CN112545906A

CN112545906A - Sun-screening and repairing day cream and preparation method thereof

Info

Publication number: CN112545906A
Application number: CN202011542024.1A
Authority: CN
Inventors: 余涧坤; 任昱曈
Original assignee: China Medical University
Current assignee: China Medical University
Priority date: 2020-12-23
Filing date: 2020-12-23
Publication date: 2021-03-26

Abstract

The invention belongs to the field of cosmetics, and particularly relates to day cream containing a sun-screening component and a repairing component and a preparation method thereof. A sun-screening and repairing day cream mainly comprises: the sunscreen cream comprises a humectant, a thickener, an emulsifier, an emollient, a preservative, a sunscreen component, a repairing component and water, and is prepared by the following steps: putting the oil phase components into an emulsifying pot, mixing and heating to 70-80 ℃, and stirring for 30 minutes at constant temperature; simultaneously putting the water phase components into another emulsifying pot, mixing and heating to 70-80 ℃, and stirring at constant temperature until the components are completely dissolved or dispersed; slowly adding the water phase into the oil phase under the condition of constant-temperature stirring, keeping the temperature of 70-80 ℃, stirring for 15 minutes to fully emulsify the water phase, stopping heating, and cooling under the condition of room-temperature stirring; cooling to 35-40 ℃, adding other components, uniformly stirring, cooling to below 30 ℃, and discharging after inspection. The sunscreen repair day cream provided by the invention has the advantages of good skin protection and repair capability, high safety, fine skin feel, simple preparation method and better application prospect.

Description

Sun-screening and repairing day cream and preparation method thereof

Technical Field

The invention belongs to the field of cosmetics, relates to a skin-care day cream, and particularly relates to a day cream containing a sun-screening component and a repairing component and a preparation method thereof.

Background

Ultraviolet radiation in the sun is a major environmental factor causing skin aging and skin cancer, and sunscreen products are increasingly used in order to prevent skin damage and skin diseases. However, the traditional chemical sunscreen agents have the problems of low solubility, high irritation, poor light stability, greasy skin feel, low ultraviolet absorptivity and the like, so that the sunscreen day cream which is good in sunscreen performance, good in light stability, fresh and non-greasy is required to be provided.

The sunscreen ingredients in the current commercially available sunscreen skin care product formula system are roughly divided into three types: a pure physical uv screening agent sunscreen component, a pure chemical uv absorbing sunscreen component, and a formulation system in which a physical sunscreen component is combined with a chemical sunscreen component. However, the sun-screening day cream alone cannot provide good repairing capability and cannot meet the requirements of consumers, so that an effective repairing component needs to be added into the formula to improve the repairing capability of the day cream.

The growth factor secreted by the stem cell has extremely low content in vivo but extremely high biological activity, can promote cell differentiation and proliferation, induce and chemotaxis inflammatory cells, and influence cell division and migration. Thus, growth factors secreted by stem cells play an important role in skin repair. The stem cell factor extracting solution is a supernatant culture solution collected in the culture process of stem cells which are extracted from human umbilical cords and induced to differentiate, wherein the stem cell factor extracting solution contains the following stem cell factor types: epidermal Growth Factor (EGF), Fibroblast Growth Factor (FGF), Platelet Derived Growth Factor (PDGF), platelet endothelial growth factor (VEGF), and the like. Epidermal Growth Factor (EGF) can promote metabolism of skin cells, and indirectly promote secretion of collagen and hyaluronic acid.

Disclosure of Invention

Aiming at the problems in the prior art, the invention aims to provide a day cream containing a sun-screening component and a repairing component and a preparation method thereof.

In order to achieve the above purpose, the invention adopts the following technical scheme.

The sun-screening and repairing day cream mainly comprises the following components in percentage by mass: 5-15% of a humectant, 0.2-1.2% of a thickener, 5-10% of an emulsifier, 5-10% of an emollient, 0.1-0.5% of a preservative, 20-25% of a sunscreen component, 1-2% of a repairing component and the balance of water.

