CN112545960A - Bionic structure-based multifunctional repair sleep mask and preparation method thereof - Google Patents
Bionic structure-based multifunctional repair sleep mask and preparation method thereof Download PDFInfo
- Publication number
- CN112545960A CN112545960A CN202011567526.XA CN202011567526A CN112545960A CN 112545960 A CN112545960 A CN 112545960A CN 202011567526 A CN202011567526 A CN 202011567526A CN 112545960 A CN112545960 A CN 112545960A
- Authority
- CN
- China
- Prior art keywords
- parts
- weight
- ceramide
- preparation
- mask
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a bionic structure multi-effect repair-based sleep mask and a preparation method thereof. The mask is prepared from the following raw materials in parts by weight: 15-30 parts of mask base material, 7-16 parts of efficacy material and 55-70 parts of distilled water; the facial mask base material comprises a first base material, a second base material and preservative components, and the functional substances comprise a functional substance I and a functional substance II. The facial mask disclosed by the invention is rich in all kinds of ceramides, is matched with lecithin and cholesterol, realizes a bilayer liquid crystal structure with a bionic structure, is characterized by being highly compatible with skin, free from washing, mild, non-irritant, easy to absorb, convenient to use, capable of improving scurf caused by skin dryness, capable of improving skin darkness after long-term use, enabling the skin state to be full and plump, simple in preparation method and capable of realizing industrial production.
Description
Technical Field
The invention relates to the technical field of daily cosmetics, in particular to a sleep mask based on bionic structure multi-effect repair and a preparation method thereof.
Background
In the life of people at present, the skin barrier is easily damaged due to factors such as environmental pollution, huge pressure, anxiety, light radiation, irregular diet and the like, and further, the skin barrier is expressed by various problems such as dryness, water shortage, scurf, dry and yellow skin, susceptibility to sensitivity, inflammation, red swelling and the like. The damaged skin barrier causes the reduction or loss of the skin's ability to protect and absorb', which in turn causes the accumulation of nutrients on the skin surface, rather it becomes a burden on the skin, and a 'bionic skin' with the function of repairing the absorption of the skin barrier is produced. The bionic skin simulates the molecular composition and the layered structure of lipid among corneous layers, can prevent water and electrolyte from losing, and can replace the damaged skin to provide a natural protective barrier function, thereby gaining time for skin repair.
The skin renewal rate at night is faster than that at daytime, and particularly the skin cell metabolism is the fastest period from 11 nights to 2 nights, so that the skin can be repaired by the sleep mask at the time, and the effects of moisture supplement, nourishing, anti-aging and the like can be achieved.
Disclosure of Invention
Aiming at the technical defects, the invention aims to provide a sleep mask based on bionic structure multi-effect repair and a preparation method thereof, which can solve various skin problems caused by skin barrier damage.
In order to solve the technical problems, the invention adopts the following technical scheme:
the multifunctional sleep mask based on the bionic structure is characterized by comprising the following raw materials in parts by weight: 15-30 parts of mask base material, 7-16 parts of efficacy material and 55-70 parts of distilled water.
