CN112933028A - Skin lotion containing anti-aging composition and preparation method thereof - Google Patents
Skin lotion containing anti-aging composition and preparation method thereof Download PDFInfo
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- CN112933028A CN112933028A CN202110420505.3A CN202110420505A CN112933028A CN 112933028 A CN112933028 A CN 112933028A CN 202110420505 A CN202110420505 A CN 202110420505A CN 112933028 A CN112933028 A CN 112933028A
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- aging composition
- skin
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- extract
- aging
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Abstract
The invention provides skin lotion containing an anti-aging composition and a preparation method thereof. The preparation raw materials of the emollient water containing the anti-aging composition comprise the anti-aging composition, a skin conditioner, a humectant and water; the anti-aging composition comprises a ginger root extract, a scutellaria root extract and a cacao seed extract; the skin conditioning agent comprises lactobacillus fermentation lysate, carrageen crispus extract and acetyl chitosamine. The skin lotion containing the anti-aging composition promotes the synthesis of extracellular matrix, improves the skin hydration degree, reduces the percutaneous water loss, reduces fine lines of the skin, improves the rough skin, can inhibit the activity of tyrosinase, reduces the generation of melanin, improves uneven skin color and brightens the skin color.
Description
Technical Field
The invention belongs to the technical field of cosmetic production and application, and particularly relates to skin moisturizing lotion containing an anti-aging composition and a preparation method thereof.
Background
The skin of a human body gradually enters a natural aging state from about 25 years old, the aging speed shows a certain difference due to different genetic genes and living habits, and the early-aged manifestation is not obvious at this moment and reaches the early end of the age of about 30 years old. In addition to the multiple stresses and environmental pollution from modern society, the primary signs of early age are: the appearance of fine lines, superficial wrinkles and dry lines, obvious skin saccharification phenomenon, yellowing and roughness, pigmentation, dullness and darkness; the moisture content of the horny layer is reduced, and the skin is dry or pores are large and emit oil; the skin defense ability and blood circulation ability are reduced, and the skin is sensitive. The onset of aging manifests itself as a general decline in the condition of the skin, which is not completely the same as the signs of aging, such as wrinkling and atrophy, and requires relief from multiple skin care dimensions. The demand of people for products for resisting the premature aging is increasing day by day, and the products for resisting the premature aging must be capable of effectively preventing and delaying the skin aging caused by internal and external causes. The main effects of the skin care products on the market at present are mainly moisturizing, the effects are single, and the skin care products are weak in the aspect of resisting the premature senility.
Modern living is under great pressure, skin can be tired, cell metabolism can be slowed down, muscle is repeatedly contracted to form wrinkles due to stress emotion, and the skin is more sensitive due to long-term pressure accumulation, so that inflammatory reaction of the skin is caused, and skin aging is accelerated. The skin of people is constantly exposed to various pressures, air pollution is caused, ultraviolet rays and blue light can induce the skin to generate a large amount of free radicals and inflammatory factors, aging is accelerated, internal pressure can aggravate inflammatory generation, if the body cannot clear harmful substances in time, the tolerance of the body is enhanced, the state of the skin is aggravated, the skin is senilism, the skin color is obviously not transparent before, the skin is recovered slowly after being decocted, the skin is dark, and small dry lines are formed on the skin.
CN111840205A discloses a multiple anti-aging composition, essence water and a preparation method thereof, wherein the multiple anti-aging composition comprises retinol, resveratrol, turmeric root extract and lactobacillus fermentation lysate. The multiple anti-aging composition comprises specifically selected retinol, resveratrol, turmeric root extract and lactobacillus fermentation lysate, the four components are mutually blended and synergized, and the multiple anti-aging composition has multiple anti-oxidation and anti-aging effects, and has good prospects when being applied to anti-aging cosmetics.
CN111973508A discloses a soothing and moisturizing anti-aging composition, which comprises the following components in percentage by weight: 0.02-0.2% of dipotassium glycyrrhizinate, 1-3% of chamomile extract, 1-15% of anti-aging composition, 1-20% of humectant, 0.05-1% of thickening agent, 0.5-2.5% of emulsifier, 1-10% of emollient and the balance of pure water; wherein the anti-aging composition is acetyl hexapeptide-8, a split yeast fermentation product lysate, a tea extract, a grape seed extract, and a blackberry leaf extract; the composition disclosed by the invention has the advantages that through reasonable matching of various components, the damage to the skin caused by various light sources is relieved and repaired, deep water is provided for the skin, and the effect of resisting aging in time is achieved.
Therefore, the development of a skin care product with moisturizing and skin lightening functions is the focus of research in the field.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide the skin moistening lotion containing the anti-aging composition and the preparation method thereof. The lotion containing the anti-aging composition has the capabilities of long-acting moisturizing and brightening skin.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the invention provides an anti-aging composition-containing emollient water, which is prepared from an anti-aging composition, a skin conditioner, a humectant and water;
the anti-aging composition comprises a ginger root extract, a scutellaria root extract and a cacao seed extract;
the skin conditioning agent comprises lactobacillus fermentation lysate, carrageen crispus extract and acetyl chitosamine.
In the invention, the anti-aging composition improves the tolerance of the skin by regulating the redox balance of cells, regulating cell autophagy and promoting cell detoxification, and can be matched with each component in a skin conditioner of the emollient water to realize synergistic interaction, so that the effects of moisturizing and brightening the skin of the emollient water are further improved.