Further, in the sunscreen and repair day cream, the humectant consists of one or more of the following components in percentage by weight: 0.1% of allantoin, 1-10% of glycerol, 1-5% of propylene glycol, 1-5% of butanediol, 2-5% of beta-glucan and 1-1.3% of D-panthenol.

Further, in the sunscreen and repair day cream, the emulsifier is composed of one or more of the following components in percentage by weight: 3% of a mixture of arachidyl alcohol, behenyl alcohol and arachidyl alcohol glucoside, 5-10% of stearyl alcohol, 3-5% of cetostearyl alcohol, 2-4% of polydimethylsiloxane, 1.5-2% of potassium lauryl sulfate, 5% of isononyl isononanoate, 5% of C12-15 alcohol benzoate and 5-7% of cyclopentyldimethylsiloxane.

Further, in the sunscreen and repair day cream, the emollient is composed of one or more of the following components in percentage by weight: 0.1% of allantoin, 1-10% of glycerol, 1-5% of propylene glycol, 1-5% of butanediol, 2-5% of beta-glucan and 1-1.3% of D-panthenol.

Further, in the sunscreen and repair day cream, the thickening agent is composed of one or more of the following components in percentage by weight: 5-15% of liquid paraffin, 0.5-1% of glycerin monostearate, 0.05-0.2% of xanthan gum, 0.05-0.25% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and 0.1-0.2% of sodium acrylate/sodium acryloyldimethyl taurate copolymer.

Further, in the sunscreen repair day cream, the sunscreen component comprises one or more of the following components in percentage by weight: 10-15% of titanium dioxide, 5-10% of zinc oxide, 2-7% of diethylamino hydroxybenzoyl hexyl benzoate, 5-10% of octyl methoxycinnamate, 5-7% of 2-ethylhexyl 4-methoxycinnamate and 2.5-5% of methylene bis-benzotriazolyl tetramethyl butylphenol.

Further, in the sunscreen repair day cream, the repair components comprise one or more of the following components in percentage by weight: 2-7% of diethyl amino hydroxybenzoyl hexyl benzoate, 5-10% of octyl methoxycinnamate and 5-7% of 2-ethylhexyl 4-methoxycinnamate.

Furthermore, in the sunscreen repair day cream, the repair component contains a stem cell repair factor extracting solution, and the dosage is 1-2%: the stem cell factor extracting solution is supernatant collected from mesenchymal stem cells from human umbilical cords in the culture process, mainly comprises amino acids, vitamins, inorganic salts, growth factors, trace elements and other components, does not contain antibiotics, serum or heterologous components, has the pH value of 7.0 +/-0.5 and the osmotic pressure of 280-340 mOsmol/kg.

Further, in the sunscreen and repair day cream, the preservative comprises one or more of the following components in percentage by weight: 0.01-0.03% of EDTA-disodium, 0.07-0.15% of chlorphenesin, 0.05-0.2% of phenoxyethanol and 0.1-0.2% of methylparaben.

Further, the preparation method of the sun-screening and repairing day cream specifically comprises the following steps.

Step 1, putting the oil phase components into an emulsifying pot, mixing and heating to 70-80 ℃, and stirring for 30 minutes at constant temperature. Wherein the oil phase component comprises a majority of emulsifier, sunscreen component and a portion of thickener.

And 2, simultaneously putting the water phase components into another emulsifying pot, mixing and heating to 70-80 ℃, and stirring at constant temperature until the components are completely dissolved or dispersed. Wherein the water phase component comprises most of humectant, antiseptic antibacterial agent, and part of thickener.

And 3, slowly adding the water phase into the oil phase under the condition of constant-temperature stirring, keeping the temperature of 70-80 ℃, stirring for 15 minutes to fully emulsify the water phase, stopping heating, and cooling under the condition of stirring at room temperature.