Further, the mask base comprises a first substrate, a second substrate and a preservative component;
further, the first matrix comprises the following raw materials in parts by weight: 2-4 parts of butanediol, 0.1-0.3 part of 5-120 ten thousand molecular weight sodium hyaluronate, 0.2-0.5 part of p-hydroxyacetophenone, 0.2-0.6 part of hydrogenated lecithin, 0.05-0.1 part of cholesterol, 0.1-0.3 part of glycerol stearate, 0.1-0.3 part of PEG-10 rapeseed sterol, 0.1-0.2 part of dipropylene glycol, 0.05-0.1 part of soyasterol, 30.05-0.2 part of ceramide, 10.03-0.2 part of ceramide, 20.03-0.15 part of ceramide, 40.03-0.1 part of ceramide, 6II (II) 0.03-0.1 part of ceramide and 0.3-0.8 part of caprylic/capric triglyceride;
further, the second matrix comprises the following raw materials in parts by weight: 3-6 parts of cyclopentasiloxane, 3-5 parts of cyclohexasiloxane, 0.6-1.5 parts of squalane, 0.3-0.8 part of cetearyl alcohol, 0.5-1.5 parts of cetearyl glucoside, 0.5-1 part of polydimethylsiloxane, 0.2-0.8 part of dioctyl carbonate, 0.3-0.5 part of jojoba seed oil, 0.1-0.4 part of bisabolol, 0.5-1.5 parts of C18-21 alkane, 0.3-0.8 part of sodium polyacrylate and 60.05-0.1 part of tridecanol polyether;
further, the antiseptic component comprises the following raw materials in parts by weight: 0.3-0.5 part of glycerol caprylate, 0.03-0.06 part of caprylyl hydroximic acid and 0.5-0.8 part of 1, 2-hexanediol;
further, the functional substances comprise a functional substance I and a functional substance II;
further, the functional substance I comprises the following raw materials in parts by weight: 0.03-0.05 part of recombinant human collagen and 0.1-0.5 part of tetrahydro-methyl pyrimidine carboxylic acid;
further, the functional substance II comprises at least two of the following raw materials in parts by weight: 13-6 parts of biological carbohydrate gum, 1-2 parts of glycerol acrylate/acrylic acid copolymer, 1-2 parts of PVM/MA copolymer, 0.2-0.8 part of carbohydrate isomer, 0.5-1.5 parts of Artocarpus heterophyllus leaf/stem extract, 0.3-0.6 part of oat beta-glucan, 0.2-0.5 part of dipotassium glycyrrhizinate, 0.01-0.2 part of Astragalus membranaceus root extract, 0.01-0.2 part of radix sileris root extract, 0.01-0.2 part of calendula extract, 0.01-0.2 part of albizia flower extract, 0.01-0.2 part of rhizoma gastrodiae root extract and 0.05-0.1 part of panthenol.
The invention also relates to a preparation method of the sleep mask based on bionic structure multifunctional repair, which is characterized by comprising the following steps:
(1) preparation of pre-dissolved phase a 1: according to the weight parts, adding butanediol, 5-120 ten thousand molecular weight sodium hyaluronate and p-hydroxyacetophenone into 75 ℃ distilled water in sequence according to the proportion, and stirring until the materials are completely dissolved and kept warm for later use;
(2) pre-dissolved phase ceramide emulsion a2 preparation: according to the weight portion, adding hydrogenated lecithin, cholesterol, glycerol stearate, PEG-10 rapeseed sterol, dipropylene glycol, wild soybean sterol, ceramide 3, ceramide 1, ceramide 2, ceramide 4, ceramide 6II and caprylic/capric triglyceride into 75 ℃ distilled water in sequence according to the proportion under the stirring state, homogenizing for 5 minutes under the condition of 3000rpm after complete dissolution, and keeping the temperature at 75 ℃ for later use;
(3) preparing a first matrix: mixing A1 and A2, stirring uniformly, and keeping the temperature at 75 ℃ for later use;
(4) oil pre-dissolved phase B1 preparation: mixing cyclopentadimethylsiloxane, cyclohexasiloxane, squalane, cetearyl alcohol, cetearyl glucoside, polydimethylsiloxane and dioctyl carbonate uniformly according to the weight part, heating and melting at 75-80 ℃, and keeping the temperature at 75 ℃ for later use;
(5) preparing a second matrix: uniformly mixing jojoba seed oil and bisabolol in a ratio by weight, slowly adding into B1, and keeping the temperature at 75 deg.C for use;
(6) preparation of emulsion C: slowly adding the second matrix into the first matrix under the stirring condition of 75 ℃, stirring for 45 minutes, then adding the thickening agent, and homogenizing for 15 minutes at 3000 rmp; gradually cooling the emulsified body to below 45 ℃ for later use;
(7) preparation of the functional substance I: respectively dissolving the recombinant human collagen and the tetrahydro-methyl pyrimidine carboxylic acid in distilled water at the temperature of 20-40 ℃ for later use;
(8) preparation of an effect substance II: selecting at least two of bioglycasin-1, glyceryl acrylate/acrylic acid copolymer, PVM/MA copolymer, saccharide isomerate, millettia leaf/stem extract, oat beta-glucan, dipotassium glycyrrhizinate, astragalus membranaceus root extract, divaricate saposhnikovia root extract, calendula extract, albizia flower extract, gastrodia elata root extract and panthenol according to parts by weight, and adding distilled water to dissolve the two for later use within the range of 20-40 ℃;
(9) mixing the functional substance I and the functional substance II at 20-40 deg.C, stirring, adding antiseptic, and mixing to obtain functional substance D;
(10) the temperature is in the range of 20-40 ℃, D is slowly added into C and stirred until the mixture is evenly finished.
