CN108888589A - A kind of antiallergic moisture-keeping composition containing seawater - Google Patents
A kind of antiallergic moisture-keeping composition containing seawater Download PDFInfo
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- CN108888589A CN108888589A CN201810838699.7A CN201810838699A CN108888589A CN 108888589 A CN108888589 A CN 108888589A CN 201810838699 A CN201810838699 A CN 201810838699A CN 108888589 A CN108888589 A CN 108888589A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The present invention relates to a kind of antiallergic moisture-keeping composition containing seawater, it is characterised in that：It is grouped as by the group of following mass fraction：Seawater 60 ~ 75%, thermus thermophilus tunning 5 ~ 18%, starfish branch tube algae extract 16 ~ 25%；Magnesium element content is 6000 ~ 12000 mg/L in the seawater, and calcium element content is 820 ~ 1160mg/L, and silicon content is 3 ~ 9mg/L, and Zn-ef ficiency content is 0.05 ~ 0.26mg/L.The present invention has the skin-care effect of antiallergic, moisturizing, can be directly appended in cosmetics, has the advantages that safely, effectively, conducive to use.
Description
Technical field
The present invention relates to cosmetic field, in particular to a kind of antiallergic moisture-keeping composition containing seawater.
Technical background
Skin sensitivity refers to susceptible to many factors and the subjective sensation symptom of induction skin condition, i.e. dermoreaction
Property high, poor resistance even easy allergy.Climate variation, air pollution and the influence of cosmetics type and complicated component, it is quick
A possibility that sense skin occurs is increasing.For daily state, sensitive skin has no objective skin lesion or skin disease evidence,
Be mainly characterized by more drying, be easy it is tight and rubescent；It by minimal irritation, that is, can produce itch, furfur, or even burn and pierce
Pain etc. is felt.
The origin cause of formation of sensitive skin is not the contact and effect of predetermined substance, but skin self structure and affective neuron
Given state.Its origin cause of formation includes following possible factor：1）Barrier function：Skin barrier function is impaired, is skin sensitivity
Major reason, this is because the skin permeability of cuticula weakness is strong, stimulant is easier to enter and cause the inflammatory of skin
Reaction.2）Neural factors：The generation of sensitive skin is related with peripheral nerve dysfunction and central functions change, especially
It is related with its cutaneous nerve increased response.3）Inflammatory reaction：Since there are barrier function damage or nervous function are different for sensitive skin
Normal feature is more difficult to resist the invasion of environmental stimuli object and anaphylactogen compared with normal skin, is easy to happen a series of stimulations
Or the reaction of scytitis caused by allergy, skin barrier structure and nerve endings are then further damaged, vicious circle is caused.
Antiallergic in cosmetics refers to a series of maintenance effects for sensitive skin, including to its daily nursing and
Improve, inhibits stimulate the reaction, inflammation of releiving and allergy.Currently, cosmetic industry has carried out extensive related antiallergic object
Quality Research：Chinese invention patent application《Antiallergic is releived composition and its application》（Application number：201710883290 .2 applications
Day：2017-09-26）It discloses a kind of antiallergic to releive composition and its application, can be used for mildy wash, toner, cream, essence
In liquid, facial mask or color make-up, composition is evaluated by macrophage nitric oxide inflammation releasing theory, nitric oxide releasing inhibiting rate
Up to 46.07%, histamine inhibiting rate is up to 61.59%.Chinese invention patent application《Plant is releived antipruritic》（Application number：
201510670658.8 the applying date：2015.10.09）It discloses a kind of plant to releive antipruritic, using natural pure plant medium-height grass
Medicine composition can not only be effectively prevented and treated skin allergy and itch, and without any toxic side effect.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of antiallergic moisture-keeping composition containing seawater, the composition have
Antiallergic, moisturizing skin-care effect, can be directly appended in cosmetics, have the advantages that safely, effectively, be conducive to use.
In order to solve the above technical problems, the present invention uses following technical scheme：A kind of antiallergic moisturizing combination containing seawater
Object, it is characterised in that composed of the following components：Seawater 60 ~ 75%, thermus thermophilus tunning 5 ~ 18%, starfish branch tube algae are extracted
Object 16 ~ 25%；Magnesium in the seawater（Mg）Constituent content is 6000 ~ 12000 mg/L, calcium（Ca）Constituent content be 820 ~
1160mg/L, silicon（Si）Constituent content is 3 ~ 9mg/L, zinc（Zn）Constituent content is 0.05 ~ 0.26mg/L.
Preferably, the antiallergic moisture-keeping composition containing seawater is grouped as by the group of following mass parts：Seawater 70%, it is thermophilic
Thermus tunning 10%, starfish branch tube algae extract 20%.
Seawater of the present invention is derived from the sea area 150 ~ 250m under sea level, compared with general surface seawater, has minerals
（Microelement）Abundant, the limpid clean, advantages such as pathogen is few.The seawater is rich in magnesium（Mg）, calcium（Ca）, silicon（Si）, zinc
（Zn）Element.Mg is important neurotransmitter, can coordinate nerve conduction, has to releive and loosens effect, while to cell week
Phase, cell Proliferation and cell differentiation etc. have regulating and controlling effect, maintain the skin normal update cycle, induce epidermal layer cells proliferation
With differentiation, to guarantee the normal barrier function of skin；Ca is natural nervous system stabilizer, has good work of releiving
With；Si is the key element for directly affecting internal collagen and articular cartilage tissue manufacture, while can also promote skin cell renewal,
Consolidate the defencive function between cell tissue；Trace elements zn has facilitation to human body non-specific immune function, simultaneously also
With certain anti-inflammatory bacteriostasis efficacy.Usually also contain potassium in seawater（K）, selenium（Se）, copper（Cu）Etc. biologically active element：K
It can help to maintain skin acid-base balance, conducive to the Tiny ecosystem barrier for consolidating skin surface；Se can promote human body non-specificity to exempt from
Epidemic disease function；Cu is the prothetic group of numerous enzyme systems such as superoxide dismutase, can enhance skin antioxygen power, while can also promote skin angle
Cell plastid proliferation, the impaired skin barrier of maintenance, and staphylococcus aureus, Escherichia coli etc. are made with specific antibacterial
With.
Thermus thermophilus tunning of the present invention（INCI：Thermus thermophilus（THERMUS THERMOPHILLUS）
Tunning, in China《Cosmetic material Names Catalogue is used（2015 editions）》Middle serial number 06177）Contain Polyphenols object
Matter can timely and effectively remove the reactive oxygen species caused by ambient pressure environments such as ultraviolet light, infrared rays（ROS）, help
Skin resists external environment injury, protects skin structure, safeguards skin barrier function.Thermus thermophilus fermentation of the present invention produces
Object is purchased from French Sederma company, and trade name Venuceane, wherein total polyphenols mass content is greater than 5%.
Starfish branch tube algae extract（INCI：Starfish branch tube algae（CLADOSIPHON NOVAE-CALEDONIAE）It extracts
Object, in China《Cosmetic material Names Catalogue is used（2015 editions）》Middle serial number 02737）Also known as Tang Jiahai accumulates, rich in brown
Algae carbohydrate gum.Fucoidin can play its antiallergic moisture-keeping efficacy from the following aspects：1. fucoidin can inhibit inflammatory factor
Release reduces the adverse reaction after skin is stimulated；Cell damage caused by ROS is reduced simultaneously, maintains skin structure；2.
Fucoidin has good bioactivity, can significantly increase macrophage phagocytic function, improve the immunoregulation effect of body,
Enhance the tolerance of skin；3. fucoidin is a kind of macromolecule polysaccharide, there is potent moisture-keeping efficacy.Tang Jiahai of the present invention
Accumulate and be purchased from Japanese tango wood Co., Ltd., trade name LIMUVEIL ORG, wherein fucoidin mass content is greater than 20%, brown alga
The average molecular weight of carbohydrate gum is 1,700,000 dalton.
For the antiallergic moisture-keeping efficacy for proving composition of the present invention, tested as follows：
Experiment 1：DPPH removes experiment
Inhibit free radical activity that the excessive free radicals generated after environmental stimuli can be effectively relieved and acts on lower structure function of cell
It degenerates, and then safeguards the normal barrier structure of the various organs including skin.
In ethanol solution, DPPH molecule produces stable purple containing nitrogen free radical, there is strong absorption at 517nm,
Free radical scavenger can match with its single electron and make solution decolourization.If determinand can quantitatively remove DPPH, illustrate that it has
It reduces the effective concentration of hydroxy radical, alkane free radical or oxyradical and interrupts the effect of lipid peroxidation chain reaction, be used for
Evaluate the free radical scavenging ability of determinand.