And 4, cooling to 35-40 ℃, adding other components, uniformly stirring, cooling to below 30 ℃, checking to ensure that the pH value and the viscosity value reach the standard, and discharging qualified products. Wherein the other components comprise a preservative which is not high temperature resistant, stem cell repair factor extracting solution and the like.

Compared with the prior art, the invention has the following beneficial effects.

The sunscreen and repairing day cream provided by the invention is added with the humectant, the emulsifier and the emollient, the humectant can form a protective layer similar to an oil film on the surface of the skin, the loss of water in the horny layer is reduced, the water content of the horny layer is ensured, the dry skin is prevented from being dried, and a lubricating component which is lacked by the dry skin is provided; the emulsifier can sufficiently emulsify the water phase and the oil phase to form stable emulsion; the emollient can keep skin soft and smooth, fill the space on the skin surface, and improve skin appearance.

The sunscreen and repair day cream provided by the invention is added with sunscreen and repair components, the physical sunscreen agent is mild, and can block external ultraviolet rays through reflection or scattering; the chemical sunscreen agent is light and thin, can realize sunscreen by absorbing harmful ultraviolet rays, and can simultaneously realize the purposes of better skin feel and higher sunscreen times by combining the chemical sunscreen agent and the chemical sunscreen agent. The repairing component has the functions of keeping skin elasticity, repairing skin injury, resisting external stimulation and the like.

The repair component in the sunscreen repair day cream provided by the invention contains a stem cell repair factor extracting solution, and stem cell exosomes can act on a plurality of inflammation signal channels or channels formed by collagen, so that the effects of regulating the immune state of local skin, supplementing water, moisturizing and the like are exerted, and the physiological state of the skin is improved and the aging is delayed.

The sunscreen repair day cream provided by the invention has the advantages of good skin protection and repair capability, high safety, fine skin feel, simple preparation method and better application prospect.

Drawings

FIG. 1 is a flow chart of a preparation method of the sunscreen day cream.

Detailed Description

The present invention is further described in detail with reference to the following specific examples, which are only examples of the present application and are not intended to limit the scope of the present application. Various modifications and changes may occur to those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Example 1 prescription screening.

In the embodiment, four formulas are prepared, and the specific components are calculated according to weight percentage, and the balance is water. The composition is shown in Table 1 (in the table, "-" indicates that the component content in the prescription is the same as that in the prescription 1, and "/" indicates that the component is not contained in the prescription).

Table 1. prescription dose.

The preparation methods of the four sun-proof repairing day cream formulas are basically the same, and the preparation methods comprise the following steps: (1) and (3) putting the oil phase components into an emulsifying pot, mixing and heating to 70-80 ℃, and stirring for 30 minutes at constant temperature. Wherein the oil phase component comprises a majority of emulsifier, sunscreen component and a portion of thickener. (2) And simultaneously putting the water phase components into another emulsifying pot, mixing and heating to 70-80 ℃, and stirring at constant temperature until the components are completely dissolved or dispersed. Wherein the water phase component comprises most of humectant, antiseptic antibacterial agent, and part of thickener. (3) And slowly adding the water phase into the oil phase under the condition of constant-temperature stirring, keeping the temperature of 70-80 ℃, stirring for 15 minutes to fully emulsify the water phase, stopping heating, and cooling under the condition of stirring at room temperature. (4) Cooling to 35-40 ℃, adding other components, uniformly stirring, cooling to below 30 ℃, checking to ensure that the pH value and the viscosity value reach the standard, and discharging qualified products. Wherein other components comprise a preservative which is not high temperature resistant, a stem cell repair factor extracting solution and the like. The flow chart of the preparation method of the sun-screening and repairing day cream formula is shown in figure 1.

Example 2 day cream quality and effect evaluation.