Further, the thickening agent comprises the following raw materials in parts by weight: 0.5-1.5 parts of C18-21 alkyl, 0.3-0.8 part of sodium polyacrylate and 60.05-0.1 part of tridecyl polyether;
further, the antiseptic component comprises the following raw materials in parts by weight: 0.3-0.5 part of glycerol caprylate, 0.03-0.06 part of caprylyl hydroximic acid and 0.5-0.8 part of 1, 2-hexanediol.
The invention has the beneficial effects that: 1. the skin moisturizing cream contains all kinds of ceramides contained in the skin, and is matched with lecithin and cholesterol to realize a bimolecular layered liquid crystal structure similar to the skin, so that the skin moisturizing cream can promote complete skin keratinization while keeping moisture for a long time, improve the environment of horny layers, and improve the strength and the long-acting property of skin barrier functions;
2. the skin renewal rate at night is faster than that at daytime, and the skin nourishing effect of materials with the repairing effect is better facilitated, and the period from 11 nights to 2 nights is the fastest period of skin cell metabolism, so that the skin can be well protected by selecting functional skin care such as repairing, moisture supplementing, nourishing and anti-aging of the skin by the sleep mask at the time. The invention contains various materials with strong skin-friendly property, and can realize more rapid and efficient skin care.
3. Compared with the traditional animal collagen, the recombinant human collagen has the characteristics of small molecular weight, high biocompatibility, easy absorption, better cell adhesion and the like, has no virus hidden trouble, rejection reaction and cytotoxicity to human cells. The recombinant human collagen is prepared by gene recombination and bioengineering technology, is water-soluble biological collagen, is very similar to human collagen in the aspects of structure and characteristics, has higher denaturation temperature of 72 ℃ in terms of chemical performance, is easy to store, and has high homogeneity and stability due to a single-spiral linear structure, so the recombinant human collagen is very suitable for developing skin care products.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a bar graph of the change in skin moisture content provided in example 3 of the present invention;
fig. 2 is a bar graph of changes in the R2 value of the skin provided in example 4 of the present invention;
fig. 3 is a bar graph of changes in skin Q1 values provided in example 4 of the present invention;
FIG. 4 is a histogram of changes in ITA ° of skin provided in example 5 of the present invention;
fig. 5 is a subjective evaluation chart of efficacy impression provided in example 6 of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A multifunctional sleep restoration mask based on a bionic structure is composed of the following raw materials: the preservative comprises a first substrate, a second substrate, an effective substance I, an effective substance II, a preservative component and distilled water;
the first matrix consists of the following raw materials in parts by weight: 2 parts of butanediol, 0.2 part of sodium hyaluronate, 0.3 part of p-hydroxyacetophenone, 0.4 part of hydrogenated lecithin, 0.08 part of cholesterol, 0.1 part of glyceryl stearate, 0.3 part of PEG-10 rapeseed sterol, 0.2 part of dipropylene glycol, 0.06 part of soyasterol, 30.1 parts of ceramide, 10.15 parts of ceramide, 20.1 parts of ceramide, 40.1 parts of ceramide, 0.05 part of ceramide 6II and 0.3 part of caprylic/capric triglyceride;
the second matrix is composed of the following raw materials in parts by weight: 6 parts of cyclopenta dimethyl silicone polymer, 4 parts of cyclohexasiloxane, 1 part of squalane, 0.6 part of cetearyl alcohol, 1.5 parts of cetearyl glucoside, 0.5 part of polydimethylsiloxane, 0.5 part of dioctyl carbonate, 0.3 part of jojoba seed oil, 0.1 part of bisabolol, 0.6 part of C18-C21 alkane, 0.4 part of sodium polyacrylate and 60.05 parts of tridecanol polyether;
the functional substance I is prepared from the following raw materials in parts by weight: 0.05 part of recombinant human collagen and 0.3 part of tetrahydro-methyl pyrimidine carboxylic acid;
the functional substance II is prepared from the following raw materials in parts by weight: 0.2 part of Artocarpus heterophyllus leaf/stem extract and 0.8 part of oat beta-glucan;
the anticorrosive component comprises the following raw materials in parts by weight: 0.4 part of glycerol caprylate, 0.05 part of caprylyl hydroximic acid and 0.6 part of 1, 2-hexanediol.
