CN107362129A

CN107362129A - Skin matrix, preparation method and applications and cosmetics and preparation method thereof

Info

Publication number: CN107362129A
Application number: CN201710732936.7A
Authority: CN
Inventors: 聂艳峰; 裴运林; 刘露
Original assignee: Guangdong Marubi Biological Technology Co Ltd
Current assignee: Guangdong Marubi Biological Technology Co Ltd
Priority date: 2017-08-23
Filing date: 2017-08-23
Publication date: 2017-11-21
Anticipated expiration: 2037-08-23
Also published as: CN107362129B

Abstract

The invention discloses a kind of skin matrix, preparation method and applications and cosmetics and preparation method thereof, it is related to cosmetic technical field.The skin matrix of the present invention includes following component：Tetrahydrochysene methylpyrimidine carboxylic acid, thermus thermophilus tunning, Flos Buddlejae extract, recombination human source collagen and water；Each component accounts for the percentage by weight of skin matrix not less than 1% in tetrahydrochysene methylpyrimidine carboxylic acid, thermus thermophilus tunning, Flos Buddlejae extract and recombination human source collagen.The present invention alleviates traditional anti-aging product more based on single anti-oxidant or single replenishing collagen etc., and anti-aging effects are not notable, and the problem of no resistance infrared effect.Main functional component is used as by tetrahydrochysene methylpyrimidine carboxylic acid, thermus thermophilus tunning and Flos Buddlejae extract in matrix of the present invention, synergistic complex recombination human source collagen again, by the synergistic function between each composition, have and resist infrared ray, senile-resistant efficacy.

Description

Skin matrix, preparation method and applications and cosmetics and preparation method thereof

Technical field

The present invention relates to cosmetic technical field, in particular to a kind of skin matrix, preparation method and applications and Cosmetics and preparation method thereof.

Background technology

With advancing age and environmental pollution and the increasing of life stress, the skin senescence of people is more and more obvious, Anti-aging beauty-care skin care is also increasingly valued by people.

Skin senescence is usually expressed as skin elasticity reduction, wrinkle of skin is added, the roughness of skin increases and occurs Color spot etc..In daily life it is simple be clearly for prevention skin senescence using moisturizer skin care it is inadequate, environment, sunlight and The factors such as pressure promote skin ageing to accelerate, and at this time skin also easily goes out spot, and phenomena such as microgroove, while the years can cause body Aging, skin metabolism slow down, and the collagen and elastic fibrous tissue fiber of skin change, and reduce texture and content, skin Skin gradually follows the string, and becomes loose.Infrared ray is longer compared to ultraviolet, visible ray, wavelength, it may have very strong energy, and And there is profound penetration power, human skin can be penetrated and damaged to hypodermis, and then to skin, there is data table It is bright：Skin is damaged because of sunlight, infrared ray is one of arch-criminal.

Anti-aging product at present on the market is more to turn to effect point of penetration with simple antioxygen, carries out anti-aging publicity, but anti- Oxidation is not fully equal to anti-aging, while these products also have the shortcomings that effect difference, in addition, the skin that compacts, resist it is infrared Line has turned into another emphasis of research on anti-senescence, although being related to the precedent of anti-aging on the market, they are more with single antioxygen Based on change or single replenishing collagen etc., anti-aging effects are not apparent.

In view of this, it is special to propose the present invention.

The content of the invention

An object of the present invention is to provide a kind of skin matrix, and the matrix passes through tetrahydrochysene methylpyrimidine carboxylic acid, thermophilic Thermus tunning and Flos Buddlejae extract are as main functional component, then synergistic complex recombination human source collagen, by each Synergistic function between composition, have and resist infrared ray, senile-resistant efficacy.

The second object of the present invention is to provide a kind of preparation method of skin matrix, can obtained by using this method Uniformly, stable emulsion, has simple, an easily operated advantage of method, and preparation method do not interfere with composition validity and The final using effect of product.

The third object of the present invention is in the application in a kind of described skin matrix of offer in anti-aging cosmetics are prepared.

The fourth object of the present invention is to provide a kind of cosmetics for including the skin matrix, for example, eye cream, face cream and In the cosmetics such as Essence, good skin effect can be brought to these products, there is good resist after smearing the cosmetics The effect of infrared ray and anti-aging.

The fifth object of the present invention is to provide a kind of preparation method of the cosmetics, can obtained by using this method The cosmetics of stable homogeneous are obtained, there is simple, the easily operated advantage of method, suitable for standardized production and popularization and application.

In order to realize the above-mentioned purpose of the present invention, spy uses following technical scheme：

A kind of skin matrix, the skin matrix include following component：Tetrahydrochysene methylpyrimidine carboxylic acid, thermus thermophilus fermentation Product, Flos Buddlejae extract and recombination human source collagen；

In tetrahydrochysene methylpyrimidine carboxylic acid, thermus thermophilus tunning, Flos Buddlejae extract and recombination human source collagen The percentage by weight that each component accounts for skin matrix is not less than 1%.

Preferably, on the basis of technical scheme provided by the invention, the skin matrix include percentage by weight as Lower component：Tetrahydrochysene methylpyrimidine carboxylic acid 3~10%, thermus thermophilus tunning 15~50%, Flos Buddlejae extract 10~ 20%, recombination human source collagen 1~2%, surplus is water.

Preferably, on the basis of technical scheme provided by the invention, the skin matrix include percentage by weight as Lower component：Tetrahydrochysene methylpyrimidine carboxylic acid 5~8%, thermus thermophilus tunning 20~40%, Flos Buddlejae extract 12~ 18%, recombination human source collagen 1~2%, surplus is water.

Preferably, on the basis of technical scheme provided by the invention, the skin matrix include percentage by weight as Lower component：Tetrahydrochysene methylpyrimidine carboxylic acid 5~6%, thermus thermophilus tunning 20~30%, Flos Buddlejae extract 12~ 15%, recombination human source collagen 1~1.5%, surplus is water.

A kind of preparation method of above-mentioned skin matrix, comprises the following steps：

By tetrahydrochysene methylpyrimidine carboxylic acid, thermus thermophilus tunning, Flos Buddlejae extract, recombination human source collagen and Water obtains skin matrix after being sufficiently mixed.

Preferably, on the basis of technical scheme provided by the invention, the preparation method of skin matrix, including following step Suddenly：

(a) tetrahydrochysene methylpyrimidine carboxylic acid, recombination human source collagen and water are sufficiently mixed, obtain settled solution；

(b) by the settled solution of thermus thermophilus tunning and Flos Buddlejae extract and step (a) be sufficiently mixed with it is cold But, skin matrix is obtained；

Preferably, mixing temperature is 35~45 DEG C, preferably 40~45 DEG C, further preferred 42~45 DEG C in step (a)； And/or

Mixing velocity is 800~1000rpm in step (a)；And/or

Incorporation time is 15~30min, preferably 20~30min in step (a), further preferred 25~30min；

Preferably, mixing velocity is 800~1000rpm in step (b)；And/or

Incorporation time is 5~10min, preferably 6~10min in step (b), further preferred 8~10min；And/or

Chilling temperature is 15~25 DEG C, preferably 20~25 DEG C, further preferred 22~25 DEG C in step (b).

A kind of application of above-mentioned skin matrix in anti-aging cosmetics are prepared.

A kind of cosmetics for including above-mentioned skin matrix.

Preferably, on the basis of technical scheme provided by the invention, weight hundred of the skin matrix in cosmetics Divide than being 10~20%.

Preferably, on the basis of technical scheme provided by the invention, the cosmetics include the as follows of percentage by weight Component：

Component A：Dipropylene glycol 3.0~6.0%, Sodium Hyaluronate 0.05~0.15%；

B component：Butanediol 5.0~8.0%, methyl hydroxybenzoate 0.1~0.2%；

Component C：Cremophor RH40 0.05~0.15%；

D components：Skin matrix 10~20%；

Surplus is water；

Preferably, the cosmetics include the following component of percentage by weight：

Component A：Dipropylene glycol 4.0~6.0%, Sodium Hyaluronate 0.08~0.15%；

B component：Butanediol 5.0~7.0%, methyl hydroxybenzoate 0.15~0.2%；

Component C：Cremophor RH40 0.08~0.15%；

D components：Skin matrix 15~20%；

Surplus is water；

Component A：Dipropylene glycol 5.0~6.0%, Sodium Hyaluronate 0.1~0.15%；

B component：Butanediol 5.0~6.0%, methyl hydroxybenzoate 0.15~0.2%；

Component C：Cremophor RH40 0.1~0.15%；

D components：Skin matrix 15~20%；

Surplus is water.