1. And (4) measuring the pH.

The method comprises the following specific steps: (1) adjusting the temperature of the deionized water and the standard solution to be the same according to the instruction of the instrument, recording the measured temperature, and selecting the standard solution with the pH value different from that of the deionized water by no more than 2 pH units to calibrate the instrument. (2) The electrode was removed from the first standard solution, rinsed with deionized water and gently blotted dry with the edge of filter paper, and the electrode was immersed in a second standard solution at a pH approximately 3 pH units different from the previous one. If the difference between the measured value and the pH value of the second standard solution is greater than 0.1, it is necessary to check whether the instrument, the electrode or the standard solution has a problem. When all the three are abnormal, the sample can be measured. (3) And (3) sample determination: both electrodes were first carefully rinsed with deionized water, and the sample was rinsed with deionized water at a rate of 1: 10 ratio dilution, then the electrode is immersed in the diluted sample, carefully stirred or shaken to homogenize it, and the pH is recorded after the reading has stabilized. Each sample was assayed in triplicate and the average was taken. The results are shown in Table 2.

Table 2 pH measurement results.

Sample numbering	Prescription 1	Prescription 2	Prescription 3	Prescription 4
					pH1	6.71	7.22	7.01	7.56
pH2	6.83	7.01	6.81	7.24
					pH3	6.65	7.82	6.98	7.11
Average pH	6.73	7.35	6.93	7.30

Commercial creams have a pH of about 6 to 8, which is close to skin pH and thus have minimal irritation. From the above table, it can be concluded that the day creams prepared according to the formulas 1 to 4 in the embodiments of the present invention all meet the pH requirement of the face cream, and belong to the normal range.

2. And (4) measuring the viscosity.

The viscosity is measured specifically: (1) the viscometer is cleaned and the two leveling feet are adjusted until the bubble at the top of the viscometer remains in the center position. (2) The rotor guard frame was mounted on the viscometer. (3) And selecting a proper rotor (No. 4 rotor is selected in the invention), and screwing the selected rotor into the connecting screw rod. (4) And (5) connecting a power supply and turning on a switch button of the viscometer. (5) And inputting the number of the selected rotor, vertically immersing the rotor into the sample, leveling the scale mark with the surface of the sample, and starting the instrument. (6) And recording the corresponding numerical value after the reading number is stable. Each sample was assayed in triplicate and the average was taken. The results are shown in Table 3.

TABLE 3 results of viscosity measurements.

Sample numbering	Prescription 1	Prescription 2	Prescription 3	Prescription 4
					Viscosity 1	37000	40100	39000	44900
Viscosity 2	36510	42900	39100	41300
					Viscosity 3	33700	41300	42000	40200
Average viscosity	35737	41433	40033	42133

The measurement result is basically consistent with the viscosity of the commercial cream and meets the requirement.

3. Skin moisture improvement test.

The specific steps of the skin moisture improvement test are as follows: selecting 20 men and women with the ages of 20-45 years and no special facial flaws, randomly dividing into 4 groups, cleaning the face every morning, uniformly wiping the face with a proper amount of face cream, and measuring the skin moisture by using an instrument after 10 minutes. The effect after 5, 10, 20, 40 days of use is shown in table 4.

TABLE 4 skin moisture measurement.

Number of days/prescription	Prescription 1	Prescription 2	Prescription 3	Prescription 4
					5d	+2％	+1％	+2％	+2％
10d	+5％	+4％	+3％	+2％
					20d	+7％	+5％	+3％	+5％
40d	+7％	+6％	+4％	+7％

The measurement result proves that the water locking capacity of the sample is good.

4. And (4) testing the sun protection effect.

The sun protection effect test comprises the following specific steps: groups of mice were back-dehaired with 0.8% sodium sulfate, exposing a 6cm x 6cm test area. Before the sunscreen cream is applied, the skin is cleaned by warm water, the mice coated with the sunscreen cream are placed in a sunlight simulation test box for 1 hour, the operation is continuously carried out for 3 months, and new mouse hair is timely shaved off in the period. Finally, the melanin content of the skin of the tested mice is tested by using a skin melanin instrument, and the experimental results are shown in table 5.

