CN107362129B

CN107362129B - Skin matrix, preparation method and applications and cosmetics and preparation method thereof

Info

Publication number: CN107362129B
Application number: CN201710732936.7A
Authority: CN
Inventors: 聂艳峰; 裴运林; 刘露
Original assignee: Guangdong Marubi Biological Technology Co Ltd
Current assignee: Guangdong Marubi Biological Technology Co Ltd
Priority date: 2017-08-23
Filing date: 2017-08-23
Publication date: 2019-10-18
Anticipated expiration: 2037-08-23
Also published as: CN107362129A

Abstract

The invention discloses a kind of skin matrix, preparation method and applications and cosmetics and preparation method thereof, are related to cosmetic technical field.Skin matrix of the invention includes following component: tetrahydro methylpyrimidine carboxylic acid, thermus thermophilus tunning, Flos Buddlejae extract, recombination human source collagen and water；The weight percent that each component accounts for skin matrix in tetrahydro methylpyrimidine carboxylic acid, thermus thermophilus tunning, Flos Buddlejae extract and recombination human source collagen is not less than 1%.The present invention alleviates traditional anti-aging product mostly based on single anti-oxidant or single replenishing collagen etc., and anti-aging effects are not significant, and no the problem of resisting infrared effect.By tetrahydro methylpyrimidine carboxylic acid, thermus thermophilus tunning and Flos Buddlejae extract as main functional component in matrix of the present invention, synergistic complex recombination human source collagen again, by the synergistic function between each ingredient, has and resist infrared ray, senile-resistant efficacy.

Description

Skin matrix, preparation method and applications and cosmetics and preparation method thereof

Technical field

The present invention relates to cosmetic technical field, in particular to a kind of skin matrix, preparation method and applications and Cosmetics and preparation method thereof.

Background technique

With advancing age and the increasing of environmental pollution and life stress, the skin aging of people are more and more obvious, Anti-aging beauty-care skin care is also increasingly valued by people.

Skin aging is usually expressed as skin elasticity reduction, wrinkle of skin is added, the roughness of skin increases and occurs Color spot etc..In daily life it is simple be clearly for prevention skin aging using moisturizer skin care it is inadequate, environment, sunlight and The factors such as pressure promote skin ageing to accelerate, and at this time skin also is easy spot, and phenomena such as microgroove, while the years can cause body Aging, skin metabolism slow down, and the collagen and elastic fibrous tissue fiber of skin change, and reduce texture and content, skin Skin gradually loses elasticity, becomes loose.Infrared ray compares ultraviolet light, visible light, and wavelength is longer, it may have very strong energy, and And there is profound penetration power, human skin can be penetrated to subcutaneous tissue, and then damage to skin, there is data table It is bright: skin to be damaged because of sunlight irradiation, infrared ray is one of arch-criminal.

Anti-aging product on the market mostly turns to effect point of penetration with simple antioxygen at present, carries out anti-aging publicity, but anti- Oxidation is not fully equal to anti-aging, while these products also have effects that the disadvantages of poor, in addition, compact skin, resist it is infrared Line has become another emphasis of research on anti-senescence, although they are mostly with single antioxygen on the market about the precedent of anti-aging Based on change or single replenishing collagen etc., anti-aging effects are not apparent.

In view of this, the present invention is specifically proposed.

Summary of the invention

One of the objects of the present invention is to provide a kind of skin matrix, which passes through tetrahydro methylpyrimidine carboxylic acid, thermophilic Thermus tunning and Flos Buddlejae extract are as main functional component, then synergistic complex recombination human source collagen, by each Synergistic function between ingredient has and resists infrared ray, senile-resistant efficacy.

The second object of the present invention is to provide a kind of preparation method of skin matrix, can be obtained by using this method Uniform and stable lotion, with simple, the easily operated advantage of method, and preparation method will not influence ingredient validity and The final using effect of product.

The third object of the present invention is that providing skin matrix described in one kind is preparing the application in anti-aging cosmetics.

The fourth object of the present invention is to provide a kind of cosmetics including the skin matrix, for example, eye cream, face cream and In the cosmetics such as Essence, good skin effect can be brought to these products, and there is good resist after smearing the cosmetics The effect of infrared ray and anti-aging.

The fifth object of the present invention is to provide a kind of preparation method of cosmetics, can be obtained by using this method The cosmetics for obtaining stable homogeneous are suitable for standardized production and popularization and application with simple, the easily operated advantage of method.

In order to realize above-mentioned purpose of the invention, the following technical scheme is adopted:

A kind of skin matrix, the skin matrix include following component: tetrahydro methylpyrimidine carboxylic acid, thermus thermophilus fermentation Product, Flos Buddlejae extract and recombination human source collagen；

In tetrahydro methylpyrimidine carboxylic acid, thermus thermophilus tunning, Flos Buddlejae extract and recombination human source collagen The weight percent that each component accounts for skin matrix is not less than 1%.

Preferably, on the basis of technical solution provided by the invention, the skin matrix include weight percent as Lower component: tetrahydro methylpyrimidine carboxylic acid 3~10%, thermus thermophilus tunning 15~50%, Flos Buddlejae extract 10~ 20%, recombination human source collagen 1~2%, surplus is water.

Preferably, on the basis of technical solution provided by the invention, the skin matrix include weight percent as Lower component: tetrahydro methylpyrimidine carboxylic acid 5~8%, thermus thermophilus tunning 20~40%, Flos Buddlejae extract 12~ 18%, recombination human source collagen 1~2%, surplus is water.

Preferably, on the basis of technical solution provided by the invention, the skin matrix include weight percent as Lower component: tetrahydro methylpyrimidine carboxylic acid 5~6%, thermus thermophilus tunning 20~30%, Flos Buddlejae extract 12~ 15%, recombination human source collagen 1~1.5%, surplus is water.

A kind of preparation method of above-mentioned skin matrix, comprising the following steps:

By tetrahydro methylpyrimidine carboxylic acid, thermus thermophilus tunning, Flos Buddlejae extract, recombination human source collagen and Water obtains skin matrix after being sufficiently mixed.

Preferably, on the basis of technical solution provided by the invention, the preparation method of skin matrix, including following step It is rapid:

(a) tetrahydro methylpyrimidine carboxylic acid, recombination human source collagen and water are sufficiently mixed, obtain clear solution；

(b) by the clear solution of thermus thermophilus tunning and Flos Buddlejae extract and step (a) be sufficiently mixed with it is cold But, skin matrix is obtained；

Preferably, mixing temperature is 35~45 DEG C, preferably 40~45 DEG C, further preferred 42~45 DEG C in step (a)； And/or

Mixing velocity is 800~1000rpm in step (a)；And/or

Incorporation time is 15~30min, preferably 20~30min, further preferred 25~30min in step (a)；

Preferably, mixing velocity is 800~1000rpm in step (b)；And/or

Incorporation time is 5~10min, preferably 6~10min, further preferred 8~10min in step (b)；And/or

Cooling temperature is 15~25 DEG C, preferably 20~25 DEG C, further preferred 22~25 DEG C in step (b).

A kind of above-mentioned skin matrix is preparing the application in anti-aging cosmetics.

A kind of cosmetics including above-mentioned skin matrix.

Preferably, on the basis of technical solution provided by the invention, weight hundred of the skin matrix in cosmetics Divide than being 10~20%.

Preferably, on the basis of technical solution provided by the invention, the cosmetics include the as follows of weight percent Component:

Component A: dipropylene glycol 3.0~6.0%, Sodium Hyaluronate 0.05~0.15%；

B component: butanediol 5.0~8.0%, methylparaben 0.1~0.2%；

Component C: Cremophor RH40 0.05~0.15%；

D component: skin matrix 10~20%；

Surplus is water；

Preferably, the cosmetics include the following component of weight percent:

Component A: dipropylene glycol 4.0~6.0%, Sodium Hyaluronate 0.08~0.15%；

B component: butanediol 5.0~7.0%, methylparaben 0.15~0.2%；

Component C: Cremophor RH40 0.08~0.15%；

D component: skin matrix 15~20%；

Surplus is water；

Preferably, the cosmetics include the following component of weight percent:

Component A: dipropylene glycol 5.0~6.0%, Sodium Hyaluronate 0.1~0.15%；

B component: butanediol 5.0~6.0%, methylparaben 0.15~0.2%；

Component C: Cremophor RH40 0.1~0.15%；

D component: skin matrix 15~20%；

Surplus is water.

