CN107822939A - A kind of potent moisturiser and preparation method thereof - Google Patents

A kind of potent moisturiser and preparation method thereof Download PDF

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Publication number
CN107822939A
CN107822939A CN201711375162.3A CN201711375162A CN107822939A CN 107822939 A CN107822939 A CN 107822939A CN 201711375162 A CN201711375162 A CN 201711375162A CN 107822939 A CN107822939 A CN 107822939A
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parts
moisturiser
potent
lecithin
added
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黄楚明
黄楚佳
徐立志
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GUANGDONG ZHENLIS COSMETICS Co Ltd
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GUANGDONG ZHENLIS COSMETICS Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/342Alcohols having more than seven atoms in an unbroken chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55Phosphorus compounds
    • A61K8/553Phospholipids, e.g. lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63Steroids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/678Tocopherol, i.e. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/48Thickener, Thickening system

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)

Abstract

The present invention relates to technical field of skin care, and in particular to a kind of potent moisturiser and preparation method thereof, the moisturiser are made up of following parts by weight raw material:37 parts of glycyrrhizin, 14 parts of panthenol, 10 15 parts of Rosa Damascana, 3 parts of vitamin e1,0.5 1 parts of hyaluronic acid, 0.5 1 parts of konjac glucomannan, 0.4 0.8 parts of Sodium Polyacrylate, 14 parts of polyglycerolmethacrylate, 25 parts of lecithin, 0.1 0.5 parts of docosyl alcohol, 50 60 parts of deionized water;Moisturiser provided by the invention can effectively make up the defects of function existing for the moisturiser that prior art is provided is single, and water lock moisture-keeping functions are limited to a certain extent.