TABLE 5 sunscreen effectiveness test.

Group of	Melanin content before experiment	Melanin content after test
			Blank group	17	32
Prescription 1	18	24
			Prescription 2	19	25
Prescription 3	16	20
			Prescription 4	16	21

As can be seen from table 5, the experimental group had a significant sunscreen effect compared to the blank group, and the sunscreen effects of formula 3 and formula 4 were better.

5. And evaluating the safety performance of the sunscreen skin care product.

The safety performance evaluation method of the sunscreen skin care product comprises the following specific steps: the potential allergen or irritant in the face cream is detected by adopting a human skin patch experiment. The experimental method is formulated according to technical Specification for cosmetic safety. And (3) selecting 50 qualified volunteers to take part in the test, and adding the tested sample and the blank control into the spot test equipment according to a sample random distribution table. The spot test device with the test object is applied to the inner side of the forearm of the subject, the test device is lightly pressed by hands to be uniformly applied to the skin for 24 hours, the skin reaction is observed according to the standard of the table 6 after 30min (after the indentation disappears), 24 hours and 48 hours of removing the spot test device of the test object respectively, and the observation result is recorded. The results are shown in Table 7 below.

Table 6 closed patch experimental skin response grading standard.

TABLE 7 Patch test results.

As can be seen from Table 7, no adverse reaction occurred in the control group and the experimental group, which indicates that the cream product has mild formula and high safety.

Claims

1. The sun-screening and repairing day cream is characterized by mainly comprising the following components in percentage by weight: 5-15% of a humectant, 0.2-1.2% of a thickener, 5-10% of an emulsifier, 5-10% of an emollient, 0.1-0.5% of a preservative, 20-25% of a sunscreen component, 1-2% of a repairing component and the balance of water.

2. The sunscreen day cream as claimed in claim 1, wherein the moisturizer comprises one or more of the following components in percentage by weight: 0.1% of allantoin, 1-10% of glycerol, 1-5% of propylene glycol, 1-5% of butanediol, 2-5% of beta-glucan and 1-1.3% of D-panthenol.

3. The sunscreen day cream as claimed in claim 1, wherein the emulsifier comprises one or more of the following components in percentage by weight: 3% of a mixture of arachidyl alcohol, behenyl alcohol and arachidyl alcohol glucoside, 5-10% of stearyl alcohol, 3-5% of cetostearyl alcohol, 2-4% of polydimethylsiloxane, 1.5-2% of potassium lauryl sulfate, 5% of isononyl isononanoate, 5% of C12-15 alcohol benzoate and 5-7% of cyclopentadimethylsiloxane; the emollient is composed of one or more of the following components in percentage by weight: 0.1% of allantoin, 1-10% of glycerol, 1-5% of propylene glycol, 1-5% of butanediol, 2-5% of beta-glucan and 1-1.3% of D-panthenol.

4. The sunscreen day cream as claimed in claim 1, wherein the thickener comprises one or more of the following components in percentage by weight: 5-15% of liquid paraffin, 0.5-1% of glycerin monostearate, 0.05-0.2% of xanthan gum, 0.05-0.25% of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and 0.1-0.2% of sodium acrylate/sodium acryloyldimethyl taurate copolymer.

5. The sun-blocking and repairing day cream as claimed in claim 1, wherein the sun-blocking component comprises one or more of the following components in percentage by weight: 10-15% of titanium dioxide, 5-10% of zinc oxide, 2-7% of diethylamino hydroxybenzoyl hexyl benzoate, 5-10% of octyl methoxycinnamate, 5-7% of 2-ethylhexyl 4-methoxycinnamate and 2.5-5% of methylene bis-benzotriazolyl tetramethyl butylphenol.