Preferably, on the basis of technical solution provided by the invention, the cosmetics further include essence；

Weight percent of the essence in cosmetics is 0.01~0.03%.

A kind of preparation method of above-mentioned cosmetics, comprising the following steps:

Fully emulsified and homogeneous after component A, B component and component C are carried out mixing heating and kept the temperature, is added D group after cooling Divide, optional essence and water, obtains cosmetics after mixing；

Preferably, comprising the following steps:

(a) dipropylene glycol and Sodium Hyaluronate are mixed, obtains prefabricated component A；

(b) butanediol and methylparaben are mixed and heats up and keeps the temperature, obtain prefabricated B component；

(c) Cremophor RH40 and optional essence are mixed and heats up and keeps the temperature, obtain prefabricated component C；

(d) it prefabricated component C is added keeps the temperature again after prefabricated component A to be mixed to heating, heat preservation with prefabricated B component, mixed Liquid；

(e) mixed liquor for obtaining step (d) carries out emulsification and homogeneous；

(f) D component and water are added after cooling down, obtains cosmetics after mixing；

Preferably, mixing velocity is 500~1000rpm in step (a)；And/or

Incorporation time is 10~20min；

Preferably, mixing velocity is 500~1000rpm in step (b)；And/or

Warming temperature is 60~70 DEG C；

Preferably, mixing velocity is 500~700rpm in step (c)；And/or

Warming temperature is 45~50 DEG C；

Preferably, mixing velocity is 600~1000rpm in step (d)；And/or

Warming temperature is 75~85 DEG C；And/or

Soaking time is 10~25min；

Preferably, emulsifying rate is 300~500rpm in step (e)；And/or

Vacuum degree is -0.05~-0.1MPa when emulsification；And/or

Homogeneous speed is 1000~1500rpm；And/or

Homogenizing time is 3~5min；

Preferably, step (f) cooling temperature is 40~45 DEG C；And/or

Mixing velocity is 300~500rpm；And/or

Incorporation time is 15~25min.

Compared with the prior art, the invention has the following beneficial effects:

(1) skin matrix of the invention passes through selection tetrahydro methylpyrimidine carboxylic acid, thermus thermophilus tunning and Mi Meng Flower extract passes through as the main functional component for resisting infrared ray, then synergistic complex recombination human source collagen, each active constituent Different role target spot resists infrared ray damage caused by skin, under the collective effect of different target spots, has between each ingredient Good synergistic function can play to greatest extent and resist infrared ray and senile-resistant efficacy.In addition, activity of the invention Ingredient can be degraded Transdermal absorption by skin, can supply nutrition for skin.

(2) skin matrix of the present invention can be used as raw material and be added to cream, lotion, eye essence, toner and essence In the cosmetics such as magnificent liquid, good skin effect can be brought to these products, smear after the cosmetics have it is good resist it is red The effect of outside line and anti-aging.

(3) skin matrix of the invention and the manufacture craft of cosmetics are simple, easy to use, can obtain stable homogeneous Lotion and cosmetics are suitable for standardized production and popularization and application, and preparation method with simple, the easily operated advantage of method It will not influence the validity of ingredient and the using effect that product is final.

Specific embodiment

Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is The conventional products that can be obtained by commercially available purchase.

According to the first aspect of the invention, a kind of skin matrix is provided, skin matrix includes following component: tetrahydro first Yl pyrimidines carboxylic acid, thermus thermophilus tunning, Flos Buddlejae extract and recombination human source collagen；

Tetrahydro methylpyrimidine carboxylic acid

Tetrahydro methylpyrimidine carboxylic acid is originated from a kind of microorganism in Egypt salt lake desert area WadiEI Natrun, is one Derived from amino acid object, have powerful resistance to compression defencive function, can fetter surrounding water molecules formed complex, be wrapped in cell, Around enzyme, protein and other organic molecules, being formed has protection, nourishes and stablize the protective shell of aquation, and then resists Radiation injury of the skin by infrared ray.Commercial product, preferably the four of the production of Bitop company can be selected in tetrahydro methylpyrimidine carboxylic acid Hydrogen methylpyrimidine carboxylic acid.

Thermus thermophilus tunning

Thermus thermophilus (THERMUS THERMOPHILLUS) tunning is produced by biofermentation technique, is a kind of Multi-functional heat activated stable enzyme has injury caused by resisting infrared ray, the effect of inflammation is reduced, by stress situation Under maintain mitochondrial integrity, optimization ability generates, and maintains the normal physiological of skin to construct and reduces wrinkle and generate.Thermophilic heat of dwelling Commercial product, preferably the thermus thermophilus tunning of sederma company production can be selected in bacterium tunning.

Flos Buddlejae extract

Butterflybush flower (BUDDLEJA OFFICINALIS) extract is for loganiaceae plant butterflybush flower Buddleja The bud of officinalis Maxim. and the extract of inflorescence have containing highly concentrated verbascoside and echinacoside The effect for protecting skin barrier integrity maintains immunologic balance to being converted for cis-urocanic acid by reducing trans-urocanic acid, Extracellular matrix degradation caused by preventing because of infrared radiation and skin early ageing.Commercial product can be selected in Flos Buddlejae extract, excellent Select the Flos Buddlejae extract of GREENTECH company, France production.

Recombination human source collagen

Collagen is the major structural protein of human body and vertebrate, is synthesized by fibroblast, as tissue and knot The main component of tissue is formed, it is a variety of that support, protection, connection etc. can be played.Recombination human source collagen, also known as biological source collagen Albumen (Recombinant Human-source Collagen, RHC) is a kind of using molecular biology engineering technology, by people Collagen gene sequence import the product that obtains through everfermentation of yeast cells.RHC- recombined collagen possesses stronger anti- Aging, anti-wrinkle, Shu Min repair effect, can arrive at flesh bottom rapidly after contacting skin, improve cell activity, promote fibrocyte Skin metabolism is accelerated in growth, repairs impaired cuticula, RHC possesses the consummate quality of pharmaceutical grade and highest safety is protected Card, the preventing virus hidden danger from source, more without animal tissue and the residual risk of extraction process impurity.Recombination human source collagen egg White optional commercial product, such as the recombination human source collagen selected from the production of Jiangsu rivers and mountains Ju Yuan Bioisystech Co., Ltd.

It is understood that tetrahydro methylpyrimidine carboxylic acid, thermus thermophilus tunning, butterflybush flower are extracted in skin matrix The content of object, recombination human source collagen and water is not construed as limiting, as long as meeting tetrahydro methylpyrimidine carboxylic acid, thermus thermophilus fermentation The weight percent that every kind of component accounts for skin matrix in product, Flos Buddlejae extract and recombination human source collagen is not less than 1%, to guarantee effect.

Traditional anti-aging product is mostly based on single anti-oxidant or single replenishing collagen etc., and anti-aging effects are not Significantly, it and without resisting infrared effect, and studies discovery infrared ray and plays an important role to the aging of skin.The present invention passes through choosing Select tetrahydro methylpyrimidine carboxylic acid, thermus thermophilus tunning and Flos Buddlejae extract as resist main effect of infrared ray at Point, tetrahydro methylpyrimidine carboxylic acid forms protective shell, resists skin and damaged by infrared radiation, and thermus thermophilus tunning can In the case that stress maintain mitochondrial integrity, maintain skin normal physiological construct reduce wrinkle generate, butterflybush flower extract Object maintains immunologic balance to being converted for cis-urocanic acid by reducing trans-urocanic acid, thin caused by preventing because of infrared radiation Extracellular matrix degradation and skin early ageing, each active constituent can resist infrared ray damage caused by skin by different role target spot Wound has collaboration well under the collective effect of different target spots, then synergistic complex recombination human source collagen, between each ingredient Synergistic effect can play to greatest extent and resist infrared ray and senile-resistant efficacy.In addition, active constituent of the invention can be by Skin degradation Transdermal absorption can supply nutrition for skin.

In a preferred embodiment, skin matrix includes the following component of weight percent: tetrahydro methylpyrimidine Carboxylic acid 3~10%, thermus thermophilus tunning 15~50%, Flos Buddlejae extract 10~20%, recombination human source collagen 1 ~2%, surplus is water.

The typical but non-limiting weight percent of tetrahydro methylpyrimidine carboxylic acid is, for example, 3%, 4%, 5%, 6%, 7%, 8%, 9% or 10%.

