MX375674B - Compuestos de carboxamida inhibidores de la actividad de cinasa rip2. - Google Patents
Compuestos de carboxamida inhibidores de la actividad de cinasa rip2.Info
- Publication number
- MX375674B MX375674B MX2017013556A MX2017013556A MX375674B MX 375674 B MX375674 B MX 375674B MX 2017013556 A MX2017013556 A MX 2017013556A MX 2017013556 A MX2017013556 A MX 2017013556A MX 375674 B MX375674 B MX 375674B
- Authority
- MX
- Mexico
- Prior art keywords
- rip2 kinase
- kinase activity
- carboxamide compounds
- compounds inhibiting
- inhibiting rip2
- Prior art date
Links
- 101001109137 Homo sapiens Receptor-interacting serine/threonine-protein kinase 2 Proteins 0.000 title abstract 4
- 102100022502 Receptor-interacting serine/threonine-protein kinase 2 Human genes 0.000 title abstract 4
- 230000000694 effects Effects 0.000 title abstract 2
- -1 CARBOXAMIDE COMPOUNDS Chemical class 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000000593 degrading effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a compuestos, composiciones, combinaciones y medicamentos que contienen dichos compuestos y a procedimientos para su preparación. La invención también se refiere al uso de dichos compuestos, combinaciones, composiciones y medicamentos, por ejemplo como inhibidores de la actividad de cinasa RIP2, incluyendo la degradación de cinasa RIP2, el tratamiento de enfermedades y estados mediados por la cinasa RIP2, en particular para el tratamiento de enfermedades o estados inflamatorios.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1506872.9A GB201506872D0 (en) | 2015-04-22 | 2015-04-22 | Novel compounds |
| PCT/US2016/028332 WO2016172134A2 (en) | 2015-04-22 | 2016-04-20 | Novel compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017013556A MX2017013556A (es) | 2018-08-01 |
| MX375674B true MX375674B (es) | 2025-03-06 |
Family
ID=53299021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017013556A MX375674B (es) | 2015-04-22 | 2016-04-20 | Compuestos de carboxamida inhibidores de la actividad de cinasa rip2. |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US10435391B2 (es) |
| EP (1) | EP3286169B1 (es) |
| JP (1) | JP2018513867A (es) |
| KR (1) | KR20170139096A (es) |
| CN (1) | CN107709305B (es) |
| AU (1) | AU2016252404B2 (es) |
| BR (1) | BR112017022604A2 (es) |
| CA (1) | CA2983414A1 (es) |
| CL (1) | CL2017002650A1 (es) |
| CO (1) | CO2017011851A2 (es) |
| CR (1) | CR20170478A (es) |
| EA (1) | EA033343B1 (es) |
| ES (1) | ES2841548T3 (es) |
| GB (1) | GB201506872D0 (es) |
| HK (1) | HK1243410A1 (es) |
| IL (1) | IL255067A0 (es) |
| MX (1) | MX375674B (es) |
| PE (1) | PE20180044A1 (es) |
| PH (1) | PH12017501921A1 (es) |
| SG (1) | SG11201708311UA (es) |
| WO (1) | WO2016172134A2 (es) |
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| US10071164B2 (en) * | 2014-08-11 | 2018-09-11 | Yale University | Estrogen-related receptor alpha based protac compounds and associated methods of use |
| HK1245791A1 (zh) | 2015-01-20 | 2018-08-31 | 阿尔维纳斯运营股份有限公司 | 用於雄激素受体的靶向降解的化合物和方法 |
| US12312316B2 (en) | 2015-01-20 | 2025-05-27 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| JP7269731B2 (ja) | 2015-03-18 | 2023-05-09 | アルビナス・オペレーションズ・インコーポレイテッド | 標的タンパク質の分解向上のための化合物および方法 |
| GB201506872D0 (en) | 2015-04-22 | 2015-06-03 | Ge Oil & Gas Uk Ltd | Novel compounds |
| WO2016197114A1 (en) | 2015-06-05 | 2016-12-08 | Arvinas, Inc. | Tank-binding kinase-1 protacs and associated methods of use |
| CN108137507A (zh) | 2015-07-10 | 2018-06-08 | 阿尔维纳斯股份有限公司 | 基于mdm2的蛋白水解调节剂和相关的使用方法 |
| EP3337476A4 (en) | 2015-08-19 | 2019-09-04 | Arvinas, Inc. | Compounds and methods for the targeted degradation of bromodomain-containing proteins |
| US20170281784A1 (en) | 2016-04-05 | 2017-10-05 | Arvinas, Inc. | Protein-protein interaction inducing technology |
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| LT3660004T (lt) | 2016-10-11 | 2023-06-12 | Arvinas Operations, Inc. | Junginiai ir metodai, skirti tikslinei androgeno receptoriaus degradacijai |
| EP3535265A4 (en) | 2016-11-01 | 2020-07-08 | Arvinas, Inc. | PROTACS TARGETING ON TAU PROTEIN AND RELATED METHODS FOR USE |
