MX386256B - Derivados de acido oleanolico modificado en c4 para la inhibicion de il-17 y otros usos. - Google Patents
Derivados de acido oleanolico modificado en c4 para la inhibicion de il-17 y otros usos.Info
- Publication number
- MX386256B MX386256B MX2018003569A MX2018003569A MX386256B MX 386256 B MX386256 B MX 386256B MX 2018003569 A MX2018003569 A MX 2018003569A MX 2018003569 A MX2018003569 A MX 2018003569A MX 386256 B MX386256 B MX 386256B
- Authority
- MX
- Mexico
- Prior art keywords
- acid derivatives
- oleanolic acid
- inhibition
- modified
- formula
- Prior art date
Links
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical class C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000012261 overproduction Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Rheumatology (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562222632P | 2015-09-23 | 2015-09-23 | |
| PCT/US2016/053545 WO2017053868A1 (en) | 2015-09-23 | 2016-09-23 | C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018003569A MX2018003569A (es) | 2018-11-29 |
| MX386256B true MX386256B (es) | 2025-03-18 |
Family
ID=57137257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018003569A MX386256B (es) | 2015-09-23 | 2016-09-23 | Derivados de acido oleanolico modificado en c4 para la inhibicion de il-17 y otros usos. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11584775B2 (https=) |
| EP (1) | EP3353190B1 (https=) |
| JP (1) | JP7074674B2 (https=) |
| KR (1) | KR102796889B1 (https=) |
| CN (1) | CN108290922B (https=) |
| AU (1) | AU2016326704B2 (https=) |
| BR (1) | BR112018005861B1 (https=) |
| CA (1) | CA2998681C (https=) |
| EA (1) | EA201890767A1 (https=) |
| ES (1) | ES2865163T3 (https=) |
| IL (1) | IL258185B (https=) |
| MX (1) | MX386256B (https=) |
| NZ (1) | NZ741082A (https=) |
| WO (1) | WO2017053868A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5529851B2 (ja) | 2008-04-18 | 2014-06-25 | リアタ ファーマシューティカルズ インコーポレイテッド | 抗酸化炎症モジュレーター：ｃ−１７においてアミノ改変およびその他の改変を加えたオレアノール酸誘導体 |
| TWI623548B (zh) | 2012-04-27 | 2018-05-11 | 瑞塔醫藥有限責任公司 | 齊墩果酸（ｂａｒｄｏｘｏｌｏｎｅ ｍｅｔｈｙｌ）之２，２-二氟基丙醯胺衍生物、多晶型及其使用方法 |
| US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
| JP6243428B2 (ja) | 2012-09-10 | 2017-12-06 | リアタ ファーマシューティカルズ インコーポレイテッド | オレアノール酸のｃ１７−アルカンジイルおよびアルケンジイル誘導体ならびにその使用方法 |
| AR096046A1 (es) | 2013-04-24 | 2015-12-02 | Abbvie Inc | Derivados de 2,2-difluoropropanamida de metil bardoxolona, formas polimórficas y métodos de uso |
| JP7074674B2 (ja) | 2015-09-23 | 2022-05-24 | リアタ ファーマシューティカルズ インコーポレイテッド | Ｉｌ－１７の阻害及び他の使用のためのｃ４修飾オレアノール酸誘導体 |
| CN110198718B (zh) | 2016-11-08 | 2023-01-10 | 里亚塔医药控股有限责任公司 | 使用甲基巴多索隆或其类似物治疗阿尔波特综合征的方法 |
| CN108299541B (zh) * | 2018-01-18 | 2020-12-11 | 华南师范大学 | 海洋微生物来源的二倍半萜AsperterpinolB衍生物及合成方法与抗炎应用 |
| CN108191944B (zh) * | 2018-01-18 | 2020-12-11 | 华南师范大学 | 海洋微生物来源的二倍半萜AsperterpinolB衍生物及合成方法与糖酶应用 |
| US12060340B2 (en) | 2018-06-20 | 2024-08-13 | Reata Pharmaceuticals, Inc | Cysteine-dependent inverse agonists of nuclear receptors ROR-gamma/ROR-gamma-t and methods of treating diseases or disorders therewith |
| CN109248168A (zh) * | 2018-10-30 | 2019-01-22 | 武汉卫无忧生物科技有限公司 | 齐墩果酸在制备抗幽门螺杆菌的药物中的用途 |
| TWI752400B (zh) | 2019-01-07 | 2022-01-11 | 美商美國禮來大藥廠 | Il-17a抑制劑 |