Wherein, the ginger flower root extract can regulate autophagy of fibroblast, thereby realizing metabolism requirement of cells, update of certain organelles and maintain cell homeostasis; even under the blue light pressure, the lysosome network of the fibroblast can be protected, the skin is helped to improve the natural protective ability of the skin, so that the blue light/UV injury can be resisted, the cell detoxification can be promoted, the skin regeneration can be promoted, and the like. The radix Scutellariae extract has effects of inhibiting elastase, interfering secretion, and scavenging free radicals, thereby increasing skin metabolism, skin elasticity and wrinkle resistance, and resisting aging; promoting cerebral amide, improving sebum, and moistening skin; has effects in inhibiting dermatitis, enhancing skin resistance, and resisting inflammation; can neutralize released histamine, and has effect in preventing allergy. The cocoa seed extract is rich in molecular peptide, saccharide and polyphenol, reduces active oxygen under the blue light pressure, protects opsin photoreceptor under the blue light pressure, increases the content of collagen I, fibrillarin-1 and syndecan-4, and obviously improves the fiber network structure of elastin, thereby improving the skin elasticity and obviously improving the skin wrinkles.
Wherein, the lactobacillus fermentation lysate repairs the microbial barrier by increasing host defense peptide activity, maintaining the skin micro-ecological balance and promoting the skin microbial diversity. The lactobacillus fermentation lysate contains components beneficial to skin care, such as amino acid, small peptide, polysaccharide, B vitamins and the like, effectively enhances the hydration of the cuticle and prevents the water loss of the skin. The acetyl chitosamine is an important component of hyaluronic acid and chondroitin, is considered as the same component of skin, is the minimum unit molecule of mucopolysaccharide, and can promote the synthesis of hyaluronic acid by human body, accelerate the healing of wound, improve the hydration degree of skin, reduce fine lines of skin and improve rough skin; it also has effects in inhibiting tyrosinase activity, reducing melanin production, and improving uneven skin color. The carrageen crispus can form a film on the surface of the skin, the skin protein and the carrageen gum are bonded together, a layer of non-closed barrier is formed on the surface of the skin, the harmful effect of the surrounding environment on the skin is prevented, and the skin moisture loss is effectively prevented if the second layer of skin is common.
Preferably, in the anti-aging composition, the mass ratio of the ginger flower root extract, the scutellaria root extract and the cacao seed extract is (3-8): (5-15): (2-7);
wherein "3-8" can be 3, 4, 5, 6, 7, 8, etc.;
wherein, 5-15 can be 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, etc.;
wherein "2-7" may be 2, 3, 4, 5, 6, 7, etc.
Preferably, in the skin conditioner, the mass ratio of the lactobacillus fermentation lysate, the carrageen crispus extract and the acetyl chitosamine is (1-5): (0.1-1);
wherein "1-5" can be 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, etc.;
wherein the first "0.1-1" can be 0.1, 0.2, 0.4, 0.6, 0.8, 1, etc.;
wherein the second "0.1-1" can be 0.1, 0.2, 0.4, 0.6, 0.8, 1, etc.
Preferably, the raw materials for preparing the emollient water containing the anti-aging composition comprise, by mass, 0.01-5% of the anti-aging composition, 0.01-10% of a skin conditioner, 5-25% of a humectant and the balance of water, wherein the mass of the raw materials is 100%.
The content of the anti-premature composition is 0.01 to 5%, and may be, for example, 0.01%, 0.02%, 0.05%, 0.1%, 0.15%, 0.2%, 0.4%, 0.5%, 0.6%, 0.8%, 1%, 2%, 3%, 4%, 5%, or the like.
The content of the skin conditioner is 0.01 to 10%, and may be, for example, 0.01%, 0.02%, 0.05%, 0.1%, 0.15%, 0.2%, 0.4%, 0.5%, 0.6%, 0.8%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, or the like.
The content of the humectant may be 5 to 25%, for example, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 22%, 25%, or the like.
Preferably, the skin conditioner further comprises any one or a combination of at least two of a sophora flavescens root extract, a glycyrrhiza inflate root extract, niacinamide, alpha-arbutin, a yeast/Sichuan millet fermentation product filtrate, a schizosaccharomyces cerevisiae fermentation product lysate, an animal umbilical cord extract, animal placental protein, animal placental enzyme or cajeput oil.
Preferably, the skin conditioner comprises 1-5% of lactobacillus fermentation lysate, 0.1-1% of carrageen crispus extract, 0.1-1% of acetyl chitosamine, 0.01-0.1% of sophora flavescens root extract, 0.01-0.1% of glycyrrhiza inflate root extract, 0.1-1% of nicotinamide, 0.05-0.3% of alpha-arbutin, 0.01-0.1% of yeast/Sichuan millet seed fermentation product filtrate, 0.01-0.3% of schizosaccharomyces cerevisiae fermentation product lysate, 0.01-0.1% of animal umbilical cord extract, 0.01-0.1% of animal placental protein, 0.01-0.1% of animal placental enzyme and 0.01-0.1% of melaleuca oil by mass of 100% of the raw materials for preparing the emollient water containing the anti-premature aging composition.
The content of the lactic acid bacterium fermentation lysate is 1 to 5%, for example, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, etc.
The content of the Chondrus crispus extract is 0.1-1%, and may be, for example, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, etc.
The content of the acetylchitosamine may be, for example, 0.1 to 1%, such as 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%.
Wherein the content of radix Sophorae Flavescentis extract is 0.01-0.1%, such as 0.01%, 0.02%, 0.04%, 0.06%, 0.08%, 0.1%.
Wherein the content of the extract of Glycyrrhiza inflata root is 0.01-0.1%, such as 0.01%, 0.02%, 0.04%, 0.06%, 0.08%, 0.1%.
The nicotinamide content is 0.1-1%, and may be, for example, 0.1%, 0.2%, 0.4%, 0.6%, 0.8%, 1%, etc.