Description

A kind of potent moisturiser and preparation method thereof
Technical field
The present invention relates to technical field of skin care, and in particular to a kind of potent moisturiser and preparation method thereof.
Background technology
Currently, people increasingly focus on the maintenance of skin, for people seeking beauty basic skin nursing work to pass It is important, carry out skin replenishing water and preserving moisture this Basic application, can delay skin aging, avoid skin peeling, long acne etc., Jin Erbao Hold skin to be among good state, and this demand is just being catered to the effect of moisturiser.Work(also be present in existing moisturiser The defects of energy is single, and water lock moisture-keeping functions are limited.
Chinese patent CN105769643A discloses a kind of water outlet moisturiser at present, and its is composed of the following components:Ring five is poly- Dimethyl siloxane, dimethyl silicone polymer, cetyl PEG/PPG-10/1 dimethyl silicone polymers, the polydimethylsiloxanes of ring five Alkane/Dimethicone Crosspolymer, essence, glycerine, butanediol, propane diols, panthenol, glycine betaine, sodium chloride, acrylic acid (ester) class/methacrylate copolymer of docosyl alcohol polyethers -25, sodium hydroxide, Sodium Hyaluronate, daisy flower extract, the long heart Kappa algae extract, chlorella/Lupinus albus protein fermentation product, glycyrrhiza glabra root extract, false portulaca oleracea extracts, biology Carbohydrate gum, Phenoxyethanol/Sensiva SC50, deionized water.Moisturiser stability of the invention is good, closure is good, moisture retention is held Long, while there is soft smooth smearing sense.
A kind of moisturiser and its system for being used to treat xerodermia is disclosed in Chinese patent CN105232357A at present Preparation Method.The moisturiser of described treatment xerodermia by add 3% after Aqueous Phase Raw Material and oil phase raw material mixing and emulsifying~ 20% ammonium lactate is prepared, and described Aqueous Phase Raw Material includes water, butanediol, trehalose, EDETATE SODIUM, PEG-100 stearic acid Ester, methyl hydroxybenzoate, oil phase raw material include stearic acid, cetanol, docosyl alcohol, dimethyl silicone polymer, saualane, sad glycerine Three esters, Triglyceride DDD, hydrogenated coco glycerolipid, Nipasol, the smooth stearate of sorb.Make with skin keratin is removed With, and moisture of skin is helped to maintain, the barrier of skin is formed, improves the moisture-keeping functions of skin, reduces the scabies of allergic skin Itch, reduce dry skin furfur phenomena such as.In addition, working as ammonium lactate with skin, the cohesion of cuticula can be reduced.
But also there is the defects of function is single, and water lock moisture-keeping functions are limited in the potent moisturiser that prior art is provided.
The content of the invention
For above-mentioned problem, the present invention proposes a kind of potent moisturiser and preparation method thereof.The present invention provides Technical scheme can to make up function existing for the potent moisturiser that prior art is provided to a certain extent single, water lock is protected The defects of wet function is limited.
In order to realize above-mentioned purpose, it is achieved by the following technical programs:
A kind of potent moisturiser, the moisturiser are made up of following parts by weight raw material:Glycyrrhizin 3-7 parts, panthenol 1-4 Part, Rosa Damascana 10-15 parts, -3 parts of vitamin e1, hyaluronic acid 0.5-1 parts, konjac glucomannan 0.5-1 parts, Sodium Polyacrylate 0.4- 0.8 part, polyglycerolmethacrylate 1-4 parts, lecithin 2-5 parts, docosyl alcohol 0.1-0.5 parts, deionized water 50-60 parts.
Preferably, the moisturiser is made up of following parts by weight raw material:Glycyrrhizin 5-6 parts, panthenol 2-3 parts, rhodamine toner Oily 11-13 parts, -2 parts of vitamin e1, hyaluronic acid 0.6-0.8 parts, konjac glucomannan 0.6-0.8 parts, Sodium Polyacrylate 0.5-0.7 parts, Polyglycerolmethacrylate 2-3 parts, lecithin 3-4 parts, docosyl alcohol 0.2-0.4 parts, deionized water 55-60 parts.
Preferably, the lecithin is liquid lecithin.
The preparation method of the moisturiser includes the following steps:
(1) deionized water is added into aqueous phase pot, is heated to certain temperature, 30min is incubated, in the case where being stirred continuously Glycyrrhizin, panthenol, Rosa Damascana, vitamin E, hyaluronic acid, konjac glucomannan are added, stir to obtain mixture one;
(2) Sodium Polyacrylate, polyglycerolmethacrylate, lecithin, docosyl alcohol are added in another aqueous phase pot, heating To 80-85 DEG C, 30min sterilizings are maintained, viscous pasty state is evenly stirred until, obtains mixture two;
(3) mixture one and mixture two are well mixed, added in homogeneous agitator, regulation rotating speed is 2800- 3000r/min, temperature are 80-90 DEG C, and emulsifying certain time, then cool at a slow speed to obtain potent moisturiser.
Preferably, aqueous phase pot heating-up temperature is 80-85 DEG C in step (1).
Preferably, the emulsifying time is 3-5min in step (3).
It is as follows using above-mentioned technical scheme, beneficial effects of the present invention:Glycyrrhizin, dimension life are added in matrix formulations Plain E, panthenol, Rosa Damascana, hyaluronic acid isoreactivity composition, can strengthen anti-inflammatory, the immunization of moisturiser, prevent that cell is old Change, promote cell synthesis, there is good antipollution, anti-oxidation efficacy, epidermal growth and wound healing are stimulated, in addition, carrying The high moisturizing of moisturiser, wrinkle improvement effect, enhance elasticity of skin, have delayed aging;Konjac glucomannan has excellent as thickener Thickening property, film forming, water-retaining property, safety and stability;Sodium Polyacrylate, polyglycerolmethacrylate, lecithin and Docosyl alcohol mating reaction prepares moisturiser, and skin can be caused to reach bright and springiness, is formed in skin surface one layer thin Film, sealing process is played, reduce transdermal dehydration value, and then improve the water lock moistening effect of moisturiser.
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with the embodiment of the present invention, Technical scheme in the embodiment of the present invention is clearly and completely described.Based on embodiments of the invention, the common skill in this area The every other embodiment that art personnel are obtained under the premise of creative work is not made, belong to the model that the present invention protects Enclose.
Embodiment 1:
A kind of potent moisturiser, the moisturiser are made up of following parts by weight raw material:3 parts of glycyrrhizin, 4 parts of panthenol, rose Rare 10 parts of essential oil, 3 parts of vitamin E, 0.5 part of hyaluronic acid, 1 part of konjac glucomannan, 0.4 part of Sodium Polyacrylate, polymethylacrylic acid are sweet 4 parts of grease, 2 parts of lecithin, 0.5 part of docosyl alcohol, 50 parts of deionized water.
The preparation method of the moisturiser includes the following steps:
(1) deionized water is added into aqueous phase pot, is heated to 80 DEG C, be incubated 30min, added in the case where being stirred continuously Glycyrrhizin, panthenol, Rosa Damascana, vitamin E, hyaluronic acid, konjac glucomannan, stir to obtain mixture one;
(2) Sodium Polyacrylate, polyglycerolmethacrylate, lecithin, docosyl alcohol are added in another aqueous phase pot, heating To 85 DEG C, 30min sterilizings are maintained, viscous pasty state is evenly stirred until, obtains mixture two;
(3) mixture one and mixture two being well mixed, added in homogeneous agitator, regulation rotating speed is 2800r/min, Temperature is 90 DEG C, emulsifying 3min, and then cool at a slow speed to obtain potent moisturiser.
Embodiment 2:
A kind of potent moisturiser, the moisturiser are made up of following parts by weight raw material:7 parts of glycyrrhizin, 1 part of panthenol, rose Rare 15 parts of essential oil, vitamin e1 part, 1 part of hyaluronic acid, 0.5 part of konjac glucomannan, 0.8 part of Sodium Polyacrylate, polymethylacrylic acid are sweet 1 part of grease, 5 parts of lecithin, 0.1 part of docosyl alcohol, 60 parts of deionized water.
The preparation method of the moisturiser includes the following steps:
(1) deionized water is added into aqueous phase pot, is heated to 85 DEG C, be incubated 30min, added in the case where being stirred continuously Glycyrrhizin, panthenol, Rosa Damascana, vitamin E, hyaluronic acid, konjac glucomannan, stir to obtain mixture one;
(2) Sodium Polyacrylate, polyglycerolmethacrylate, lecithin, docosyl alcohol are added in another aqueous phase pot, heating To 80 DEG C, 30min sterilizings are maintained, viscous pasty state is evenly stirred until, obtains mixture two;
(3) mixture one and mixture two being well mixed, added in homogeneous agitator, regulation rotating speed is 3000r/min, Temperature is 80 DEG C, emulsifying 5min, and then cool at a slow speed to obtain potent moisturiser.
Embodiment 3:
A kind of potent moisturiser, the moisturiser are made up of following parts by weight raw material:5 parts of glycyrrhizin, 3 parts of panthenol, rose Rare 11 parts of essential oil, vitamin E2 part, 0.6 part of hyaluronic acid, 0.8 part of konjac glucomannan, 0.5 part of Sodium Polyacrylate, polymethylacrylic acid 3 parts of glyceride, 3 parts of lecithin, 0.4 part of docosyl alcohol, 55 parts of deionized water.
The preparation method of the moisturiser includes the following steps:
(1) deionized water is added into aqueous phase pot, is heated to 80 DEG C, be incubated 30min, added in the case where being stirred continuously Glycyrrhizin, panthenol, Rosa Damascana, vitamin E, hyaluronic acid, konjac glucomannan, stir to obtain mixture one;
(2) Sodium Polyacrylate, polyglycerolmethacrylate, lecithin, docosyl alcohol are added in another aqueous phase pot, heating To 85 DEG C, 30min sterilizings are maintained, viscous pasty state is evenly stirred until, obtains mixture two;
(3) mixture one and mixture two being well mixed, added in homogeneous agitator, regulation rotating speed is 2900r/min, Temperature is 85 DEG C, emulsifying 4min, and then cool at a slow speed to obtain potent moisturiser.
Embodiment 4:
A kind of potent moisturiser, the moisturiser are made up of following parts by weight raw material:6 parts of glycyrrhizin, 2 parts of panthenol, rose Rare 13 parts of essential oil, vitamin e1 part, 0.8 part of hyaluronic acid, 0.6 part of konjac glucomannan, 0.7 part of Sodium Polyacrylate, polymethylacrylic acid 2 parts of glyceride, 4 parts of lecithin, 0.2 part of docosyl alcohol, 60 parts of deionized water.
The preparation method of the moisturiser includes the following steps:
(1) deionized water is added into aqueous phase pot, is heated to 85 DEG C, be incubated 30min, added in the case where being stirred continuously Glycyrrhizin, panthenol, Rosa Damascana, vitamin E, hyaluronic acid, konjac glucomannan, stir to obtain mixture one;
(2) Sodium Polyacrylate, polyglycerolmethacrylate, lecithin, docosyl alcohol are added in another aqueous phase pot, heating To 80 DEG C, 30min sterilizings are maintained, viscous pasty state is evenly stirred until, obtains mixture two;
(3) mixture one and mixture two being well mixed, added in homogeneous agitator, regulation rotating speed is 2950r/min, Temperature is 90 DEG C, emulsifying 5min, and then cool at a slow speed to obtain potent moisturiser.
Reference examples using the embodiment in documents CN105769643A as the present invention, contrast two kinds of moisturisers and smear After hand 30min, the moisture measured with skinanalysis apparatus is as a result as follows:
Moisture/%
Embodiment 1 70
Embodiment 2 71
Embodiment 3 69
Embodiment 4 70
Reference examples 1 58
Reference examples 2 60
Reference examples 3 65
Above example is only to illustrate the technical scheme of type of the present invention, rather than its limitations;Although with reference to foregoing implementation Type of the present invention is described in detail example, it will be understood by those within the art that:It still can be to foregoing each Technical scheme described in embodiment is modified, or carries out equivalent substitution to which part technical characteristic;And these are changed Or replace, the essence of appropriate technical solution is departed from the spirit and scope of each embodiment technical scheme of type of the present invention.