The preparation method comprises the following steps:
(1) preparation of pre-dissolved phase a 1: according to the weight portion, 2 portions of butanediol, 0.2 portion of sodium hyaluronate (5-120 ten thousand D) and 0.3 portion of p-hydroxyacetophenone are sequentially added into distilled water at 75 ℃, and stirred until the materials are completely dissolved and kept warm for standby;
(2) pre-dissolved phase ceramide emulsion a2 preparation: according to parts by weight, 0.4 part of hydrogenated lecithin, 0.08 part of cholesterol, 0.1 part of glycerol stearate, 0.3 part of PEG-10 rapeseed sterol, 0.2 part of dipropylene glycol, 0.06 part of soyasterol, 30.1 parts of ceramide, 10.15 parts of ceramide, 20.1 parts of ceramide, 40.1 parts of ceramide, 0.05 part of ceramide 6II and 0.3 part of caprylic/capric triglyceride are added into distilled water at 75 ℃ in sequence according to the proportion under the stirring state, and after the components are completely dissolved, the mixture is homogenized for 5 minutes under the condition of 3000rpm, and the temperature is kept at 75 ℃ for standby;
(3) preparing a first matrix: mixing A1 and A2, stirring uniformly, and keeping the temperature at 75 ℃ for later use;
(4) oil pre-dissolved phase B1 preparation: according to parts by weight, 6 parts of cyclopenta dimethyl silicone polymer, 4 parts of cyclohexasiloxane, 1 part of squalane, 0.6 part of cetearyl alcohol, 1.5 parts of cetearyl glucoside, 0.5 part of polydimethylsiloxane and 0.5 part of dioctyl carbonate are uniformly mixed, heated and melted at the temperature of 75-80 ℃, and kept warm at the temperature of 75 ℃ for later use;
(5) preparing a second matrix: 0.3 part of jojoba seed oil and 0.1 part of bisabolol are uniformly mixed according to the parts by weight, and then slowly added into B1, and the mixture is kept at 75 ℃ for standby;
(6) preparation of emulsion C: slowly adding the second matrix into the first matrix under the stirring condition of 75 ℃, stirring for 45 minutes, then adding 0.6 part of thickening agent C18-C21 alkane, 0.4 part of sodium polyacrylate, 60.05 parts of tridecyl alcohol polyether, and homogenizing for 15 minutes under 3000 rmp. Gradually cooling the emulsified body to below 45 ℃ for later use;
(7) preparation of the functional substance I: dissolving 0.05 part of recombinant human collagen (soluble collagen) and 0.3 part of tetrahydro-methyl pyrimidine carboxylic acid in distilled water at 20-40 ℃ for later use;
(8) preparation of an effect substance II: selecting 13 parts of biological carbohydrate gum, 0.5 part of carbohydrate isomer, 0.2 part of millettia leaves/stems extract and 0.8 part of oat beta-glucan according to parts by weight, and adding distilled water to dissolve at the temperature of 20-40 ℃ for later use;
(9) mixing and stirring the functional substance I and the functional substance II uniformly at the temperature of 20-40 ℃, adding 0.4 part of antiseptic component glycerate, 0.05 part of caprylyl hydroximic acid and 0.6 part of 1, 2-hexanediol, and uniformly mixing to obtain a functional substance D for later use;
(10) the temperature is in the range of 20-40 ℃, D is slowly added into C and stirred until uniform.