Preferably, on the basis of technical scheme provided by the invention, the cosmetics also include essence；

Percentage by weight of the essence in cosmetics is 0.01~0.03%.

A kind of preparation method of above-mentioned cosmetics, comprises the following steps：

Component A, B component and component C are subjected to fully emulsified and homogeneous after mixing heating and being incubated, D groups are added after cooling Divide, optional essence and water, cosmetics are obtained after mixing；

Preferably, comprise the following steps：

(a) dipropylene glycol and Sodium Hyaluronate are mixed, obtains prefabricated component A；

(b) butanediol and methyl hydroxybenzoate are mixed and heats up and be incubated, obtain prefabricated B component；

(c) Cremophor RH40 and optional essence are mixed and heats up and be incubated, obtain prefabricated component C；

(d) add prefabricated component C after prefabricated component A to be mixed to heating, insulation with prefabricated B component and be incubated again, mixed Liquid；

(e) mixed liquor for obtaining step (d) is emulsified and homogeneous；

(f) D components and water are added after cooling, cosmetics are obtained after mixing；

Preferably, mixing velocity is 500~1000rpm in step (a)；And/or

Incorporation time is 10~20min；

Preferably, mixing velocity is 500~1000rpm in step (b)；And/or

Warming temperature is 60~70 DEG C；

Preferably, mixing velocity is 500~700rpm in step (c)；And/or

Warming temperature is 45~50 DEG C；

Preferably, mixing velocity is 600~1000rpm in step (d)；And/or

Warming temperature is 75~85 DEG C；And/or

Soaking time is 10~25min；

Preferably, emulsifying rate is 300~500rpm in step (e)；And/or

Vacuum is -0.05~-0.1MPa during emulsification；And/or

Homogeneous speed is 1000~1500rpm；And/or

Homogenizing time is 3~5min；

Preferably, step (f) cooling temperature is 40~45 DEG C；And/or

Mixing velocity is 300~500rpm；And/or

Incorporation time is 15~25min.

Compared with the prior art, the present invention has the advantages that：

(1) skin matrix of the invention is by selecting tetrahydrochysene methylpyrimidine carboxylic acid, thermus thermophilus tunning and Mi Meng Flower extract passes through as the main functional component for resisting infrared ray, then synergistic complex recombination human source collagen, each active component Different action target spots are resisted infrared ray and damaged to caused by skin, under the collective effect of different target spots, have between each composition Good synergistic function, it can to greatest extent play and resist infrared ray and senile-resistant efficacy.In addition, the activity of the present invention Composition can be degraded Transdermal absorption by skin, can be that skin supplies nutrition.

(2) skin matrix of the present invention can be added to cream, emulsion, eye essence, toner and essence as raw material In the cosmetics such as magnificent liquid, good skin effect can be brought to these products, smear have after the cosmetics it is good resist it is red Outside line and the effect of anti-aging.

(3) skin matrix of the invention and the manufacture craft of cosmetics are simple, easy to use, can obtain stable homogeneous Emulsion and cosmetics, there is simple, the easily operated advantage of method, suitable for standardized production and popularization and application, and preparation method The validity of composition and the using effect that product is final are not interfered with.

Embodiment

Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.It is unreceipted specific in embodiment Condition person, the condition suggested according to normal condition or manufacturer are carried out.Agents useful for same or the unreceipted production firm person of instrument, it is The conventional products that can be obtained by commercially available purchase.

According to the first aspect of the invention, there is provided a kind of skin matrix, skin matrix include following component：Tetrahydrochysene first Yl pyrimidines carboxylic acid, thermus thermophilus tunning, Flos Buddlejae extract and recombination human source collagen；

Tetrahydrochysene methylpyrimidine carboxylic acid

Tetrahydrochysene methylpyrimidine carboxylic acid is derived from a kind of microorganism in Egyptian desert area WadiEI Natrun salt lakes, is one Derived from amino acid thing, there is powerful resistance to compression defencive function, can fetter surrounding water molecules formed complex, be wrapped in cell, Around enzyme, protein and other organic molecules, the containment vessel with protection, nourishing and stable aquation is formed, and then resist Radiation injury of the skin by infrared ray.The four of commercially available prod, the preferably production of Bitop companies can be selected in tetrahydrochysene methylpyrimidine carboxylic acid Hydrogen methylpyrimidine carboxylic acid.

Thermus thermophilus tunning

Thermus thermophilus (THERMUS THERMOPHILLUS) tunning is produced by biofermentation technique, is a kind of Multi-functional heat activated stable enzyme, have and injure caused by resistance infrared ray, reduce the effect of inflammation, by stress situation Under maintain mitochondrial integrity, optimization ability generation, maintain the normal physiological of skin to construct and reduce wrinkle and produce.Thermophilic heat of dwelling The thermus thermophilus tunning of commercially available prod, the preferably production of sederma companies can be selected in bacterium tunning.

Flos Buddlejae extract

Butterflybush flower (BUDDLEJA OFFICINALIS) extract is for loganiaceae plant butterflybush flower Buddleja Officinalis Maxim. bud and the extract of inflorescence, containing highly concentrated verbascoside and echinacoside, have The effect of skin barrier integrity is protected, immunologic balance is maintained to being converted for cis-urocanic acid by reducing trans-urocanic acid, Prevent the extracellular matrix degradation caused by infrared radiation and skin early ageing.Commercially available prod can be selected in Flos Buddlejae extract, excellent Select the Flos Buddlejae extract of French GREENTECH companies production.

Recombination human source collagen

Collagen is human body and the major structural protein of vertebrate, is synthesized by fibroblast, as tissue and knot The key component of tissue is formed, it is a variety of that support, protection, connection etc. can be played.Recombination human source collagen, also known as biological source collagen Albumen (Recombinant Human-source Collagen, RHC) is that one kind utilizes molecular biology engineering technology, by people Collagen gene sequence import the product that is drawn through everfermentation of yeast cells.RHC- recombined collagens possess stronger resist Aging, anti-wrinkle, Shu Min repair effect, can arrive at flesh bottom rapidly after contacting skin, improve cytoactive, promote fibrocyte Growth, accelerate skin metabolism, repair impaired cuticula, the consummate quality and highest that RHC possesses pharmaceutical grade are protected safely Card, the preventing virus hidden danger from source, more without animal tissue and the residual risk of extraction process impurity.Recombination human source collagen egg Optional commercially available prod in vain, it is selected from the recombination human source collagen of Jiangsu rivers and mountains Ju Yuan Bioisystech Co., Ltd production.

It is understood that tetrahydrochysene methylpyrimidine carboxylic acid, thermus thermophilus tunning, butterflybush flower extraction in skin matrix The content of thing, recombination human source collagen and water is not construed as limiting, as long as meeting tetrahydrochysene methylpyrimidine carboxylic acid, thermus thermophilus fermentation Every kind of component accounts for the percentage by weight of skin matrix and is not less than in product, Flos Buddlejae extract and recombination human source collagen 1%, to ensure effect.

