CN108697746A - 编码抗tcr复合体抗体或片段的病毒 - Google Patents

编码抗tcr复合体抗体或片段的病毒 Download PDF

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Publication number
CN108697746A
CN108697746A CN201680076032.7A CN201680076032A CN108697746A CN 108697746 A CN108697746 A CN 108697746A CN 201680076032 A CN201680076032 A CN 201680076032A CN 108697746 A CN108697746 A CN 108697746A
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Prior art keywords
virus
oncolytic virus
cells
antibody
replication
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Pending
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CN201680076032.7A
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English (en)
Chinese (zh)
Inventor
A·C·N·布朗利
B·R·查普恩
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Akamis Bio Ltd
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Psioxus Therapeutics Ltd
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Priority claimed from GBGB1522334.0A external-priority patent/GB201522334D0/en
Priority claimed from GBGB1607463.5A external-priority patent/GB201607463D0/en
Priority claimed from GBGB1617207.4A external-priority patent/GB201617207D0/en
Priority claimed from GBGB1617206.6A external-priority patent/GB201617206D0/en
Application filed by Psioxus Therapeutics Ltd filed Critical Psioxus Therapeutics Ltd
Publication of CN108697746A publication Critical patent/CN108697746A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
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    • C12N2710/00011—Details
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
CN201680076032.7A 2015-12-17 2016-12-19 编码抗tcr复合体抗体或片段的病毒 Pending CN108697746A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GBGB1522334.0A GB201522334D0 (en) 2015-12-17 2015-12-17 Method
GB1522334.0 2015-12-17
GB1607463.5 2016-04-29
GBGB1607463.5A GB201607463D0 (en) 2016-04-29 2016-04-29 Method
GB1617206.6 2016-10-10
GB1617207.4 2016-10-10
GBGB1617207.4A GB201617207D0 (en) 2016-10-10 2016-10-10 Method
GBGB1617206.6A GB201617206D0 (en) 2016-10-10 2016-10-10 Method
PCT/EP2016/081818 WO2017103291A1 (en) 2015-12-17 2016-12-19 Virus encoding an anti-tcr-complex antibody or fragment

Publications (1)

Publication Number Publication Date
CN108697746A true CN108697746A (zh) 2018-10-23

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CN201680076032.7A Pending CN108697746A (zh) 2015-12-17 2016-12-19 编码抗tcr复合体抗体或片段的病毒
CN201680074772.7A Pending CN108697745A (zh) 2015-12-17 2016-12-19 编码抗tcr复合体抗体或片段的b组腺病毒

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CN201680074772.7A Pending CN108697745A (zh) 2015-12-17 2016-12-19 编码抗tcr复合体抗体或片段的b组腺病毒

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US (3) US11970536B2 (https=)
EP (2) EP3389682B1 (https=)
JP (2) JP7064437B2 (https=)
KR (2) KR102857666B1 (https=)
CN (2) CN108697746A (https=)
AU (2) AU2016372576A1 (https=)
BR (2) BR112018012179A2 (https=)
CA (1) CA3006859A1 (https=)
CL (1) CL2018001611A1 (https=)
CO (1) CO2018005945A2 (https=)
DK (1) DK3389682T3 (https=)
EA (2) EA201891022A1 (https=)
IL (2) IL260027B (https=)
MX (1) MX2018007249A (https=)
MY (1) MY193281A (https=)
PH (1) PH12018501291A1 (https=)
SG (2) SG11201805137XA (https=)
WO (2) WO2017103291A1 (https=)
ZA (1) ZA201803523B (https=)

Cited By (9)

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CN110551222A (zh) * 2019-08-27 2019-12-10 重庆市畜牧科学院 一种新型双功能抗体及其用途
CN112300991A (zh) * 2019-07-29 2021-02-02 赛雅思株式会社 抗原特异性t细胞的制造方法
WO2021073624A1 (zh) * 2019-10-17 2021-04-22 北京门罗生物科技有限公司 用于免疫治疗的嵌合抗原受体、制备方法及其应用
CN113355296A (zh) * 2021-06-07 2021-09-07 中国人民解放军空军军医大学 一种表达人ccl19的重组溶瘤新城疫病毒及其应用
CN114729031A (zh) * 2019-09-13 2022-07-08 艾德梅尔治疗协会 抗溶瘤病毒抗原抗体及其使用方法
CN114891126A (zh) * 2022-06-23 2022-08-12 上海安库生医生物科技有限公司 一种靶向fshr和cd3分子的双结合蛋白及其应用
CN115443332A (zh) * 2020-03-04 2022-12-06 生物日食治疗公司 制备活化免疫细胞的方法
CN115667292A (zh) * 2020-04-06 2023-01-31 朗格生物技术公共公益股份有限公司 模块化合成受体和使用方法
CN116333999A (zh) * 2020-07-14 2023-06-27 广州泛恩生物科技有限公司 基于cxcl13阳性t细胞的用于杀伤肿瘤的tcr-t细胞及其制备方法和应用

