CN109096192A - 8-位取代的苯并氮杂*作为类toll受体调节剂 - Google Patents
8-位取代的苯并氮杂*作为类toll受体调节剂 Download PDFInfo
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- CN109096192A CN109096192A CN201810884424.7A CN201810884424A CN109096192A CN 109096192 A CN109096192 A CN 109096192A CN 201810884424 A CN201810884424 A CN 201810884424A CN 109096192 A CN109096192 A CN 109096192A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71000405P | 2005-08-19 | 2005-08-19 | |
| US60/710004 | 2005-08-19 | ||
| CNA2006800380964A CN101309906A (zh) | 2005-08-19 | 2006-08-17 | 8－位取代的苯并氮杂䓬作为类toll受体调节剂 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006800380964A Division CN101309906A (zh) | 2005-08-19 | 2006-08-17 | 8－位取代的苯并氮杂䓬作为类toll受体调节剂 |
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| CN201810884657.7A Pending CN109096193A (zh) | 2005-08-19 | 2006-08-17 | 8-位取代的苯并氮杂*作为类toll受体调节剂 |
| CN201510165871.3A Pending CN104910072A (zh) | 2005-08-19 | 2006-08-17 | 8-位取代的苯并氮杂*作为类toll受体调节剂 |
| CNA2006800380964A Pending CN101309906A (zh) | 2005-08-19 | 2006-08-17 | 8－位取代的苯并氮杂䓬作为类toll受体调节剂 |
| CN201510192094.1A Pending CN104945323A (zh) | 2005-08-19 | 2006-08-17 | 8-位取代的苯并氮杂*作为类toll受体调节剂 |
| CN201510118046.8A Pending CN104803915A (zh) | 2005-08-19 | 2006-08-17 | 8-位取代的苯并氮杂*作为类toll受体调节剂 |
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| CN201810884657.7A Pending CN109096193A (zh) | 2005-08-19 | 2006-08-17 | 8-位取代的苯并氮杂*作为类toll受体调节剂 |
| CN201510165871.3A Pending CN104910072A (zh) | 2005-08-19 | 2006-08-17 | 8-位取代的苯并氮杂*作为类toll受体调节剂 |
| CNA2006800380964A Pending CN101309906A (zh) | 2005-08-19 | 2006-08-17 | 8－位取代的苯并氮杂䓬作为类toll受体调节剂 |
| CN201510192094.1A Pending CN104945323A (zh) | 2005-08-19 | 2006-08-17 | 8-位取代的苯并氮杂*作为类toll受体调节剂 |
| CN201510118046.8A Pending CN104803915A (zh) | 2005-08-19 | 2006-08-17 | 8-位取代的苯并氮杂*作为类toll受体调节剂 |
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Families Citing this family (194)
| Publication number | Priority date | Publication date | Assignee | Title |
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| TWI382019B (zh) | 2005-08-19 | 2013-01-11 | Array Biopharma Inc | 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之胺基二氮雜呯 |
| DK2313111T3 (da) | 2008-08-01 | 2013-12-02 | Ventirx Pharmaceuticals Inc | Toll-lignende receptoragonistformuleringer og anvendelse deraf |
| JP5727937B2 (ja) * | 2008-11-06 | 2015-06-03 | ベンティアールエックス ファーマシューティカルズ， インコーポレイテッドＶｅｎｔｉＲｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | ベンゾアセピン誘導体の合成方法 |
| US8524702B2 (en) * | 2009-08-18 | 2013-09-03 | Ventirx Pharmaceuticals, Inc. | Substituted benzoazepines as toll-like receptor modulators |
| US8691809B2 (en) * | 2009-08-18 | 2014-04-08 | Ventirx Pharmaceuticals, Inc. | Substituted benzoazepines as toll-like receptor modulators |
| US20130236449A1 (en) | 2010-04-21 | 2013-09-12 | Ventirx Pharmaceuticals, Inc. | Methods of enhancing antibody-dependent cellular cytotoxicity |
| CN103118700A (zh) | 2010-05-26 | 2013-05-22 | 西莱克塔生物科技公司 | 合成纳米载体联合疫苗 |
| US9045468B2 (en) | 2010-08-17 | 2015-06-02 | Albany Molecular Research, Inc. | 2,5-methano- and 2,5-ethano-tetrahydrobenzazepine derivatives and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| BR112013007678A2 (pt) * | 2010-10-01 | 2017-07-04 | Ventirx Pharmaceuticals Inc | método para tratamento de doenças alérgicas |
| RU2603467C2 (ru) * | 2010-10-01 | 2016-11-27 | Вентиркс Фармасьютикалз, Инк. | Терапевтическое применение агониста tlr и комбинированная терапия |
| EA201390660A1 (ru) | 2010-11-05 | 2013-11-29 | Селекта Байосайенсиз, Инк. | Модифицированные никотиновые соединения и связанные способы |
| GB201022049D0 (en) * | 2010-12-29 | 2011-02-02 | Imp Innovations Ltd | Methods |
| US20140088085A1 (en) * | 2011-01-12 | 2014-03-27 | Array Biopharma, Inc | Substituted Benzoazepines As Toll-Like Receptor Modulators |
| CN103562186B (zh) * | 2011-01-12 | 2017-02-15 | 帆德制药股份有限公司 | 作为toll样受体调节剂的取代的苯并氮杂卓 |
| EA027792B1 (ru) | 2011-04-08 | 2017-09-29 | Янссен Сайенсиз Айрлэнд Юси | Производные пиримидина для лечения вирусных инфекций |
| CN103566377A (zh) | 2012-07-18 | 2014-02-12 | 上海博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| US9868955B2 (en) | 2012-09-29 | 2018-01-16 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
| US9228184B2 (en) | 2012-09-29 | 2016-01-05 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
| US9409888B2 (en) * | 2012-12-11 | 2016-08-09 | Hoffmann-La Roche Inc. | Dimeric compounds |
| KR101482999B1 (ko) * | 2013-06-17 | 2015-01-14 | 순천향대학교 산학협력단 | 톨-유사 수용체(tlr)에 의해 유도되는 trif-의존성 신호전달 경로의 억제제로서의 (e)-1-(2-(2-니트로 비닐)페닐)피롤리딘(nvpp)을 유효성분으로 포함하는 항염증제 |
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