CN109431843A - Cream and preparation method thereof is repaired in a kind of moisturizing - Google Patents
Cream and preparation method thereof is repaired in a kind of moisturizing Download PDFInfo
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- CN109431843A CN109431843A CN201811539377.9A CN201811539377A CN109431843A CN 109431843 A CN109431843 A CN 109431843A CN 201811539377 A CN201811539377 A CN 201811539377A CN 109431843 A CN109431843 A CN 109431843A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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Abstract
The invention discloses a kind of moisturizings to repair cream and preparation method thereof, it includes thickener that cream is repaired in moisturizing, moisturizer, preservative, chelating agent, emulsifier, emollients, deionized water, functional component agent, the functional component agent includes seawater/parahydroxyacet-ophenone, C10-30 acid cholesterine/lanosterol mixed ester, urea and tetrahydro methylpyrimidine carboxylic acid, it is seawater/parahydroxyacet-ophenone 5~15% that each ingredient, which repairs the weight percentage in cream in moisturizing, in the functional component agent, C10-30 acid cholesterine/lanosterol mixed ester 2~8%, urea 3~8%, tetrahydro methylpyrimidine carboxylic acid 0.3~1.5%.Moisturizing of the invention repairs cream and passes through addition seawater/parahydroxyacet-ophenone, C10-30 acid cholesterine/lanosterol mixed ester, urea and tetrahydro methylpyrimidine carboxylic acid composition, the effect of playing moisturizing, antiallergic of releiving, repairing, impaired epidermis can be repaired, enhance stratum corneum barrier function, improve dry skin, exsiccosis and easy to use, moisture of skin can be lockked.
Description
Technical field
The present invention relates to cosmetic technical field, it is specifically related to repair cream and preparation method thereof with moisturizing.
Background technique
It is one of pathomechanism of aged appearance that skin water content, which gradually decreases, when the water content of cuticula is lower than 10%
When, there is crack in dry skin, furfur, imbricate keratinocyte layer arranged in parallel, and skin is easy by external environment physics
The erosion of factor, water, electrolyte in skin are also easy evaporation or are lost.Skin moisture-keeping be guarantee cuticula barrier function and
The most important basic means improved looks.Moisturizing Journal of Sex Research is the hot spot of current cosmetics and dermatology research.Environment is dirty
Dye, Seasonal conversion so that because of caused by cuticula water shortage dry skin and thus caused by skin itch, furfur etc. it is common
Skin problem it is increasingly severe, moisturizing is very urgent.The moisturizer sold currently on the market is many kinds of, but its mainly at
Divide nothing more than grease type, moisturizer, emulsifier, deionized water and auxiliary material etc..These generally all lay particular emphasis on independent moisturizing or
It repairs, rarer moisturizing and repairs two-in-one, moisturizing while repairs skin.
Summary of the invention
Also has the moisturizing of repairing effect while providing a kind of moisturizing it is an object of the invention to overcome the above problem
Repair cream and preparation method thereof.
To achieve the above object, the technical solution adopted by the present invention is that cream, including thickener, moisturizing are repaired in a kind of moisturizing
Agent, preservative, chelating agent, emulsifier, emollients, deionized water further include functional component agent, and the functional component agent includes sea
Water/parahydroxyacet-ophenone, C10-30 acid cholesterine/lanosterol mixed ester, urea and tetrahydro methylpyrimidine carboxylic acid, described effect
It is seawater/parahydroxyacet-ophenone 5~15%, C10-30 that each ingredient, which repairs the weight percentage in cream in moisturizing, in ingredient agent
Sour cholesterine/lanosterol mixed ester 2~8%, urea 3~8%, tetrahydro methylpyrimidine carboxylic acid 0.3~1.5%.
