoin, Cer EOS, nerve
At least one of amide 2, Cer NP, ceramide 4 and Cer AP；
The skin conditioning agent be hydroxyethyl piperazine ethane sulfonic acid, hydroxypropyl cyclodextrin, Chondrus crispus, adenosine, cyclodextrin,
Silk amino acid, natto gum, HERBA DENDROBII stem extraction, Angelica roots, Herba Verbenae, Radix Notoginseng root extract, open country
At least one of peony extract and Chinese herbaceous peony root extract.
2. anti-aging Essence according to claim 1, which is characterized in that the chelating agent is ethylenediamine tetra-acetic acid two
Sodium and/or phytic acid.
3. anti-aging Essence described in a kind of claim 1-2 any one is preparing the application in skin nursing products.
4. a kind of method for preparing anti-aging Essence described in claim 1-2 any one, which is characterized in that the system
Preparation Method, comprising the following steps:
(1) active peptide is added to the polyalcohol of 1/4-3/4 formula ratio, is added deionized water after impregnating 10-20min, stirring and dissolving,
Obtain polypeptide liquid；
(2) polyalcohol of 1/4-3/4 formula ratio, moisturizer and chelating agent are mixed, is heated to 80-85 DEG C, stirring and dissolving, obtains
A phase；
(3) plant antiseptic agent is mixed with deionized water, is heated to 50-60 DEG C, dissolution obtains B phase；
(4) the A phase for obtaining step (2) after being cooled to 45 DEG C, sequentially adds polypeptide liquid, the anti-inflammatory reparation that step (1) obtains
Agent, skin conditioning agent and B phase, stirring, are cooled to 35-40 DEG C to get the anti-aging Essence.
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