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KR20180006916A (ko) 2015-04-17 2018-01-19 메모리얼 슬로안-케터링 캔서 센터 고형 종양에 대한 면역치료제로서 mva 또는 mva델타e3l의 용도
PE20180241A1 (es) 2015-04-30 2018-01-31 Psioxus Therapeutics Ltd Adenovirus oncolitico que codifica una proteina b7
AU2016350701B2 (en) 2015-11-02 2021-08-19 Five Prime Therapeutics, Inc. CD80 extracellular domain polypeptides and their use in cancer treatment
EA201891022A1 (ru) 2015-12-17 2019-01-31 Псайоксус Терапьютикс Лимитед Вирус, кодирующий антитело к комплексу tcr или фрагмент указанного антитела
JP7025339B2 (ja) 2016-02-25 2022-02-24 メモリアル スローン ケタリング キャンサー センター 癌免疫療法のための、チミジンキナーゼの欠失を伴い、ヒトｆｌｔ３ｌまたはｇｍ－ｃｓｆの発現を伴うかまたは伴わない、複製可能な弱毒化ワクシニアウイルス
CN109152827B (zh) 2016-02-25 2023-07-21 纪念斯隆凯特琳癌症中心 重组mva或表达人flt3l的mvaδe3l及其作为抗固体肿瘤的免疫治疗剂的用途
US12590321B2 (en) 2016-03-19 2026-03-31 Exuma Biotech Corp. Methods and compositions for genetically modifying and expanding lymphocytes and regulating the activity thereof
US11325948B2 (en) 2016-03-19 2022-05-10 Exuma Biotech Corp. Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL
WO2022047417A1 (en) * 2020-08-31 2022-03-03 Exuma Biotech Corp. Anti-idiotype compositions and methods of use thereof
US11111505B2 (en) 2016-03-19 2021-09-07 Exuma Biotech, Corp. Methods and compositions for transducing lymphocytes and regulating the activity thereof
RU2021127872A (ru) 2016-06-30 2021-11-09 Онкорус, Инк. Доставка терапевтических полипептидов посредством псевдотипированных онколитических вирусов
CN119614520A (zh) 2016-08-29 2025-03-14 阿卡米斯生物公司 携带双特异性t细胞衔接器的腺病毒
GB201713765D0 (en) 2017-08-28 2017-10-11 Psioxus Therapeutics Ltd Modified adenovirus
WO2018083258A1 (en) * 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding at least three transgenes
WO2018083257A1 (en) * 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding transgenes
WO2018083259A1 (en) * 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding transgenes
WO2018201014A1 (en) 2017-04-28 2018-11-01 Five Prime Therapeutics, Inc. Methods of treatment with cd80 extracellular domain polypeptides
EP3621646A4 (en) 2017-05-12 2021-06-02 Memorial Sloan Kettering Cancer Center VACCINIA VIRUS MUTANTS FOR CANCER IMMUNOTHERAPY
AU2018306455A1 (en) 2017-07-26 2020-02-27 Virogin Biotech Canada Ltd Oncolytic viral vectors and uses thereof
US11865081B2 (en) 2017-12-29 2024-01-09 Virogin Biotech Canada Ltd. Oncolytic viral delivery of therapeutic polypeptides
WO2019173334A1 (en) * 2018-03-05 2019-09-12 The Schepens Eye Research Institute, Inc. Engineered vegf variants for retinal neuroprotection, promotion of axon growth and axon regeneration
CN118001307A (zh) * 2018-03-30 2024-05-10 藤堂具纪 肿胀发生抑制型溶瘤病毒
EP3866924A4 (en) * 2018-06-29 2022-07-06 Krystal Biotech, Inc. COMPOSITIONS AND METHODS OF ANTIBODY DELIVERY
WO2020050630A1 (ko) 2018-09-07 2020-03-12 주식회사 케이티 비면허 대역에서 무선 통신을 수행하는 방법 및 장치
BR112021004692A2 (pt) 2018-09-15 2021-06-08 Memorial Sloan Kettering Cancer Center poxvírus recombinantes para imunoterapia de câncer
WO2020143221A1 (zh) * 2019-01-07 2020-07-16 四川安可康生物医药有限公司 增强系统免疫应答的免疫溶瘤病毒组合药物及其应用
US20200215133A1 (en) * 2019-01-07 2020-07-09 Sichuan Oncocare Biopharmaceutical, Inc. Combination of immuno-oncolytic virus drugs for enhancing systemic immune response and application thereof
US12589132B2 (en) 2019-02-22 2026-03-31 Five Prime Therapeutics, Inc. CD80 extracellular domain Fc fusion proteins for treating PD-L1 negative tumors
IL322315A (en) 2019-05-14 2025-09-01 Provention Bio Inc Methods and preparations for preventing type 1 diabetes
AU2021287998B2 (en) 2020-06-11 2026-03-12 Benaroya Research Institute At Virginia Mason Methods and compositions for preventing type 1 diabetes
CN112063588A (zh) * 2020-08-13 2020-12-11 南京北恒生物科技有限公司 工程化免疫细胞及其用途
WO2022158844A1 (ko) * 2021-01-19 2022-07-28 광주과학기술원 Igsf4의 막 관통 도메인을 발현하는 t 세포 및 이의 이용
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