1 DPPH radicals scavenging experimental group of table
0.2 mmol/L DPPH ethanol solution of preparation in advance, 0 ~ 4oIt is kept in dark place under C；By antiallergic moisturizing group described in embodiment 1
Close object and ethyl alcohol by volume 1:1 is mixed, and the sample deposit that antiallergic moisture-keeping composition concentration expressed in percentage by volume is 50% is configured to
Liquid.According to table 1, DPPH, solvent are first accurately pipetted with pipette（Ethyl alcohol）In cuvette, the sample storage of respective volume is added
Standby liquid, anabolic reaction liquid start the DPPH absorbance value and the change curve of time that measure reaction solution at once, it is anti-to read 1-6 group
It answers liquid in the absorbance value of a certain set time, is denoted as Ai（I is group number）, when not being added stock sample solution in cuvette wherein
Absorbance value is denoted as A1。
Clearance rate（%）=[1-Ai/ A1] × 100%
Under sample various concentration, 2 are shown in Table to the clearance rate of DPPH, illustrates antiallergic moisture-keeping composition of the present invention, is had good
Radicals scavenging effect, can help skin under extraneous incentive condition, maintain cellular morphology function-stable, have good anti-
Quick effect.
2 antiallergic moisture-keeping composition DPPH free radical scavenging activity situation of table
Experiment 2：Skin barrier function maintenance and moisture-keeping efficacy experiment
Skin barrier can effectively prevent the invasion of extraneous adverse factor and the loss of endotrophic substance, be lost through transepidermal water
（TEWL value）Cuticula moisture loss situation can be characterized, TEWL value is lower, and skin barrier function is better.
Using antiallergic moisture-keeping composition is test group described in this patent embodiment 1, as a control group with deionized water, selection is special
Anisotropic dermatitis patients（Except pregnant or breast feeding women）For subject.It is smeared after early daily, the late cleaning skin of subject,
It need to guarantee that applying amount is identical.TEWL and water content of stratum corneum test are carried out respectively within 0,2,4 week in test.Subject is before testing
All strenuous exercises and obvious perspiration phenomenon should be avoided in 3h, confirmation is not used sun-proof, isolation, foundation cream and color make-up, first clear water and washes
Face, paper handkerchief wipe it is dry after in temperature 20 ~ 25oC, sit quietly in the test environment of relative humidity 40 ~ 60% 30min.Use TewameterTM 300 measurement TEWL values, test skin moisture content using Corneometer CM 825.It the results are shown in Table 3 and table 4.
As can be seen from Table 3, after using described in embodiment 1 antiallergic moisture-keeping composition 4 weeks, test zone TEWL value is in extremely aobvious
Write sex differernce（P<0.01）, and there was no significant difference for control group（P>0.05）, illustrate antiallergic moisture-keeping composition tool of the present invention
There is the effect of restoring skin barrier function.After 4 result of table then shows using inventing the antiallergic moisture-keeping composition 4 weeks, test section
Domain cuticula moisture and content are in extremely significant sex differernce（P<0.01）, and there was no significant difference for control group（P>0.05）, indicate this
The antiallergic moisture-keeping composition is invented with moisture-keeping efficacy.
TEWL value changes during 3 subject of table tests
Cuticula moisture content change during 4 subject of table tests
Test 3 lactic acid shouting pains experiment
Select 30 18 ~ 60 years old lactic acid shouting pain persons（Except pregnant or breast feeding women）As subject.In subject's nasolabial groove
Portion carries out measured zone label, and test area area is 1.5cm × 1.5cm, the same side 1 region of muffle ditch portion label.By 5%
50 μ l drop of lactic acid solution is placed in trial zone and the control at subject's nasolabial groove position on the single layer filter paper that diameter is 1.0 cm
Area.The tingling sensation that subject trial zone and check plot are inquired in 2.5min, scores by 4 point-scores（0 point is no shouting pain, 1 point
For slight shouting pain, 2 points are moderate shouting pain, and 3 points are severe shouting pain）；Then it is pressed in trial zone（2.0±0.1）mg/cm2Dosage
Smear added with antiallergic moisture-keeping composition cream described in 20% embodiment 1, check plot smear same amount be not added with active constituent and
Matrix identical cream inquires the tingling sensation in two regions of subject after 2.5min.The result shows that antiallergic moisturizing of the present invention
Composition has effects that significant antiallergic immediately is releived（P<0.05）.