Traditional anti-aging product is more based on single anti-oxidant or single replenishing collagen etc., and anti-aging effects are not Significantly, and without resistance infrared effect, and study and find that aging of the infrared ray to skin plays an important role.The present invention passes through choosing Select tetrahydrochysene methylpyrimidine carboxylic acid, thermus thermophilus tunning and Flos Buddlejae extract as resist main effect of infrared ray into Point, tetrahydrochysene methylpyrimidine carboxylic acid forms containment vessel, resists skin and damaged by infrared radiation, and thermus thermophilus tunning can Stress in the case of maintain mitochondrial integrity, maintain skin normal physiological construct reduce wrinkle produce, butterflybush flower extraction Thing maintains immunologic balance by reducing trans-urocanic acid to being converted for cis-urocanic acid, prevents thin caused by infrared radiation Extracellular matrix is degraded and skin early ageing, each active component can resist infrared ray by different action target spots and be damaged to caused by skin Wound, there is collaboration well under the collective effect of different target spots, then synergistic complex recombination human source collagen, between each composition Synergistic effect, it can to greatest extent play and resist infrared ray and senile-resistant efficacy.In addition, the active component of the present invention can be by Skin degraded Transdermal absorption, can be that skin supplies nutrition.

In a preferred embodiment, skin matrix includes the following component of percentage by weight：Tetrahydrochysene methylpyrimidine Carboxylic acid 3~10%, thermus thermophilus tunning 15~50%, Flos Buddlejae extract 10~20%, recombination human source collagen 1 ~2%, surplus is water.

The typical but non-limiting percentage by weight of tetrahydrochysene methylpyrimidine carboxylic acid is for example 3%, 4%, 5%, 6%, 7%, 8%th, 9% or 10%.

The typical but non-limiting percentage by weight of thermus thermophilus tunning is for example 15%, 20%, 25%, 30%th, 35%, 40%, 45% or 50%.

The typical but non-limiting percentage by weight of Flos Buddlejae extract is for example 10%, 12%, 14%, 16%, 18% Or 20%.

The typical but non-limiting percentage by weight of recombination human source collagen is for example 1%, 1.2%, 1.4%, 1.6%th, 1.8% or 2%.

" comprising " of the present invention, it is intended that it can also include other raw materials, these other raw materials in addition to the raw material Assign the skin matrix different characteristics.In addition, " comprising " of the present invention, may be replaced by enclosed " for " or " by ... form ".

For example, it is also possible to the other components such as including preservative.

It should be noted that surplus is water, refers to and tetrahydrochysene methylpyrimidine carboxylic acid is removed in the raw material of matrix of the present invention, thermophilic is dwelt Hot bacterium tunning, Flos Buddlejae extract, recombination human source collagen and the surplus optionally outside other components are water, water With tetrahydrochysene methylpyrimidine carboxylic acid, thermus thermophilus tunning, Flos Buddlejae extract, recombination human source collagen and optionally The weight percentage sum of other components is 100%.

By using tetrahydrochysene methylpyrimidine carboxylic acid of the percentage by weight for 3~10%, 15~50% thermus thermophilus hair Ferment product, 10~20% Flos Buddlejae extract and 1~2% recombination human source collagen can obtain significantly resist it is red Outside line and the effect of anti-aging.

The preferred deionized water of water.

In a preferred embodiment, skin matrix includes the following component of percentage by weight：Tetrahydrochysene methylpyrimidine Carboxylic acid 5~8%, thermus thermophilus tunning 20~40%, Flos Buddlejae extract 12~18%, recombination human source collagen 1 ~2%, surplus is water.

In a preferred embodiment, skin matrix includes the following component of percentage by weight：Tetrahydrochysene methylpyrimidine Carboxylic acid 5~6%, thermus thermophilus tunning 20~30%, Flos Buddlejae extract 12~15%, recombination human source collagen 1 ~1.5%, surplus is water.

Pass through preferred tetrahydrochysene methylpyrimidine carboxylic acid, thermus thermophilus tunning, Flos Buddlejae extract and recombination human source glue The percentage by weight of former albumen, the infrared resistant and anti-aging effects of skin matrix can be further enhanced.

According to the second aspect of the invention, there is provided a kind of preparation method of above-mentioned skin matrix, comprise the following steps：

Homogeneous, stable emulsion is obtained after mixing, makes to be sufficiently mixed between each active ingredient, it is abundant to be advantageous to active component Release.

Specifically, the preparation method of skin matrix, comprises the following steps：

Preferably, in step (a) mixing temperature be 35~45 DEG C, such as 35 DEG C, 36 DEG C, 37 DEG C, 38 DEG C, 39 DEG C, 40 DEG C, 41 DEG C, 42 DEG C, 43 DEG C, 44 DEG C or 45 DEG C, preferably 40~45 DEG C, further preferred 42~45 DEG C；And/or

Mixing velocity is 800~1000rpm in step (a), such as 800rpm, 900rpm or 1000rpm；And/or

Incorporation time is 15~30min in step (a), such as 15min, 20min, 25min or 30min, preferably 20~ 30min, further preferred 25~30min；

Preferably, mixing velocity is 800~1000rpm in step (b), such as 800rpm, 900rpm or 1000rpm；

Incorporation time is 5~10min in step (b), such as 5min, 6min, 7min, 8min, 9min or 10min, preferably 6 ~10min, further preferred 8~10min；And/or

Chilling temperature is 15~25 DEG C in step (b), such as 15 DEG C, 18 DEG C, 20 DEG C, 22 DEG C or 25 DEG C, preferably 20~25 DEG C, further preferred 22~25 DEG C.

(1) stirring is opened, under the conditions of 35~45 DEG C, by the tetrahydrochysene methylpyrimidine carboxylic acid and 1~2 weight of 3~10 parts by weight The RHC- recombination human source collagens of amount part are slowly added in the water of 36~53 parts by weight, constant temperature stirring, obtain settled solution；

(2) by thermus thermophilus (THERMUS THERMOPHILLUS) tunning and 10~20 of 15~50 parts by weight Butterflybush flower (BUDDLEJA OFFICINALIS) extract of parts by weight is added in settled solution, is stirred 5~10min, cooling, is gone out Material, obtains skin matrix.

Mixing speed described in step (1) is 800~1000rpm；The time of the constant temperature stirring is 15~30min；

Mixing speed described in step (2) is 800~1000rpm；

Chilling temperature described in step (2) is 20~25 DEG C.

By the stirring under certain condition and and cooling treatment, temperature and mixing speed pair in preparation process can be avoided The destruction of the 26S Proteasome Structure and Function of active ingredient, retain active component therein, obtain the emulsion matrix of stable homogeneous.

According to the third aspect of the present invention, there is provided a kind of above-mentioned skin matrix answering in anti-aging cosmetics are prepared With.

Cosmetics are skin-care cosmetics, and typical but non-limiting skin-care cosmetics include cream, emulsion, eye essence Hua Su, toner or Essence etc..

Cosmetics are functional cosmetics, and typical but non-limiting functional cosmetics include Skin whitening care cosmeticses, crease-resistant Skin care item or Moisturizer etc..

According to the fourth aspect of the present invention, there is provided a kind of cosmetics for including above-mentioned skin matrix.

Preferably, percentage by weight of the skin matrix in cosmetics is 10~20%.

Skin matrix typical but non-limiting percentage by weight in cosmetics is for example 10%, 12%, 14%, 16%th, 18% or 20%.

The skin matrix of the invention of special ratios is added in cosmetics, good resist can be brought to these products The effect of infrared ray and anti-aging.

As a preferred embodiment, a kind of typical cosmetics, include the following component of percentage by weight：

Component A：Dipropylene glycol 3.0~6.0%, Sodium Hyaluronate 0.05~0.15%；

B component：Butanediol 5.0~8.0%, methyl hydroxybenzoate 0.1~0.2%；

Component C：Cremophor RH40 0.05~0.15%；

D components：Skin matrix 10~20%；

Surplus is water.

The percentage by weight is used as calculating benchmark in itself using cosmetics.

The typical but non-limiting percentage by weight of dipropylene glycol is for example 3%, 4%, 5% or 6%.

The typical but non-limiting percentage by weight of Sodium Hyaluronate is for example 0.05%, 0.1% or 0.15%.

The typical but non-limiting percentage by weight of butanediol is for example 5%, 5.5%, 6%, 6.5%, 7%, 7.5% or 8%.

The typical but non-limiting percentage by weight of methyl hydroxybenzoate is for example 0.1%, 0.12%, 0.14%, 0.16%, 0.18% or 0.2%.