Claims (6)

1. a kind of potent moisturiser, it is characterised in that the moisturiser is made up of following parts by weight raw material:Glycyrrhizin 3-7 parts, Panthenol 1-4 parts, Rosa Damascana 10-15 parts, -3 parts of vitamin e1, hyaluronic acid 0.5-1 parts, konjac glucomannan 0.5-1 parts, polyacrylic acid Sodium 0.4-0.8 parts, polyglycerolmethacrylate 1-4 parts, lecithin 2-5 parts, docosyl alcohol 0.1-0.5 parts, deionized water 50-60 Part.
2. potent moisturiser according to claim 1, it is characterised in that the moisturiser is by following parts by weight raw material system Into:Glycyrrhizin 5-6 parts, panthenol 2-3 parts, Rosa Damascana 11-13 parts, -2 parts of vitamin e1, hyaluronic acid 0.6-0.8 parts, evil spirit Taro glue 0.6-0.8 parts, Sodium Polyacrylate 0.5-0.7 parts, polyglycerolmethacrylate 2-3 parts, lecithin 3-4 parts, docosyl alcohol 0.2-0.4 parts, deionized water 55-60 parts.
3. potent moisturiser according to claim 1, it is characterised in that the lecithin is liquid lecithin.
4. potent moisturiser according to claim 1, it is characterised in that the preparation method of the moisturiser includes following several Step:
(1) deionized water is added into aqueous phase pot, is heated to certain temperature, be incubated 30min, added in the case where being stirred continuously Glycyrrhizin, panthenol, Rosa Damascana, vitamin E, hyaluronic acid, konjac glucomannan, stir to obtain mixture one;
(2) Sodium Polyacrylate, polyglycerolmethacrylate, lecithin, docosyl alcohol are added in another aqueous phase pot, are heated to 80-85 DEG C, 30min sterilizings are maintained, viscous pasty state is evenly stirred until, obtains mixture two;
(3) mixture one and mixture two are well mixed, added in homogeneous agitator, regulation rotating speed is 2800-3000r/ Min, temperature are 80-90 DEG C, and emulsifying certain time, then cool at a slow speed to obtain potent moisturiser.
5. the preparation method of potent moisturiser according to claim 1, it is characterised in that aqueous phase pot in the step (1) Heating-up temperature is 80-85 DEG C.
6. the preparation method of potent moisturiser according to claim 1, it is characterised in that homogenized milk in the step (3) The change time is 3-5min.
CN201711375162.3A 2017-12-19 2017-12-19 A kind of potent moisturiser and preparation method thereof Pending CN107822939A (en)

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WO2020048838A1 (en) * 2018-09-04 2020-03-12 Beiersdorf Ag Hydrodispersion with panthenol

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Publication number Priority date Publication date Assignee Title
WO2020048838A1 (en) * 2018-09-04 2020-03-12 Beiersdorf Ag Hydrodispersion with panthenol
CN109602620A (en) * 2018-12-18 2019-04-12 横琴智库转化医学有限公司 A kind of potent moisture retention water and preparation method thereof

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Application publication date: 20180323