The essence that seawater/parahydroxyacet-ophenone of the invention is extracted from natural ooze uses 100% natural extraction
Journey and be made.Element and rare earth element rich in really embody the complicated composition and effect of natural ooze, provide nature
The mineral element of balance；C10-30 acid cholesterine/lanosterol mixed ester is by being largely saturated fatty acid, the fat of branched structure
Pure and mild sterol is constituted, and structure is similar to the sebum of human skin.Facilitate moisture penetration epidermis, penetrate into skin corium, is skin
Keep moistening softening skin, the moment keeps water profit, plays tender, healthy, forms one layer of waterproof, rich glossiness screen in skin surface
Barrier, repairs dry and cracked skin；Urea of the invention is moisturizer, bleeding agent, skin conditioning agent.The ingredient contain natural moisture preserving because
Son can work as the moisturizer of skin, and can assist the absorption of other skin care products.Urea is a kind of useful moisturizing ingredient, it is just
It is present in the cuticula of skin, belongs to the main component of skin natural moisturizing factor NMF.For skin, urea has
The effect of moisturizing and soft cutin, so the problem of capable of also preventing cuticula from blocking pore, improve acne whereby；Tetrahydro
Methylpyrimidine carboxylic acid is also known as Ectoin (Ectoin), is present in Facultative Halophiles as a kind of compensatory solute of osmotic pressure, thin
It is intracellular to play the role of chemical mediator sample, there is the protective effect of stability in inverse ring border to cell, can also stablize enzyme in organism
The structure of albumen has the function that skin-active is anti-ageing；It can provide good moisturizing and sun-screening function, and play the role of skin whitening；Four
Hydrogen methylpyrimidine carboxylic acid can also protect neutrophil leucocyte, show anti-inflammatory effect.
Present inventor has found seawater/parahydroxyacet-ophenone, C10-30 acid cholesterine/lanosterol mixed ester, urine
Element and tetrahydro methylpyrimidine carboxylic acid use simultaneously, wherein C10-30 acid cholesterine/lanosterol similar with sebum structure mixes
Ester forms moisture barrier in skin surface, reduces skin moisture and scatters and disappears, and can be by seawater/parahydroxyacet-ophenone, urea and tetrahydro
Methylpyrimidine carboxylic acid is locked in skin, and the urea as NMF main component can preferably permeate cuticula in conjunction with moisture；Tetrahydro
Methylpyrimidine carboxylic acid then repairs injured cell, reinforces cell water lock ability, and four combine, and dramatically increases skin moisturizing reparation effect
Fruit.Synergistic function with significant moisturizing reparation.
The preferred embodiment of cream is repaired as moisturizing of the invention, each ingredient is repaired in moisturizing in the functional component agent
Weight percentage in emulsion is seawater/parahydroxyacet-ophenone 5~12%, C10-30 acid cholesterine/lanosterol mixed ester 4
~7%, urea 4~7.5%, tetrahydro methylpyrimidine carboxylic acid 0.6~1.5%.
Moisturizing of the present invention is repaired in cream, and constituent content will affect effect, the study found that containing in the preferred weight percent
It measures in ratio range, the present invention has significant moisturizing repairing effect.
The preferred embodiment of cream is repaired as moisturizing of the invention, each ingredient is repaired in moisturizing in the functional component agent
Weight percentage in emulsion is seawater/parahydroxyacet-ophenone 8~12%, C10-30 acid cholesterine/lanosterol mixed ester 5
~7%, urea 5~7.5%, tetrahydro methylpyrimidine carboxylic acid 1~1.5%.
The preferred embodiment of cream is repaired as moisturizing of the invention, each ingredient is repaired in moisturizing in the functional component agent
Weight percentage in emulsion be seawater/parahydroxyacet-ophenone 10%, C10-30 acid cholesterine/lanosterol mixed ester 5%,
Urea 5%, tetrahydro methylpyrimidine carboxylic acid 1%.Present inventor has found by lot of experiments, when effect ingredient
Specific weight percentage, moisturizing reach best with repairing effect simultaneously herein for agent.
The preferred embodiment of cream is repaired as moisturizing of the invention, the thickener includes polyacrylate cross-linked polymeric
Object -6, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers/isohexadecane/polysorbate -60, the thickening
It is polyacrylate cross-linked polymer -6 0.15~0.5%, third that each ingredient of agent, which repairs the weight percentage in cream in moisturizing,
Olefin(e) acid hydroxyl ethyl ester/sodium acryloyldimethyl taurate copolymers/isohexadecane/polysorbate -60 0.5~2%；
The moisturizer includes 1,3-PD, Sodium Hyaluronate, panthenol, isopropyl palmitate, and the moisturizer is each
Ingredient moisturizing repair the weight percentage in cream be 1,3- propylene glycol 2~8%, it is Sodium Hyaluronate 0.03~0.15%, general
Alcohol 0.5~5%, isopropyl palmitate 2~7%；
The preservative includes methyl hydroxybenzoate, Phenoxyethanol/Sensiva SC50, and each ingredient of preservative is in moisturizing
Repairing the weight percentage in cream is methyl hydroxybenzoate 0.1~0.25%, Phenoxyethanol/Sensiva SC50 0.2~0.8%；
The chelating agent is EDETATE SODIUM, and the EDETATE SODIUM weight percentage is 0.02~0.1%；
The emulsifier includes cetostearyl alcohol/cetearyl glucoside, stearine/PEG-100 stearic acid
Ester, cetostearyl alcohol；It is cetostearyl alcohol/spermaceti that each ingredient of emulsifier, which repairs the weight percentage in cream in moisturizing,
Stearyl glucoside 1~2.5%, stearine/PEG-100 stearate 1~2.5%, cetostearyl alcohol 0.5~
2.5%；
The emollients include saualane, dimethyl silicone polymer, and each ingredient of emollients is repaired in cream in moisturizing
Weight percentage be saualane 2~7%, dimethyl silicone polymer 1~4%.
The preferred embodiment of cream is repaired as moisturizing of the invention, the moisturizing reparation cream further includes tocopherol, described
It is 0.5~2% that tocopherol, which repairs the weight percentage in cream in moisturizing,.The tocopherol is renovation agent, has to skin and repairs
Multiple effect and antioxidation.
The preferred embodiment of cream is repaired as moisturizing of the invention, the moisturizing reparation cream further includes antioxidant high mountain
HUORONGCAO extract, it is 0.5~8% that the edelweiss extract, which repairs the weight percentage in cream in moisturizing,.It is described
Contain minerals in edelweiss extract active constituent, there is antioxidation to skin, play the effect of anti-wrinkle whitening.
The preferred embodiment of cream is repaired as moisturizing of the invention, the moisturizing reparation cream includes that following weight percent contains
The ingredient of amount: polyacrylate cross-linked polymer -6 0.3%, 1,3- propylene glycol 5%, methyl hydroxybenzoate 0.2%, EDETATE SODIUM
0.05%, Sodium Hyaluronate 0.1%, panthenol 3%, seawater/parahydroxyacet-ophenone 10%, cetostearyl alcohol/cetearyl Portugal
Glucosides 2%, stearine/PEG-100 stearate 1.5%, cetostearyl alcohol 1%, isopropyl palmitate 5%, C10-
30 sour cholesterine/lanosterol mixed esters 5%, saualane 5%, dimethyl silicone polymer 2%, tocopherol 1%, acrylic acid hydroxyl second
Ester/sodium acryloyldimethyl taurate copolymers/isohexadecane/polysorbate -60 1%, urea 5%, edelweiss mention
Take the deionized water of object 5%, tetrahydro methylpyrimidine carboxylic acid 1%, Phenoxyethanol/Sensiva SC50 0.4% and surplus.
The present invention also provides the preparation methods that cream is repaired in a kind of moisturizing, comprising the following steps: 1) by 1,3 propylene glycol, hydroxyl
Benzene methyl is miscible in advance；By deionized water, polyacrylate cross-linked polymer -6,1,3 propylene glycol, methyl hydroxybenzoate, EDETATE SODIUM,
Sodium Hyaluronate, panthenol, seawater/parahydroxyacet-ophenone sequentially add emulsion pot, are warming up to 80~85 DEG C of unlatching homogeneous, stir molten
Solution is complete；2) by cetostearyl alcohol/cetearyl glucoside, stearine/PEG-100 stearate, cetearyl alcohol
Alcohol, isopropyl palmitate, C10-30 acid cholesterine/lanosterol mixed ester, saualane, dimethyl silicone polymer and tocopherol according to
The oily phase pot of secondary addition, is warming up to 80~85 DEG C of stirrings and makes it completely dissolved；3) it will 2) be added and 1) open homogeneous, close after five minutes,
Hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers/isohexadecane/polysorbate -60 is added, homogeneous is continued
3 minutes, stop homogeneous, stirring heat preservation 10 minutes；4) 45~50 DEG C are cooled to by urea, edelweiss extract, tetrahydro first
Yl pyrimidines carboxylic acid, Phenoxyethanol/Sensiva SC50 sequentially add, stirring cooling；5) temperature is down to 45 DEG C and is stirred evenly, out
Material.
Beneficial effects of the present invention: moisturizing of the invention repairs cream and passes through addition seawater/parahydroxyacet-ophenone, C10-30 acid
Cholesterine/lanosterol mixed ester, urea and tetrahydro methylpyrimidine carboxylic acid composition, play the function of moisturizing, antiallergic of releiving, reparation
Effect can repair impaired epidermis, enhance stratum corneum barrier function, improve dry skin, exsiccosis and easy to use, Neng Gousuo
Firmly moisture of skin.
Specific embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Each raw material involved by following embodiment is commercially available versatile material unless otherwise instructed.
What seawater of the present invention/parahydroxyacet-ophenone indicated is made of compound seawater and parahydroxyacet-ophenone
Object, what cetostearyl alcohol/cetearyl glucoside indicated is answered by what the pure and mild cetearyl glucoside of cetearyl alcohol formed
Object is closed, what stearine/PEG-100 stearate indicated is made of stearine and PEG-100 stearate
Compound, what C10-30 acid cholesterine/lanosterol mixed ester indicated is mixed by C10-30 acid cholesterine and lanosterol
The compound of ester composition, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers/isohexadecane/polysorbate -60
What is indicated is made of hydroxy-ethyl acrylate, sodium acryloyldimethyl taurate copolymers and isohexadecane/polysorbate -60
Compound, the compound being made of Phenoxyethanol, Sensiva SC50 that Phenoxyethanol/Sensiva SC50 indicates.
Examples 1 to 6
Examples 1 to 6 is the of the invention embodiment that cream is repaired with moisturizing, the moisturizing of Examples 1 to 6 repair cream at
Divide and parts by weight percentage composition be shown in Table 1:
Cream formula is repaired in 1 Examples 1 to 6 moisturizing of table
The preparation method of cream is repaired in moisturizing of the invention, comprising the following steps: 1) 1,3 propylene glycol, methyl hydroxybenzoate is preparatory
It is miscible；By deionized water, polyacrylate cross-linked polymer -6,1,3 propylene glycol, methyl hydroxybenzoate, EDETATE SODIUM, hyaluronic acid
Sodium, panthenol, seawater/parahydroxyacet-ophenone sequentially add emulsion pot, are warming up to 80~85 DEG C of unlatching homogeneous, and stirring and dissolving is complete；
2) by cetostearyl alcohol (and) cetearyl glucoside, stearine (and) PEG-100 stearate, cetearyl alcohol
Alcohol, isopropyl palmitate, C10-30 acid cholesterine/lanosterol mixed ester, saualane, dimethyl silicone polymer and tocopherol according to
The oily phase pot of secondary addition, is warming up to 80~85 DEG C of stirrings and makes it completely dissolved；3) it will 2) be added and 1) open homogeneous, close after five minutes,
Hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers (and) isohexadecane (and) polysorbate -60 is added, after
Continuous homogeneous 3 minutes, stop homogeneous, stirring heat preservation 10 minutes；4) be cooled to 45~50 DEG C by urea, edelweiss extract,
Tetrahydro methylpyrimidine carboxylic acid, Phenoxyethanol/Sensiva SC50 sequentially add, stirring cooling；5) it is equal to be down to 45 DEG C of stirrings for temperature
It is even, discharging.
