CN111920728A - Cosmetic relieving and repairing composition and cosmetic - Google Patents

Cosmetic relieving and repairing composition and cosmetic Download PDF

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CN111920728A
CN111920728A CN202010677820.XA CN202010677820A CN111920728A CN 111920728 A CN111920728 A CN 111920728A CN 202010677820 A CN202010677820 A CN 202010677820A CN 111920728 A CN111920728 A CN 111920728A
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extract
parts
cosmetic
soothing
chamomile
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林际凤
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Aiximei Zhuhai Biotechnology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

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Abstract

The invention provides a cosmetic relieving and repairing composition and a cosmetic, wherein the relieving and repairing composition comprises the following components in parts by weight: 5-20 parts of mint leaf extract, 0.5-3 parts of pelargonium graveolens extract, 1-5 parts of golden chamomile extract, 2-10 parts of sophora flavescens root extract, 2-10 parts of purslane extract and 3-8 parts of aloe barbadensis extract. The cosmetic soothing and repairing composition has the effects of resisting allergy, relieving itching, inhibiting inflammation, reducing skin injury, repairing skin cells and maintaining skin moisture, and the cooperation of the mint leaf extract, the geranium extract, the chamomile extract, the sophora flavescens root extract, the purslane extract and the aloe barbadensis extract has the effects of synergistically improving the effects of resisting allergy, relieving itching, inhibiting inflammation, reducing skin injury, repairing skin cells and maintaining skin moisture of the cosmetic soothing and repairing composition.

Description

Cosmetic relieving and repairing composition and cosmetic
Technical Field
The invention relates to the field of cosmetics, and particularly relates to a cosmetic soothing and repairing composition and a cosmetic.
Background
With the continuous improvement of living standard, people pay more and more attention to their appearance and image after satisfying the problem of being full of warmness, and the requirements for skin care products are higher and higher, and in addition to the most basic effects of skin care and beautifying and concealing, people tend to pursue the change of their skin by using skin care products, such as whitening, spot removal, skin tension and elasticity increase, and the like. However, most of the existing cosmetic products contain many chemical components, which can cause certain stimulation to human skin, especially some chemical synthetic products also contain lead, alcohol, lemon oil, pigment, preservative and the like, so that the cosmetic products are not only extremely bad for human health but also cause skin relaxation, edema, thin horny layer, easy allergy and the like after long-term use, and especially the existing mask products are generally added with activating components to promote the absorption of nutrient components by skin, so that although the problem of skin can be temporarily relieved, the skin becomes more and more fragile and easy to age after long-term use. Therefore, how to select green, healthy and safe cosmetics is of great significance.
Disclosure of Invention
The invention aims to overcome the defects in the prior art, provides a cosmetic soothing and repairing composition and a cosmetic, and improves the effects of resisting allergy, relieving itching, inhibiting inflammation, reducing skin damage, repairing skin cells and maintaining skin moisture of the cosmetic soothing and repairing composition and the cosmetic.
In order to achieve the purpose, the invention adopts the technical scheme that: a cosmetic soothing and repairing composition comprises the following components in parts by weight: 5-20 parts of mint leaf extract, 0.5-3 parts of pelargonium graveolens extract, 1-5 parts of golden chamomile extract, 2-10 parts of sophora flavescens root extract, 2-10 parts of purslane extract and 3-8 parts of aloe barbadensis extract.
The cosmetic soothing and repairing composition is matched with the mint leaf EXTRACT (MENTHA ARVENSIS LEAF EXTRACT), the PELARGONIUM GRAVEOLENS EXTRACT (PELARGONIUM GRAVEOLENS EXTRACT), the golden chamomile EXTRACT (CHRYSANTHELLUM INDICAUM EXTRACT), the bitter ginseng ROOT EXTRACT (SOPHORA ANGUTIFOLIA ROOT EXTRACT), the purslane EXTRACT (Portulaca Oleracea EXTRACT) and the ALOE BARBADENSIS EXTRACT (ALOE BARBARBADENSIS), so that the effects of anti-allergy itching, inflammation inhibition, skin injury repair skin cell reduction and skin moisture maintenance of the cosmetic soothing and repairing composition are improved, and the matching of the mint leaf EXTRACT, the PELARGONIUM GRAVEOLENS EXTRACT, the golden chamomile EXTRACT, the bitter ginseng ROOT EXTRACT, the purslane EXTRACT and the ALOE BARBADENSIS EXTRACT synergistically improves the effects of anti-allergy itching, inflammation inhibition, skin injury repair skin cell reduction and skin moisture maintenance of the cosmetic soothing and repairing composition, compositions lacking any of the above components result in a significant reduction in anti-allergic, antipruritic, anti-inflammatory, skin damage reduction, skin cell repair and skin moisture maintenance benefits.
