EA201890767A1 - C4-модифицированные производные олеаноловой кислоты для ингибирования il-17 и других применений - Google Patents
C4-модифицированные производные олеаноловой кислоты для ингибирования il-17 и других примененийInfo
- Publication number
- EA201890767A1 EA201890767A1 EA201890767A EA201890767A EA201890767A1 EA 201890767 A1 EA201890767 A1 EA 201890767A1 EA 201890767 A EA201890767 A EA 201890767A EA 201890767 A EA201890767 A EA 201890767A EA 201890767 A1 EA201890767 A1 EA 201890767A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- acid derivatives
- oleanolic acid
- inhibition
- applications
- modified
- Prior art date
Links
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical class C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562222632P | 2015-09-23 | 2015-09-23 | |
| PCT/US2016/053545 WO2017053868A1 (en) | 2015-09-23 | 2016-09-23 | C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201890767A1 true EA201890767A1 (ru) | 2019-09-30 |
Family
ID=57137257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201890767A EA201890767A1 (ru) | 2015-09-23 | 2016-09-23 | C4-модифицированные производные олеаноловой кислоты для ингибирования il-17 и других применений |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11584775B2 (https=) |
| EP (1) | EP3353190B1 (https=) |
| JP (1) | JP7074674B2 (https=) |
| KR (1) | KR102796889B1 (https=) |
| CN (1) | CN108290922B (https=) |
| AU (1) | AU2016326704B2 (https=) |
| BR (1) | BR112018005861B1 (https=) |
| CA (1) | CA2998681C (https=) |
| EA (1) | EA201890767A1 (https=) |
| ES (1) | ES2865163T3 (https=) |
| IL (1) | IL258185B (https=) |
| MX (1) | MX386256B (https=) |
| NZ (1) | NZ741082A (https=) |
| WO (1) | WO2017053868A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009129546A1 (en) | 2008-04-18 | 2009-10-22 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17 |
| JP6410710B2 (ja) | 2012-04-27 | 2018-10-24 | リアタ ファーマシューティカルズ インコーポレイテッド | バルドキソロンメチルの２，２−ジフルオロプロピオンアミド誘導体、その多形体および使用方法 |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| WO2014040060A1 (en) | 2012-09-10 | 2014-03-13 | Reata Pharmaceuticals, Inc. | C17-alkanediyl and alkenediyl derivatives of oleanolic acid and methods of use thereof |
| TWI649330B (zh) | 2013-04-24 | 2019-02-01 | 艾伯維有限公司 | 甲基巴多索龍之２，２－二氟丙醯胺衍生物、其多晶形及其使用方法 |
| BR112018005861B1 (pt) | 2015-09-23 | 2022-11-22 | Reata Pharmaceuticals, Inc | Compostos derivados de ácido oleanólico modificado com c4 para a inibição de il-17, composição farmacêutica e usos terapêuticos dos ditos compostos |
| KR102486434B1 (ko) | 2016-11-08 | 2023-01-09 | 리아타 파마슈티컬즈 홀딩스, 엘엘씨 | 바독솔론 메틸 또는 이의 유사체를 사용하는 알포트 증후군의 치료 방법 |
| CN108191944B (zh) * | 2018-01-18 | 2020-12-11 | 华南师范大学 | 海洋微生物来源的二倍半萜AsperterpinolB衍生物及合成方法与糖酶应用 |
| CN108299541B (zh) * | 2018-01-18 | 2020-12-11 | 华南师范大学 | 海洋微生物来源的二倍半萜AsperterpinolB衍生物及合成方法与抗炎应用 |
| WO2019246461A1 (en) | 2018-06-20 | 2019-12-26 | Reata Pharmaceuticals, Inc. | Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith |
| CN109248168A (zh) * | 2018-10-30 | 2019-01-22 | 武汉卫无忧生物科技有限公司 | 齐墩果酸在制备抗幽门螺杆菌的药物中的用途 |