The typical but non-limiting weight percent of thermus thermophilus tunning is, for example, 15%, 20%, 25%, 30%, 35%, 40%, 45% or 50%.

The typical but non-limiting weight percent of Flos Buddlejae extract is, for example, 10%, 12%, 14%, 16%, 18% Or 20%.

The typical but non-limiting weight percent of recombination human source collagen is, for example, 1%, 1.2%, 1.4%, 1.6%, 1.8% or 2%.

" comprising " of the present invention, it is intended that it can also include other raw materials, these other raw materials in addition to the raw material Assign the skin matrix different characteristics.In addition to this, " comprising " of the present invention may be replaced by enclosed " for " or " by ... form ".

For example, it is also possible to the other components such as including preservative.

It should be noted that surplus is water, refers to and remove tetrahydro methylpyrimidine carboxylic acid in the raw material of matrix of the present invention, thermophilic dwell Hot bacterium tunning, Flos Buddlejae extract, recombination human source collagen and the surplus optionally except other components are water, water With tetrahydro methylpyrimidine carboxylic acid, thermus thermophilus tunning, Flos Buddlejae extract, recombination human source collagen and optionally The sum of weight percentage of other components is 100%.

It is 3~10% tetrahydro methylpyrimidine carboxylic acid by using weight percent, 15~50% thermus thermophilus hair Ferment product, 10~20% Flos Buddlejae extract and 1~2% recombination human source collagen can obtain significantly resist it is red The effect of outside line and anti-aging.

The preferred deionized water of water.

In a preferred embodiment, skin matrix includes the following component of weight percent: tetrahydro methylpyrimidine Carboxylic acid 5~8%, thermus thermophilus tunning 20~40%, Flos Buddlejae extract 12~18%, recombination human source collagen 1 ~2%, surplus is water.

In a preferred embodiment, skin matrix includes the following component of weight percent: tetrahydro methylpyrimidine Carboxylic acid 5~6%, thermus thermophilus tunning 20~30%, Flos Buddlejae extract 12~15%, recombination human source collagen 1 ~1.5%, surplus is water.

Pass through preferred tetrahydro methylpyrimidine carboxylic acid, thermus thermophilus tunning, Flos Buddlejae extract and recombination human source glue The weight percent of former albumen can further enhance the infrared resistant and anti-aging effects of skin matrix.

According to the second aspect of the invention, a kind of preparation method of above-mentioned skin matrix is provided, comprising the following steps:

Uniform, stable lotion is obtained after mixing, makes to be sufficiently mixed between each effective component, it is abundant to be conducive to active constituent Release.

Specifically, the preparation method of skin matrix, comprising the following steps:

Preferably, in step (a) mixing temperature be 35~45 DEG C, such as 35 DEG C, 36 DEG C, 37 DEG C, 38 DEG C, 39 DEG C, 40 DEG C, 41 DEG C, 42 DEG C, 43 DEG C, 44 DEG C or 45 DEG C, preferably 40~45 DEG C, further preferred 42~45 DEG C；And/or

Mixing velocity is 800~1000rpm, such as 800rpm, 900rpm or 1000rpm in step (a)；And/or

Incorporation time is 15~30min, such as 15min, 20min, 25min or 30min in step (a), preferably 20~ 30min, further preferred 25~30min；

Preferably, mixing velocity is 800~1000rpm, such as 800rpm, 900rpm or 1000rpm in step (b)；

Incorporation time is 5~10min, such as 5min, 6min, 7min, 8min, 9min or 10min in step (b), preferably 6 ~10min, further preferred 8~10min；And/or

Cooling temperature is 15~25 DEG C in step (b), such as 15 DEG C, 18 DEG C, 20 DEG C, 22 DEG C or 25 DEG C, preferably 20~25 DEG C, further preferred 22~25 DEG C.

(1) stirring is opened, under the conditions of 35~45 DEG C, by the tetrahydro methylpyrimidine carboxylic acid and 1~2 weight of 3~10 parts by weight The RHC- recombination human source collagen of amount part is slowly added in the water of 36~53 parts by weight, and constant temperature stirring obtains clear solution；

(2) by the thermus thermophilus of 15~50 parts by weight (THERMUS THERMOPHILLUS) tunning and 10~20 Butterflybush flower (BUDDLEJA OFFICINALIS) extract of parts by weight is added in clear solution, stirs 5~10min, cooling, out Material, obtains skin matrix.

Mixing speed described in step (1) is 800~1000rpm；The time of the constant temperature stirring is 15~30min；

Mixing speed described in step (2) is 800~1000rpm；

Cooling temperature described in step (2) is 20~25 DEG C.

By stirring under certain condition and and cooling treatment, can be avoided temperature during the preparation process and mixing speed pair The destruction of the structure and function of effective component retains active constituent therein, obtains the emulsion matrix of stable homogeneous.

According to the third aspect of the present invention, it provides a kind of above-mentioned skin matrix and is preparing answering in anti-aging cosmetics With.

Cosmetics are skin-care cosmetics, and typical but non-limiting skin-care cosmetics include cream, lotion, eye essence Hua Su, toner or Essence etc..

Cosmetics are functional cosmetics, and typical but non-limiting functional cosmetics include Skin whitening care cosmetics, crease-resistant Skin care item or Moisturizer etc..

According to the fourth aspect of the present invention, a kind of cosmetics including above-mentioned skin matrix are provided.

Preferably, weight percent of the skin matrix in cosmetics is 10~20%.

Skin matrix typical but non-limiting weight percent in cosmetics is, for example, 10%, 12%, 14%, 16%, 18% or 20%.

The skin matrix of the invention of special ratios is added in cosmetics, good resist can be brought to these products The effect of infrared ray and anti-aging.

As a preferred embodiment, a kind of typical cosmetics, the following component including weight percent:

Component A: dipropylene glycol 3.0~6.0%, Sodium Hyaluronate 0.05~0.15%；

B component: butanediol 5.0~8.0%, methylparaben 0.1~0.2%；

Component C: Cremophor RH40 0.05~0.15%；

D component: skin matrix 10~20%；

Surplus is water.

The weight percent is using cosmetics itself as calculating benchmark.

The typical but non-limiting weight percent of dipropylene glycol is, for example, 3%, 4%, 5% or 6%.

The typical but non-limiting weight percent of Sodium Hyaluronate is, for example, 0.05%, 0.1% or 0.15%.

The typical but non-limiting weight percent of butanediol be, for example, 5%, 5.5%, 6%, 6.5%, 7%, 7.5% or 8%.

The typical but non-limiting weight percent of methylparaben is, for example, 0.1%, 0.12%, 0.14%, 0.16%, 0.18% or 0.2%.

The typical but non-limiting weight percent of Cremophor RH40 be, for example, 0.05%, 0.1%, 0.15% or 0.15%.

The typical but non-limiting weight percent of skin matrix be, for example, 10%, 12%, 14%, 16%, 18% or 20%.

Cosmetics " comprising ", it is intended that it can also include other raw materials in addition to the raw material, these other raw materials assign institute State the different characteristic of cosmetics.In addition to this, " comprising " of the present invention, may be replaced by enclosed " for " or " by ... form ".

For example, it is also possible to include the other components such as essence, preservative.

It should be noted that surplus is water, refers to and remove skin matrix, dipropylene glycol, transparent in cosmetic material of the present invention Matter acid sodium, butanediol, methylparaben, Cremophor RH40 and optionally except other components and surplus be water, water With skin matrix, dipropylene glycol, Sodium Hyaluronate, butanediol, methylparaben, Cremophor RH40 and optionally its The sum of weight percentage of his component is 100%.

Cosmetics of the invention have cosmetics and resist by joined the skin matrixes of the present invention of 10~20% contents Infrared ray and senile-resistant efficacy, while the mutual coordinated with other cosmetic materials, bring good skin effect, smear Have the effect of significantly resisting infrared ray and anti-aging after the cosmetics, can be used as essence use.

The preferred deionized water of water.

In a kind of preferred embodiment, cosmetics include the following component of weight percent:

Component A: dipropylene glycol 4.0~6.0%, Sodium Hyaluronate 0.08~0.15%；

B component: butanediol 5.0~7.0%, methylparaben 0.15~0.2%；

Component C: Cremophor RH40 0.08~0.15%；

D component: skin matrix 15~20%；

Surplus is water；

Component A: dipropylene glycol 5.0~6.0%, Sodium Hyaluronate 0.1~0.15%；

B component: butanediol 5.0~6.0%, methylparaben 0.15~0.2%；

Component C: Cremophor RH40 0.1~0.15%；

D component: skin matrix 15~20%；

Surplus is water.