| EP3999522B1 (en) * | 2019-07-19 | 2025-09-03 | Reata Pharmaceuticals, Inc. | C17 polar-substituted heteroaromatic synthetic triterpenoids and methods of use thereof |
| AU2021397631A1 (en) | 2020-12-11 | 2023-07-20 | Reata Pharmaceuticals Holdings, LLC | Synthetic triterpenoids for use in therapy |
| MX2023008454A (es) * | 2021-01-18 | 2023-08-07 | Reata Pharmaceuticals Inc | Derivados sintéticos de ácido ursólico y métodos de uso de estos. |
| CN113185570A (zh) * | 2021-05-12 | 2021-07-30 | 张洪胜 | 一种治疗银屑病的齐墩果酸衍生物及其制备方法 |
| CN117964678A (zh) * | 2024-01-29 | 2024-05-03 | 烟台大学 | C17位杂芳族羰基修饰的齐墩果烷三萜衍生物及其制备方法和用途 |
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| JP7074674B2 (ja) | 2015-09-23 | 2022-05-24 | リアタ ファーマシューティカルズ インコーポレイテッド | Ｉｌ－１７の阻害及び他の使用のためのｃ４修飾オレアノール酸誘導体 |
| CN110198718B (zh) | 2016-11-08 | 2023-01-10 | 里亚塔医药控股有限责任公司 | 使用甲基巴多索隆或其类似物治疗阿尔波特综合征的方法 |
| EP3999522B1 (en) | 2019-07-19 | 2025-09-03 | Reata Pharmaceuticals, Inc. | C17 polar-substituted heteroaromatic synthetic triterpenoids and methods of use thereof |
| CA3159778A1 (en) | 2019-12-19 | 2021-06-24 | Reata Pharmaceuticals, Inc. | Synthetic triterpenoids with nitrogen-based substituents at c-17 and methods of use thereof |
-
2016
- 2016-09-23 JP JP2018534521A patent/JP7074674B2/ja active Active
- 2016-09-23 EA EA201890767A patent/EA201890767A1/ru unknown
- 2016-09-23 BR BR112018005861-0A patent/BR112018005861B1/pt active IP Right Grant
- 2016-09-23 KR KR1020187011430A patent/KR102796889B1/ko active Active
- 2016-09-23 CN CN201680067912.8A patent/CN108290922B/zh active Active
- 2016-09-23 ES ES16781915T patent/ES2865163T3/es active Active
- 2016-09-23 MX MX2018003569A patent/MX386256B/es unknown
- 2016-09-23 US US15/760,662 patent/US11584775B2/en active Active
- 2016-09-23 NZ NZ741082A patent/NZ741082A/en unknown
- 2016-09-23 EP EP16781915.0A patent/EP3353190B1/en active Active
- 2016-09-23 AU AU2016326704A patent/AU2016326704B2/en active Active
- 2016-09-23 CA CA2998681A patent/CA2998681C/en active Active
- 2016-09-23 WO PCT/US2016/053545 patent/WO2017053868A1/en not_active Ceased
-
2018
- 2018-03-18 IL IL258185A patent/IL258185B/en unknown
-
2023
- 2023-01-04 US US18/149,696 patent/US12545701B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20180061251A (ko) | 2018-06-07 |
| WO2017053868A8 (en) | 2018-04-19 |
| IL258185A (en) | 2018-05-31 |
| BR112018005861B1 (pt) | 2022-11-22 |
| US11584775B2 (en) | 2023-02-21 |
| BR112018005861A2 (pt) | 2018-10-16 |
| EA201890767A1 (ru) | 2019-09-30 |
| CA2998681A1 (en) | 2017-03-30 |
| AU2016326704A1 (en) | 2018-04-26 |
| IL258185B (en) | 2021-08-31 |
| JP7074674B2 (ja) | 2022-05-24 |
| MX2018003569A (es) | 2018-11-29 |
| EP3353190A1 (en) | 2018-08-01 |
| ES2865163T3 (es) | 2021-10-15 |
| CN108290922B (zh) | 2021-12-07 |
| AU2016326704B2 (en) | 2021-01-28 |
| EP3353190B1 (en) | 2021-03-17 |
| NZ741082A (en) | 2023-06-30 |
| WO2017053868A1 (en) | 2017-03-30 |
| JP2018528275A (ja) | 2018-09-27 |
| HK1258095A1 (zh) | 2019-11-01 |
| US20230250130A1 (en) | 2023-08-10 |
| US12545701B2 (en) | 2026-02-10 |
| CN108290922A (zh) | 2018-07-17 |
| CA2998681C (en) | 2024-02-06 |
| US20190153022A1 (en) | 2019-05-23 |
| KR102796889B1 (ko) | 2025-04-17 |
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