The typical but non-limiting percentage by weight of Cremophor RH40 is for example 0.05%, 0.1%, 0.15% or 0.15%.

The typical but non-limiting percentage by weight of skin matrix is for example 10%, 12%, 14%, 16%, 18% or 20%.

Cosmetics " comprising ", it is intended that it can also include other raw materials in addition to the raw material, and these other raw materials assign institute State the different characteristic of cosmetics.In addition, " comprising " of the present invention, may be replaced by enclosed " for " or " by ... form ".

For example, it is also possible to including other components such as essence, preservatives.

It should be noted that surplus is water, refers to and skin matrix, dipropylene glycol, transparent is removed in cosmetic material of the present invention Matter acid sodium, butanediol, methyl hydroxybenzoate, Cremophor RH40 and optionally outside other components and surplus is water, water With skin matrix, dipropylene glycol, Sodium Hyaluronate, butanediol, methyl hydroxybenzoate, Cremophor RH40 and optionally its The weight percentage sum of his component is 100%.

The cosmetics of the present invention have cosmetics and resisted by adding the skin matrixes of the present invention of 10~20% contents Infrared ray and senile-resistant efficacy, at the same with the mutual coordinated of other cosmetic materials, bring good skin effect, smear There is the effect for significantly resisting infrared ray and anti-aging after the cosmetics, can be used as essence use.

The preferred deionized water of water.

In a kind of preferred embodiment, cosmetics include the following component of percentage by weight：

Component A：Dipropylene glycol 4.0~6.0%, Sodium Hyaluronate 0.08~0.15%；

B component：Butanediol 5.0~7.0%, methyl hydroxybenzoate 0.15~0.2%；

Component C：Cremophor RH40 0.08~0.15%；

D components：Skin matrix 15~20%；

Surplus is water；

Component A：Dipropylene glycol 5.0~6.0%, Sodium Hyaluronate 0.1~0.15%；

B component：Butanediol 5.0~6.0%, methyl hydroxybenzoate 0.15~0.2%；

Component C：Cremophor RH40 0.1~0.15%；

D components：Skin matrix 15~20%；

Surplus is water.

By optimizing raw material percentage composition, cosmetics can be made to obtain more preferably anti-aging and using effect.

In a kind of preferred embodiment, cosmetics also include essence；Percentage by weight of the essence in cosmetics be 0.01~0.03%.

The typical but non-limiting percentage by weight of essence is for example 0.01%, 0.015%, 0.02%, 0.025% or 0.03%.

The use feeling of cosmetics can be lifted after addition essence.

According to the fifth aspect of the present invention, there is provided a kind of preparation method of above-mentioned cosmetics, comprise the following steps：

Component A, B component and component C are subjected to fully emulsified and homogeneous after mixing heating and being incubated, D groups are added after cooling Divide, optional essence and water, cosmetics are obtained after mixing.

Emulsification is the effect that a kind of liquid is evenly dispersed in atomic droplet in immiscible another liquid.

Homogeneous is also referred to as homogenized, be make dispersion micronized in suspension (or emulsion) system, homogenization it is treated Journey, it is this processing simultaneously play a part of reduce dispersion yardstick and improve dispersion distributing homogeneity, preferably homogenizing process for Whipping process under low-speed conditions of the rotating speed less than 1000r/min.

By the way that to cosmetics each component is fully emulsified, the cosmetics of stable homogeneous can be obtained after homogeneous, this method is suitable to Standardized production.

Specifically, the preparation method of above-mentioned cosmetics comprises the following steps：

(e) mixed liquor for obtaining step (d) is emulsified and homogeneous；

Preferably, mixing velocity is 500~1000rpm in step (a), for example, 500rpm, 600rpm, 700rpm, 800rpm, 900rpm or 1000rpm；And/or

Incorporation time is 10~20min, such as 10min, 12min, 14min, 15min, 16min, 18min or 20min；

Preferably, mixing velocity is 500~1000rpm in step (b), for example, 500rpm, 600rpm, 700rpm, 800rpm, 900rpm or 1000rpm；And/or

Warming temperature be 60~70 DEG C, such as 60 DEG C, 61 DEG C, 62 DEG C, 63 DEG C, 64 DEG C, 65 DEG C, 66 DEG C, 67 DEG C, 68 DEG C, 69 DEG C or 70 DEG C；

Preferably, mixing velocity is 500~700rpm in step (c), such as 500rpm, 600rpm or 700rpm；With/ Or,

Warming temperature is 45~50 DEG C, such as 45 DEG C, 46 DEG C, 47 DEG C, 48 DEG C, 49 DEG C or 50 DEG C；

By the way that component A, component B and component C raw material first are mixed to get into prefabricated component A, pre- under certain condition respectively B component processed and prefabricated component C, facilitate post-production.

Preferably, mixing velocity is 600~1000rpm in step (d), such as 600rpm, 800rpm or 1000rpm；With/ Or,

Warming temperature be 75~85 DEG C, such as 75 DEG C, 76 DEG C, 77 DEG C, 78 DEG C, 79 DEG C, 80 DEG C, 81 DEG C, 82 DEG C, 83 DEG C, 84 DEG C or 85 DEG C；And/or

Soaking time is 10~25min, such as 10min, 15min, 20min or 25min；

By mixing prefabricated component A, prefabricated B component and prefabricated component C at a temperature of 75~85 DEG C, and it is incubated, obtains Mixed liquor.

Preferably, emulsifying rate is 300~500rpm in step (e), such as 300rpm, 400rpm or 500rpm；With/ Or,

Vacuum is -0.05~-0.1MPa during emulsification, such as -0.1MPa or -0.05MPa；And/or

Homogeneous speed is 1000~1500rpm, for example, 1000rpm, 1100rpm, 1200rpm, 1300rpm, 1400rpm or 1500rpm；And/or

Homogenizing time is 3~5min, such as 3min, 4min or 5min；

By using mixed liquor is emulsified under the conditions of 300~500rpm, carried out under the conditions of 1000~1500rpm 3~5min of homogeneous, homogeneous, stable emulsion can be obtained.

Preferably, step (f) cools temperature as 40~45 DEG C, such as 40 DEG C, 41 DEG C, 42 DEG C, 43 DEG C, 44 DEG C or 45 DEG C； And/or

Mixing velocity is 300~500rpm, such as 300rpm, 400rpm or 500rpm；And/or

Incorporation time is 15~25min, such as 15min, 20min or 25min.

By the way that the mixed liquor after homogeneous is cooled into 40~45 DEG C, skin matrix and water are added, obtains essence cosmetic Product, prevent high temperature from causing to damage to active component in skin matrix, impact effect.

By being prepared under certain condition, the emulsion of stable homogeneous can be obtained, and will not be destroyed in preparation process The structure and activity of active ingredient, ensure the using effect of Essence.

In more detail, the preparation method of above-mentioned cosmetics essence, comprises the following steps：

(1) component A is mixed, opens stirring (rotating speed is 500~1000rpm) and stir 10~20min, obtain prefabricated A；

(2) B component is mixed, opens stirring (rotating speed is 500~1000rpm), and be warming up to 60~70 DEG C, insulation is standby With obtaining prefabricated B；

(3) component C being mixed, opens stirring (rotating speed is 500~700rpm), and be warming up to 45~50 DEG C, insulation is standby, Obtain prefabricated C；

(4) prefabricated B is added into aqueous phase pot, opens stirring (rotating speed is 600~1000rpm), add prefabricated A, be warming up to 75~85 DEG C, add prefabricated C after being incubated 15~25min and be incubated 10~20min again；

(5) after aqueous phase pot material being sucked into emulsification pot, emulsification pot stirring (rotating speed is 300~500rpm) is opened, keeps true Reciprocal of duty cycle (vacuum is -0.05Mpa) and mixing speed are constant, immediately open homogenizer carry out homogeneous, homogenizing time be 3~ 5min, the rotating speed of homogeneous is 1000~1500rpm；

(6) temperature lowering water is opened after the completion of homogeneous and is cooled to 40~45 DEG C, add skin matrix and water, stir 15~25min (rotating speed is 300~500rpm), discharge, obtain including the essence of skin matrix.