The content of α -arbutin is 0.05-0.3%, and may be, for example, 0.05%, 0.06%, 0.08%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, etc.
Wherein the content of yeast/Sichuan millet seed fermentation product filtrate is 0.01-0.1%, such as 0.01%, 0.02%, 0.04%, 0.06%, 0.08%, 0.1%.
The content of the secondary fission yeast fermentation product lysate may be, for example, 0.01 to 0.3%, such as 0.01%, 0.02%, 0.04%, 0.06%, 0.08%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%.
The content of the animal umbilical cord extract is 0.01-0.1%, for example, 0.01%, 0.02%, 0.04%, 0.06%, 0.08%, 0.1%, etc.
The content of animal placenta protein is 0.01-0.1%, such as 0.01%, 0.02%, 0.04%, 0.06%, 0.08%, 0.1%.
The content of animal placental enzyme is 0.01-0.1%, and may be, for example, 0.01%, 0.02%, 0.04%, 0.06%, 0.08%, 0.1%, etc.
The content of cajeput oil is 0.01-0.1%, for example, 0.01%, 0.02%, 0.04%, 0.06%, 0.08%, 0.1%, etc.
Preferably, the humectant comprises any one or a combination of at least two of butylene glycol, glyceryl polyether-26, trehalose, sodium hyaluronate, or 1, 2-hexanediol.
Preferably, the moisturizer comprises 5-10% of butanediol, 261-5% of glyceryl polyether, 0.1-2% of trehalose, 0.05-0.2% of sodium hyaluronate and 0.1-1% of 1, 2-hexanediol by mass of 100% of raw materials for preparing the emollient water containing the anti-aging composition.
The content of butanediol is 5 to 10%, and may be, for example, 5%, 5.5%, 6%, 6.5%, 7%, 7.5%, 8%, 8.5%, 9%, 9.5%, 10%, or the like.
The content of the glyceryl polyether-26 is 1 to 5%, and may be, for example, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, or the like.
The trehalose content is 0.1 to 2%, and may be, for example, 0.1%, 0.2%, 0.4%, 0.6%, 0.8%, 1%, 1.2%, 1.4%, 1.6%, 1.8%, 2%, etc.
The content of sodium hyaluronate is 0.05 to 0.2%, and may be, for example, 0.05%, 0.06%, 0.08%, 0.1%, 0.12%, 0.14%, 0.16%, 0.18%, 0.2%, or the like.
The content of 1, 2-hexanediol is 0.1 to 1%, and may be, for example, 0.1%, 0.2%, 0.4%, 0.6%, 0.8%, 1%, or the like.
Preferably, the raw materials for preparing the emollient water also comprise any one or combination of at least two of a thickening agent, a pH regulator, a chelating agent, an antioxidant, a solubilizer or a fragrance.
Preferably, the raw materials for preparing the emollient water containing the anti-aging composition further comprise 0.01-0.2% of thickening agent, 0.05-0.15% of pH regulator, 0.01-0.05% of chelating agent, 0.1-1% of antioxidant, 0.01-0.05% of solubilizer and 0.01-0.05% of aromatic, wherein the mass of the raw materials is 100%.
The content of the thickener is 0.01 to 0.2%, and may be, for example, 0.01%, 0.02%, 0.04%, 0.06%, 0.08%, 0.1%, 0.12%, 0.14%, 0.16%, 0.18%, 0.2%, or the like.
The content of the pH adjuster is 0.05 to 0.15%, and may be, for example, 0.05%, 0.06%, 0.08%, 0.1%, 0.12%, 0.15%, or the like.
The content of the chelating agent is 0.01 to 0.05%, and may be, for example, 0.01%, 0.02%, 0.03%, 0.04%, 0.05% or the like.
The content of the antioxidant is 0.1 to 1%, and may be, for example, 0.1%, 0.2%, 0.4%, 0.6%, 0.8%, 1%, or the like.
The content of the solubilizer is 0.01 to 0.05%, and may be, for example, 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, or the like.
The content of the aromatic may be 0.01 to 0.05%, for example, 0.01%, 0.015%, 0.02%, 0.025%, 0.03%, 0.04%, 0.05%, etc.
Preferably, the thickener comprises hydroxyethyl cellulose and/or carbomer.
Preferably, the pH adjusting agent is arginine.
Preferably, the chelating agent is disodium EDTA.
Preferably, the antioxidant is p-hydroxyacetophenone.
Preferably, the fragrance is a perfume.
In a second aspect, the present invention provides a method of preparing a lotion comprising an anti-aging composition according to the first aspect, the method comprising the steps of:
(1) mixing the humectant with water, heating and stirring to obtain a water phase mixed solution;
(2) and (2) cooling the water phase mixed liquor obtained in the step (1), and mixing with the anti-premature composition and the skin conditioner to obtain the skin lotion containing the anti-premature composition.
Preferably, in the step (1), the temperature for heating and stirring is 80 to 85 ℃, for example, 80 ℃, 81 ℃, 82 ℃, 83 ℃, 84 ℃, 85 ℃ and the like.
Preferably, in step (1), a thickener and a chelating agent are also added.
Preferably, in the step (2), the mixing is specifically: cooling the aqueous phase mixture obtained in step (1) to below 60 deg.C (such as 60 deg.C, 59 deg.C, 58 deg.C, 57 deg.C, 56 deg.C, 55 deg.C, 50 deg.C, etc.), adding pH regulator and antioxidant, stirring, cooling to below 45 deg.C (such as 45 deg.C, 43 deg.C, 42 deg.C, 40 deg.C, 38 deg.C, etc.), adding anti-aging composition, skin conditioner, solubilizer and aromatic, and stirring.