| TWI752400B (zh) | 2019-01-07 | 2022-01-11 | 美商美國禮來大藥廠 | Il-17a抑制劑 |
| TWI861163B (zh) * | 2019-07-19 | 2024-11-11 | 美商瑞塔醫藥有限責任公司 | C17經極性取代之雜芳合成三萜類化合物及其使用方法 |
| US20240293351A1 (en) | 2020-12-11 | 2024-09-05 | Reata Pharmaceuticals Holdings, LLC | Methods of administering synthetic triterpenoids |
| EP4277916A1 (en) * | 2021-01-18 | 2023-11-22 | Reata Pharmaceuticals, Inc. | Synthetic ursolic acid derivatives and methods of use thereof |
| CN113185570A (zh) * | 2021-05-12 | 2021-07-30 | 张洪胜 | 一种治疗银屑病的齐墩果酸衍生物及其制备方法 |
| CN117964678A (zh) * | 2024-01-29 | 2024-05-03 | 烟台大学 | C17位杂芳族羰基修饰的齐墩果烷三萜衍生物及其制备方法和用途 |
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| KR102486434B1 (ko) | 2016-11-08 | 2023-01-09 | 리아타 파마슈티컬즈 홀딩스, 엘엘씨 | 바독솔론 메틸 또는 이의 유사체를 사용하는 알포트 증후군의 치료 방법 |
| TWI861163B (zh) | 2019-07-19 | 2024-11-11 | 美商瑞塔醫藥有限責任公司 | C17經極性取代之雜芳合成三萜類化合物及其使用方法 |
| CA3159778A1 (en) | 2019-12-19 | 2021-06-24 | Reata Pharmaceuticals, Inc. | Synthetic triterpenoids with nitrogen-based substituents at c-17 and methods of use thereof |
-
2016
- 2016-09-23 BR BR112018005861-0A patent/BR112018005861B1/pt active IP Right Grant
- 2016-09-23 NZ NZ741082A patent/NZ741082A/en unknown
- 2016-09-23 US US15/760,662 patent/US11584775B2/en active Active
- 2016-09-23 JP JP2018534521A patent/JP7074674B2/ja active Active
- 2016-09-23 EA EA201890767A patent/EA201890767A1/ru unknown
- 2016-09-23 CN CN201680067912.8A patent/CN108290922B/zh active Active
- 2016-09-23 EP EP16781915.0A patent/EP3353190B1/en active Active
- 2016-09-23 MX MX2018003569A patent/MX386256B/es unknown
- 2016-09-23 ES ES16781915T patent/ES2865163T3/es active Active
- 2016-09-23 AU AU2016326704A patent/AU2016326704B2/en active Active
- 2016-09-23 KR KR1020187011430A patent/KR102796889B1/ko active Active
- 2016-09-23 WO PCT/US2016/053545 patent/WO2017053868A1/en not_active Ceased
- 2016-09-23 CA CA2998681A patent/CA2998681C/en active Active
-
2018
- 2018-03-18 IL IL258185A patent/IL258185B/en unknown
-
2023
- 2023-01-04 US US18/149,696 patent/US12545701B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| NZ741082A (en) | 2023-06-30 |
| AU2016326704A1 (en) | 2018-04-26 |
| HK1258095A1 (zh) | 2019-11-01 |
| IL258185B (en) | 2021-08-31 |
| US12545701B2 (en) | 2026-02-10 |
| JP7074674B2 (ja) | 2022-05-24 |
| KR20180061251A (ko) | 2018-06-07 |
| WO2017053868A1 (en) | 2017-03-30 |
| US20190153022A1 (en) | 2019-05-23 |
| CA2998681A1 (en) | 2017-03-30 |
| EP3353190B1 (en) | 2021-03-17 |
| WO2017053868A8 (en) | 2018-04-19 |
| MX386256B (es) | 2025-03-18 |
| KR102796889B1 (ko) | 2025-04-17 |
| EP3353190A1 (en) | 2018-08-01 |
| AU2016326704B2 (en) | 2021-01-28 |
| BR112018005861B1 (pt) | 2022-11-22 |
| MX2018003569A (es) | 2018-11-29 |
| IL258185A (en) | 2018-05-31 |
| CN108290922A (zh) | 2018-07-17 |
| CN108290922B (zh) | 2021-12-07 |
| CA2998681C (en) | 2024-02-06 |
| US20230250130A1 (en) | 2023-08-10 |
| BR112018005861A2 (pt) | 2018-10-16 |
| JP2018528275A (ja) | 2018-09-27 |
| ES2865163T3 (es) | 2021-10-15 |
| US11584775B2 (en) | 2023-02-21 |
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