In order to further appreciate that the present invention, the inventive method and effect are done with reference to specific embodiment further in detail Explanation.Each raw material of the present invention can pass through commercially available acquisition.

Tetrahydrochysene methylpyrimidine carboxylic acid is purchased from Bitop companies；Thermus thermophilus (THERMUS THERMOPHILLUS) fermentation production Thing is purchased from sederma companies；Butterflybush flower (BUDDLEJA OFFICINALIS) extract is purchased from French GREENTECH companies； RHC- recombination human sources collagen is purchased from Jiangsu rivers and mountains Ju Yuan Bioisystech Co., Ltd.Other raw materials are commercially available prod.

Embodiment 1

A kind of skin matrix, it is made up of the following component of percentage by weight：Tetrahydrochysene methylpyrimidine carboxylic acid 3%, thermophilic heat of dwelling Bacterium tunning 50%, Flos Buddlejae extract 10%, recombination human source collagen 2% and water 35%.

Embodiment 2

A kind of skin matrix, it is made up of the following component of percentage by weight：Tetrahydrochysene methylpyrimidine carboxylic acid 10%, thermophilic heat of dwelling Bacterium tunning 15%, Flos Buddlejae extract 20%, recombination human source collagen 1% and water 54%.

Embodiment 3

A kind of skin matrix, it is made up of the following component of percentage by weight：Tetrahydrochysene methylpyrimidine carboxylic acid 5%, thermophilic heat of dwelling Bacterium tunning 40%, Flos Buddlejae extract 12%, recombination human source collagen 1.5% and water 41.5%.

Embodiment 4

A kind of skin matrix, it is made up of the following component of percentage by weight：Tetrahydrochysene methylpyrimidine carboxylic acid 8%, thermophilic heat of dwelling Bacterium tunning 20%, Flos Buddlejae extract 18%, recombination human source collagen 1.2% and water 52.8%.

Embodiment 5

A kind of skin matrix, it is made up of the following component of percentage by weight：Tetrahydrochysene methylpyrimidine carboxylic acid 6%, thermophilic heat of dwelling Bacterium tunning 30%, Flos Buddlejae extract 15%, recombination human source collagen 1.8% and water 47.2%.

Embodiment 6

A kind of skin matrix, it is made up of the following component of percentage by weight：Tetrahydrochysene methylpyrimidine carboxylic acid 7%, thermophilic heat of dwelling Bacterium tunning 25%, Flos Buddlejae extract 14%, recombination human source collagen 1.5% and water 52.5%.

Comparative example 1

A kind of skin matrix, it is made up of the following component of percentage by weight：Tetrahydrochysene methylpyrimidine carboxylic acid 2%, thermophilic heat of dwelling Bacterium tunning 55%, Flos Buddlejae extract 5%, recombination human source collagen 5% and water 33%.

Comparative example 2

A kind of skin matrix, it is made up of the following component of percentage by weight：Thermus thermophilus tunning 15%, butterflybush flower Extract 20%, recombination human source collagen 1% and water 64%.

Comparative example 3

A kind of skin matrix, it is made up of the following component of percentage by weight：Tetrahydrochysene methylpyrimidine carboxylic acid 5%, butterflybush flower carries Take thing 12%, recombination human source collagen 1.5% and water 81.5%.

Comparative example 4

A kind of skin matrix, it is made up of the following component of percentage by weight：Tetrahydrochysene methylpyrimidine carboxylic acid 8%, thermophilic heat of dwelling Bacterium tunning 20%, recombination human source collagen 1.2% and water 70.8%.

Comparative example 5

A kind of skin matrix, it is made up of the following component of percentage by weight：Tetrahydrochysene methylpyrimidine carboxylic acid 6%, thermophilic heat of dwelling Bacterium tunning 30%, Flos Buddlejae extract 15% and water 49%.

Embodiment 7

A kind of preparation method of skin matrix, comprises the following steps：

(1) stirring (rotating speed 800rpm) is opened, under the conditions of 35 DEG C, by the tetrahydrochysene methylpyrimidine carboxylic acid of 3 parts by weight, 2 The RHC- recombination human source collagens of parts by weight are slowly added in the water of 35 parts by weight, constant temperature stirring 30min, obtain clarifying molten Liquid；

(2) by thermus thermophilus (THERMUS THERMOPHILLUS) tunning of 50 parts by weight, 10 parts by weight it is close Cover flower (BUDDLEJA OFFICINALIS) extract to add in settled solution, 10min stirred under 800rpm mixing speed, 20 DEG C are cooled to, discharging, obtains skin matrix.

Embodiment 8

A kind of preparation method of skin matrix, comprises the following steps：

(1) stirring (rotating speed 900rpm) is opened, under the conditions of 40 DEG C, by the tetrahydrochysene methylpyrimidine carboxylic acid of 10 parts by weight, 1 The RHC- recombination human source collagens of parts by weight are slowly added in the water of 54 parts by weight, constant temperature stirring 20min, obtain clarifying molten Liquid；

(2) by thermus thermophilus (THERMUS THERMOPHILLUS) tunning of 15 parts by weight, 20 parts by weight it is close Cover flower (BUDDLEJA OFFICINALIS) extract to add in settled solution, 5min stirred under 900rpm mixing speed, 25 DEG C are cooled to, discharging, obtains skin matrix.

Embodiment 9

A kind of preparation method of skin matrix, comprises the following steps：

(1) open stirring (rotating speed 1000rpm), under the conditions of 45 DEG C, by the tetrahydrochysene methylpyrimidine carboxylic acid of 5 parts by weight, The RHC- recombination human source collagens of 1.5 parts by weight are slowly added in the water of 41.5 parts by weight, constant temperature stirring 15min, are obtained clear Clear solution；

(2) by thermus thermophilus (THERMUS THERMOPHILLUS) tunning of 40 parts by weight, 12 parts by weight it is close Cover flower (BUDDLEJA OFFICINALIS) extract to add in settled solution, 8min stirred under 1000rpm mixing speed, 22 DEG C are cooled to, discharging, obtains skin matrix.

Embodiment 10

A kind of preparation method of skin matrix, comprises the following steps：

(1) open stirring (rotating speed 800rpm), under the conditions of 37 DEG C, by the tetrahydrochysene methylpyrimidine carboxylic acid of 8 parts by weight, The RHC- recombination human source collagens of 1.2 parts by weight are slowly added in the water of 52.8 parts by weight, constant temperature stirring 30min, are obtained clear Clear solution；

(2) by thermus thermophilus (THERMUS THERMOPHILLUS) tunning of 20 parts by weight, 18 parts by weight it is close Cover flower (BUDDLEJA OFFICINALIS) extract to add in settled solution, 10min stirred under 800rpm mixing speed, 25 DEG C are cooled to, discharging, obtains skin matrix.

Embodiment 11

A kind of preparation method of skin matrix, comprises the following steps：

(1) open stirring (rotating speed 900rpm), under the conditions of 42 DEG C, by the tetrahydrochysene methylpyrimidine carboxylic acid of 6 parts by weight, The RHC- recombination human source collagens of 1.8 parts by weight are slowly added in the water of 47.2 parts by weight, constant temperature stirring 20min, are obtained clear Clear solution；

(2) by thermus thermophilus (THERMUS THERMOPHILLUS) tunning of 30 parts by weight, 15 parts by weight it is close Cover flower (BUDDLEJA OFFICINALIS) extract to add in settled solution, 6min stirred under 900rpm mixing speed, 25 DEG C are cooled to, discharging, obtains skin matrix.

Embodiment 12

A kind of preparation method of skin matrix, comprises the following steps：

(1) open stirring (rotating speed 1000rpm), under the conditions of 45 DEG C, by the tetrahydrochysene methylpyrimidine carboxylic acid of 7 parts by weight, The RHC- recombination human source collagens of 1.5 parts by weight are slowly added in the water of 52.5 parts by weight, constant temperature stirring 15min, are obtained clear Clear solution；

(2) by thermus thermophilus (THERMUS THERMOPHILLUS) tunning of 25 parts by weight, 14 parts by weight it is close Cover flower (BUDDLEJA OFFICINALIS) extract to add in settled solution, stirred under 1000rpm mixing speed 10min, 20 DEG C are cooled to, discharging, obtains skin matrix.