6. The sun-blocking repair day cream according to claim 1, wherein the repair component comprises one or more of the following components in percentage by weight: 2-7% of diethyl amino hydroxybenzoyl hexyl benzoate, 5-10% of octyl methoxycinnamate and 5-7% of 2-ethylhexyl 4-methoxycinnamate.

7. The sunscreen day cream as claimed in claim 1, wherein the repairing component contains a stem cell repairing factor extracting solution, and the amount of the stem cell repairing factor extracting solution is 1-2%; the stem cell factor extracting solution is supernatant collected from mesenchymal stem cells from human umbilical cords in the culture process, mainly comprises amino acid, vitamin, inorganic salt, growth factors and trace element components, does not contain antibiotics, serum or heterologous components, has the pH of 7.0 +/-0.5 and the osmotic pressure of 280-340 mOsmol/kg.

8. The sunscreen day cream as claimed in claim 1, wherein the preservative comprises one or more of the following components in percentage by weight: 0.01-0.03% of EDTA-disodium, 0.07-0.15% of chlorphenesin, 0.05-0.2% of phenoxyethanol and 0.1-0.2% of methylparaben.

9. The method for preparing the sunscreen day cream according to claim 1, which comprises the following steps:

step 1, putting oil phase components into an emulsifying pot, mixing and heating to 70-80 ℃, and stirring at constant temperature for 30 minutes, wherein the oil phase components comprise most of an emulsifying agent, a sunscreen component and part of a thickening agent;

step 2, simultaneously putting the water phase components into another emulsifying pot, mixing and heating to 70-80 ℃, stirring at constant temperature until the components are completely dissolved or dispersed, wherein the water phase components comprise most of the humectant, the antiseptic antibacterial agent and part of the thickening agent;

step 3, slowly adding the water phase into the oil phase under the condition of constant-temperature stirring, keeping the temperature of 70-80 ℃, stirring for 15 minutes to fully emulsify the water phase, stopping heating, and cooling under the condition of stirring at room temperature;

and 4, cooling to 35-40 ℃, adding other components, uniformly stirring, cooling to below 30 ℃, checking to ensure that the pH value and the viscosity value reach the standard, and discharging qualified products, wherein the other components comprise a non-high temperature resistant preservative and a stem cell repair factor extracting solution.

10. The sun-screening and repairing day cream is characterized by mainly comprising the following components in percentage by weight: 7% of stearyl alcohol, 1.5% of cetearyl alcohol, 3% of polydimethylsiloxane, 1.5% of potassium lauryl sulfate, 0.1% of allantoin, 7% of glycerol, 3% of propylene glycol, 3% of butanediol, 3% of beta-glucan, 1.2% of D-panthenol, 10% of liquid paraffin, 0.15% of xanthan gum, 10% of titanium dioxide, 7% of zinc oxide, 4% of diethylamino hydroxybenzoyl hexyl benzoate, 7% of 4-methoxycinnamic acid-2-hexyl acetate, 0.01% of EDTA-2Na, 0.1% of phenoxyethanol, 0.12% of chlorphenesin, 1% of a dry cell repair factor extracting solution and the balance of water; or

The day cream mainly comprises the following components:

7% of stearyl alcohol, 1.5% of cetearyl alcohol, 3% of cyclopenta dimethyl silicone polymer, 1.5% of potassium lauryl sulfate, 0.1% of allantoin, 7% of glycerol, 3% of propylene glycol, 3% of butanediol, 3% of beta-glucan, 1.2% of D-panthenol, 10% of liquid paraffin, 0.15% of xanthan gum, 10% of titanium dioxide, 7% of zinc oxide, 4% of diethylamino hydroxybenzoyl hexyl benzoate, 7% of 4-methoxy cinnamic acid-2-hexyl acetate, 0.01% of EDTA-2Na, 0.1% of phenoxyethanol, 0.12% of chlorphenesin, 1% of a dry cell repair factor extracting solution and the balance of water.