IL258185B - Oleanolic acid derivatives are modified at carbon 4 for il–17 inhibition and other uses - Google Patents

Oleanolic acid derivatives are modified at carbon 4 for il–17 inhibition and other uses

Info

Publication number
IL258185B
IL258185B IL258185A IL25818518A IL258185B IL 258185 B IL258185 B IL 258185B IL 258185 A IL258185 A IL 258185A IL 25818518 A IL25818518 A IL 25818518A IL 258185 B IL258185 B IL 258185B
Authority
IL
Israel
Prior art keywords
inhibition
acid derivatives
oleanolic acid
modified
modified oleanolic
Prior art date
Application number
IL258185A
Other languages
English (en)
Hebrew (he)
Other versions
IL258185A (en
Inventor
Melean Visnick
Xin Jiang
Martha R Hotema
Chitase Lee
Bradley William Caprathe
William H Roark
Gary Bolton
Original Assignee
Reata Pharmaceuticals Inc
Melean Visnick
Xin Jiang
Martha R Hotema
Chitase Lee
Bradley William Caprathe
William H Roark
Gary Bolton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reata Pharmaceuticals Inc, Melean Visnick, Xin Jiang, Martha R Hotema, Chitase Lee, Bradley William Caprathe, William H Roark, Gary Bolton filed Critical Reata Pharmaceuticals Inc
Publication of IL258185A publication Critical patent/IL258185A/en
Publication of IL258185B publication Critical patent/IL258185B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
IL258185A 2015-09-23 2018-03-18 Oleanolic acid derivatives are modified at carbon 4 for il–17 inhibition and other uses IL258185B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562222632P 2015-09-23 2015-09-23
PCT/US2016/053545 WO2017053868A1 (en) 2015-09-23 2016-09-23 C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses

Publications (2)

Publication Number Publication Date
IL258185A IL258185A (en) 2018-05-31
IL258185B true IL258185B (en) 2021-08-31

Family

ID=57137257

Family Applications (1)

Application Number Title Priority Date Filing Date
IL258185A IL258185B (en) 2015-09-23 2018-03-18 Oleanolic acid derivatives are modified at carbon 4 for il–17 inhibition and other uses

Country Status (14)

Country Link
US (2) US11584775B2 (https=)
EP (1) EP3353190B1 (https=)
JP (1) JP7074674B2 (https=)
KR (1) KR102796889B1 (https=)
CN (1) CN108290922B (https=)
AU (1) AU2016326704B2 (https=)
BR (1) BR112018005861B1 (https=)
CA (1) CA2998681C (https=)
EA (1) EA201890767A1 (https=)
ES (1) ES2865163T3 (https=)
IL (1) IL258185B (https=)
MX (1) MX386256B (https=)
NZ (1) NZ741082A (https=)
WO (1) WO2017053868A1 (https=)

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TWI649330B (zh) 2013-04-24 2019-02-01 艾伯維有限公司 甲基巴多索龍之２，２－二氟丙醯胺衍生物、其多晶形及其使用方法
BR112018005861B1 (pt) 2015-09-23 2022-11-22 Reata Pharmaceuticals, Inc Compostos derivados de ácido oleanólico modificado com c4 para a inibição de il-17, composição farmacêutica e usos terapêuticos dos ditos compostos
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CN108299541B (zh) * 2018-01-18 2020-12-11 华南师范大学 海洋微生物来源的二倍半萜AsperterpinolB衍生物及合成方法与抗炎应用
WO2019246461A1 (en) 2018-06-20 2019-12-26 Reata Pharmaceuticals, Inc. Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith
CN109248168A (zh) * 2018-10-30 2019-01-22 武汉卫无忧生物科技有限公司 齐墩果酸在制备抗幽门螺杆菌的药物中的用途
TWI752400B (zh) 2019-01-07 2022-01-11 美商美國禮來大藥廠 Il-17a抑制劑
TWI861163B (zh) * 2019-07-19 2024-11-11 美商瑞塔醫藥有限責任公司 C17經極性取代之雜芳合成三萜類化合物及其使用方法
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EP4277916A1 (en) * 2021-01-18 2023-11-22 Reata Pharmaceuticals, Inc. Synthetic ursolic acid derivatives and methods of use thereof
CN113185570A (zh) * 2021-05-12 2021-07-30 张洪胜 一种治疗银屑病的齐墩果酸衍生物及其制备方法
CN117964678A (zh) * 2024-01-29 2024-05-03 烟台大学 C17位杂芳族羰基修饰的齐墩果烷三萜衍生物及其制备方法和用途

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Also Published As

Publication number Publication date
NZ741082A (en) 2023-06-30
AU2016326704A1 (en) 2018-04-26
HK1258095A1 (zh) 2019-11-01
US12545701B2 (en) 2026-02-10
JP7074674B2 (ja) 2022-05-24
KR20180061251A (ko) 2018-06-07
WO2017053868A1 (en) 2017-03-30
US20190153022A1 (en) 2019-05-23
CA2998681A1 (en) 2017-03-30
EP3353190B1 (en) 2021-03-17
WO2017053868A8 (en) 2018-04-19
MX386256B (es) 2025-03-18
KR102796889B1 (ko) 2025-04-17
EP3353190A1 (en) 2018-08-01
AU2016326704B2 (en) 2021-01-28
EA201890767A1 (ru) 2019-09-30
BR112018005861B1 (pt) 2022-11-22
MX2018003569A (es) 2018-11-29
IL258185A (en) 2018-05-31
CN108290922A (zh) 2018-07-17
CN108290922B (zh) 2021-12-07
CA2998681C (en) 2024-02-06
US20230250130A1 (en) 2023-08-10
BR112018005861A2 (pt) 2018-10-16
JP2018528275A (ja) 2018-09-27
ES2865163T3 (es) 2021-10-15
US11584775B2 (en) 2023-02-21

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