Comparative example 6

A kind of preparation method of skin matrix, comprises the following steps：

(1) stirring (rotating speed 800rpm) is opened, under the conditions of 35 DEG C, by the tetrahydrochysene methylpyrimidine carboxylic acid of 2 parts by weight, 5 The RHC- recombination human source collagens of parts by weight are slowly added in the water of 33 parts by weight, constant temperature stirring 30min, obtain clarifying molten Liquid；

(2) by thermus thermophilus (THERMUS THERMOPHILLUS) tunning of 55 parts by weight, 5 parts by weight it is close Cover flower (BUDDLEJA OFFICINALIS) extract to add in settled solution, 10min stirred under 800rpm mixing speed, 20 DEG C are cooled to, discharging, obtains skin matrix.

Comparative example 7

A kind of preparation method of skin matrix, comprises the following steps：

(1) stirring (rotating speed 900rpm) is opened, under the conditions of 40 DEG C, by the RHC- recombination human source collagen eggs of 1 parts by weight It is slowly added in vain in the water of 64 parts by weight, constant temperature stirring 20min, obtains settled solution；

Comparative example 8

A kind of preparation method of skin matrix, comprises the following steps：

(1) open stirring (rotating speed 1000rpm), under the conditions of 45 DEG C, by the tetrahydrochysene methylpyrimidine carboxylic acid of 5 parts by weight, The RHC- recombination human source collagens of 1.5 parts by weight are slowly added in the water of 81.5 parts by weight, constant temperature stirring 15min, are obtained clear Clear solution；

(2) butterflybush flower (BUDDLEJA OFFICINALIS) extract of 12 parts by weight is added in settled solution, 8min is stirred under 1000rpm mixing speed, 22 DEG C is cooled to, discharging, obtains skin matrix.

Comparative example 9

A kind of preparation method of skin matrix, comprises the following steps：

(1) open stirring (rotating speed 800rpm), under the conditions of 37 DEG C, by the tetrahydrochysene methylpyrimidine carboxylic acid of 8 parts by weight, The RHC- recombination human source collagens of 1.2 parts by weight are slowly added in the water of 70.8 parts by weight, constant temperature stirring 30min, are obtained clear Clear solution；

(2) thermus thermophilus (THERMUS THERMOPHILLUS) tunning of 20 parts by weight is added into settled solution In, 10min is stirred under 800rpm mixing speed, 25 DEG C is cooled to, discharging, obtains skin matrix.

Comparative example 10

A kind of preparation method of skin matrix, comprises the following steps：

(1) stirring (rotating speed 900rpm) is opened, under the conditions of 42 DEG C, the tetrahydrochysene methylpyrimidine carboxylic acid of 6 parts by weight is delayed It is slow to add in the water of 49 parts by weight, constant temperature stirring 20min, obtain settled solution；

Embodiment 13

A kind of essence, it is made up of the following component of percentage by weight：

Component A：Dipropylene glycol 3.0%, Sodium Hyaluronate 0.15%；

B component：Butanediol 5.0%, methyl hydroxybenzoate 0.2%；

Component C：Essence 0.01%, Cremophor RH40 0.15%；

D components：The skin matrix 10% of embodiment 1；

Water 81.49%.

Embodiment 14

Component A：Dipropylene glycol 6.0%, Sodium Hyaluronate 0.05%；

B component：Butanediol 8.0%, methyl hydroxybenzoate 0.1%；

Component C：Essence 0.03%, Cremophor RH40 0.05%；

D components：The skin matrix 20% of embodiment 2；

Water 65.77%.

Embodiment 15

Component A：Dipropylene glycol 4.5%, Sodium Hyaluronate 0.1%；

B component：Butanediol 6.5%, methyl hydroxybenzoate 0.15%；

Component C：Essence 0.02%, Cremophor RH40 0.1%；

D components：The skin matrix 15% of embodiment 3；

Water 73.63%.

Embodiment 16

Component A：Dipropylene glycol 4.0%, Sodium Hyaluronate 0.12%；

B component：Butanediol 6.0%, methyl hydroxybenzoate 0.12%；

Component C：Essence 0.01%, Cremophor RH40 0.12%；

D components：The skin matrix 20% of embodiment 4；

Water 69.63%.

Embodiment 17

Component A：Dipropylene glycol 5.0%, Sodium Hyaluronate 0.08%；

B component：Butanediol 7.0%, methyl hydroxybenzoate 0.18%；

Component C：Essence 0.03%, Cremophor RH40 0.08%；

D components：The skin matrix 10% of embodiment 5；

Water 75.63%.

Embodiment 18

Component A：Dipropylene glycol 5.5%, Sodium Hyaluronate 0.1%；

B component：Butanediol 6.5%, methyl hydroxybenzoate 0.15%；

Component C：Essence 0.02%, Cremophor RH40 0.06%；

D components：The skin matrix 15% of embodiment 6；

Water 72.67%.

Comparative example 11

A kind of essence, D components use the skin matrix of comparative example 1, and remaining component is identical with embodiment 13.

Comparative example 12

A kind of essence, D components use the skin matrix of comparative example 2, and remaining component is identical with embodiment 14.

Comparative example 13

A kind of essence, D components use the skin matrix of comparative example 3, and remaining component is identical with embodiment 15.

Comparative example 14

A kind of essence, D components use the skin matrix of comparative example 4, and remaining component is identical with embodiment 16.

Comparative example 15

A kind of essence, D components use the skin matrix of comparative example 5, and remaining component is identical with embodiment 17.

Embodiment 19

A kind of preparation method of essence, comprises the following steps：

(1) dipropylene glycol of 3 parts by weight and the Sodium Hyaluronate of 0.15 parts by weight are mixed, opening stirring, (rotating speed is 500rpm) and 20min is stirred, obtain prefabricated A；

(2) butanediol of 5 parts by weight and the methyl hydroxybenzoate of 0.2 parts by weight are mixed, opening stirring, (rotating speed is 500rpm), 60 DEG C are warming up to and, insulation is standby, obtains prefabricated B；

(3) essence of 0.01 parts by weight and the Cremophor RH40 of 0.15 parts by weight are mixed, opens stirring (rotating speed For 500rpm), and 45 DEG C are warming up to, insulation is standby, obtains prefabricated C；

(4) prefabricated B is added into aqueous phase pot, opens stirring (rotating speed 600rpm), add prefabricated A, be warming up to 80 DEG C, protected Prefabricated C is added after warm 20min and is incubated 10min again；

(5) after aqueous phase pot material being sucked into emulsification pot, emulsification pot stirring (rotating speed 400rpm) is opened, keeps vacuum (vacuum is -0.05Mpa) and mixing speed are constant, immediately unlatching homogenizer progress homogeneous, homogenizing time 3min, homogeneous Rotating speed is 1500rpm；

(6) temperature lowering water is opened after the completion of homogeneous and is cooled to 40 DEG C, add 10 parts by weight the skin matrix of embodiment 1 and The water of 81.49 parts by weight, stirring 20min (rotating speed 400rpm), discharge, obtain including the essence of skin matrix.