Preferably, the soothing repair composition comprises the following components in parts by weight: 5-20 parts of mint leaf extract, 0.5-3 parts of pelargonium graveolens extract, 1-5 parts of golden chamomile extract, 5-10 parts of sophora flavescens root extract, 5-10 parts of purslane extract and 3-8 parts of aloe barbadensis extract.
Preferably, the weight ratio of the mint leaf extract to the geranium extract to the chamomile extract to the aloe vera extract in the soothing and repairing composition is as follows: geranium extract: golden yellow chamomile extract: aloe vera extract (10-20): (0.5-3): (2-4): (3-8).
The inventor discovers, through research, that when the weight ratio of the mint leaf extract to the geranium extract to the chamomile extract to the aloe vera extract in the soothing and repairing composition is (10-20): (0.5-3): (2-4): (3-8), the soothing and repairing composition has better effects of anti-allergy, relieving itching, inhibiting inflammation, reducing skin injury, repairing skin cells and maintaining skin moisture.
Preferably, the weight ratio of the mint leaf extract to the geranium extract to the chamomile extract to the aloe vera extract in the soothing and repairing composition is as follows: geranium extract: golden yellow chamomile extract: aloe vera extract (10-20): (0.5-3): (2-4): (4.5-7).
The inventor discovers, through research, that when the weight ratio of the mint leaf extract to the geranium extract to the chamomile extract to the aloe vera extract in the soothing and repairing composition is (10-20): (0.5-3): (2-4): (4.5-7), the soothing and repairing composition has better effects of resisting allergy, relieving itching, inhibiting inflammation, reducing skin injury, repairing skin cells and maintaining skin moisture.
Preferably, the weight ratio of the mint leaf extract to the geranium extract to the chamomile extract to the aloe vera extract in the soothing and repairing composition is as follows: geranium extract: golden yellow chamomile extract: aloe vera extract (10-20): (1-2): (2-4): (4.5-7).
The inventor discovers, through research, that when the weight ratio of the mint leaf extract to the geranium extract to the chamomile extract to the aloe vera extract in the soothing and repairing composition is (10-20): (1-2): (2-4): (4.5-7), the soothing and repairing composition has better effects of resisting allergy, relieving itching, inhibiting inflammation, reducing skin injury, repairing skin cells and maintaining skin moisture.
Preferably, the weight ratio of the mint leaf extract to the geranium extract to the chamomile extract to the aloe vera extract in the soothing and repairing composition is as follows: geranium extract: golden yellow chamomile extract: aloe vera extract (10-20): (1-1.5): (2-4): (4.5-7).
The inventor discovers, through research, that when the weight ratio of the mint leaf extract to the geranium extract to the chamomile extract to the aloe vera extract in the soothing and repairing composition is (10-20): (1-1.5): (2-4): (4.5-7), the soothing and repairing composition has better effects of resisting allergy, relieving itching, inhibiting inflammation, reducing skin injury, repairing skin cells and maintaining skin moisture.
Preferably, the weight ratio of the mint leaf extract to the geranium extract to the chamomile extract to the aloe vera extract in the soothing and repairing composition is as follows: geranium extract: golden yellow chamomile extract: aloe vera extract (15-20): (1-1.5): (3-4): (4.5-7).
The inventor discovers, through research, that when the weight ratio of the mint leaf extract to the geranium extract to the chamomile extract to the aloe vera extract in the soothing and repairing composition is (15-20): (1-1.5): (3-4): (4.5-7), the soothing and repairing composition has better effects of resisting allergy, relieving itching, inhibiting inflammation, reducing skin injury, repairing skin cells and maintaining skin moisture.