The variation of 5 subject's lactic acid shouting pain score value of table
In conclusion the composition provided by the invention with antiallergic moisture-keeping efficacy has good radicals scavenging effect, energy
It helps skin under extraneous incentive condition, maintains cellular morphology function-stable, there is good antiallergic effect；Pass through comparative experiments
It is found that it also has preferable moisture-keeping efficacy；It is tested by lactic acid shouting pain it is found that it has effects that significant antiallergic immediately is releived
（P<0.05）.The composition with antiallergic moisture-keeping efficacy can be directly appended in cosmetics, also have safely, effectively, benefit
In use the advantages of.
Specific embodiment
Technical solution of the present invention is described further by the following examples, but protection scope of the present invention and unlimited
In this.
Embodiment 1：A kind of antiallergic moisture-keeping composition containing seawater, is grouped as by the group of following mass parts：Seawater 70%,
Thermus thermophilus tunning 12%, starfish branch tube algae extract 18%；Wherein, Mg content is 6420mg/L, Ca content in seawater
For 840mg/L, Si content is 4.5mg/L, and Zn content is 0.13mg/L.Total polyphenols mass content in thermus thermophilus tunning
It is 5.3%.Fucoidin mass content is 20.6% in starfish branch tube algae extract, and the average molecular weight of fucoidin is 1,700,000
Dalton.
Embodiment 2：A kind of antiallergic moisture-keeping composition containing seawater, is grouped as by the group of following mass parts：Seawater 60%,
Thermus thermophilus tunning 18%, starfish branch tube algae extract 22%；Wherein, Mg content is 9800mg/L, Ca content in seawater
For 1020mg/L, Si content is 8.8mg/L, and Zn content is 0.22mg/L.Total polyphenols quality contains in thermus thermophilus tunning
Amount is 5.1%.Fucoidin mass content is 21.3% in starfish branch tube algae extract, and the average molecular weight of fucoidin is 170
Ten thousand dalton.
Embodiment 3：A kind of antiallergic moisture-keeping composition containing seawater, is grouped as by the group of following mass parts：Seawater 75%,
Thermus thermophilus tunning 5%, starfish branch tube algae extract 20%；Wherein, Mg content is 9800mg/L in seawater, and Ca content is
1140mg/L, Si content are 7.4mg/L, and Zn content is 0.18mg/L.Total polyphenols mass content in thermus thermophilus tunning
It is 5.2%.Fucoidin mass content is 20.4% in starfish branch tube algae extract, and the average molecular weight of fucoidin is 1,700,000
Dalton.
Claims (4)
1. a kind of antiallergic moisture-keeping composition containing seawater, it is characterised in that：It is grouped as by the group of following mass fraction：Seawater 60
~ 75%, thermus thermophilus tunning 5 ~ 18%, starfish branch tube algae extract 16 ~ 25%；Magnesium element content is in the seawater
6000 ~ 12000 mg/L, calcium element content are 820 ~ 1160mg/L, and silicon content is 3 ~ 9mg/L, and Zn-ef ficiency content is 0.05
~0.26mg/L。
2. the antiallergic moisture-keeping composition according to claim 1 containing seawater, it is characterised in that：By following mass fraction
Group is grouped as：Seawater 70%, thermus thermophilus tunning 10%, starfish branch tube algae extract 20%.
3. the antiallergic moisture-keeping composition according to claim 1 or 2 containing seawater, it is characterised in that：The thermophilic heat of dwelling
Total polyphenols mass content in bacterium tunning is greater than 5%.
4. the antiallergic moisture-keeping composition according to claim 1 or 2 containing seawater, it is characterised in that：The starfish branch tube
Fucoidin mass content in algae extract is greater than 20%.
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Cited By (2)
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| CN109431843A (en) * | 2018-12-14 | 2019-03-08 | 广州艾蓓生物科技有限公司 | Cream and preparation method thereof is repaired in a kind of moisturizing |
| CN113730307A (en) * | 2021-09-22 | 2021-12-03 | 上海溪上生物科技有限公司 | Anti-allergy and soothing composition containing purslane and Cladosiphon starwort extract |
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| CN109431843A (en) * | 2018-12-14 | 2019-03-08 | 广州艾蓓生物科技有限公司 | Cream and preparation method thereof is repaired in a kind of moisturizing |
| CN113730307A (en) * | 2021-09-22 | 2021-12-03 | 上海溪上生物科技有限公司 | Anti-allergy and soothing composition containing purslane and Cladosiphon starwort extract |
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