Comparative example 1~5
Milk composition is repaired in the moisturizing of comparative example 1~5 and parts by weight percentage composition is shown in Table 2:
The formula of cream is repaired in 2 comparative example of table, 1~5 moisturizing
The preparation method that cream is repaired in the moisturizing of comparative example 1~5 is same as Example 1.
Embodiment 7
The moisturizing that the present embodiment prepares Examples 1 to 6 and comparative example 1~5 repairs cream and carries out measure of merit.
Test method is as follows:
1. moistening effect is tested
Test sample: embodiment sample
Subject: 110 20-24 years old age women
Test equipment: moisture of skin analyzer Corneometer CM 825 is for detecting keratoderma moisture content
Test zone: left hand inner forearm and right hand inner forearm
Test method: test sample presses (2.0 ± 0.1) mg/cm2Amount carry out single application, using latex finger cot will try
Sample is coated in the test zone of 3cm × 3cm.
Test period: 0h, 2h, 4h, 6h
Conceptual design: 0h: 2~3 days before recipient site do not use any product, and 1h~3h cannot contact water.System before tested
One cleaning inner forearm and wiped clean.Subject is in 21 ± 1 DEG C of temperature, the laboratory of relative humidity 50 ± 10% before testing
Sit quietly 20min, cannot drink water and beverage, forearm expose.Test carries out keratoderma moisture to sample application area after starting
The parametric measurement of content.
2h: the parametric measurement of keratoderma moisture content is carried out to sample application area.
4h: the parametric measurement of keratoderma moisture content is carried out to sample application area.
6h: the parametric measurement of keratoderma moisture content is carried out to sample application area.
Every group randomly selects 10 subjects and tests, and tests left and right inner forearm cuticula moisture content, passes through number
According to moisture content average value and right arm inside moisture content average value and its value added on the inside of 10 subject's left arms is obtained, as a result
As shown in table 3.
3 or so inner forearm cuticula moisture content average value of table and value added
As known from Table 3, the embodiment of the present invention 1 to 6 has good moistening effect, wherein most with the effect of embodiment 1
Good, the moisturizing of comparative example 1~4 repairs cream compared with Example 1, has lacked seawater/parahydroxyacet-ophenone, C10-30 acid gallbladder respectively
One or both of sterol/lanosterol mixed ester, urea, tetrahydro methylpyrimidine carboxylic acid ingredient, and as can be known from Table 3,
Effect has relative to embodiment 1 to be declined to a certain degree, shows that moisturizing reparation cream of the invention is that Multiple components interact, altogether
With using can just play good moistening effect, the moisturizing of comparative example 5 repairs the content of the fractions of cream in model of the invention
Except enclosing, and as can be known from the results, effect is also not so good as the present invention, shows that the ingredient of composition of the invention need to be in specific ratio
Just there is optimal effect, 4~6 difference from Example 1 of embodiment is, seawater/parahydroxyacet-ophenone, C10- in range
The difference of 30 sour cholesterine/lanosterol mixed esters, urea, tetrahydro methylpyrimidine carboxylic acid content, and 4~6 moisturizing of embodiment is imitated
Fruit is superior to embodiment 2~3, and four kinds of ingredients have preferable moistening effect in this weight percent ranges.
2, skin barrier recovery test
Experimental method: the aspiration trier for choosing 550 20-50 one full year of life hormon dermatitis degree carries out using examination
It tests, composition 6 months obtained by the continuous use present invention, repairs effect performance project and carry out sensory evaluation, 550 people divide at random
It is 11 groups.Statistical result is as shown in table 4 below:
Criterion is as follows:
It is effective: skin to be checked after, rubescent symptom of itching completely disappears, and skin becomes smooth, no inflammation；
It is effective: substantially reduced with rear symptom；
It is invalid: with rear symptom without mitigation, or to have exacerbation.