Preferably, the preparation method of the emollient water containing the anti-aging composition comprises the following steps:
(1) mixing humectant, water, thickener and chelating agent, heating and stirring at 80-85 deg.C to obtain water phase mixed solution;
(2) cooling the water phase mixed liquor obtained in the step (1) to below 60 ℃, adding a pH regulator and an antioxidant, uniformly stirring, cooling to below 45 ℃, adding an anti-aging composition, a skin conditioner, a solubilizer, a preservative and an aromatic, and uniformly stirring.
Compared with the prior art, the invention has the following beneficial effects:
(1) the components in the anti-aging composition and the skin conditioner are synergistic, so that the fragile and sensitive state of the skin caused by the external environment can be effectively reduced, the resistance of the skin is enhanced, the elasticity of the skin is improved, wrinkles are reduced, the skin is reddened, the moisture of the skin is increased, and the skin is kept in a healthy state of gloss and fineness;
(2) the skin lotion provided by the invention regulates the metabolism of skin through mutual matching and synergistic interaction of all components, can promote the synthesis of extracellular matrix, improve the skin hydration degree, reduce the percutaneous water loss, reduce skin fine lines, improve the skin roughness, inhibit the activity of tyrosinase, reduce the generation of melanin, improve the uneven skin color and brighten the skin color.
Detailed Description
The technical solution of the present invention is further explained by the following embodiments. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitations of the present invention.
Each of the components in the following preparation examples is commercially available.
Preparation example 1
The preparation example provides a curcuma alismatifolia root extract, which is prepared by the following preparation method:
(1) freezing root of Zingiber officinale Roscoe at-15 deg.C for 18h, pulverizing at-2 deg.C, and sieving to obtain 150 mesh Zingiber officinale Roscoe root powder;
(2) mixing the ginger flower root powder obtained in the step (1) with n-butanol, leaching for 2 hours at 25 ℃, and concentrating the solution obtained by leaching to obtain a concentrated solution; mixing the concentrated solution with ethanol, leaching at 40 deg.C for 1 hr, and filtering to obtain crude extract of rhizoma Zingiberis recens;
wherein the mass ratio of the ginger flower root powder to the n-butanol to the ethanol is 1:10: 8;
(3) and (3) passing the crude extract of the ginger flower roots obtained in the step (2) through macroporous adsorption resin AB-8, washing with deionized water, removing water solution, washing with 60 wt% ethanol water solution, collecting the washed ethanol water solution part, and concentrating to obtain the ginger flower root extract.
Preparation example 2
The preparation example provides a radix scutellariae extract, which is prepared by the following preparation method:
(a) pulverizing radix Scutellariae, and sieving to obtain 200 mesh radix Scutellariae powder;
(b) mixing the radix scutellariae powder obtained in the step (a) with an ethanol water solution with the concentration of 60 wt% according to the mass ratio of 1:10, performing microwave extraction for 8min at the power of 600W, and concentrating to obtain a radix scutellariae crude extract;
(c) dissolving the crude extract of radix scutellariae obtained in the step (b) by using 10 wt% of ethanol water solution, purifying by using a macroporous resin gel column D101, eluting by using 60 wt% of ethanol water solution, and concentrating to obtain the radix scutellariae extract.
Preparation example 3
The present preparation example provides a cocoa seed extract prepared by the following preparation method:
(A) pulverizing cacao seed to particle size of 100 mesh, mixing with n-hexane at a mass ratio of 1:10, soaking at 30 deg.C for 3 hr, filtering, and drying to obtain defatted cacao seed powder;
(B) mixing the defatted cocoa seed powder obtained in the step (A) with water, heating to 45 ℃, mixing with biological enzyme and acid, wherein the mass ratio of the defatted cocoa seed powder to the water to the cellulase is 1:15:0.006, carrying out enzymolysis reaction for 1.5h at 45 ℃ and pH of 5, and then inactivating to obtain a cocoa seed enzymolysis product;
(C) mixing the cocoa seed enzymolysis product obtained in the step (B) with 60 wt% ethanol water solution according to the mass ratio of 1:10, performing ultrasonic extraction for 50min at the power of 300W, filtering, and concentrating to obtain the crude extract of cocoa seeds.
Except that the ginger flower root extract, the scutellaria root extract and the cacao seed extract were prepared by the above-mentioned preparation methods, the remaining components in the following examples and comparative examples were all commercially available.
Example 1
This example provides an anti-aging composition comprising 5 parts of a ginger flower root extract, 12 parts of a scutellaria root extract and 3 parts of a cocoa seed extract.
Example 2
This example provides an anti-aging composition comprising, in parts by weight, 6 parts of a ginger flower root extract, 8 parts of a scutellaria root extract, and 6 parts of a cocoa seed extract.
Example 3
This example provides an anti-aging composition comprising, in parts by weight, 5 parts of a ginger flower root extract, 10 parts of a scutellaria root extract, and 5 parts of a cocoa seed extract.
Example 4
This example provides an anti-aging composition comprising, in parts by weight, 3 parts of a ginger flower root extract, 15 parts of a scutellaria root extract, and 2 parts of a cocoa seed extract.
Example 5
This example provides an anti-aging composition comprising, in parts by weight, 8 parts of a ginger flower root extract, 5 parts of a scutellaria root extract, and 7 parts of a cocoa seed extract.
Comparative example 1
This comparative example provides a composition comprising, in parts by weight, 6.5 parts of the zingiber officinale root extract, 13.5 parts of the scutellaria baicalensis root extract.
Comparative example 2
This comparative example provides a composition comprising, by weight, 11 parts of a ginger flower root extract, 9 parts of a cocoa seed extract.
Comparative example 3
The present comparative example provides a composition comprising 14.5 parts of scutellaria root extract, 5.5 parts of cocoa seed extract by weight parts.