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| EP3558994A4 (en) | 2016-12-23 | 2021-05-12 | Arvinas Operations, Inc. | COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF FAST ACCELERATED FIBROSARCOMA POLYPEPTIDES |
| US11173211B2 (en) | 2016-12-23 | 2021-11-16 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides |
| EP3559006A4 (en) | 2016-12-23 | 2021-03-03 | Arvinas Operations, Inc. | COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF F TAL LIVER KINASE POLYPEPTIDES |
| RU2019121527A (ru) | 2016-12-23 | 2021-01-15 | Эрвинэс Оперейшнс, Инк. | Химерные молекулы, нацеливающиеся на протеолиз egfr, и связанные с ними способы применения |
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| CN112638905A (zh) * | 2018-08-28 | 2021-04-09 | 南京明德新药研发有限公司 | 作为rip2激酶抑制剂的喹唑啉类衍生物 |
| US11547759B2 (en) | 2019-01-30 | 2023-01-10 | Montelino Therapeutics, Inc. | Bi-functional compounds and methods for targeted ubiquitination of androgen receptor |
| WO2020160295A1 (en) | 2019-01-30 | 2020-08-06 | Montelino Therapeutics, Llc | Bi-functional compounds and methods for targeted ubiquitination of androgen receptor |
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| ES2654623T3 (es) | 2012-08-23 | 2018-02-14 | The Regents Of The University Of Michigan | Inhibidores bivalentes de proteínas IAP y métodos terapéuticos que los usan |
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-
2015
- 2015-04-22 GB GBGB1506872.9A patent/GB201506872D0/en not_active Ceased
-
2016
- 2016-04-20 CA CA2983414A patent/CA2983414A1/en not_active Abandoned
- 2016-04-20 WO PCT/US2016/028332 patent/WO2016172134A2/en not_active Ceased
- 2016-04-20 US US15/568,025 patent/US10435391B2/en not_active Expired - Fee Related
- 2016-04-20 AU AU2016252404A patent/AU2016252404B2/en not_active Ceased
- 2016-04-20 CN CN201680036813.3A patent/CN107709305B/zh not_active Expired - Fee Related
- 2016-04-20 SG SG11201708311UA patent/SG11201708311UA/en unknown
- 2016-04-20 BR BR112017022604-9A patent/BR112017022604A2/pt not_active Application Discontinuation
- 2016-04-20 MX MX2017013556A patent/MX375674B/es active IP Right Grant
- 2016-04-20 CR CR20170478A patent/CR20170478A/es unknown
- 2016-04-20 PE PE2017002302A patent/PE20180044A1/es unknown
- 2016-04-20 JP JP2017555322A patent/JP2018513867A/ja not_active Ceased
- 2016-04-20 KR KR1020177033407A patent/KR20170139096A/ko not_active Withdrawn
- 2016-04-20 HK HK18102883.6A patent/HK1243410A1/zh unknown
- 2016-04-20 EA EA201792047A patent/EA033343B1/ru not_active IP Right Cessation
- 2016-04-20 ES ES16783708T patent/ES2841548T3/es active Active
- 2016-04-20 EP EP16783708.7A patent/EP3286169B1/en active Active
-
2017
- 2017-10-16 IL IL255067A patent/IL255067A0/en unknown
- 2017-10-18 CL CL2017002650A patent/CL2017002650A1/es unknown
- 2017-10-20 PH PH12017501921A patent/PH12017501921A1/en unknown
- 2017-11-21 CO CONC2017/0011851A patent/CO2017011851A2/es unknown
-
2019
- 2019-08-22 US US16/547,734 patent/US20190382381A1/en not_active Abandoned
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|---|---|
| EP3286169B1 (en) | 2020-10-07 |
| BR112017022604A2 (pt) | 2018-07-17 |
| CN107709305B (zh) | 2020-09-29 |
| PE20180044A1 (es) | 2018-01-15 |
| US20180134688A1 (en) | 2018-05-17 |
| CR20170478A (es) | 2018-01-22 |
| EP3286169A2 (en) | 2018-02-28 |
| US20190382381A1 (en) | 2019-12-19 |
| MX2017013556A (es) | 2018-08-01 |
| AU2016252404B2 (en) | 2018-07-26 |
| EA033343B1 (ru) | 2019-09-30 |
| IL255067A0 (en) | 2017-12-31 |
| CA2983414A1 (en) | 2016-10-27 |
| US10435391B2 (en) | 2019-10-08 |
| ES2841548T3 (es) | 2021-07-08 |
| GB201506872D0 (en) | 2015-06-03 |
| EA201792047A1 (ru) | 2018-04-30 |
| CN107709305A (zh) | 2018-02-16 |
| CO2017011851A2 (es) | 2018-02-09 |
| CL2017002650A1 (es) | 2018-03-16 |
| JP2018513867A (ja) | 2018-05-31 |
| AU2016252404A1 (en) | 2017-12-07 |
| EP3286169A4 (en) | 2018-11-21 |
| WO2016172134A3 (en) | 2016-12-01 |
| KR20170139096A (ko) | 2017-12-18 |
| PH12017501921A1 (en) | 2018-03-19 |
| SG11201708311UA (en) | 2017-11-29 |
| WO2016172134A2 (en) | 2016-10-27 |
| HK1243410A1 (zh) | 2018-07-13 |
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