Example 2
A multifunctional sleep restoration mask based on a bionic structure is composed of the following raw materials: the preservative comprises a first substrate, a second substrate, an effective substance I, an effective substance II, a preservative component and distilled water;
the first matrix consists of the following raw materials in parts by weight: 4 parts of butanediol, 0.4 part of sodium hyaluronate, 0.2 part of p-hydroxyacetophenone, 0.6 part of hydrogenated lecithin, 0.06 part of cholesterol, 0.1 part of glycerol stearate, 0.05 part of PEG-10 rapeseed sterol, 0.1 part of dipropylene glycol, 0.05 part of soyasterol, 30.05 parts of ceramide, 10.03 parts of ceramide, 20.05 parts of ceramide, 40.05 parts of ceramide, 0.06 part of ceramide 6II and 0.5 part of caprylic/capric triglyceride;
the second matrix is composed of the following raw materials in parts by weight: 3 parts of cyclopenta dimethyl silicone polymer, 3 parts of cyclohexasiloxane, 0.8 part of squalane, 0.5 part of cetostearyl alcohol, 0.6 part of cetearyl glucoside, 0.8 part of polydimethylsiloxane, 0.2 part of dioctyl carbonate, 0.4 part of jojoba seed oil, 0.2 part of bisabolol, 0.6 part of C18-C21 alkane, 0.3 part of sodium polyacrylate and 60.08 parts of tridecanol polyether;
the functional substance I is prepared from the following raw materials in parts by weight: 0.05 part of recombinant human collagen and 0.5 part of tetrahydro-methyl pyrimidine carboxylic acid;
the functional substance II is prepared from the following raw materials in parts by weight: 0.25 part of dipotassium glycyrrhizinate, 0.1 part of calendula extract, 0.05 part of gastrodia elata root extract and 0.15 part of panthenol;
the anticorrosive component comprises the following raw materials in parts by weight: 0.5 part of glycerate, 0.05 part of caprylyl hydroximic acid and 0.5 part of 1, 2-hexanediol.
After the weight ratio of the raw materials was appropriately adjusted, a mask was prepared according to the preparation method of example 1.
Example 3
Skin moisture content change test
Different reagents, sleep masks and blank substrates are smeared on the face, and the average value of the skin moisture content measurement is measured after 0.5h, 2h, 4h, 8h and 24h respectively. Number of samples: 40 persons (25-50 years old); coating Standard 6mg/cm2. The results are shown in FIG. 1.
Example 4
Test for improving skin elasticity of product
And analyzing and evaluating the change of the skin elasticity of the subjects after sleeping on the mask by adopting an MPA580 skin elasticity tester. The skin elasticity index is represented by R2 and Q1, and the larger the value, the better the skin elasticity. 30 test volunteers (age 25-50 years) were divided into two groups (sample group 20, emulsion matrix control group 10, wherein the emulsion matrix contains 0.1% HA, 5% squalane, 2% vegetable oil), used continuously for 6 weeks, all over the face, and applied twice daily, morning and evening. Before use, at 1 week, 2 weeks, 4 weeks, and 6 weeks, the same position of the face was tested for R2 and Q1 values. The results are shown in FIGS. 2-3.
Example 5
Test for improving skin brightness of product
Subjects were evaluated for changes in facial ITA ° following use of the present sleep mask using Visia-CR facial Image analysis in combination with Image-Pro Plus Image analysis software. The ITA ° values are skin individual type angles and are values related to L and b that characterize skin brightness. The greater the ITA value, the brighter and whiter the skin, whereas the darker the skin. 30 test volunteers (age 25-50 years) were divided into two groups (sample group 20, emulsion base control group 10, wherein the emulsion base is an emulsion containing 0.1% HA, 5% squalane, 2% vegetable oil, 1% magnesium ascorbyl phosphate) and used continuously for 6 weeks, all face and applied twice daily in the morning and evening. Before use, at 1 week, 2 weeks, 4 weeks, 6 weeks, the ITA ° values of the same position of the face were tested. The results are shown in FIG. 4.
