CN108697746A - 编码抗tcr复合体抗体或片段的病毒 - Google Patents

编码抗tcr复合体抗体或片段的病毒 Download PDF

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Publication number
CN108697746A
CN108697746A CN201680076032.7A CN201680076032A CN108697746A CN 108697746 A CN108697746 A CN 108697746A CN 201680076032 A CN201680076032 A CN 201680076032A CN 108697746 A CN108697746 A CN 108697746A
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Prior art keywords
virus
oncolytic virus
cells
antibody
replication
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Pending
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CN201680076032.7A
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Chinese (zh)
Inventor
A·C·N·布朗利
B·R·查普恩
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Akamis Bio Ltd
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Psioxus Therapeutics Ltd
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Priority claimed from GBGB1522334.0A external-priority patent/GB201522334D0/en
Priority claimed from GBGB1607463.5A external-priority patent/GB201607463D0/en
Priority claimed from GBGB1617207.4A external-priority patent/GB201617207D0/en
Priority claimed from GBGB1617206.6A external-priority patent/GB201617206D0/en
Application filed by Psioxus Therapeutics Ltd filed Critical Psioxus Therapeutics Ltd
Publication of CN108697746A publication Critical patent/CN108697746A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Plant Pathology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
CN201680076032.7A 2015-12-17 2016-12-19 编码抗tcr复合体抗体或片段的病毒 Pending CN108697746A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GBGB1522334.0A GB201522334D0 (en) 2015-12-17 2015-12-17 Method
GB1522334.0 2015-12-17
GB1607463.5 2016-04-29
GBGB1607463.5A GB201607463D0 (en) 2016-04-29 2016-04-29 Method
GBGB1617207.4A GB201617207D0 (en) 2016-10-10 2016-10-10 Method
GB1617207.4 2016-10-10
GB1617206.6 2016-10-10
GBGB1617206.6A GB201617206D0 (en) 2016-10-10 2016-10-10 Method
PCT/EP2016/081818 WO2017103291A1 (en) 2015-12-17 2016-12-19 Virus encoding an anti-tcr-complex antibody or fragment

Publications (1)

Publication Number Publication Date
CN108697746A true CN108697746A (zh) 2018-10-23

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Application Number Title Priority Date Filing Date
CN201680074772.7A Pending CN108697745A (zh) 2015-12-17 2016-12-19 编码抗tcr复合体抗体或片段的b组腺病毒
CN201680076032.7A Pending CN108697746A (zh) 2015-12-17 2016-12-19 编码抗tcr复合体抗体或片段的病毒

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CN201680074772.7A Pending CN108697745A (zh) 2015-12-17 2016-12-19 编码抗tcr复合体抗体或片段的b组腺病毒

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US (3) US11155622B2 (enExample)
EP (2) EP3389683B8 (enExample)
JP (2) JP7064437B2 (enExample)
KR (2) KR102857666B1 (enExample)
CN (2) CN108697745A (enExample)
AU (2) AU2016369485B2 (enExample)
BR (2) BR112018012180A2 (enExample)
CA (1) CA3006859A1 (enExample)
CL (1) CL2018001611A1 (enExample)
CO (1) CO2018005945A2 (enExample)
DK (1) DK3389682T3 (enExample)
EA (2) EA201891022A1 (enExample)
IL (2) IL260027B (enExample)
MX (1) MX2018007249A (enExample)
MY (1) MY193281A (enExample)
PH (1) PH12018501291A1 (enExample)
SG (2) SG11201805137XA (enExample)
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Cited By (7)

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CN110551222A (zh) * 2019-08-27 2019-12-10 重庆市畜牧科学院 一种新型双功能抗体及其用途
CN112300991A (zh) * 2019-07-29 2021-02-02 赛雅思株式会社 抗原特异性t细胞的制造方法
WO2021073624A1 (zh) * 2019-10-17 2021-04-22 北京门罗生物科技有限公司 用于免疫治疗的嵌合抗原受体、制备方法及其应用
CN113355296A (zh) * 2021-06-07 2021-09-07 中国人民解放军空军军医大学 一种表达人ccl19的重组溶瘤新城疫病毒及其应用
CN114729031A (zh) * 2019-09-13 2022-07-08 艾德梅尔治疗协会 抗溶瘤病毒抗原抗体及其使用方法
CN114891126A (zh) * 2022-06-23 2022-08-12 上海安库生医生物科技有限公司 一种靶向fshr和cd3分子的双结合蛋白及其应用
CN115443332A (zh) * 2020-03-04 2022-12-06 生物日食治疗公司 制备活化免疫细胞的方法

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CN107847534B (zh) 2015-04-17 2022-10-04 纪念斯隆凯特琳癌症中心 Mva或mvaδe3l作为抗实体瘤的免疫治疗剂的应用
KR20180118249A (ko) 2015-04-30 2018-10-30 싸이오서스 테라퓨틱스 엘티디. B7 단백질을 암호화하는 종양세포붕괴 아데노바이러스
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US11325948B2 (en) 2016-03-19 2022-05-10 Exuma Biotech Corp. Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL
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GB201713765D0 (en) * 2017-08-28 2017-10-11 Psioxus Therapeutics Ltd Modified adenovirus
CA3033267A1 (en) 2016-08-29 2018-03-08 Psioxus Therapeutics Limited Adenovirus armed with bispecific t cell engager (bite)
WO2018083259A1 (en) * 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding transgenes
WO2018083258A1 (en) * 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding at least three transgenes
WO2018083257A1 (en) * 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding transgenes
EA201992586A1 (ru) 2017-04-28 2020-03-03 Файв Прайм Терапьютикс, Инк. Способы лечения с помощью полипептидов внеклеточного домена cd80
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US12404312B2 (en) 2018-03-05 2025-09-02 Massachusetts Eye And Ear Infirmary Engineered VEGF variants for retinal neuroprotection, promotion of axon growth and axon regeneration
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WO2020050630A1 (ko) 2018-09-07 2020-03-12 주식회사 케이티 비면허 대역에서 무선 통신을 수행하는 방법 및 장치
US12252702B2 (en) 2018-09-15 2025-03-18 Memorial Sloan Kettering Cancer Center Recombinant poxviruses for cancer immunotherapy
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KR20230031981A (ko) 2019-05-14 2023-03-07 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
IL298999A (en) 2020-06-11 2023-02-01 Provention Bio Inc Methods and compositions for the prevention of type 1 diabetes
CN112063588A (zh) * 2020-08-13 2020-12-11 南京北恒生物科技有限公司 工程化免疫细胞及其用途
CN116249559A (zh) * 2020-08-31 2023-06-09 埃克苏马生物技术公司 抗独特型组合物及其使用方法
WO2022158844A1 (ko) * 2021-01-19 2022-07-28 광주과학기술원 Igsf4의 막 관통 도메인을 발현하는 t 세포 및 이의 이용
EP4288140A1 (en) 2021-02-05 2023-12-13 Iovance Biotherapeutics, Inc. Adjuvant therapy for cancer
JP7697147B2 (ja) * 2021-06-03 2025-06-23 上▲海▼允英生物医▲薬▼科技有限公司 腫瘍溶解性ウイルスベクターおよびその適用
CN116024175A (zh) * 2021-10-27 2023-04-28 南京北恒生物科技有限公司 工程化免疫细胞及其用途
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