CA2998681C - C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses - Google Patents

C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses Download PDF

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Publication number
CA2998681C
CA2998681C CA2998681A CA2998681A CA2998681C CA 2998681 C CA2998681 C CA 2998681C CA 2998681 A CA2998681 A CA 2998681A CA 2998681 A CA2998681 A CA 2998681A CA 2998681 C CA2998681 C CA 2998681C
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substituted
alkyl
hydrogen
alkoxy
compound
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CA2998681A
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English (en)
French (fr)
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CA2998681A1 (en
Inventor
Melean Visnick
Xin Jiang
Martha R. Hotema
Chitase Lee
Bradley William Caprathe
William H. Roark
Gary Bolton
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Reata Pharmaceuticals Inc
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Reata Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CA2998681A 2015-09-23 2016-09-23 C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses Active CA2998681C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562222632P 2015-09-23 2015-09-23
US62/222,632 2015-09-23
PCT/US2016/053545 WO2017053868A1 (en) 2015-09-23 2016-09-23 C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses

Publications (2)

Publication Number Publication Date
CA2998681A1 CA2998681A1 (en) 2017-03-30
CA2998681C true CA2998681C (en) 2024-02-06

Family

ID=57137257

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2998681A Active CA2998681C (en) 2015-09-23 2016-09-23 C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses

Country Status (14)

Country Link
US (2) US11584775B2 (https=)
EP (1) EP3353190B1 (https=)
JP (1) JP7074674B2 (https=)
KR (1) KR102796889B1 (https=)
CN (1) CN108290922B (https=)
AU (1) AU2016326704B2 (https=)
BR (1) BR112018005861B1 (https=)
CA (1) CA2998681C (https=)
EA (1) EA201890767A1 (https=)
ES (1) ES2865163T3 (https=)
IL (1) IL258185B (https=)
MX (1) MX386256B (https=)
NZ (1) NZ741082A (https=)
WO (1) WO2017053868A1 (https=)

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CN108191944B (zh) * 2018-01-18 2020-12-11 华南师范大学 海洋微生物来源的二倍半萜AsperterpinolB衍生物及合成方法与糖酶应用
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Also Published As

Publication number Publication date
KR20180061251A (ko) 2018-06-07
WO2017053868A8 (en) 2018-04-19
IL258185A (en) 2018-05-31
BR112018005861B1 (pt) 2022-11-22
US11584775B2 (en) 2023-02-21
BR112018005861A2 (pt) 2018-10-16
EA201890767A1 (ru) 2019-09-30
CA2998681A1 (en) 2017-03-30
AU2016326704A1 (en) 2018-04-26
IL258185B (en) 2021-08-31
JP7074674B2 (ja) 2022-05-24
MX2018003569A (es) 2018-11-29
EP3353190A1 (en) 2018-08-01
ES2865163T3 (es) 2021-10-15
CN108290922B (zh) 2021-12-07
AU2016326704B2 (en) 2021-01-28
EP3353190B1 (en) 2021-03-17
NZ741082A (en) 2023-06-30
MX386256B (es) 2025-03-18
WO2017053868A1 (en) 2017-03-30
JP2018528275A (ja) 2018-09-27
HK1258095A1 (zh) 2019-11-01
US20230250130A1 (en) 2023-08-10
US12545701B2 (en) 2026-02-10
CN108290922A (zh) 2018-07-17
US20190153022A1 (en) 2019-05-23
KR102796889B1 (ko) 2025-04-17

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