Example 6
Subjective evaluation of product efficacy
The volunteers were tested for 50 total from four dimensions of improved sensitivity, tenderness, softness, increased gloss, improved roughness, investigation of immediate use by the user and evaluation after 30 days of use. The results are shown in FIG. 5.
It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.
Claims (9)
1. The multifunctional sleep mask based on the bionic structure is characterized by comprising the following raw materials in parts by weight: 15-30 parts of mask base material, 7-16 parts of efficacy material and 55-70 parts of distilled water; the facial mask base material comprises a first base material, a second base material and preservative components, and the functional substances comprise a functional substance I and a functional substance II.
2. The mask according to claim 1, wherein the first substrate comprises the following raw materials in parts by weight: 2-4 parts of butanediol, 0.1-0.3 part of sodium hyaluronate with 5-120 ten thousand molecular weight, 0.2-0.5 part of p-hydroxyacetophenone, 0.2-0.6 part of hydrogenated lecithin, 0.05-0.1 part of cholesterol, 0.1-0.3 part of glycerol stearate, 0.1-0.3 part of PEG-10 rapeseed sterol, 0.1-0.2 part of dipropylene glycol, 0.05-0.1 part of soyasterol, 30.05-0.2 part of ceramide, 10.03-0.2 part of ceramide, 20.03-0.15 part of ceramide, 40.03-0.1 part of ceramide, 6 II-0.1 part of ceramide and 0.3-0.8 part of caprylic/capric triglyceride.
3. The mask according to claim 1, wherein the second substrate comprises the following raw materials in parts by weight: 3-6 parts of cyclopentasiloxane, 3-5 parts of cyclohexasiloxane, 0.6-1.5 parts of squalane, 0.3-0.8 part of cetearyl alcohol, 0.5-1.5 parts of cetearyl glucoside, 0.5-1 part of polydimethylsiloxane, 0.2-0.8 part of dioctyl carbonate, 0.3-0.5 part of jojoba seed oil, 0.1-0.4 part of bisabolol, 0.5-1.5 parts of C18-21 alkane, 0.3-0.8 part of sodium polyacrylate and 60.05-0.1 part of tridecanol polyether.
4. The mask for sleep based on biomimetic structure multifunctional restoration as claimed in claim 1, characterized in that the antiseptic component comprises the following raw materials in parts by weight: 0.3-0.5 part of glycerol caprylate, 0.03-0.06 part of caprylyl hydroximic acid and 0.5-0.8 part of 1, 2-hexanediol.
5. The mask as claimed in claim 5, wherein the functional substance I comprises the following raw materials in parts by weight: 0.03-0.05 part of recombinant human collagen and 0.1-0.5 part of tetrahydro-methyl pyrimidine carboxylic acid.
6. The sleep mask based on biomimetic structure multifunctional restoration as claimed in claim 1, characterized in that the functional substance II comprises at least two of the following raw materials in parts by weight: 13-6 parts of biological carbohydrate gum, 1-2 parts of glycerol acrylate/acrylic acid copolymer, 1-2 parts of PVM/MA copolymer, 0.2-0.8 part of carbohydrate isomer, 0.5-1.5 parts of Artocarpus heterophyllus leaf/stem extract, 0.3-0.6 part of oat beta-glucan, 0.2-0.5 part of dipotassium glycyrrhizinate, 0.01-0.2 part of Astragalus membranaceus root extract, 0.01-0.2 part of radix sileris root extract, 0.01-0.2 part of calendula extract, 0.01-0.2 part of albizia flower extract, 0.01-0.2 part of rhizoma gastrodiae root extract and 0.05-0.1 part of panthenol.