Application example 1
The application example provides a lotion containing an anti-aging composition, and the lotion containing the anti-aging composition comprises the following raw materials in percentage by mass:
the preparation method of the emollient water containing the anti-aging composition comprises the following steps:
(1) mixing the humectant, water, thickener and chelating agent, and heating and stirring at 82 deg.C to obtain water phase mixed solution;
(2) cooling the water phase mixed liquor obtained in the step (1) to 55 ℃, adding a pH regulator and an antioxidant, uniformly stirring, cooling to 45 ℃, adding an anti-aging composition, a skin conditioner, a solubilizer, a preservative and an aromatic, and uniformly stirring.
Application example 2
The application example provides a lotion containing an anti-aging composition, and the lotion containing the anti-aging composition comprises the following raw materials in percentage by mass:
the preparation method of the emollient water containing the anti-aging composition in the application example is the same as that in application example 1.
Application example 3
The application example provides a lotion containing an anti-aging composition, and the lotion containing the anti-aging composition comprises the following raw materials in percentage by mass:
the preparation method of the emollient water containing the anti-aging composition in the application example is the same as that in application example 1.
Application example 4
The application example provides a lotion containing an anti-aging composition, and the lotion containing the anti-aging composition comprises the following raw materials in percentage by mass:
the preparation method of the emollient water containing the anti-aging composition in the application example is the same as that in application example 1.
Application example 5
The application example provides a lotion containing an anti-aging composition, and the lotion containing the anti-aging composition comprises the following raw materials in percentage by mass:
the preparation method of the emollient water containing the anti-aging composition in the application example is the same as that in application example 1.
Application example 6
The application example provides the emollient water containing the anti-aging composition, and the emollient water is only different from the application example 1 in that alpha-arbutin is not added, the content of cajeput oil is increased to 0.15%, and the content of other components and the preparation method are the same as the application example 1.
Application example 7
The application example provides the emollient water containing the anti-aging composition, and the emollient water is only different from the emollient water of the application example 1 in that the cajeput oil is not added, the content of alpha-arbutin is increased to 0.15%, and the content of other components and the preparation method are the same as the application example 1.
Application example 8
The present application example provides a skin lotion containing an anti-aging composition, which is different from application example 1 in that the anti-aging composition provided in example 1 is replaced with the anti-aging composition provided in example 4 of equal mass, and the contents of other components and the preparation method are the same as those of application example 1.
Application example 9
The present application example provides a skin lotion containing an anti-aging composition, which is different from application example 1 in that the anti-aging composition provided in example 1 is replaced with the anti-aging composition provided in example 5 of equal mass, and the contents of other components and the preparation method are the same as those of application example 1.
Comparative application example 1
The comparative application example provides a lotion which is different from the application example 1 in that the anti-aging composition provided in the example 1 is replaced by the composition provided in the comparative example 1 with equal mass, and the contents of other components and the preparation method are the same as those in the application example 1.
Comparative application example 2
The comparative application example provides a lotion, which is different from the application example 1 in that the anti-aging composition provided in the example 1 is replaced by the composition provided in the comparative example 2 with equal mass, and the contents of other components and the preparation method are the same as those in the application example 1.
Comparative application example 3
The comparative application example provides a lotion, which is different from the application example 1 in that the anti-aging composition provided in the example 1 is replaced by the composition provided in the comparative example 3 with equal quality, and the contents of other components and the preparation method are the same as those in the application example 1.
Comparative application example 4
This comparative application example provides a skin lotion, which is different from application example 1 in that, without addition of a lactobacillus fermentation lysate, the content of Chondrus crispus extract was increased to 1.5%, the content of acetylcysteine was increased to 1.5%, and the contents of other components and the preparation method were the same as in application example 1.
Comparative application example 5
This comparative application example provides a skin lotion, which is different from application example 1 in that, without addition of Chondrus crispus extract, the content of lactobacillus fermentation lysate was increased to 2.3%, the content of chitosamine was increased to 0.7%, and the contents of other components and preparation method were the same as in application example 1.
Comparative application example 6
The comparative application example provides a skin lotion, which is different from application example 1 in that, without adding acetyl chitosamine, the lactobacillus fermentation lysate content was increased to 2.2%, the carrageen crispus extract content was increased to 0.8%, and the contents of other components and the preparation method were the same as in application example 1.
Test example 1
Safety performance testing
Safety performance tests were performed on the skin lotions provided in application examples 1-9 and on the skin lotions provided in comparative application examples 1-6, as follows:
(1) haemolysis test of erythrocytes
Preparation of erythrocyte suspension: selecting healthy rabbits, taking 9mL of blood from heart, adding 1mL of 2% potassium oxalate solution, centrifuging, discarding supernatant, diluting the precipitate to 20mL with 20mmol/L PBS solution, and storing at 4 ℃ for later use. Select samples were diluted with PBS solution to different concentrations, with 5 concentration gradients set for each sample. Adding 200 μ L of the above erythrocyte suspension (final concentration of the sample is controlled to be 5, 10, 20, 50, 100mg/mL respectively) into 10mL of diluent of the sample to be tested, taking distilled water as total blood-dissolving control, taking PBS solution as negative control, mixing gently, incubating at 37 deg.C for 30min, centrifuging at 2000r/min for 10min, collecting supernatant, and testing its absorbance at 560nm with spectrophotometer (A)560) Calculating the hemolysis rate according to the following formula;
drawing a standard curve of hemolysis rate-sample concentration and calculating 50% erythrocyteConcentration of sample when hemolysis occurs (HD)50)。
(2) Protein denaturation experiments:
diluting the sample to 10g/L with PBS solution, collecting 10mL dilution of the sample to be tested, adding 200 μ L of the erythrocyte suspension, using distilled water as blank control, 1mg/mL Sodium Dodecyl Sulfate (SDS) solution as positive control, mixing gently, incubating at 37 deg.C for 30min, centrifuging at 2000r/min for 10min, collecting supernatant, and testing absorbance A at 540nm and 575nm with spectrophotometer540And A575Calculating a protein denaturation index (D) according to the following formula;
wherein R is1Blank control group a575Blank control group A540，R2Experimental group a575Experimental group A540，R3Positive control group A575Positive control group A540。
Evaluating the irritation of the sample to be tested according to the L/D value, wherein the L/D value is HD50The following table 1 shows the experimental irritation grading criteria for erythrocyte hemolysis:
TABLE 1
The results of the above-described hemolysis test and protein denaturation test are shown in Table 2 below:
TABLE 2
| Test sample | HD50(mg/L) | DI(％) | L/D | Evaluation of |
| Application example 1 | 24982 | 2.18 | >100 | Has no irritation |
| Application example 2 | 25054 | 2.16 | >100 | Has no irritation |
| Application example 3 | 25105 | 2.20 | >100 | Has no irritation |
| Application example 4 | 24723 | 2.05 | >100 | Has no irritation |
| Application example 5 | 24750 | 2.03 | >100 | Has no irritation |
| Application example 6 | 24450 | 2.29 | >100 | Has no irritation |
| Application example 7 | 24294 | 2.25 | >100 | Has no irritation |
| Application example 8 | 24025 | 2.24 | >100 | Has no irritation |
| Application example 9 | 24016 | 2.30 | >100 | Has no irritation |
| Comparative application example 1 | 20485 | 5.23 | ﹥100 | Has no irritation |
| Comparative application example 2 | 20120 | 5.82 | ﹥100 | Has no irritation |
| Comparative application example 3 | 19825 | 5.57 | ﹥100 | Has no irritation |
| Comparative application example 4 | 19942 | 5.87 | ﹥100 | Has no irritation |
| Comparative application example 5 | 20117 | 5.80 | ﹥100 | Has no irritation |
| Comparative application example 6 | 20230 | 5.75 | ﹥100 | Has no irritation |
As can be seen from the safety performance test, the skin moistening water temperature prepared by the application examples 1-9 is not stimulated according to the test result; the sample concentration HD of the skin lotion prepared by the invention when 50% of red blood cells are subjected to hemolysis50HD of more than 17000mg/L which is larger than that of the emollient water prepared in the comparative application examples 1-650(ii) a Simultaneous denaturation of proteinsThe index DI is below 2.3 percent and is also obviously smaller than the emollient water prepared in the comparative application examples 1-6, which shows that the addition of the anti-aging composition can obviously reduce the toxic and side effects and irritation of the emollient water, and is safer and more reliable.
Test example 2
Test for moisture retention
The moisturizing performance of the emollient water containing the anti-aging composition provided in the application examples 1-9 and the emollient water provided in the comparative application examples 1-6 were tested, and the method was as follows:
(1) in vitro weighing method for testing moisture retention performance
Weighing 0.2g of sample, respectively and uniformly coating the sample on a 5cm × 5cm glass plate stuck with the microporous breathable adhesive tape, putting the glass plate into a dryer with constant temperature and constant humidity, respectively weighing the mass of the glass plate after being placed for 4 hours, and calculating the moisture retention rate. The moisture retention rate calculation formula is as follows:
moisture retention rate/% (M)2-M0)/(M1-M0)×100％。
Wherein M is0Is the mass/g, M, of the glass sheet1For the mass/g, M of the glass plate after sample application2The glass sheet mass/g after standing in the desiccator for several hours.
(2) Rate of change of percutaneous water loss
150 healthy skin volunteers 18-55 years old were selected and randomly divided into 15 groups of 5 males and 5 females for each group, and each sample was used separately. The test apparatus is Tewameter TM300 from CK corporation, Germany, and the external environment is tested: room temperature 25 ℃ and humidity 60%.
Before the skin composition was applied, and after 4 consecutive days of application, the change rate of transepidermal water loss of each subject was measured, three times for each data, and after taking the average value, the average value of each group was calculated, and one decimal place was retained.
(3) Water retention rate
150 healthy skin volunteers 18-55 years old were selected and randomly divided into 15 groups of 5 males and 5 females for each group, and each sample was used separately. The instrument is of the German Courage + Khazaka electronic type: derma Unit SSC, test temperature 25 ℃, humidity 60%.
Respectively testing the moisture content of the skin of each subject before use and after use for 4h, testing each data for three times, calculating the average value of each group after taking the average value, and keeping one digit after the decimal point;
specific test results are shown in table 3.
TABLE 3
| Test sample | Moisture retention/degree | Percutaneous rate of change of water loss/%) | Moisture content of skin/%) |
| Application example 1 | 90.7 | 11.8 | 50.0 |
| Application example 2 | 90.8 | 12.0 | 49.5 |
| Application example 3 | 90.4 | 11.9 | 49.7 |
| Application example 4 | 89.6 | 12.5 | 48.2 |
| Application example 5 | 89.5 | 12.7 | 48.3 |
| Application example 6 | 88.9 | 13.4 | 48.5 |
| Application example 7 | 88.7 | 12.9 | 48.4 |
| Application example 8 | 87.3 | 14.0 | 47.8 |
| Application example 9 | 88.1 | 13.9 | 47.5 |
| Comparative application example 1 | 62.3 | 36.8 | 36.2 |
| Comparative application example 2 | 70.4 | 34.7 | 34.0 |
| Comparative application example3 | 71.3 | 35.2 | 33.5 |
| Comparative application example 4 | 65.2 | 32.8 | 34.1 |
| Comparative application example 5 | 64.8 | 33.1 | 31.9 |
| Comparative application example 6 | 68.4 | 36.0 | 32.7 |
As shown in the test data in Table 3, the moisturizing rate of the lotion containing the anti-aging composition is more than 88% after 4 hours; the change rate of percutaneous water loss is maintained below 14 percent; the water content of skin is above 45% after 4 hr. Therefore, the skin moisturizer disclosed by the invention can promote the synthesis of extracellular matrix, stabilize the self moisture and lipid barrier of skin, keep the cell moist, improve the skin hydration degree, reduce the loss of percutaneous moisture, ensure better skin absorbability, be beneficial to the damage repair of skin and nourish the skin.
Test example 3
Anti-wrinkle efficacy test
The anti-wrinkle efficacy test was performed on the emollient water containing the anti-aging composition provided in application examples 1-9 and on the emollient water provided in application examples 1-6, and the method was as follows:
(1) elastin production promotion test: inoculating human fibroblasts on a 96-well plate according to the density of 20000 cells per well, adding a culture medium, culturing for 24h in an incubator at 37 ℃, replacing a new culture medium after the cells adhere to the wall, respectively adding each test sample composition (controlling the final concentration of the sample to be 50mg/mL), taking a PBS solution of 20mmol/L as a blank control, and then culturing for 2 days in the incubator at 37 ℃;
(2) clinical anti-wrinkle efficacy testing: 150 healthy 18-55 year old volunteers were selected and randomized into 15 groups of 5 males and 5 females, and the wrinkles on the face of the subjects were blotted with silicone resin and applied to the wrinkles on the face of the subjects 2 times a day for 60 consecutive days. Wrinkle imprints were taken from the test sites of the subjects 30 days and 60 days after treatment, respectively, and wrinkle depth was measured with a confocal microscope. Calculating the percentage of wrinkle depth reduction after 30 and 60 days of treatment;
the specific test results are shown in table 4:
TABLE 4
As shown in the test data in Table 4, the emollient water containing the anti-aging composition can promote the expression of elastin, and the expression level of elastin is more than 4.5; the wrinkle depth reduction value reaches more than 14% after 30 days of use, and the wrinkle depth reduction value reaches more than 18% after 60 days of use, which shows that the skin lotion containing the anti-aging composition supplements each other, has a synergistic effect, can adjust the oxidation-reduction balance of cells, adjust autophagy of cells, promote the growth of cells, promote the synthesis and repair of collagen and fibronectin, improve the symptoms of cracks, and further lighten fine lines; can quickly consume older protein and unstable peptide chain, eliminate sunken wrinkles and tighten skin, thereby essentially repairing fine lines of the skin.
Test example 4
Anti-aging and brightening effect test
The anti-aging and brightening effect test is carried out on the emollient water containing the anti-aging composition provided in the application examples 1-9 and the emollient water provided in the comparative application examples 1-6, and the method comprises the following steps:
150 healthy 18-55-year-old volunteers were selected and randomly divided into 15 groups of 5 males and 5 females, each group using the samples of each group on the face, 1 time each day, morning and evening, for a total of 4 weeks.
(1) The skin melanin content changes before and after application of the mask composition were evaluated by a skin melanin tester (Hexameter MX 18). The measurement range of the used instrument is 0-999, and the higher the measurement value, the higher the melanin content in the skin is. The amount of melanin reduction on the skin of the front and back of a subject using the mask composition prepared according to the present invention;
(2) VISIA skin assay evaluation: after the face of the tested volunteer is cleaned, a VISIA facial image analyzer is used for carrying out facial shooting, the detection data of facial pigment spots, textures and wrinkles are analyzed, and the phenomenon that the pigment spots and the textures are more obvious when the numerical value is higher is represented. After the treatment course is finished, comparing the information obtained by the VISIA facial image analyzer with the information before treatment, and analyzing the improvement condition of facial pigmented spots, textures and wrinkles of the tested volunteers, wherein p is less than 0.02, and the statistical significance is achieved;
(3) the brightening effect is as follows: the skin color difference tester (probe CL400 and multi-probe skin test system MPA10) was used to test the skin color of the face of the test volunteers before and after treatment, respectively, and the ITA was calculated. The test conditions are a constant temperature and humidity environment with the temperature of 22 ℃ and the humidity of 50 percent.
The specific test results are shown in table 5:
TABLE 5
As can be seen from the test data in table 5, by comparing the results of the VISIA test before and after treatment, the melanin reduction of the subject is up to 54% or more, the pigmented spots are reduced by 19% or more, the texture reduction is up to 23% or more, and the brightening efficacy is up to 24% or more after the skin moisturizing lotion provided in application examples 1 to 9 is used. The reduction of melanin of a tested subject is obvious, the skin color spots and the texture of the tested volunteer are obviously improved, the brightening effect of the facial skin color is obvious, and the curative effect evaluation is effective. Therefore, the skin lotion provided by the invention has reasonable compatibility of components, has a synergistic effect, can promote the synthesis of extracellular matrix, improve the skin hydration degree, reduce the percutaneous water loss, reduce the skin fine lines, improve the skin roughness, inhibit the activity of tyrosinase, reduce the generation of melanin, improve the uneven skin color and brighten the skin color.
The applicants state that the present invention is illustrated by the above examples to provide a lotion containing an anti-aging composition and a method of making the same, but the present invention is not limited to the above examples, which is not meant to imply that the present invention must be practiced by the above examples. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
Claims (10)
1. The lotion containing the anti-aging composition is characterized in that the lotion containing the anti-aging composition is prepared from the raw materials of the anti-aging composition, a skin conditioner, a humectant and water;
the anti-aging composition comprises a ginger root extract, a scutellaria root extract and a cacao seed extract;
the skin conditioning agent comprises lactobacillus fermentation lysate, carrageen crispus extract and acetyl chitosamine.