4 repairing effect of table
As known from Table 4, there is good repairing effect, wherein with the effect of embodiment 1 while the embodiment of the present invention 1 to 6
Fruit is best, and the moisturizing of comparative example 1,2,4 repairs cream compared with Example 1, has lacked seawater/parahydroxyacet-ophenone, C10- respectively
One of 30 sour cholesterine/lanosterol mixed esters, tetrahydro methylpyrimidine carboxylic acid ingredient, and as can be known from Table 4, repair effect
Fruit has relative to embodiment 1 to be declined to a certain degree, show moisturizing reparation cream of the invention be seawater/parahydroxyacet-ophenone,
C10-30 acid cholesterine/lanosterol mixed ester, tetrahydro methylpyrimidine carboxylic acid composition interact, be used in conjunction with can just play it is good
Good repairing effect, the moisturizing of comparative example 5 repair the content of the fractions of cream except the scope of the present invention, and can from result
Know, effect is also not so good as the present invention, and it is best to show that the ingredient of composition of the invention need to just have in specific proportional region
Effect, 4~6 difference from Example 1 of embodiment is, seawater/parahydroxyacet-ophenone, C10-30 acid cholesterine/wool
The difference of sterol mixed ester, urea, tetrahydro methylpyrimidine carboxylic acid content, and 4~6 repairing effect of embodiment is superior to embodiment 2
~3, four kinds of ingredients have preferable moisturizing repairing effect in this weight percent ranges.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent substitution, improvement and etc. done be should be included within the scope of the present invention.
Claims (9)
1. cream, including thickener, moisturizer, preservative, chelating agent, emulsifier, emollients, deionized water are repaired in a kind of moisturizing,
It is characterized in that, further including functional component agent, the functional component agent includes seawater/parahydroxyacet-ophenone, C10-30 acid cholesteric
Alcohol/lanosterol mixed ester, urea and tetrahydro methylpyrimidine carboxylic acid, each ingredient repairs cream in moisturizing in the functional component agent
In weight percentage be seawater/parahydroxyacet-ophenone 5~15%, C10-30 acid cholesterine/lanosterol mixed ester 2~
8%, urea 3~8%, tetrahydro methylpyrimidine carboxylic acid 0.3~1.5%.
2. cream is repaired in moisturizing according to claim 1, which is characterized in that each ingredient is in moisturizing in the functional component agent
Repairing the weight percentage in cream is seawater/parahydroxyacet-ophenone 5~12%, C10-30 acid cholesterine/lanosterol mixing
Ester 4~7%, urea 4~7.5%, tetrahydro methylpyrimidine carboxylic acid 0.6~1.5%.
3. cream is repaired in moisturizing according to claim 1, which is characterized in that each ingredient is in moisturizing in the functional component agent
Repairing the weight percentage in cream is seawater/parahydroxyacet-ophenone 8~12%, C10-30 acid cholesterine/lanosterol mixing
Ester 5~7%, urea 5~7.5%, tetrahydro methylpyrimidine carboxylic acid 1~1.5%.
4. cream is repaired in moisturizing according to claim 1, which is characterized in that each ingredient is in moisturizing in the functional component agent
Repairing the weight percentage in cream is seawater/parahydroxyacet-ophenone 10%, C10-30 acid cholesterine/lanosterol mixed ester
5%, urea 5%, tetrahydro methylpyrimidine carboxylic acid 1%.
5. cream is repaired in moisturizing according to claim 1, which is characterized in that the thickener includes that polyacrylate crosslinking is poly-
Close object -6, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers/isohexadecane/polysorbate -60, the increasing
Thick dose of each ingredient moisturizing repair cream in weight percentage be polyacrylate cross-linked polymer -6 0.15~0.5%,
Hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers/isohexadecane/polysorbate -60 0.5~2%；
The moisturizer includes 1,3-PD, Sodium Hyaluronate, panthenol, isopropyl palmitate, each ingredient of moisturizer
Repairing the weight percentage in cream in moisturizing is 1,3- propylene glycol 2~8%, Sodium Hyaluronate 0.03~0.15%, panthenol 0.5
~5%, isopropyl palmitate 2~7%；
The preservative includes methyl hydroxybenzoate, Phenoxyethanol/Sensiva SC50, and each ingredient of preservative is in moisturizing reparation
Weight percentage in cream is methyl hydroxybenzoate 0.1~0.25%, Phenoxyethanol/Sensiva SC50 0.2~0.8%；
The chelating agent is EDETATE SODIUM, and the EDETATE SODIUM weight percentage is 0.02~0.1%；
The emulsifier includes cetostearyl alcohol/cetearyl glucoside, stearine/PEG-100 stearate, whale
Wax stearyl alcohol, it is cetostearyl alcohol/cetearyl alcohol that each ingredient of emulsifier, which repairs the weight percentage in cream in moisturizing,
Base glucoside 1~2.5%, stearine/PEG-100 stearate 1~2.5%, cetostearyl alcohol 0.5~2.5%；
The emollients include saualane, dimethyl silicone polymer, and each ingredient of emollients repairs the weight in cream in moisturizing
Amount percentage composition is saualane 2~7%, dimethyl silicone polymer 1~4%.
