CA2998681C - Derives d'acide oleanolique modifie en c4 pour l'inhibition de l'il-17 et d'autres utilisations - Google Patents

Derives d'acide oleanolique modifie en c4 pour l'inhibition de l'il-17 et d'autres utilisations Download PDF

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Publication number
CA2998681C
CA2998681C CA2998681A CA2998681A CA2998681C CA 2998681 C CA2998681 C CA 2998681C CA 2998681 A CA2998681 A CA 2998681A CA 2998681 A CA2998681 A CA 2998681A CA 2998681 C CA2998681 C CA 2998681C
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Prior art keywords
substituted
alkyl
hydrogen
alkoxy
compound
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CA2998681A1 (fr
Inventor
Melean Visnick
Xin Jiang
Martha R. Hotema
Chitase Lee
Bradley William Caprathe
William H. Roark
Gary Bolton
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Reata Pharmaceuticals Inc
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Reata Pharmaceuticals Inc
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Publication of CA2998681A1 publication Critical patent/CA2998681A1/fr
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

L'invention concerne des dérivés d'acide oléanolique modifiés en C4 de formule : formule (X) ou formule (XII), ainsi que des analogues de ces derniers, dans lesquelles les variables sont telles que définies dans la description. En outre, l'invention concerne des compositions pharmaceutiques de ces dérivés ou analogues, des procédés pour leur fabrication, et des procédés pour leur utilisation, y compris pour la prévention et le traitement de maladies ou de troubles associés à la surproduction d'IL-17.
CA2998681A 2015-09-23 2016-09-23 Derives d'acide oleanolique modifie en c4 pour l'inhibition de l'il-17 et d'autres utilisations Active CA2998681C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562222632P 2015-09-23 2015-09-23
US62/222,632 2015-09-23
PCT/US2016/053545 WO2017053868A1 (fr) 2015-09-23 2016-09-23 Dérivés d'acide oléanolique modifié en c4 pour l'inhibition de l'il-17 et d'autres utilisations

Publications (2)

Publication Number Publication Date
CA2998681A1 CA2998681A1 (fr) 2017-03-30
CA2998681C true CA2998681C (fr) 2024-02-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2998681A Active CA2998681C (fr) 2015-09-23 2016-09-23 Derives d'acide oleanolique modifie en c4 pour l'inhibition de l'il-17 et d'autres utilisations

Country Status (15)

Country Link
US (2) US11584775B2 (fr)
EP (1) EP3353190B1 (fr)
JP (1) JP7074674B2 (fr)
KR (1) KR20180061251A (fr)
CN (1) CN108290922B (fr)
AU (1) AU2016326704B2 (fr)
BR (1) BR112018005861B1 (fr)
CA (1) CA2998681C (fr)
EA (1) EA201890767A1 (fr)
ES (1) ES2865163T3 (fr)
HK (1) HK1258095A1 (fr)
IL (1) IL258185B (fr)
MX (1) MX2018003569A (fr)
NZ (1) NZ741082A (fr)
WO (1) WO2017053868A1 (fr)

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US10953020B2 (en) 2016-11-08 2021-03-23 Reata Pharmaceuticals, Inc. Methods of treating Alport syndrome using bardoxolone methyl or analogs thereof
CN108299541B (zh) * 2018-01-18 2020-12-11 华南师范大学 海洋微生物来源的二倍半萜AsperterpinolB衍生物及合成方法与抗炎应用
CN108191944B (zh) * 2018-01-18 2020-12-11 华南师范大学 海洋微生物来源的二倍半萜AsperterpinolB衍生物及合成方法与糖酶应用
CN109248168A (zh) * 2018-10-30 2019-01-22 武汉卫无忧生物科技有限公司 齐墩果酸在制备抗幽门螺杆菌的药物中的用途
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WO2022126129A1 (fr) 2020-12-11 2022-06-16 Reata Pharmaceuticals, Inc. Triterpénoïdes synthétiques destinés à être utilisés en thérapie
AU2022208727A1 (en) * 2021-01-18 2023-08-03 Reata Pharmaceuticals, Inc. Synthetic ursolic acid derivatives and methods of use thereof
CN113185570A (zh) * 2021-05-12 2021-07-30 张洪胜 一种治疗银屑病的齐墩果酸衍生物及其制备方法

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Also Published As

Publication number Publication date
NZ741082A (en) 2023-06-30
EA201890767A1 (ru) 2019-09-30
EP3353190A1 (fr) 2018-08-01
KR20180061251A (ko) 2018-06-07
AU2016326704B2 (en) 2021-01-28
AU2016326704A1 (en) 2018-04-26
WO2017053868A1 (fr) 2017-03-30
CN108290922A (zh) 2018-07-17
ES2865163T3 (es) 2021-10-15
US20190153022A1 (en) 2019-05-23
US11584775B2 (en) 2023-02-21
JP7074674B2 (ja) 2022-05-24
IL258185A (en) 2018-05-31
CA2998681A1 (fr) 2017-03-30
MX2018003569A (es) 2018-11-29
BR112018005861A2 (pt) 2018-10-16
US20230250130A1 (en) 2023-08-10
WO2017053868A8 (fr) 2018-04-19
IL258185B (en) 2021-08-31
CN108290922B (zh) 2021-12-07
HK1258095A1 (zh) 2019-11-01
EP3353190B1 (fr) 2021-03-17
BR112018005861B1 (pt) 2022-11-22
JP2018528275A (ja) 2018-09-27

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