2. The emollient water containing anti-aging composition according to claim 1, wherein in said anti-aging composition, the mass ratio of said ginger root extract, scutellaria root extract and cacao seed extract is (3-8): (5-15): (2-7);
preferably, in the skin conditioner, the mass ratio of the lactobacillus fermentation lysate, the carrageen crispus extract and the acetyl chitosamine is (1-5): (0.1-1).
3. The lotion containing the anti-aging composition according to claim 1 or 2, wherein the lotion containing the anti-aging composition is prepared from 0.01 to 5% by mass of the anti-aging composition, 0.01 to 10% by mass of a skin conditioner, 5 to 25% by mass of a humectant, and the balance of water, based on 100% by mass of the raw materials for preparing the lotion containing the anti-aging composition.
4. The emollient water containing anti-aging composition according to any of claims 1-3, wherein said skin conditioner further comprises any one or a combination of at least two of Sophora flavescens root extract, Glycyrrhiza inflate root extract, niacinamide, alpha-arbutin, yeast/Sichuan millet fermentation product filtrate, yeast dehiscence product lysate, animal umbilical cord extract, animal placental protein, animal placental enzyme or cajeput oil;
preferably, the skin conditioner comprises 1-5% of lactobacillus fermentation lysate, 0.1-1% of carrageen crispus extract, 0.1-1% of acetyl chitosamine, 0.01-0.1% of sophora flavescens root extract, 0.01-0.1% of glycyrrhiza inflate root extract, 0.1-1% of nicotinamide, 0.05-0.3% of alpha-arbutin, 0.01-0.1% of yeast/Sichuan millet seed fermentation product filtrate, 0.01-0.3% of schizosaccharomyces cerevisiae fermentation product lysate, 0.01-0.1% of animal umbilical cord extract, 0.01-0.1% of animal placental protein, 0.01-0.1% of animal placental enzyme and 0.01-0.1% of melaleuca oil by mass of 100% of the raw materials for preparing the emollient water containing the anti-premature aging composition.
5. The emollient water containing anti-aging composition according to any of claims 1 to 4, wherein said humectant comprises any one or combination of at least two of butylene glycol, glyceryl polyether-26, trehalose, sodium hyaluronate or 1, 2-hexanediol;
preferably, the moisturizer comprises 5-10% of butanediol, 261-5% of glyceryl polyether, 0.1-2% of trehalose, 0.05-0.2% of sodium hyaluronate and 0.1-1% of 1, 2-hexanediol by mass of 100% of raw materials for preparing the emollient water containing the anti-aging composition.
6. The emollient water containing the anti-aging composition according to any of claims 1 to 5, wherein the raw materials for preparing the emollient water further comprise any one or a combination of at least two of a thickener, a pH regulator, a chelating agent, an antioxidant, a solubilizer or a fragrance;
preferably, the raw materials for preparing the emollient water containing the anti-aging composition further comprise 0.01-0.2% of thickening agent, 0.05-0.15% of pH regulator, 0.01-0.05% of chelating agent, 0.1-1% of antioxidant, 0.01-0.05% of solubilizer and 0.01-0.05% of aromatic, wherein the mass of the raw materials is 100%.
7. The emollient water containing anti-aging composition according to claim 6, wherein said thickener comprises hydroxyethylcellulose and/or carbomer;
preferably, the pH adjusting agent is arginine;
preferably, the chelating agent is disodium EDTA;
preferably, the antioxidant is p-hydroxyacetophenone;
preferably, the solubilizer is PEG-40 hydrogenated castor oil;
preferably, the fragrance is a perfume.
8. A method of preparing a lotion comprising an anti-aging composition according to any of claims 1-7, wherein the lotion is prepared by a method comprising the steps of:
(1) mixing the humectant with water, heating and stirring to obtain a water phase mixed solution;
(2) and (2) cooling the water phase mixed liquor obtained in the step (1), and mixing with the anti-premature composition and the skin conditioner to obtain the skin lotion containing the anti-premature composition.
9. The method for preparing the anti-aging composition-containing emollient water according to claim 8, wherein in step (1), the temperature of the heating and stirring is 80-85 ℃;
preferably, in the step (1), a thickening agent and a chelating agent are also added;
preferably, in the step (2), the mixing is specifically: cooling the water phase mixed liquor obtained in the step (1) to below 60 ℃, adding a pH regulator and an antioxidant, uniformly stirring, cooling to below 45 ℃, adding an anti-aging composition, a skin conditioner, a solubilizer and an aromatic, and uniformly stirring.
10. The method for preparing the anti-aging composition-containing emollient water according to claim 8 or 9, wherein said anti-aging composition-containing emollient water is prepared by the steps of:
(1) mixing humectant, water, thickener and chelating agent, heating and stirring at 80-85 deg.C to obtain water phase mixed solution;
(2) cooling the water phase mixed liquor obtained in the step (1) to below 60 ℃, adding a pH regulator and an antioxidant, uniformly stirring, cooling to below 45 ℃, adding an anti-aging composition, a skin conditioner, a solubilizer, a preservative and an aromatic, and uniformly stirring.
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| CN116115540A (en) * | 2023-03-20 | 2023-05-16 | 广东雅丽洁精细化工有限公司 | Skin anti-aging composition, application and daily chemical product |
| CN116115540B (en) * | 2023-03-20 | 2023-10-24 | 广东雅丽洁精细化工有限公司 | Skin anti-aging composition, application and daily chemical product |
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