By optimizing raw material percentage composition, cosmetics can be made to obtain more preferably anti-aging and using effect.

In a kind of preferred embodiment, cosmetics further include essence；Weight percent of the essence in cosmetics be 0.01~0.03%.

The typical but non-limiting weight percent of essence be, for example, 0.01%, 0.015%, 0.02%, 0.025% or 0.03%.

The use feeling of cosmetics can be promoted after addition essence.

According to the fifth aspect of the present invention, a kind of preparation method of above-mentioned cosmetics is provided, comprising the following steps:

Fully emulsified and homogeneous after component A, B component and component C are carried out mixing heating and kept the temperature, is added D group after cooling Divide, optional essence and water, obtains cosmetics after mixing.

Emulsification is the effect that a kind of liquid is evenly dispersed in immiscible another liquid with atomic droplet.

Homogeneous is also referred to as homogenized, be make dispersion micronized in suspension (or emulsion) system, homogenization it is processed Journey, it is this processing simultaneously play a part of reduce dispersion scale and raising dispersion distributing homogeneity, preferably homogenizing process for Whipping process under low-speed conditions of the revolving speed less than 1000r/min.

By cosmetics fully emulsified to cosmetics each component, can obtaining stable homogeneous after homogeneous, this method is suitable for Standardized production.

Specifically, above-mentioned cosmetics preparation method the following steps are included:

Preferably, in step (a) mixing velocity be 500~1000rpm, such as 500rpm, 600rpm, 700rpm, 800rpm, 900rpm or 1000rpm；And/or

Incorporation time is 10~20min, such as 10min, 12min, 14min, 15min, 16min, 18min or 20min；

Preferably, in step (b) mixing velocity be 500~1000rpm, such as 500rpm, 600rpm, 700rpm, 800rpm, 900rpm or 1000rpm；And/or

Warming temperature be 60~70 DEG C, such as 60 DEG C, 61 DEG C, 62 DEG C, 63 DEG C, 64 DEG C, 65 DEG C, 66 DEG C, 67 DEG C, 68 DEG C, 69 DEG C or 70 DEG C；

Preferably, mixing velocity is 500~700rpm, such as 500rpm, 600rpm or 700rpm in step (c)；With/ Or,

Warming temperature is 45~50 DEG C, such as 45 DEG C, 46 DEG C, 47 DEG C, 48 DEG C, 49 DEG C or 50 DEG C；

By the way that the raw material of component A, component B and component C are first mixed to get prefabricated component A, pre- under certain condition respectively B component processed and prefabricated component C, facilitate post-production.

Preferably, mixing velocity is 600~1000rpm, such as 600rpm, 800rpm or 1000rpm in step (d)；With/ Or,

Warming temperature be 75~85 DEG C, such as 75 DEG C, 76 DEG C, 77 DEG C, 78 DEG C, 79 DEG C, 80 DEG C, 81 DEG C, 82 DEG C, 83 DEG C, 84 DEG C or 85 DEG C；And/or

Soaking time is 10~25min, such as 10min, 15min, 20min or 25min；

It by mixing prefabricated component A, prefabricated B component and prefabricated component C at a temperature of 75~85 DEG C, and keeps the temperature, obtains Mixed liquor.

Preferably, emulsifying rate is 300~500rpm, such as 300rpm, 400rpm or 500rpm in step (e)；With/ Or,

Vacuum degree is -0.05~-0.1MPa, such as -0.1MPa or -0.05MPa when emulsification；And/or

Homogeneous speed be 1000~1500rpm, such as 1000rpm, 1100rpm, 1200rpm, 1300rpm, 1400rpm or 1500rpm；And/or

Homogenizing time is 3~5min, such as 3min, 4min or 5min；

By using mixed liquor is emulsified under the conditions of 300~500rpm, is carried out under the conditions of 1000~1500rpm 3~5min of homogeneous can obtain uniform, stable lotion.

Preferably, step (f) cooling temperature is 40~45 DEG C, such as 40 DEG C, 41 DEG C, 42 DEG C, 43 DEG C, 44 DEG C or 45 DEG C； And/or

Mixing velocity is 300~500rpm, such as 300rpm, 400rpm or 500rpm；And/or

Incorporation time is 15~25min, such as 15min, 20min or 25min.

By the way that the mixed liquor after homogeneous is cooled to 40~45 DEG C, skin matrix and water are added, essence makeup is obtained Product prevent high temperature from causing to damage to active constituent in skin matrix, impact effect.

By being prepared under certain condition, the lotion of stable homogeneous can be obtained, and will not be destroyed in preparation process The structure and activity of effective component, guarantee the using effect of Essence.

In more detail, the preparation method of above-mentioned cosmetics essence, comprising the following steps:

(1) component A is mixed, open stirring (revolving speed is 500~1000rpm) and stirs 10~20min, obtain prefabricated A；

(2) B component is mixed, opens stirring (revolving speed is 500~1000rpm), and be warming up to 60~70 DEG C, keeps the temperature standby With obtaining prefabricated B；

(3) component C being mixed, opens stirring (revolving speed is 500~700rpm), and be warming up to 45~50 DEG C, heat preservation is spare, Obtain prefabricated C；

(4) water phase pot is added in prefabricated B, opens stirring (revolving speed is 600~1000rpm), adds prefabricated A, be warming up to It 75~85 DEG C, prefabricated C is added keeps the temperature 10~20min again after keeping the temperature 15~25min；

(5) after water phase pot material being sucked emulsion pot, emulsion pot stirring (revolving speed is 300~500rpm) is opened, keeps true Reciprocal of duty cycle (vacuum degree be -0.05Mpa) and mixing speed are constant, open homogenizer immediately and carry out homogeneous, homogenizing time for 3~ 5min, the revolving speed of homogeneous are 1000~1500rpm；

(6) temperature lowering water is opened after the completion of homogeneous and be cooled to 40~45 DEG C, skin matrix and water is added, stir 15~25min (revolving speed is 300~500rpm), discharging obtains the essence comprising skin matrix.

In order to further appreciate that the present invention, the method for the present invention and effect are done further in detail combined with specific embodiments below Explanation.Each raw material of the present invention can pass through commercially available acquisition.

Tetrahydro methylpyrimidine carboxylic acid is purchased from Bitop company；Thermus thermophilus (THERMUS THERMOPHILLUS) fermentation produces Object is purchased from sederma company；Butterflybush flower (BUDDLEJA OFFICINALIS) extract is purchased from GREENTECH company, France； RHC- recombination human source collagen is purchased from Jiangsu rivers and mountains Ju Yuan Bioisystech Co., Ltd.Other raw materials are commercial product.

Embodiment 1

A kind of skin matrix is grouped as by following group of weight percent: tetrahydro methylpyrimidine carboxylic acid 3%, thermophilic heat of dwelling Bacterium tunning 50%, Flos Buddlejae extract 10%, recombination human source collagen 2% and water 35%.

Embodiment 2

A kind of skin matrix is grouped as by following group of weight percent: tetrahydro methylpyrimidine carboxylic acid 10%, thermophilic heat of dwelling Bacterium tunning 15%, Flos Buddlejae extract 20%, recombination human source collagen 1% and water 54%.

Embodiment 3

A kind of skin matrix is grouped as by following group of weight percent: tetrahydro methylpyrimidine carboxylic acid 5%, thermophilic heat of dwelling Bacterium tunning 40%, Flos Buddlejae extract 12%, recombination human source collagen 1.5% and water 41.5%.

Embodiment 4

A kind of skin matrix is grouped as by following group of weight percent: tetrahydro methylpyrimidine carboxylic acid 8%, thermophilic heat of dwelling Bacterium tunning 20%, Flos Buddlejae extract 18%, recombination human source collagen 1.2% and water 52.8%.

Embodiment 5

A kind of skin matrix is grouped as by following group of weight percent: tetrahydro methylpyrimidine carboxylic acid 6%, thermophilic heat of dwelling Bacterium tunning 30%, Flos Buddlejae extract 15%, recombination human source collagen 1.8% and water 47.2%.

Embodiment 6

A kind of skin matrix is grouped as by following group of weight percent: tetrahydro methylpyrimidine carboxylic acid 7%, thermophilic heat of dwelling Bacterium tunning 25%, Flos Buddlejae extract 14%, recombination human source collagen 1.5% and water 52.5%.

Comparative example 1

A kind of skin matrix is grouped as by following group of weight percent: tetrahydro methylpyrimidine carboxylic acid 2%, thermophilic heat of dwelling Bacterium tunning 55%, Flos Buddlejae extract 5%, recombination human source collagen 5% and water 33%.

Comparative example 2

A kind of skin matrix is grouped as: thermus thermophilus tunning 15%, butterflybush flower by following group of weight percent Extract 20%, recombination human source collagen 1% and water 64%.

Comparative example 3

A kind of skin matrix is grouped as by following group of weight percent: tetrahydro methylpyrimidine carboxylic acid 5%, butterflybush flower mentions Take object 12%, recombination human source collagen 1.5% and water 81.5%.

Comparative example 4

A kind of skin matrix is grouped as by following group of weight percent: tetrahydro methylpyrimidine carboxylic acid 8%, thermophilic heat of dwelling Bacterium tunning 20%, recombination human source collagen 1.2% and water 70.8%.

Comparative example 5

A kind of skin matrix is grouped as by following group of weight percent: tetrahydro methylpyrimidine carboxylic acid 6%, thermophilic heat of dwelling Bacterium tunning 30%, Flos Buddlejae extract 15% and water 49%.

Embodiment 7

A kind of preparation method of skin matrix, comprising the following steps:

(1) stirring (revolving speed 800rpm) is opened, under the conditions of 35 DEG C, by the tetrahydro methylpyrimidine carboxylic acid of 3 parts by weight, 2 The RHC- recombination human source collagen of parts by weight is slowly added in the water of 35 parts by weight, and constant temperature stirs 30min, obtains clarifying molten Liquid；

(2) by the thermus thermophilus of 50 parts by weight (THERMUS THERMOPHILLUS) tunning, 10 parts by weight it is close It covers flower (BUDDLEJA OFFICINALIS) extract to be added in clear solution, stirs 10min under the mixing speed of 800rpm, 20 DEG C are cooled to, discharging obtains skin matrix.

Embodiment 8

A kind of preparation method of skin matrix, comprising the following steps:

(1) stirring (revolving speed 900rpm) is opened, under the conditions of 40 DEG C, by the tetrahydro methylpyrimidine carboxylic acid of 10 parts by weight, 1 The RHC- recombination human source collagen of parts by weight is slowly added in the water of 54 parts by weight, and constant temperature stirs 20min, obtains clarifying molten Liquid；

(2) by the thermus thermophilus of 15 parts by weight (THERMUS THERMOPHILLUS) tunning, 20 parts by weight it is close It covers flower (BUDDLEJA OFFICINALIS) extract to be added in clear solution, stirs 5min under the mixing speed of 900rpm, 25 DEG C are cooled to, discharging obtains skin matrix.

Embodiment 9

A kind of preparation method of skin matrix, comprising the following steps:

(1) open stirring (revolving speed 1000rpm), under the conditions of 45 DEG C, by the tetrahydro methylpyrimidine carboxylic acid of 5 parts by weight, The RHC- recombination human source collagen of 1.5 parts by weight is slowly added in the water of 41.5 parts by weight, and constant temperature stirs 15min, is obtained clear Clear solution；

(2) by the thermus thermophilus of 40 parts by weight (THERMUS THERMOPHILLUS) tunning, 12 parts by weight it is close It covers flower (BUDDLEJA OFFICINALIS) extract to be added in clear solution, stirs 8min under the mixing speed of 1000rpm, 22 DEG C are cooled to, discharging obtains skin matrix.

Embodiment 10

A kind of preparation method of skin matrix, comprising the following steps:

(1) open stirring (revolving speed 800rpm), under the conditions of 37 DEG C, by the tetrahydro methylpyrimidine carboxylic acid of 8 parts by weight, The RHC- recombination human source collagen of 1.2 parts by weight is slowly added in the water of 52.8 parts by weight, and constant temperature stirs 30min, is obtained clear Clear solution；

(2) by the thermus thermophilus of 20 parts by weight (THERMUS THERMOPHILLUS) tunning, 18 parts by weight it is close It covers flower (BUDDLEJA OFFICINALIS) extract to be added in clear solution, stirs 10min under the mixing speed of 800rpm, 25 DEG C are cooled to, discharging obtains skin matrix.

Embodiment 11

A kind of preparation method of skin matrix, comprising the following steps:

(1) open stirring (revolving speed 900rpm), under the conditions of 42 DEG C, by the tetrahydro methylpyrimidine carboxylic acid of 6 parts by weight, The RHC- recombination human source collagen of 1.8 parts by weight is slowly added in the water of 47.2 parts by weight, and constant temperature stirs 20min, is obtained clear Clear solution；

(2) by the thermus thermophilus of 30 parts by weight (THERMUS THERMOPHILLUS) tunning, 15 parts by weight it is close It covers flower (BUDDLEJA OFFICINALIS) extract to be added in clear solution, stirs 6min under the mixing speed of 900rpm, 25 DEG C are cooled to, discharging obtains skin matrix.

Embodiment 12

A kind of preparation method of skin matrix, comprising the following steps:

(1) open stirring (revolving speed 1000rpm), under the conditions of 45 DEG C, by the tetrahydro methylpyrimidine carboxylic acid of 7 parts by weight, The RHC- recombination human source collagen of 1.5 parts by weight is slowly added in the water of 52.5 parts by weight, and constant temperature stirs 15min, is obtained clear Clear solution；

(2) by the thermus thermophilus of 25 parts by weight (THERMUS THERMOPHILLUS) tunning, 14 parts by weight it is close It covers flower (BUDDLEJA OFFICINALIS) extract to be added in clear solution, be stirred under the mixing speed of 1000rpm 10min, is cooled to 20 DEG C, and discharging obtains skin matrix.

Comparative example 6

A kind of preparation method of skin matrix, comprising the following steps:

(1) stirring (revolving speed 800rpm) is opened, under the conditions of 35 DEG C, by the tetrahydro methylpyrimidine carboxylic acid of 2 parts by weight, 5 The RHC- recombination human source collagen of parts by weight is slowly added in the water of 33 parts by weight, and constant temperature stirs 30min, obtains clarifying molten Liquid；

(2) by the thermus thermophilus of 55 parts by weight (THERMUS THERMOPHILLUS) tunning, 5 parts by weight it is close It covers flower (BUDDLEJA OFFICINALIS) extract to be added in clear solution, stirs 10min under the mixing speed of 800rpm, 20 DEG C are cooled to, discharging obtains skin matrix.

Comparative example 7

A kind of preparation method of skin matrix, comprising the following steps:

(1) stirring (revolving speed 900rpm) is opened, under the conditions of 40 DEG C, by the RHC- recombination human source collagen egg of 1 parts by weight In the white water for being slowly added to 64 parts by weight, constant temperature stirs 20min, obtains clear solution；

Comparative example 8

A kind of preparation method of skin matrix, comprising the following steps:

(1) open stirring (revolving speed 1000rpm), under the conditions of 45 DEG C, by the tetrahydro methylpyrimidine carboxylic acid of 5 parts by weight, The RHC- recombination human source collagen of 1.5 parts by weight is slowly added in the water of 81.5 parts by weight, and constant temperature stirs 15min, is obtained clear Clear solution；

(2) butterflybush flower of 12 parts by weight (BUDDLEJA OFFICINALIS) extract is added in clear solution, 8min is stirred under the mixing speed of 1000rpm, is cooled to 22 DEG C, discharging obtains skin matrix.

Comparative example 9

A kind of preparation method of skin matrix, comprising the following steps:

(1) open stirring (revolving speed 800rpm), under the conditions of 37 DEG C, by the tetrahydro methylpyrimidine carboxylic acid of 8 parts by weight, The RHC- recombination human source collagen of 1.2 parts by weight is slowly added in the water of 70.8 parts by weight, and constant temperature stirs 30min, is obtained clear Clear solution；

(2) clear solution is added in the thermus thermophilus of 20 parts by weight (THERMUS THERMOPHILLUS) tunning In, 10min is stirred under the mixing speed of 800rpm, is cooled to 25 DEG C, discharging obtains skin matrix.

Comparative example 10

A kind of preparation method of skin matrix, comprising the following steps:

(1) stirring (revolving speed 900rpm) is opened to delay the tetrahydro methylpyrimidine carboxylic acid of 6 parts by weight under the conditions of 42 DEG C In the slow water that 49 parts by weight are added, constant temperature stirs 20min, obtains clear solution；

Embodiment 13

A kind of essence is grouped as by following group of weight percent:

Component A: dipropylene glycol 3.0%, Sodium Hyaluronate 0.15%；

B component: butanediol 5.0%, methylparaben 0.2%；

Component C: essence 0.01%, Cremophor RH40 0.15%；

D component: the skin matrix 10% of embodiment 1；

Water 81.49%.

Embodiment 14

A kind of essence is grouped as by following group of weight percent:

Component A: dipropylene glycol 6.0%, Sodium Hyaluronate 0.05%；

B component: butanediol 8.0%, methylparaben 0.1%；

Component C: essence 0.03%, Cremophor RH40 0.05%；

D component: the skin matrix 20% of embodiment 2；

Water 65.77%.

Embodiment 15

A kind of essence is grouped as by following group of weight percent:

Component A: dipropylene glycol 4.5%, Sodium Hyaluronate 0.1%；

B component: butanediol 6.5%, methylparaben 0.15%；

Component C: essence 0.02%, Cremophor RH40 0.1%；

D component: the skin matrix 15% of embodiment 3；

Water 73.63%.

Embodiment 16

A kind of essence is grouped as by following group of weight percent:

Component A: dipropylene glycol 4.0%, Sodium Hyaluronate 0.12%；

B component: butanediol 6.0%, methylparaben 0.12%；

Component C: essence 0.01%, Cremophor RH40 0.12%；

D component: the skin matrix 20% of embodiment 4；

Water 69.63%.

Embodiment 17

A kind of essence is grouped as by following group of weight percent:

Component A: dipropylene glycol 5.0%, Sodium Hyaluronate 0.08%；

B component: butanediol 7.0%, methylparaben 0.18%；

Component C: essence 0.03%, Cremophor RH40 0.08%；

D component: the skin matrix 10% of embodiment 5；

Water 75.63%.

Embodiment 18

A kind of essence is grouped as by following group of weight percent:

Component A: dipropylene glycol 5.5%, Sodium Hyaluronate 0.1%；

B component: butanediol 6.5%, methylparaben 0.15%；

Component C: essence 0.02%, Cremophor RH40 0.06%；

D component: the skin matrix 15% of embodiment 6；

Water 72.67%.

Comparative example 11

A kind of essence, D component use the skin matrix of comparative example 1, remaining component is identical as embodiment 13.

Comparative example 12

A kind of essence, D component use the skin matrix of comparative example 2, remaining component is identical as embodiment 14.

Comparative example 13

A kind of essence, D component use the skin matrix of comparative example 3, remaining component is identical as embodiment 15.

Comparative example 14

A kind of essence, D component use the skin matrix of comparative example 4, remaining component is identical as embodiment 16.

Comparative example 15

A kind of essence, D component use the skin matrix of comparative example 5, remaining component is identical as embodiment 17.

Embodiment 19

A kind of preparation method of essence, comprising the following steps:

(1) dipropylene glycol of 3 parts by weight and the Sodium Hyaluronate of 0.15 parts by weight are mixed, opening stirring, (revolving speed is 500rpm) and 20min is stirred, obtains prefabricated A；

(2) methylparaben of the butanediol of 5 parts by weight and 0.2 parts by weight is mixed, opening stirring, (revolving speed is 500rpm), 60 DEG C are warming up to and, keeps the temperature spare, obtains prefabricated B；

(3) essence of 0.01 parts by weight and the Cremophor RH40 of 0.15 parts by weight are mixed, opens stirring (revolving speed For 500rpm), and 45 DEG C are warming up to, keep the temperature spare, obtains prefabricated C；

(4) water phase pot is added in prefabricated B, opens stirring (revolving speed 600rpm), adds prefabricated A, be warming up to 80 DEG C, protected Prefabricated C is added after warm 20min and keeps the temperature 10min again；

(5) after water phase pot material being sucked emulsion pot, emulsion pot stirring (revolving speed 400rpm) is opened, keeps vacuum degree (vacuum degree is -0.05Mpa) and mixing speed are constant, immediately unlatching homogenizer progress homogeneous, homogenizing time 3min, homogeneous Revolving speed is 1500rpm；

(6) open temperature lowering water after the completion of homogeneous and be cooled to 40 DEG C, be added 10 parts by weight 1 skin matrix of embodiment and The water of 81.49 parts by weight stirs 20min (revolving speed 400rpm), and discharging obtains the essence comprising skin matrix.

Embodiment 20

A kind of preparation method of essence, comprising the following steps:

(1) dipropylene glycol of 6 parts by weight and the Sodium Hyaluronate of 0.05 parts by weight are mixed, opening stirring, (revolving speed is 1000rpm) and 10min is stirred, obtains prefabricated A；

(2) methylparaben of the butanediol of 8 parts by weight and 0.1 parts by weight is mixed, opening stirring, (revolving speed is 1000rpm), 70 DEG C are warming up to and, keeps the temperature spare, obtains prefabricated B；

(3) essence of 0.03 parts by weight and the Cremophor RH40 of 0.05 parts by weight are mixed, opens stirring (revolving speed For 700rpm), and 50 DEG C are warming up to, keep the temperature spare, obtains prefabricated C；

(4) water phase pot is added in prefabricated B, opens stirring (revolving speed 1000rpm), adds prefabricated A, be warming up to 82 DEG C, Prefabricated C is added after heat preservation 18min and keeps the temperature 20min again；

(5) after water phase pot material being sucked emulsion pot, emulsion pot stirring (revolving speed 450rpm) is opened, keeps vacuum degree (vacuum degree is -0.05Mpa) and mixing speed are constant, immediately unlatching homogenizer progress homogeneous, homogenizing time 5min, homogeneous Revolving speed is 1000rpm；

(6) open temperature lowering water after the completion of homogeneous and be cooled to 45 DEG C, be added 20 parts by weight 2 skin matrix of embodiment and The water of 65.77 parts by weight stirs 22min (revolving speed 350rpm), and discharging obtains the essence comprising skin matrix.

Embodiment 21

A kind of preparation method of essence, comprising the following steps:

(1) dipropylene glycol of 4.5 parts by weight and the Sodium Hyaluronate of 0.1 parts by weight are mixed, opening stirring, (revolving speed is 800rpm) and 15min is stirred, obtains prefabricated A；

(2) methylparaben of the butanediol of 6.5 parts by weight and 0.15 parts by weight is mixed, opening stirring, (revolving speed is 800rpm), 65 DEG C are warming up to and, keeps the temperature spare, obtains prefabricated B；

(3) essence of 0.02 parts by weight and the Cremophor RH40 of 0.1 parts by weight are mixed, opens stirring (revolving speed For 600rpm), and 46 DEG C are warming up to, keep the temperature spare, obtains prefabricated C；

(4) water phase pot is added in prefabricated B, opens stirring (revolving speed 800rpm), adds prefabricated A, be warming up to 78 DEG C, protected Prefabricated C is added after warm 22min and keeps the temperature 15min again；

(5) after water phase pot material being sucked emulsion pot, emulsion pot stirring (revolving speed 350rpm) is opened, keeps vacuum degree (vacuum degree is -0.05Mpa) and mixing speed are constant, immediately unlatching homogenizer progress homogeneous, homogenizing time 4min, homogeneous Revolving speed is 1200rpm；

(6) open temperature lowering water after the completion of homogeneous and be cooled to 43 DEG C, be added 15 parts by weight 3 skin matrix of embodiment and The water of 73.63 parts by weight stirs 18min (revolving speed 450rpm), and discharging obtains the essence comprising skin matrix.

Embodiment 22

A kind of preparation method of essence, comprising the following steps:

(1) dipropylene glycol of 4 parts by weight and the Sodium Hyaluronate of 0.12 parts by weight are mixed, opening stirring, (revolving speed is 600rpm) and 16min is stirred, obtains prefabricated A；

(2) methylparaben of the butanediol of 6 parts by weight and 0.12 parts by weight is mixed, opening stirring, (revolving speed is 600rpm), 68 DEG C are warming up to and, keeps the temperature spare, obtains prefabricated B；

(3) essence of 0.01 parts by weight and the Cremophor RH40 of 0.12 parts by weight are mixed, opens stirring (revolving speed For 550rpm), and 42 DEG C are warming up to, keep the temperature spare, obtains prefabricated C；

(4) water phase pot is added in prefabricated B, opens stirring (revolving speed 700rpm), adds prefabricated A, be warming up to 80 DEG C, protected Prefabricated C is added after warm 15min and keeps the temperature 20min again；

(5) after water phase pot material being sucked emulsion pot, emulsion pot stirring (revolving speed 400rpm) is opened, keeps vacuum degree (vacuum degree is -0.05Mpa) and mixing speed are constant, immediately unlatching homogenizer progress homogeneous, homogenizing time 4min, homogeneous Revolving speed is 1300rpm；

(6) open temperature lowering water after the completion of homogeneous and be cooled to 42 DEG C, be added 20 parts by weight 4 skin matrix of embodiment and The water of 69.63 parts by weight stirs 20min (revolving speed 400rpm), and discharging obtains the essence comprising skin matrix.

Embodiment 23

A kind of preparation method of essence, comprising the following steps:

(1) dipropylene glycol of 5 parts by weight and the Sodium Hyaluronate of 0.08 parts by weight are mixed, opening stirring, (revolving speed is 800rpm) and 12min is stirred, obtains prefabricated A；

(2) methylparaben of the butanediol of 7 parts by weight and 0.18 parts by weight is mixed, opening stirring, (revolving speed is 700rpm), 62 DEG C are warming up to and, keeps the temperature spare, obtains prefabricated B；

(3) essence of 0.03 parts by weight and the Cremophor RH40 of 0.08 parts by weight are mixed, opens stirring (revolving speed For 650rpm), and 48 DEG C are warming up to, keep the temperature spare, obtains prefabricated C；

(4) water phase pot is added in prefabricated B, opens stirring (revolving speed 900rpm), adds prefabricated A, be warming up to 75 DEG C, protected Prefabricated C is added after warm 25min and keeps the temperature 10min again；

(5) after water phase pot material being sucked emulsion pot, emulsion pot stirring (revolving speed 500rpm) is opened, keeps vacuum degree (vacuum degree is -0.05Mpa) and mixing speed are constant, immediately unlatching homogenizer progress homogeneous, homogenizing time 5min, homogeneous Revolving speed is 1200rpm；

(6) open temperature lowering water after the completion of homogeneous and be cooled to 41 DEG C, be added 10 parts by weight 5 skin matrix of embodiment and The water of 75.63 parts by weight stirs 15min (revolving speed 500rpm), and discharging obtains the essence comprising skin matrix.

Embodiment 24

A kind of preparation method of essence, comprising the following steps:

(1) dipropylene glycol of 5.5 parts by weight and the Sodium Hyaluronate of 0.1 parts by weight are mixed, opening stirring, (revolving speed is 750rpm) and 16min is stirred, obtains prefabricated A；

(2) methylparaben of the butanediol of 6.5 parts by weight and 0.15 parts by weight is mixed, opening stirring, (revolving speed is 900rpm), 65 DEG C are warming up to and, keeps the temperature spare, obtains prefabricated B；

(3) essence of 0.02 parts by weight and the Cremophor RH40 of 0.06 parts by weight are mixed, opens stirring (revolving speed For 640rpm), and 47 DEG C are warming up to, keep the temperature spare, obtains prefabricated C；

(4) water phase pot is added in prefabricated B, opens stirring (revolving speed 800rpm), adds prefabricated A, be warming up to 85 DEG C, protected Prefabricated C is added after warm 15min and keeps the temperature 15min again；

(5) after water phase pot material being sucked emulsion pot, emulsion pot stirring (revolving speed 300rpm) is opened, keeps vacuum degree (vacuum degree is -0.05Mpa) and mixing speed are constant, immediately unlatching homogenizer progress homogeneous, homogenizing time 3min, homogeneous Revolving speed is 1400rpm；

(6) open temperature lowering water after the completion of homogeneous and be cooled to 44 DEG C, be added 15 parts by weight 6 skin matrix of embodiment and The water of 72.67 parts by weight stirs 25min (revolving speed 300rpm), and discharging obtains the essence comprising skin matrix.

Comparative example 16

A kind of preparation method of essence, wherein step (6) uses the skin matrix of comparative example 1, remaining step and implementation Example 19 is identical.

Comparative example 17

A kind of preparation method of essence, wherein step (6) uses the skin matrix of comparative example 2, remaining step and implementation Example 20 is identical.

Comparative example 18

A kind of preparation method of essence, wherein step (6) uses the skin matrix of comparative example 3, remaining step and implementation Example 21 is identical.

Comparative example 19

A kind of preparation method of essence, wherein step (6) uses the skin matrix of comparative example 4, remaining step and implementation Example 22 is identical.

Comparative example 20

A kind of preparation method of essence, wherein step (6) uses the skin matrix of comparative example 5, remaining step and implementation Example 23 is identical.

Test example

Skin matrix and essence to embodiment and comparative example carry out infrared resistant and anti-aging test, and not contain The essence of skin matrix is as control.

Experimental material: vitro in fibroblast；

Test method: infra red treatment is used again after handling experimental material with a certain amount of matrix sample, using ELISA method point Not Kao Cha vitro in fibroblast cause under a certain amount of infrared radiation that the burst size of MMP-1 changes and collagen contains Amount variation two indices.

Its test result is as shown in table 1.

Table 1 resists infrared ray and anti-aging test result using the skin matrix and essence of embodiment and comparative example

Note: matrix metalloproteinase (matrix metalloproteinase, MMP).

As it can be seen from table 1 the obtained skin matrix of the embodiment of the present invention 7~12 has good infrared resistant and anti-ageing Old effect, the Essence MMP-1 burst size of the embodiment of the present invention 19~24 is in 168~215pg/ml, and collagen concentration is 12 ~15ng/ml shows significant infrared resistant and anti-aging effects by joined skin matrix, without adding the present invention The Essence MMP-1 burst size of skin matrix is up to 270pg/ml or more, and collagen concentration only has 8ng/ml or so, it is seen then that Skin matrix of the invention has good infrared resistant and anti-aging effects.

Embodiment 7 optimizes tetrahydro methylpyrimidine carboxylic acid in skin matrix, thermus thermophilus fermentation compared with comparative example 6 The weight percent of product, Flos Buddlejae extract and recombination human source collagen in skin matrix, 7 skin matrix of embodiment Infrared resistant and anti-aging effects have further promotion compared with comparative example 6.

Comparative example 7 compared with Example 8, does not contain tetrahydro methylpyrimidine carboxylic acid in used matrix；Comparative example 8 and reality It applies example 9 to compare, thermus thermophilus tunning is not contained in matrix；Comparative example 9 does not contain close compared with Example 10, in matrix Cover flower extract；Comparative example 10 does not contain recombination human source collagen, obtained matrix and essence compared with embodiment 11 in matrix Magnificent liquid resist infrared ray and anti-aging effects are bad, it is seen then that tetrahydro methylpyrimidine carboxylic acid, thermophilic is added only in skin matrix Hot Thermus tunning, Flos Buddlejae extract and recombination human source collagen whole active constituent can be obtained and preferably be mentioned Bright effect, collocation of the skin matrix of the present invention Jing Guo several effective components, can effectively resist infrared ray and anti-aging, illustrate this A few money effective components play synergistic effect by reasonable collocation, can just give full play to and resist infrared ray and anti-aging effect Fruit.

Although illustrate and describing the present invention with specific embodiment, it will be appreciated that without departing substantially from of the invention Many other change and modification can be made in the case where spirit and scope.It is, therefore, intended that wrapping in the following claims Include all such changes and modifications belonged in the scope of the invention.

Claims

1. a kind of skin matrix, which is characterized in that the skin matrix includes following component: tetrahydro methylpyrimidine carboxylic acid, thermophilic Thermus tunning, Flos Buddlejae extract and recombination human source collagen；

Tetrahydro methylpyrimidine carboxylic acid 3~10%, thermus thermophilus tunning 15~50%, Flos Buddlejae extract 10~20%, Recombination human source collagen 1~2%, surplus are water.

2. skin matrix according to claim 1, which is characterized in that the skin matrix includes the as follows of weight percent Component: tetrahydro methylpyrimidine carboxylic acid 5~8%, thermus thermophilus tunning 20~40%, Flos Buddlejae extract 12~18%, Recombination human source collagen 1~2%, surplus are water.