6. cream is repaired in moisturizing according to claim 1, which is characterized in that the moisturizing reparation cream further includes tocopherol, institute
It is 0.5~2% that tocopherol, which is stated, in the weight percentage that moisturizing is repaired in cream.
7. cream is repaired in moisturizing according to claim 1, which is characterized in that further include that antioxidant edelweiss extracts
Object, it is 0.5~8% that the edelweiss extract, which repairs the weight percentage in cream in moisturizing,.
8. cream is repaired in moisturizing according to claim 1, which is characterized in that the ingredient including following weight percentage: poly-
Acrylate crosspolymers -6 0.3%, 1,3- propylene glycol 5%, methyl hydroxybenzoate 0.2%, EDETATE SODIUM 0.05%, hyalomitome
Sour sodium 0.1%, panthenol 3%, seawater/parahydroxyacet-ophenone 10%, cetostearyl alcohol/cetearyl glucoside 2%, glycerol are hard
Resin acid ester/PEG-100 stearate 1.5%, cetostearyl alcohol 1%, isopropyl palmitate 5%, C10-30 acid cholesterine/wool
Sterol mixed ester 5%, saualane 5%, dimethyl silicone polymer 2%, tocopherol 1%, hydroxy-ethyl acrylate/acryloyldimethyl
Taurate Copolymer/isohexadecane/polysorbate -60 1%, urea 5%, edelweiss extract 5%, tetrahydro first
The deionized water of yl pyrimidines carboxylic acid 1%, Phenoxyethanol/Sensiva SC50 0.4% and surplus.
9. the preparation method that cream is repaired in a kind of moisturizing as claimed in claim 8, which comprises the following steps: 1) will
1,3 propylene glycol, methyl hydroxybenzoate are miscible in advance；By deionized water, polyacrylate cross-linked polymer -6,1,3 propylene glycol, oxybenzene first
Ester, EDETATE SODIUM, Sodium Hyaluronate, panthenol, seawater/parahydroxyacet-ophenone sequentially add emulsion pot, are warming up to 80~85 DEG C and open
Homogeneous is opened, stirring and dissolving is complete；2) cetostearyl alcohol/cetearyl glucoside, stearine/PEG-100 is stearic
Acid esters, cetostearyl alcohol, isopropyl palmitate, C10-30 acid cholesterine/lanosterol mixed ester, saualane, poly dimethyl silicon
Oxygen alkane and tocopherol sequentially add oily phase pot, are warming up to 80~85 DEG C of stirrings and make it completely dissolved；3) it will 2) be added and 1) open
Matter is closed after five minutes, by hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers/isohexadecane/polysorbate-
60 are added, and continue homogeneous 3 minutes, stop homogeneous, stirring heat preservation 10 minutes；4) 45~50 DEG C are cooled to by urea, high mountain tinder
Careless extract, tetrahydro methylpyrimidine carboxylic acid, Phenoxyethanol/Sensiva SC50 sequentially add, stirring cooling；5) temperature is down to 45
It DEG C stirs evenly, discharges.
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| CN115721596A (en) * | 2022-10-25 | 2023-03-03 | 广州欧兰化妆品有限公司 | Repairing anti-wrinkle beauty lotion |
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| CN116327630A (en) * | 2023-05-19 | 2023-06-27 | 华东理工大学 | Preparation and application of giant salamander peptide composite liquid crystal emulsion |
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