7. A preparation method of a sleep mask based on bionic structure multifunctional restoration is characterized by comprising the following steps:
(1) preparation of pre-dissolved phase a 1: according to the weight parts, adding butanediol, 5-120 ten thousand molecular weight sodium hyaluronate and p-hydroxyacetophenone into 75 ℃ distilled water in sequence according to the proportion, and stirring until the materials are completely dissolved and kept warm for later use;
(2) pre-dissolved phase ceramide emulsion a2 preparation: according to the weight portion, adding hydrogenated lecithin, cholesterol, glycerol stearate, PEG-10 rapeseed sterol, dipropylene glycol, wild soybean sterol, ceramide 3, ceramide 1, ceramide 2, ceramide 4, ceramide 6II and caprylic/capric triglyceride into 75 ℃ distilled water in sequence according to the proportion under the stirring state, homogenizing for 5 minutes under the condition of 3000rpm after complete dissolution, and keeping the temperature at 75 ℃ for later use;
(3) preparing a first matrix: mixing A1 and A2, stirring uniformly, and keeping the temperature at 75 ℃ for later use;
(4) oil pre-dissolved phase B1 preparation: mixing cyclopentadimethylsiloxane, cyclohexasiloxane, squalane, cetearyl alcohol, cetearyl glucoside, polydimethylsiloxane and dioctyl carbonate uniformly according to the weight part, heating and melting at 75-80 ℃, and keeping the temperature at 75 ℃ for later use;
(5) preparing a second matrix: uniformly mixing jojoba seed oil and bisabolol in a ratio by weight, slowly adding into B1, and keeping the temperature at 75 deg.C for use;
(6) preparation of emulsion C: slowly adding the second matrix into the first matrix under the stirring condition of 75 ℃, stirring for 45 minutes, then adding the thickening agent, and homogenizing for 15 minutes at 3000 rmp; gradually cooling the emulsified body to below 45 ℃ for later use;
(7) preparation of the functional substance I: respectively dissolving the recombinant human collagen and the tetrahydro-methyl pyrimidine carboxylic acid in distilled water at the temperature of 20-40 ℃ for later use;
(8) preparation of an effect substance II: selecting at least two of bioglycasin-1, glyceryl acrylate/acrylic acid copolymer, PVM/MA copolymer, saccharide isomerate, millettia leaf/stem extract, oat beta-glucan, dipotassium glycyrrhizinate, astragalus membranaceus root extract, divaricate saposhnikovia root extract, calendula extract, albizia flower extract, gastrodia elata root extract and panthenol according to parts by weight, and adding distilled water to dissolve at the temperature of 20-40 ℃ for later use;
(9) mixing the functional substance I and the functional substance II at 20-40 deg.C, stirring, adding antiseptic, and mixing to obtain functional substance D;
(10) the temperature is in the range of 20-40 ℃, D is slowly added into C and stirred until the mixture is evenly finished.
8. The preparation method of the bionic structure multifunctional repair-based sleep mask as claimed in claim 7, wherein the thickener in step 6 comprises the following raw materials in parts by weight: 0.5-1.5 parts of C18-21 alkyl, 0.3-0.8 part of sodium polyacrylate and 60.05-0.1 part of tridecyl alcohol polyether.
9. The preparation method of the bionic structure multifunctional repair-based sleep mask as claimed in claim 7, wherein the antiseptic component in the step 9 comprises the following raw materials in parts by weight: 0.3-0.5 part of glycerol caprylate, 0.03-0.06 part of caprylyl hydroximic acid and 0.5-0.8 part of 1, 2-hexanediol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011567526.XA CN112545960A (en) | 2020-12-25 | 2020-12-25 | Bionic structure-based multifunctional repair sleep mask and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011567526.XA CN112545960A (en) | 2020-12-25 | 2020-12-25 | Bionic structure-based multifunctional repair sleep mask and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112545960A true CN112545960A (en) | 2021-03-26 |
Family
ID=75034299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011567526.XA Pending CN112545960A (en) | 2020-12-25 | 2020-12-25 | Bionic structure-based multifunctional repair sleep mask and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112545960A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113332175A (en) * | 2021-06-04 | 2021-09-03 | 吉林省国大生物工程有限公司 | Medical wet repairing plaster |