Preferably, the weight ratio of the mint leaf extract to the geranium extract to the chamomile extract to the aloe vera extract in the soothing and repairing composition is as follows: geranium extract: golden yellow chamomile extract: aloe vera extract (15-20): (1-1.5): (3-4): (6-7).
The inventor discovers, through research, that when the weight ratio of the mint leaf extract to the geranium extract to the chamomile extract to the aloe vera extract in the soothing and repairing composition is (15-20): (1-1.5): (3-4): (6-7), the soothing and repairing composition has better effects of anti-allergy, relieving itching, inhibiting inflammation, reducing skin injury, repairing skin cells and maintaining skin moisture.
The present invention also provides a cosmetic product comprising a cosmetic soothing repair composition as described in any of the above.
When the cosmetic soothing and repairing composition is applied to cosmetics, the effects of resisting allergy, relieving itching, inhibiting inflammation, reducing skin injury, repairing skin cells and maintaining skin moisture of the cosmetics can be improved.
Preferably, the cosmetic soothing and repairing composition accounts for 0.5-0.8% of the total weight of the cosmetic, and the cosmetic further comprises glycerin, water, butanediol and potassium sorbate.
When the cosmetic soothing and repairing composition accounts for 0.5-0.8% of the total weight of the cosmetic, the cosmetic has good effects of resisting allergy, relieving itching, inhibiting inflammation, reducing skin injury, repairing skin cells and maintaining skin moisture, and is low in cost.
The invention has the beneficial effects that: the invention provides a cosmetic relieving and repairing composition and a cosmetic, the cosmetic relieving and repairing composition is matched with a mint leaf extract, a pelargonium graveolens extract, a chamomile extract, a sophora flavescens root extract, a purslane extract and an aloe vera extract, so that the anti-allergy itching relieving, inflammation inhibiting, skin injury reduction, skin cell repair and skin moisture maintaining effects of the cosmetic relieving and repairing composition are improved, the matching of the mint leaf extract, the pelargonium graveolens extract, the chamomile extract, the sophora flavescens root extract, the purslane extract and the aloe vera extract has the effects of synergistically improving the anti-allergy itching relieving, inflammation inhibiting, skin injury reduction, skin cell repair and skin moisture maintaining effects of the cosmetic relieving and repairing composition, and the composition lacking any one of the components can cause the anti-allergy itching relieving, inflammation inhibiting, itching relieving, skin injury, skin cell repair and skin moisture maintaining effects of the cosmetic relieving and repairing composition, The efficacy of inhibiting inflammation, reducing skin injury, repairing skin cells and maintaining skin moisture is obviously reduced. The invention firstly uses low temperature technology to extract monomer effective active substances in single plants, and then carries out gold proportioning to obtain the effects of anti-allergy and relieving itching.
Drawings
FIG. 1 is a graph of the effect of scavenging free radicals of a cosmetic soothing repair composition according to an embodiment of the present invention.
FIG. 2 is a graph of the effect of a cosmetic soothing repair composition of an embodiment of the present invention in reducing histamine release.
FIG. 3 is a graph of the effect of a cosmetic soothing repair composition of an embodiment of the present invention in reducing interleukin 1-alpha release.
FIG. 4 is a graph of the cell detoxification efficacy of a cosmetic soothing repair composition according to an embodiment of the present invention.
FIG. 5 is a graph of the skin soothing effect of a cosmetic soothing repair composition according to an embodiment of the present invention.
FIG. 6 is a graph of the effect of reducing water loss of a cosmetic soothing repair composition according to an embodiment of the present invention.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
A cosmetic soothing and repairing composition comprises the following components in parts by weight: 5-20 parts of mint leaf extract, 0.5-3 parts of pelargonium graveolens extract, 1-5 parts of golden chamomile extract, 2-10 parts of sophora flavescens root extract, 2-10 parts of purslane extract and 3-8 parts of aloe barbadensis extract.
Example 1
As an embodiment of the present invention, a cosmetic soothing repair composition comprises the following components in parts by weight: 15 parts of mint leaf extract, 1.5 parts of pelargonium graveolens extract, 4 parts of chamomile extract, 5 parts of sophora flavescens root extract, 5 parts of purslane extract and 6 parts of aloe barbadensis extract.