Embodiment 20

A kind of preparation method of essence, comprises the following steps：

(1) dipropylene glycol of 6 parts by weight and the Sodium Hyaluronate of 0.05 parts by weight are mixed, opening stirring, (rotating speed is 1000rpm) and 10min is stirred, obtain prefabricated A；

(2) butanediol of 8 parts by weight and the methyl hydroxybenzoate of 0.1 parts by weight are mixed, opening stirring, (rotating speed is 1000rpm), 70 DEG C are warming up to and, insulation is standby, obtains prefabricated B；

(3) essence of 0.03 parts by weight and the Cremophor RH40 of 0.05 parts by weight are mixed, opens stirring (rotating speed For 700rpm), and 50 DEG C are warming up to, insulation is standby, obtains prefabricated C；

(4) prefabricated B is added into aqueous phase pot, opens stirring (rotating speed 1000rpm), add prefabricated A, be warming up to 82 DEG C, Prefabricated C, which is added, after insulation 18min is incubated 20min again；

(5) after aqueous phase pot material being sucked into emulsification pot, emulsification pot stirring (rotating speed 450rpm) is opened, keeps vacuum (vacuum is -0.05Mpa) and mixing speed are constant, immediately unlatching homogenizer progress homogeneous, homogenizing time 5min, homogeneous Rotating speed is 1000rpm；

(6) temperature lowering water is opened after the completion of homogeneous and is cooled to 45 DEG C, add 20 parts by weight the skin matrix of embodiment 2 and The water of 65.77 parts by weight, stirring 22min (rotating speed 350rpm), discharge, obtain including the essence of skin matrix.

Embodiment 21

A kind of preparation method of essence, comprises the following steps：

(1) dipropylene glycol of 4.5 parts by weight and the Sodium Hyaluronate of 0.1 parts by weight are mixed, opening stirring, (rotating speed is 800rpm) and 15min is stirred, obtain prefabricated A；

(2) butanediol of 6.5 parts by weight and the methyl hydroxybenzoate of 0.15 parts by weight are mixed, opening stirring, (rotating speed is 800rpm), 65 DEG C are warming up to and, insulation is standby, obtains prefabricated B；

(3) essence of 0.02 parts by weight and the Cremophor RH40 of 0.1 parts by weight are mixed, opens stirring (rotating speed For 600rpm), and 46 DEG C are warming up to, insulation is standby, obtains prefabricated C；

(4) prefabricated B is added into aqueous phase pot, opens stirring (rotating speed 800rpm), add prefabricated A, be warming up to 78 DEG C, protected Prefabricated C is added after warm 22min and is incubated 15min again；

(5) after aqueous phase pot material being sucked into emulsification pot, emulsification pot stirring (rotating speed 350rpm) is opened, keeps vacuum (vacuum is -0.05Mpa) and mixing speed are constant, immediately unlatching homogenizer progress homogeneous, homogenizing time 4min, homogeneous Rotating speed is 1200rpm；

(6) temperature lowering water is opened after the completion of homogeneous and is cooled to 43 DEG C, add 15 parts by weight the skin matrix of embodiment 3 and The water of 73.63 parts by weight, stirring 18min (rotating speed 450rpm), discharge, obtain including the essence of skin matrix.

Embodiment 22

A kind of preparation method of essence, comprises the following steps：

(1) dipropylene glycol of 4 parts by weight and the Sodium Hyaluronate of 0.12 parts by weight are mixed, opening stirring, (rotating speed is 600rpm) and 16min is stirred, obtain prefabricated A；

(2) butanediol of 6 parts by weight and the methyl hydroxybenzoate of 0.12 parts by weight are mixed, opening stirring, (rotating speed is 600rpm), 68 DEG C are warming up to and, insulation is standby, obtains prefabricated B；

(3) essence of 0.01 parts by weight and the Cremophor RH40 of 0.12 parts by weight are mixed, opens stirring (rotating speed For 550rpm), and 42 DEG C are warming up to, insulation is standby, obtains prefabricated C；

(4) prefabricated B is added into aqueous phase pot, opens stirring (rotating speed 700rpm), add prefabricated A, be warming up to 80 DEG C, protected Prefabricated C is added after warm 15min and is incubated 20min again；

(5) after aqueous phase pot material being sucked into emulsification pot, emulsification pot stirring (rotating speed 400rpm) is opened, keeps vacuum (vacuum is -0.05Mpa) and mixing speed are constant, immediately unlatching homogenizer progress homogeneous, homogenizing time 4min, homogeneous Rotating speed is 1300rpm；

(6) temperature lowering water is opened after the completion of homogeneous and is cooled to 42 DEG C, add 20 parts by weight the skin matrix of embodiment 4 and The water of 69.63 parts by weight, stirring 20min (rotating speed 400rpm), discharge, obtain including the essence of skin matrix.

Embodiment 23

A kind of preparation method of essence, comprises the following steps：

(1) dipropylene glycol of 5 parts by weight and the Sodium Hyaluronate of 0.08 parts by weight are mixed, opening stirring, (rotating speed is 800rpm) and 12min is stirred, obtain prefabricated A；

(2) butanediol of 7 parts by weight and the methyl hydroxybenzoate of 0.18 parts by weight are mixed, opening stirring, (rotating speed is 700rpm), 62 DEG C are warming up to and, insulation is standby, obtains prefabricated B；

(3) essence of 0.03 parts by weight and the Cremophor RH40 of 0.08 parts by weight are mixed, opens stirring (rotating speed For 650rpm), and 48 DEG C are warming up to, insulation is standby, obtains prefabricated C；

(4) prefabricated B is added into aqueous phase pot, opens stirring (rotating speed 900rpm), add prefabricated A, be warming up to 75 DEG C, protected Prefabricated C is added after warm 25min and is incubated 10min again；

(5) after aqueous phase pot material being sucked into emulsification pot, emulsification pot stirring (rotating speed 500rpm) is opened, keeps vacuum (vacuum is -0.05Mpa) and mixing speed are constant, immediately unlatching homogenizer progress homogeneous, homogenizing time 5min, homogeneous Rotating speed is 1200rpm；

(6) temperature lowering water is opened after the completion of homogeneous and is cooled to 41 DEG C, add 10 parts by weight the skin matrix of embodiment 5 and The water of 75.63 parts by weight, stirring 15min (rotating speed 500rpm), discharge, obtain including the essence of skin matrix.

Embodiment 24

A kind of preparation method of essence, comprises the following steps：

(1) dipropylene glycol of 5.5 parts by weight and the Sodium Hyaluronate of 0.1 parts by weight are mixed, opening stirring, (rotating speed is 750rpm) and 16min is stirred, obtain prefabricated A；

(2) butanediol of 6.5 parts by weight and the methyl hydroxybenzoate of 0.15 parts by weight are mixed, opening stirring, (rotating speed is 900rpm), 65 DEG C are warming up to and, insulation is standby, obtains prefabricated B；

(3) essence of 0.02 parts by weight and the Cremophor RH40 of 0.06 parts by weight are mixed, opens stirring (rotating speed For 640rpm), and 47 DEG C are warming up to, insulation is standby, obtains prefabricated C；

(4) prefabricated B is added into aqueous phase pot, opens stirring (rotating speed 800rpm), add prefabricated A, be warming up to 85 DEG C, protected Prefabricated C is added after warm 15min and is incubated 15min again；

(5) after aqueous phase pot material being sucked into emulsification pot, emulsification pot stirring (rotating speed 300rpm) is opened, keeps vacuum (vacuum is -0.05Mpa) and mixing speed are constant, immediately unlatching homogenizer progress homogeneous, homogenizing time 3min, homogeneous Rotating speed is 1400rpm；

(6) temperature lowering water is opened after the completion of homogeneous and is cooled to 44 DEG C, add 15 parts by weight the skin matrix of embodiment 6 and The water of 72.67 parts by weight, stirring 25min (rotating speed 300rpm), discharge, obtain including the essence of skin matrix.

Comparative example 16

A kind of preparation method of essence, wherein step (6) use the skin matrix of comparative example 1, and remaining step is with implementing Example 19 is identical.

Comparative example 17

A kind of preparation method of essence, wherein step (6) use the skin matrix of comparative example 2, and remaining step is with implementing Example 20 is identical.

Comparative example 18

A kind of preparation method of essence, wherein step (6) use the skin matrix of comparative example 3, and remaining step is with implementing Example 21 is identical.

Comparative example 19

A kind of preparation method of essence, wherein step (6) use the skin matrix of comparative example 4, and remaining step is with implementing Example 22 is identical.

Comparative example 20

A kind of preparation method of essence, wherein step (6) use the skin matrix of comparative example 5, and remaining step is with implementing Example 23 is identical.

Test example

Infrared resistant and anti-aging test are carried out to the skin matrix and essence of embodiment and comparative example, and not contain The essence of skin matrix is as control.