| CN115363987A (en) * | 2022-08-24 | 2022-11-22 | 深圳中科欣扬生物科技有限公司 | Scalp care formula containing collagen and ectoin |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107362129A (en) * | 2017-08-23 | 2017-11-21 | 广东丸美生物技术股份有限公司 | Skin matrix, preparation method and applications and cosmetics and preparation method thereof |
| CN108159102A (en) * | 2018-01-31 | 2018-06-15 | 山西医科大学 | A kind of preparation method and application of wormwood extract nano-emulsion gel |
| CN108186480A (en) * | 2018-03-31 | 2018-06-22 | 佛山文森特知识产权服务有限公司 | A kind of skin care compositions of beauty treatment moisturizing and its application |
| CN111700833A (en) * | 2020-07-13 | 2020-09-25 | 黄伟 | Facial cream for repairing plateau red skin and preparation method and application thereof |
-
2020
- 2020-12-25 CN CN202011567526.XA patent/CN112545960A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107362129A (en) * | 2017-08-23 | 2017-11-21 | 广东丸美生物技术股份有限公司 | Skin matrix, preparation method and applications and cosmetics and preparation method thereof |
| CN108159102A (en) * | 2018-01-31 | 2018-06-15 | 山西医科大学 | A kind of preparation method and application of wormwood extract nano-emulsion gel |
| CN108186480A (en) * | 2018-03-31 | 2018-06-22 | 佛山文森特知识产权服务有限公司 | A kind of skin care compositions of beauty treatment moisturizing and its application |
| CN111700833A (en) * | 2020-07-13 | 2020-09-25 | 黄伟 | Facial cream for repairing plateau red skin and preparation method and application thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113332175A (en) * | 2021-06-04 | 2021-09-03 | 吉林省国大生物工程有限公司 | Medical wet repairing plaster |
| CN115363987A (en) * | 2022-08-24 | 2022-11-22 | 深圳中科欣扬生物科技有限公司 | Scalp care formula containing collagen and ectoin |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103330658B (en) | Skin care composition with functions of repairing damaged skin surface lipid film and relieving skin pressure | |
| WO2024045952A1 (en) | Recombinant collagen-containing composition having effects of repairing and soothing, eye cream containing same, preparation method therefor, and use thereof | |
| CN112545960A (en) | Bionic structure-based multifunctional repair sleep mask and preparation method thereof | |
| CN109549893A (en) | A kind of preparation method with anti-blue light contamination and the composition repaired and essence cream and its essence cream | |
| CN113616561A (en) | Composition with moisturizing and repairing effects and cosmetic | |
| US20220347086A1 (en) | Composition and application thereof in preparation of skincare products for night owls | |
| CN110302091A (en) | A kind of anti aging effect composition of niacinamide-containing adenine-dinucleotide and its preparation method and application | |
| CN110013447A (en) | A kind of cream and preparation method thereof for dispelling striae of pregnancy | |
| CN109568240A (en) | A kind of liquid crystal structure essence cream with humectant energy | |
| CN115177566A (en) | Synergistic hydroxy pinacolone retinoic acid ester anti-aging essence and preparation method thereof | |
| CN114376949A (en) | Essence mask and preparation method thereof | |
| CN115317385A (en) | Foundation make-up composition and preparation method thereof | |
| CN106109391B (en) | A kind of potent moisture retention water and preparation method thereof | |
| CN117122523B (en) | Bionic liquid crystal composition and preparation method and application thereof | |
| CN111419744A (en) | Anti-saccharification skin cream and preparation method thereof | |
| CN110496090A (en) | A kind of composition and its application in the skin care item that impaired skin is stayed up late in preparation reparation | |
| CN113940909B (en) | Composition for regulating circadian rhythm and application thereof | |
| CN112641695B (en) | Moisturizing and anti-aging mask and preparation method thereof | |
| CN109512732A (en) | Have effects that repair exterior-applied plant extract, cosmetics of skin barrier and preparation method thereof | |
| CN113749972A (en) | Composition with anti-wrinkle effect and application of composition in cosmetics | |
| CN112545906A (en) | Sun-screening and repairing day cream and preparation method thereof | |
| CN108619018B (en) | Skin barrier repair cream and preparation method thereof | |
| CN113384483A (en) | Composition for improving skin elasticity and delaying aging and preparation method thereof | |
| CN108653167A (en) | A kind of composition and cosmetics with brilliant white and maintenance | |
| CN117860638B (en) | Preparation method and application of repairing and anti-aging composition containing vitrine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |