CN108290922B - 用于抑制il-17和其它用途的c4-改性的齐墩果酸衍生物 - Google Patents

用于抑制il-17和其它用途的c4-改性的齐墩果酸衍生物 Download PDF

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CN108290922B
CN108290922B CN201680067912.8A CN201680067912A CN108290922B CN 108290922 B CN108290922 B CN 108290922B CN 201680067912 A CN201680067912 A CN 201680067912A CN 108290922 B CN108290922 B CN 108290922B
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compound
substituted
alkoxy
hydrogen
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CN108290922A (zh
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麦琳·维斯尼克
江昕
M·R·奥特玛
芝塔斯·李
B·W·卡普拉瑟
威廉·H·洛克
加里·波尔顿
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Reata Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
CN201680067912.8A 2015-09-23 2016-09-23 用于抑制il-17和其它用途的c4-改性的齐墩果酸衍生物 Active CN108290922B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562222632P 2015-09-23 2015-09-23
US62/222,632 2015-09-23
PCT/US2016/053545 WO2017053868A1 (en) 2015-09-23 2016-09-23 C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses

Publications (2)

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CN108290922A CN108290922A (zh) 2018-07-17
CN108290922B true CN108290922B (zh) 2021-12-07

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US (2) US11584775B2 (https=)
EP (1) EP3353190B1 (https=)
JP (1) JP7074674B2 (https=)
KR (1) KR102796889B1 (https=)
CN (1) CN108290922B (https=)
AU (1) AU2016326704B2 (https=)
BR (1) BR112018005861B1 (https=)
CA (1) CA2998681C (https=)
EA (1) EA201890767A1 (https=)
ES (1) ES2865163T3 (https=)
IL (1) IL258185B (https=)
MX (1) MX386256B (https=)
NZ (1) NZ741082A (https=)
WO (1) WO2017053868A1 (https=)

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TWI649330B (zh) 2013-04-24 2019-02-01 艾伯維有限公司 甲基巴多索龍之２，２－二氟丙醯胺衍生物、其多晶形及其使用方法
BR112018005861B1 (pt) 2015-09-23 2022-11-22 Reata Pharmaceuticals, Inc Compostos derivados de ácido oleanólico modificado com c4 para a inibição de il-17, composição farmacêutica e usos terapêuticos dos ditos compostos
KR102486434B1 (ko) 2016-11-08 2023-01-09 리아타 파마슈티컬즈 홀딩스, 엘엘씨 바독솔론 메틸 또는 이의 유사체를 사용하는 알포트 증후군의 치료 방법
CN108191944B (zh) * 2018-01-18 2020-12-11 华南师范大学 海洋微生物来源的二倍半萜AsperterpinolB衍生物及合成方法与糖酶应用
CN108299541B (zh) * 2018-01-18 2020-12-11 华南师范大学 海洋微生物来源的二倍半萜AsperterpinolB衍生物及合成方法与抗炎应用
WO2019246461A1 (en) 2018-06-20 2019-12-26 Reata Pharmaceuticals, Inc. Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith
CN109248168A (zh) * 2018-10-30 2019-01-22 武汉卫无忧生物科技有限公司 齐墩果酸在制备抗幽门螺杆菌的药物中的用途
TWI752400B (zh) 2019-01-07 2022-01-11 美商美國禮來大藥廠 Il-17a抑制劑
TWI861163B (zh) * 2019-07-19 2024-11-11 美商瑞塔醫藥有限責任公司 C17經極性取代之雜芳合成三萜類化合物及其使用方法
US20240293351A1 (en) 2020-12-11 2024-09-05 Reata Pharmaceuticals Holdings, LLC Methods of administering synthetic triterpenoids
EP4277916A1 (en) * 2021-01-18 2023-11-22 Reata Pharmaceuticals, Inc. Synthetic ursolic acid derivatives and methods of use thereof
CN113185570A (zh) * 2021-05-12 2021-07-30 张洪胜 一种治疗银屑病的齐墩果酸衍生物及其制备方法
CN117964678A (zh) * 2024-01-29 2024-05-03 烟台大学 C17位杂芳族羰基修饰的齐墩果烷三萜衍生物及其制备方法和用途

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NZ741082A (en) 2023-06-30
AU2016326704A1 (en) 2018-04-26
HK1258095A1 (zh) 2019-11-01
IL258185B (en) 2021-08-31
US12545701B2 (en) 2026-02-10
JP7074674B2 (ja) 2022-05-24
KR20180061251A (ko) 2018-06-07
WO2017053868A1 (en) 2017-03-30
US20190153022A1 (en) 2019-05-23
CA2998681A1 (en) 2017-03-30
EP3353190B1 (en) 2021-03-17
WO2017053868A8 (en) 2018-04-19
MX386256B (es) 2025-03-18
KR102796889B1 (ko) 2025-04-17
EP3353190A1 (en) 2018-08-01
AU2016326704B2 (en) 2021-01-28
EA201890767A1 (ru) 2019-09-30
BR112018005861B1 (pt) 2022-11-22
MX2018003569A (es) 2018-11-29
IL258185A (en) 2018-05-31
CN108290922A (zh) 2018-07-17
CA2998681C (en) 2024-02-06
US20230250130A1 (en) 2023-08-10
BR112018005861A2 (pt) 2018-10-16
JP2018528275A (ja) 2018-09-27
ES2865163T3 (es) 2021-10-15
US11584775B2 (en) 2023-02-21

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