Experiment material：Vitro in fibroblast；

Test method：Infra red treatment is used again after handling experiment material with a certain amount of matrix sample, using ELISA method point Not Kao Cha vitro in fibroblast cause under a certain amount of infrared radiation that MMP-1 burst size changes and collagen contains Amount change two indices.

Its test result is as shown in table 1.

Table 1 resists infrared ray and anti-aging test result using the skin matrix and essence of embodiment and comparative example

Note：Matrix metalloproteinase (matrix metalloproteinase, MMP).

As it can be seen from table 1 the skin matrix that the embodiment of the present invention 7~12 obtains has good infrared resistant and anti-ageing Old effect, the Essence MMP-1 burst sizes of the embodiment of the present invention 19~24 are in 168~215pg/ml, and collagen concentration is 12 ~15ng/ml, significant infrared resistant and anti-aging effects are shown by adding skin matrix, without adding the present invention The Essence MMP-1 burst sizes of skin matrix are up to more than 270pg/ml, and collagen concentration only has 8ng/ml or so, it is seen then that The skin matrix of the present invention has good infrared resistant and anti-aging effects.

Embodiment 7 optimizes tetrahydrochysene methylpyrimidine carboxylic acid in skin matrix, thermus thermophilus fermentation compared with comparative example 6 The percentage by weight of product, Flos Buddlejae extract and recombination human source collagen in skin matrix, the skin matrix of embodiment 7 Infrared resistant and anti-aging effects have further lifting compared with comparative example 6.

Comparative example 7 compared with Example 8, does not contain tetrahydrochysene methylpyrimidine carboxylic acid in used matrix；Comparative example 8 and reality Apply example 9 to compare, thermus thermophilus tunning is not contained in matrix；Comparative example 9 does not contain close compared with Example 10, in matrix Cover flower extract；Comparative example 10 does not contain recombination human source collagen compared with embodiment 11, in matrix, obtained matrix and essence Magnificent liquid resist infrared ray and anti-aging effects are bad, it is seen then that tetrahydrochysene methylpyrimidine carboxylic acid, thermophilic is added only in skin matrix Hot Thermus tunning, Flos Buddlejae extract and recombination human source collagen whole active component can be obtained and preferably carried Bright effect, collocation of the skin matrix of the present invention Jing Guo several active ingredients, can effectively resist infrared ray and anti-aging, illustrate this A few money active ingredients play a part of Synergistic by rational collocation, can just give full play to and resist infrared ray and anti-aging effect Fruit.

Although illustrate and describing the present invention with specific embodiment, but will be appreciated that without departing substantially from the present invention's Many other change and modification can be made in the case of spirit and scope.It is, therefore, intended that wrap in the following claims Include all such changes and modifications belonged in the scope of the invention.

Claims

1. a kind of skin matrix, it is characterised in that the skin matrix includes following component：It is tetrahydrochysene methylpyrimidine carboxylic acid, thermophilic Thermus tunning, Flos Buddlejae extract and recombination human source collagen；

Each group in tetrahydrochysene methylpyrimidine carboxylic acid, thermus thermophilus tunning, Flos Buddlejae extract and recombination human source collagen The percentage by weight for accounting for skin matrix is divided to be not less than 1%.

2. according to the skin matrix described in claim 1, it is characterised in that the skin matrix includes the as follows of percentage by weight Component：Tetrahydrochysene methylpyrimidine carboxylic acid 3~10%, thermus thermophilus tunning 15~50%, Flos Buddlejae extract 10~20%, Recombination human source collagen 1~2%, surplus are water；

Preferably, the skin matrix includes the following component of percentage by weight：Tetrahydrochysene methylpyrimidine carboxylic acid 5~8%, it is thermophilic to dwell Hot bacterium tunning 20~40%, Flos Buddlejae extract 12~18%, recombination human source collagen 1~2%, surplus are water；

Preferably, the skin matrix includes the following component of percentage by weight：Tetrahydrochysene methylpyrimidine carboxylic acid 5~6%, it is thermophilic to dwell Hot bacterium tunning 20~30%, Flos Buddlejae extract 12~15%, recombination human source collagen 1~1.5%, surplus are water.

3. the preparation method of the skin matrix described in a kind of claim 1 or 2, it is characterised in that comprise the following steps：

Tetrahydrochysene methylpyrimidine carboxylic acid, thermus thermophilus tunning, Flos Buddlejae extract, recombination human source collagen and water are filled Skin matrix is obtained after dividing mixing.

4. according to the preparation method of the skin matrix described in claim 3, it is characterised in that comprise the following steps：

(b) settled solution of thermus thermophilus tunning and Flos Buddlejae extract and step (a) is sufficiently mixed and cooled down, obtained To skin matrix；

Preferably, mixing temperature is 35~45 DEG C, preferably 40~45 DEG C, further preferred 42~45 DEG C in step (a)；And/or

Mixing velocity is 800~1000rpm in step (a)；And/or

Preferably, mixing velocity is 800~1000rpm in step (b)；And/or

5. application of the skin matrix described in claim 1 or 2 in anti-aging cosmetics are prepared.

A kind of 6. cosmetics of the skin matrix including described in claim 1 or 2.

7. according to the cosmetics described in claim 6, it is characterised in that percentage by weight of the skin matrix in cosmetics For 10~20%.

8. according to the cosmetics described in claim 6 or 7, it is characterised in that the cosmetics include the as follows of percentage by weight Component：

Component A：Dipropylene glycol 3.0~6.0%, Sodium Hyaluronate 0.05~0.15%；

B component：Butanediol 5.0~8.0%, methyl hydroxybenzoate 0.1~0.2%；

Component C：Cremophor RH40 0.05~0.15%；

D components：Skin matrix 10~20%；

Surplus is water；

Component A：Dipropylene glycol 4.0~6.0%, Sodium Hyaluronate 0.08~0.15%；

B component：Butanediol 5.0~7.0%, methyl hydroxybenzoate 0.15~0.2%；

Component C：Cremophor RH40 0.08~0.15%；

D components：Skin matrix 15~20%；

Surplus is water；

Component A：Dipropylene glycol 5.0~6.0%, Sodium Hyaluronate 0.1~0.15%；

B component：Butanediol 5.0~6.0%, methyl hydroxybenzoate 0.15~0.2%；

Component C：Cremophor RH40 0.1~0.15%；

D components：Skin matrix 15~20%；

Surplus is water；

Preferably, the cosmetics also include essence；Percentage by weight of the essence in cosmetics is 0.01~0.03%.

9. the preparation method of the cosmetics described in a kind of claim 8, it is characterised in that comprise the following steps：

Component A, B component and component C are subjected to fully emulsified and homogeneous after mixing heating and being incubated, D components are added after cooling, are appointed The essence and water of choosing, cosmetics are obtained after mixing.

10. according to the preparation method of the cosmetics described in claim 9, it is characterised in that comprise the following steps：

(d) prefabricated component A is mixed with prefabricated B component to heat up and add prefabricated component C after being incubated and be incubated again, obtain mixed liquor；

(e) mixed liquor for obtaining step (d) is emulsified and homogeneous；

Preferably, mixing velocity is 500~1000rpm in step (a)；And/or

Incorporation time is 10~20min；

Preferably, mixing velocity is 500~1000rpm in step (b)；And/or

Warming temperature is 60~70 DEG C；

Preferably, mixing velocity is 500~700rpm in step (c)；And/or

Warming temperature is 45~50 DEG C；

Preferably, mixing velocity is 600~1000rpm in step (d)；And/or

Warming temperature is 75~85 DEG C；And/or

Soaking time is 10~25min；

Preferably, emulsifying rate is 300~500rpm in step (e)；And/or

Vacuum is -0.05~-0.1MPa during emulsification；And/or

Homogeneous speed is 1000~1500rpm；And/or

Homogenizing time is 3~5min；

Preferably, step (f) cooling temperature is 40~45 DEG C；And/or

Mixing velocity is 300~500rpm；And/or

Incorporation time is 15~25min.