Example 2
As an embodiment of the present invention, a cosmetic soothing repair composition comprises the following components in parts by weight: 15 parts of mint leaf extract, 1.5 parts of pelargonium graveolens extract, 4 parts of chamomile extract, 5 parts of sophora flavescens root extract, 5 parts of purslane extract and 3 parts of aloe vera extract.
Example 3
As an embodiment of the present invention, a cosmetic soothing repair composition comprises the following components in parts by weight: 15 parts of mint leaf extract, 1.5 parts of pelargonium graveolens extract, 4 parts of chamomile extract, 5 parts of sophora flavescens root extract, 5 parts of purslane extract and 4.5 parts of aloe vera extract.
Example 4
As an embodiment of the present invention, a cosmetic soothing repair composition comprises the following components in parts by weight: 15 parts of mint leaf extract, 1.5 parts of pelargonium graveolens extract, 4 parts of chamomile extract, 5 parts of sophora flavescens root extract, 5 parts of purslane extract and 7 parts of aloe barbadensis extract.
Example 5
As an embodiment of the present invention, a cosmetic soothing repair composition comprises the following components in parts by weight: 15 parts of mint leaf extract, 1.5 parts of pelargonium graveolens extract, 4 parts of chamomile extract, 5 parts of sophora flavescens root extract, 5 parts of purslane extract and 8 parts of aloe barbadensis extract.
Example 6
As an embodiment of the present invention, a cosmetic soothing repair composition comprises the following components in parts by weight: 15 parts of mint leaf extract, 1.5 parts of pelargonium graveolens extract, 1 part of chamomile extract, 5 parts of sophora flavescens root extract, 5 parts of purslane extract and 6 parts of aloe barbadensis extract.
Example 7
As an embodiment of the present invention, a cosmetic soothing repair composition comprises the following components in parts by weight: 15 parts of mint leaf extract, 1.5 parts of pelargonium graveolens extract, 2 parts of chamomile extract, 5 parts of sophora flavescens root extract, 5 parts of purslane extract and 6 parts of aloe barbadensis extract.
Example 8
As an embodiment of the present invention, a cosmetic soothing repair composition comprises the following components in parts by weight: 15 parts of mint leaf extract, 1.5 parts of pelargonium graveolens extract, 3 parts of chamomile extract, 5 parts of sophora flavescens root extract, 5 parts of purslane extract and 6 parts of aloe barbadensis extract.
Example 9
As an embodiment of the present invention, a cosmetic soothing repair composition comprises the following components in parts by weight: 15 parts of mint leaf extract, 1.5 parts of pelargonium graveolens extract, 5 parts of chamomile extract, 5 parts of sophora flavescens root extract, 5 parts of purslane extract and 6 parts of aloe barbadensis extract.
Example 10
As an embodiment of the present invention, a cosmetic soothing repair composition comprises the following components in parts by weight: 15 parts of mint leaf extract, 0.5 part of pelargonium graveolens extract, 4 parts of chamomile extract, 5 parts of sophora flavescens root extract, 5 parts of purslane extract and 6 parts of aloe barbadensis extract.
Example 11
As an embodiment of the present invention, a cosmetic soothing repair composition comprises the following components in parts by weight: 15 parts of mint leaf extract, 1 part of pelargonium graveolens extract, 4 parts of golden chamomile extract, 5 parts of sophora flavescens root extract, 5 parts of purslane extract and 6 parts of aloe vera extract.
Example 12
As an embodiment of the present invention, a cosmetic soothing repair composition comprises the following components in parts by weight: 15 parts of mint leaf extract, 2 parts of pelargonium graveolens extract, 4 parts of golden chamomile extract, 5 parts of sophora flavescens root extract, 5 parts of purslane extract and 6 parts of aloe vera extract.
Example 13
As an embodiment of the present invention, a cosmetic soothing repair composition comprises the following components in parts by weight: 15 parts of mint leaf extract, 3 parts of pelargonium graveolens extract, 4 parts of golden chamomile extract, 5 parts of sophora flavescens root extract, 5 parts of purslane extract and 6 parts of aloe vera extract.
Example 14
The cosmetic provided by the embodiment of the invention comprises the soothing and repairing composition provided by any one of embodiments 1-13, wherein the soothing and repairing composition is 0.2% -0.8% of the weight of the cosmetic, and the cosmetic further comprises glycerol, water, butanediol and potassium sorbate.
Effect example 1
1. DPPH radical scavenging test for cosmetic soothing repair compositions
The test was carried out according to the method specified in Larrauri JA, preparing a 20mmol/L DPPH solution.
Test sample solution: the cosmetic soothing restoration composition of example 1 was dissolved in a mixed solvent of glycerin and water at a volume ratio of 1:5, and the mass concentration of the cosmetic soothing restoration composition was 0.1%, 0.2%, 0.4%, 0.5%, 0.8%.
Taking 2.0mL of test sample solution and 2.0mL of 20mmol/LDPPH solution in a test tube, mixing uniformly, reacting for 30min, measuring absorbance value at 517nm, and using absolute ethyl alcohol as blank control. And calculating the DPPH inhibition rate according to the absorbance value.
DPPH free radical inhibition (%) [1- (a1-a2)/A3] x 100%
Wherein A1 is the absorbance of 2.0mL of PPH solution and 2.0mL of test sample solution; a2 is the absorbance of 2.0mL of the test sample solution with 2.0mL of absolute ethanol; a3 is the absorbance of 2.0mL of DPPH solution with 2.0mL of absolute ethanol.
Triplicate tests were averaged.
The results are shown in table 1 and fig. 1.
Figure BDA0002584114500000081
Figure BDA0002584114500000091
2. Effect of cosmetic soothing repair compositions on histamine release from KU812 cells
Human peripheral blood basophilic (KU812) cells were often used as effector cells for studying allergic reactions, and the effect of samples on histamine release from KU812 cells was examined using KU812 cell histamine release model.
Preparing and treating a test sample: the solution of the cosmetic soothing repair composition of example 1 was prepared in DMSO and diluted in 10% fetal bovine serum medium to a cosmetic soothing repair composition concentration of 0.2%, 0.4%, 0.5%, 0.8%.
Cell culture and model establishment: the cells were diluted with IMDM medium containing 10% fetal bovine serum to adjust the cell density to 2.2X 106Per mL, then will getThe resulting cell suspension was seeded in a 96-well plate in an amount of 180. mu.L per well.
Divided into model control group, cosmetic slow repair composition experimental group, blank control group, each group is provided with 3 parallels, 37 deg.C, 5% CO2Culturing and standing for 10min in an incubator, adding 20 mu L of a test sample into each experimental component of the cosmetic soothing repair composition, adding 20 mu L of culture solution into each blank control component and each model control component, placing the mixture into the incubator for pre-incubation, adding 40nM crotyl alcohol-12-tetradecanoate-13-acetate (PMA) and 1 mu m calcium ionophore A23187 into each group of cells except the cell blank control group after 2h, and preparing the PMA and the A23187 by using DMSO. The blank control group was added to the same volume of medium containing equal concentrations of DMSO.
Index detection: and centrifuging the cells after 2 hours, collecting cell supernatant, and determining the content of histamine in the supernatant according to the instruction of a histamine ELISA detection kit.
The histamine release inhibition rate (%) (histamine content in model group-histamine content in experimental group)/histamine content in model group × 100%.
Triplicate tests were averaged. The results are shown in FIG. 2.
3. Effect of cosmetic soothing repair composition on expression of KU812 cell proinflammatory cytokines
The effect of the sample on the expression of pro-inflammatory cytokines by KU812 cells was examined using KU812 cell histamine release model.
Preparing and treating a test sample: the solution of the cosmetic soothing and repairing composition of example 1 was prepared with DMSO at 10% mass and diluted with 10% fetal bovine serum medium to 0.05%, 0.10%, 0.20%, 1.00% concentration. Sodium lauryl sulfate at the same concentration was used as a control.
KU812 cells were diluted with 10% fetal bovine serum-containing IMDM medium to adjust the cell density to 2.2X 106one/mL, the resulting cell suspension was then seeded in 96-well plates at 180 μ L per well.
Divided into model control group, cosmetic soothing and repairing composition experimental group, blank control group, perThe group is provided with 3 parallels of 5% CO at 37 ℃2Culturing and standing for 10min in an incubator, adding 20 mu L of a test sample into each experimental component of the cosmetic soothing repair composition, adding 20 mu L of culture solution into each blank control component and each model control component, pre-incubating in the incubator, adding 40nM PMA and 1 mu m A23187 into each group of cells after 2h except the blank control group of the cells, and preparing the PMA and the A23187 by using DMSO. The blank control group was added to the same volume of medium containing equal concentrations of DMSO.
Index detection: and after 2h of culture, centrifugally separating the cells, collecting cell supernatant, and determining the content of the IL-1 alpha in the cell supernatant.
Triplicate tests were averaged. The results are shown in FIG. 3.
4. Cell detoxification experiment.
The test scheme is as follows:
test objects: human fibroblast cells are generated by the human body,
destructive solution: 0.5% chloroform
Antidote: the cosmetic soothing restoration composition of example 1 was dissolved in a mixed solvent of glycerin and water in a volume ratio of 1:5, and the mass concentration of the cosmetic soothing restoration composition was 0.5%.
The results are shown in fig. 4, where 4(a) is a blank control, fig. 4(b) is a picture after applying a destructive solution, the cell damage is more, and fig. 4(c) is a picture after detoxifying the cosmetic soothing repair composition of the example, the cell damage is reduced, which shows that the cosmetic soothing repair composition of example 1 at a concentration of 0.5% has a good detoxifying effect on human fibroblasts.
5. Test for soothing Effect
The method comprises the following steps: double-blind test method
Test objects: adult arm inner skin
Destructive testing: and blocking the sodium dodecyl sulfate solution with the mass concentration of 12% for 6 hours.
Time: and 3 days.
A: 12% strength by mass sodium lauryl sulfate solution + placebo
B: sodium dodecyl sulfate solution with mass concentration of 12%
C: 12% by mass sodium lauryl sulfate solution + 0.5% by mass cosmetic soothing repair composition of example 1.
The results are shown in FIG. 5. As shown in fig. 5, the cosmetic soothing and restoring composition of example 1 having a mass concentration of 0.5% is effective in suppressing erythema caused by a highly irritating surfactant and a solvent and soothing the skin.
6. Moisture percutaneous loss (TEWL) determination
The magnitude of TEWL is also an important indicator for evaluating the strength of the skin barrier function.
15 healthy subjects of 20-40 years old are selected and divided into 3 groups, the subjects have no history of skin diseases, the tested parts are normal, and no medicine or cosmetics which are irrelevant to the experiment are smeared during the testing period. The temperature of the test environment is controlled at 25 +/-1 ℃, the relative humidity is 40 +/-5%, pure water at about 36 ℃ is used for wiping the two arms of the testee before the test, and the testee is allowed to sit still for 30min in the test environment for testing.
Test sample solution: (a) sodium dodecyl sulfate solution with mass concentration of 12%
(b) 12% strength by mass sodium lauryl sulfate solution + placebo
(c) The cosmetic soothing restoration composition of example 1 was dissolved in a mixed solvent of glycerin and water in a volume ratio of 1:5, and the mass concentration of the cosmetic soothing restoration composition was 0.5%.
The area of each subject was marked 5cm inside the arm from the base of the palm, with an area size of 4X 4cm2A plurality of regions are marked on the arm of the same subject, and each region is spaced by about 1 cm. The test sample, the blank control and the positive control sample are coated on different areas of the arm of the same subject, and are randomly distributed when being coated. After the original value of each tested area is measured, about 500 mu L of the test solution is applied to each tested area, and the skin water dispersion loss of the tested area is measured by an instrument after 3h of application, so that the moisturizing performance of the cosmetic soothing and repairing composition is evaluated according to the relative moisturizing value. All experimental data were read after stable data was obtainedNumber, measurement is the average of readings.
The results are shown in FIG. 6. From fig. 6, it can be seen that the cosmetic soothing repair composition of example 1 at a concentration of 0.5% is effective in protecting the skin barrier, reducing the loss of water from the skin, and reducing the irritation of the skin by external substances.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims (10)

1. The cosmetic soothing and repairing composition is characterized by comprising the following components in parts by weight: 5-20 parts of mint leaf extract, 0.5-3 parts of pelargonium graveolens extract, 1-5 parts of golden chamomile extract, 2-10 parts of sophora flavescens root extract, 2-10 parts of purslane extract and 3-8 parts of aloe barbadensis extract.
2. The cosmetic soothing repair composition of claim 1, wherein the soothing repair composition comprises the following components in parts by weight: 5-20 parts of mint leaf extract, 0.5-3 parts of pelargonium graveolens extract, 1-5 parts of golden chamomile extract, 5-10 parts of sophora flavescens root extract, 5-10 parts of purslane extract and 3-8 parts of aloe barbadensis extract.
3. The cosmetic soothing repair composition according to claim 1 or 2, wherein the weight ratio of mint leaf extract, geranium extract, chamomile extract and aloe vera extract in the soothing repair composition is mint leaf extract: geranium extract: golden yellow chamomile extract: aloe vera extract (10-20): (0.5-3): (2-4): (3-8).
4. The cosmetic soothing repair composition of claim 3, wherein the weight ratio of mint leaf extract, geranium extract, chamomile extract, aloe vera extract in the soothing repair composition is mint leaf extract: geranium extract: golden yellow chamomile extract: aloe vera extract (10-20): (0.5-3): (2-4): (4.5-7).
5. The cosmetic soothing repair composition of claim 3, wherein the weight ratio of mint leaf extract, geranium extract, chamomile extract, aloe vera extract in the soothing repair composition is mint leaf extract: geranium extract: golden yellow chamomile extract: aloe vera extract (10-20): (1-2): (2-4): (4.5-7).
6. The cosmetic soothing repair composition of claim 3, wherein the weight ratio of mint leaf extract, geranium extract, chamomile extract, aloe vera extract in the soothing repair composition is mint leaf extract: geranium extract: golden yellow chamomile extract: aloe vera extract (10-20): (1-1.5): (2-4): (4.5-7).
7. The cosmetic soothing repair composition of claim 3, wherein the weight ratio of mint leaf extract, geranium extract, chamomile extract, aloe vera extract in the soothing repair composition is mint leaf extract: geranium extract: golden yellow chamomile extract: aloe vera extract (15-20): (1-1.5): (3-4): (4.5-7).
8. The cosmetic soothing repair composition of claim 3, wherein the weight ratio of mint leaf extract, geranium extract, chamomile extract, aloe vera extract in the soothing repair composition is mint leaf extract: geranium extract: golden yellow chamomile extract: aloe vera extract (15-20): (1-1.5): (3-4): (6-7).
9. A cosmetic product comprising a cosmetic soothing repair composition according to any of claims 1 to 8.
10. The cosmetic according to claim 9, wherein the cosmetic soothing repair composition according to any one of claims 1 to 8 further comprises glycerin, water, butylene glycol and potassium sorbate, in an amount of 0.5% to 0.8% by weight of the total weight of the cosmetic.
CN202010677820.XA 2020-07-14 2020-07-14 Cosmetic relieving and repairing composition and cosmetic Pending CN111920728A (en)

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CN112641701A (en) * 2020-12-25 2021-04-13 云南科妍医药生物科技有限公司 Whitening and freckle removing composition, repairing cream and preparation method thereof
CN112915055A (en) * 2021-03-08 2021-06-08 广州智尚生物科技有限公司 Multi-effect mite-killing-relieving composition and application thereof
CN113018222A (en) * 2021-04-12 2021-06-25 东晟源研究院(广州)有限公司 Multi-effect cream for barrier repair of sensitive skin
CN115554202A (en) * 2022-04-15 2023-01-03 广州市万千粉丝化妆品有限公司 Application of anti-allergic and red-repairing vitamin funingmyotonin liquid cosmetic for stably soothing skin
CN114948770A (en) * 2022-05-10 2022-08-30 上海枫萃生物科技有限公司 Cosmetic ingredient formula for repairing skin lipid membrane damage
CN115054562A (en) * 2022-07-29 2022-09-16 维怡美生物科技(广州)有限公司 Repairing composition, application thereof, essence and milk containing repairing composition
CN116077368A (en) * 2023-02-20 2023-05-09 广州熙源化妆品有限公司 Repairing composition containing palmitoyl tetrapeptide-7, and preparation method and application thereof

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