3. skin matrix according to claim 1, which is characterized in that the skin matrix includes the as follows of weight percent Component: tetrahydro methylpyrimidine carboxylic acid 5~6%, thermus thermophilus tunning 20~30%, Flos Buddlejae extract 12~15%, Recombination human source collagen 1~1.5%, surplus are water.

4. a kind of preparation method of the described in any item skin matrixes of claim 1-3, which comprises the following steps:

Tetrahydro methylpyrimidine carboxylic acid, thermus thermophilus tunning, Flos Buddlejae extract, recombination human source collagen and water are filled Skin matrix is obtained after dividing mixing.

5. the preparation method of skin matrix according to claim 4, which comprises the following steps:

(b) clear solution of thermus thermophilus tunning and Flos Buddlejae extract and step (a) is sufficiently mixed and is cooled down, obtained To skin matrix.

6. preparation method according to claim 5, which is characterized in that mixing temperature is 35~45 DEG C in step (a)；With/ Or,

Mixing velocity is 800~1000rpm in step (a)；And/or

Incorporation time is 15~30min in step (a).

7. preparation method according to claim 5, which is characterized in that mixing temperature is 35~45 DEG C in step (a)；With/ Or,

Mixing velocity is 800~1000rpm in step (a)；And/or

Incorporation time is 20~30min in step (a).

8. preparation method according to claim 5, which is characterized in that mixing temperature is 35~45 DEG C in step (a)；With/ Or,

Mixing velocity is 800~1000rpm in step (a)；And/or

Incorporation time is 25~30min in step (a).

9. preparation method according to claim 5, which is characterized in that mixing temperature is 40~45 DEG C in step (a)；With/ Or,

Mixing velocity is 800~1000rpm in step (a)；And/or

Incorporation time is 15~30min in step (a).

10. preparation method according to claim 5, which is characterized in that mixing temperature is 40~45 DEG C in step (a)；With/ Or,

Mixing velocity is 800~1000rpm in step (a)；And/or

Incorporation time is 20~30min in step (a).

11. preparation method according to claim 5, which is characterized in that mixing temperature is 40~45 DEG C in step (a)；With/ Or,

Mixing velocity is 800~1000rpm in step (a)；And/or

Incorporation time is 25~30min in step (a).

12. preparation method according to claim 5, which is characterized in that mixing temperature is 42~45 DEG C in step (a)；With/ Or,

Mixing velocity is 800~1000rpm in step (a)；And/or

Incorporation time is 15~30min in step (a).

13. preparation method according to claim 5, which is characterized in that mixing temperature is 42~45 DEG C in step (a)；With/ Or,

Mixing velocity is 800~1000rpm in step (a)；And/or

Incorporation time is 20~30min in step (a).

14. preparation method according to claim 5, which is characterized in that mixing temperature is 42~45 DEG C in step (a)；With/ Or,

Mixing velocity is 800~1000rpm in step (a)；And/or

Incorporation time is 25~30min in step (a).

15. preparation method according to claim 5, which is characterized in that in step (b) mixing velocity be 800~ 1000rpm；And/or

Incorporation time is 5~10min in step (b)；And/or

Cooling temperature is 15~25 DEG C in step (b).

16. preparation method according to claim 5, which is characterized in that in step (b) mixing velocity be 800~ 1000rpm；And/or

Incorporation time is 5~10min in step (b)；And/or

Cooling temperature is 20~25 DEG C in step (b).

17. preparation method according to claim 5, which is characterized in that in step (b) mixing velocity be 800~ 1000rpm；And/or

Incorporation time is 5~10min in step (b)；And/or

Cooling temperature is 22~25 DEG C in step (b).

18. preparation method according to claim 5, which is characterized in that in step (b) mixing velocity be 800~ 1000rpm；And/or

Incorporation time is 6~10min in step (b)；And/or

Cooling temperature is 15~25 DEG C in step (b).

19. preparation method according to claim 5, which is characterized in that in step (b) mixing velocity be 800~ 1000rpm；And/or

Incorporation time is 6~10min in step (b)；And/or

Cooling temperature is 20~25 DEG C in step (b).

20. preparation method according to claim 5, which is characterized in that in step (b) mixing velocity be 800~ 1000rpm；And/or

Incorporation time is 6~10min in step (b)；And/or

Cooling temperature is 22~25 DEG C in step (b).

21. preparation method according to claim 5, which is characterized in that in step (b) mixing velocity be 800~ 1000rpm；And/or

Incorporation time is 8~10min in step (b)；And/or

Cooling temperature is 15~25 DEG C in step (b).

22. preparation method according to claim 5, which is characterized in that in step (b) mixing velocity be 800~ 1000rpm；And/or

Incorporation time is 8~10min in step (b)；And/or

Cooling temperature is 20~25 DEG C in step (b).

23. preparation method according to claim 5, which is characterized in that in step (b) mixing velocity be 800~ 1000rpm；And/or

Incorporation time is 8~10min in step (b)；And/or

Cooling temperature is 22~25 DEG C in step (b).

24. the described in any item skin matrixes of claim 1-3 are preparing the application in anti-aging cosmetics.

25. a kind of cosmetics including the described in any item skin matrixes of claim 1-3.

26. according to the cosmetics described in claim 25, which is characterized in that weight percent of the skin matrix in cosmetics Than being 10~20%.

27. according to cosmetics described in claim 25 or 26, which is characterized in that the cosmetics include weight percent as Lower component:

Component A: dipropylene glycol 3.0~6.0%, Sodium Hyaluronate 0.05~0.15%；

B component: butanediol 5.0~8.0%, methylparaben 0.1~0.2%；

Component C: Cremophor RH40 0.05~0.15%；

D component: skin matrix 10~20%；

Surplus is water.

28. the cosmetics according to claim 25 or 26, which is characterized in that the cosmetics include weight percent as Lower component:

Component A: dipropylene glycol 4.0~6.0%, Sodium Hyaluronate 0.08~0.15%；

B component: butanediol 5.0~7.0%, methylparaben 0.15~0.2%；

Component C: Cremophor RH40 0.08~0.15%；

D component: skin matrix 15~20%；

Surplus is water.

29. the cosmetics according to claim 25 or 26, which is characterized in that the cosmetics include weight percent as Lower component:

Component A: dipropylene glycol 5.0~6.0%, Sodium Hyaluronate 0.1~0.15%；

B component: butanediol 5.0~6.0%, methylparaben 0.15~0.2%；

Component C: Cremophor RH40 0.1~0.15%；

D component: skin matrix 15~20%；

Surplus is water.

30. cosmetics according to claim 25, which is characterized in that the cosmetics further include essence；The essence exists Weight percent in cosmetics is 0.01~0.03%.

31. a kind of preparation method of the described in any item cosmetics of claim 25-30, which comprises the following steps:

Fully emulsified and homogeneous after component A, B component and component C are carried out mixing heating and kept the temperature is added D component, appoints after cooling The essence and water of choosing, obtain cosmetics after mixing.

32. according to the preparation method of the cosmetics described in claim 31, which comprises the following steps:

(d) prefabricated component A is mixed to heat up and prefabricated component C is added after keeping the temperature with prefabricated B component and is kept the temperature again, obtain mixed liquor；

(f) D component and water are added after cooling down, obtains cosmetics after mixing.

33. the preparation method of cosmetics according to claim 32, which is characterized in that mixing velocity is 500 in step (a) ~1000rpm；And/or

Incorporation time is 10~20min.

34. the preparation method of cosmetics according to claim 32, which is characterized in that mixing velocity is 500 in step (b) ~1000rpm；And/or

Warming temperature is 60~70 DEG C.

35. the preparation method of cosmetics according to claim 32, which is characterized in that mixing velocity is 500 in step (c) ~700rpm；And/or

Warming temperature is 45~50 DEG C.

36. the preparation method of cosmetics according to claim 32, which is characterized in that mixing velocity is 600 in step (d) ~1000rpm；And/or

Warming temperature is 75~85 DEG C；And/or

Soaking time is 10~25min.

37. the preparation method of cosmetics according to claim 32, which is characterized in that emulsifying rate is 300 in step (e) ~500rpm；And/or

Vacuum degree is -0.05~-0.1MPa when emulsification；And/or

Homogeneous speed is 1000~1500rpm；And/or

Homogenizing time is 3~5min.

38. the preparation method of cosmetics according to claim 32, which is characterized in that step (f) cool down temperature be 40~ 45℃；And/or

Mixing velocity is 300~500rpm；And/or

Incorporation time is 15~25min.