CN108178733A - 苯基取代的环烷胺作为一元胺再摄取抑制剂 - Google Patents

苯基取代的环烷胺作为一元胺再摄取抑制剂 Download PDF

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Publication number
CN108178733A
CN108178733A CN201710885364.6A CN201710885364A CN108178733A CN 108178733 A CN108178733 A CN 108178733A CN 201710885364 A CN201710885364 A CN 201710885364A CN 108178733 A CN108178733 A CN 108178733A
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China
Prior art keywords
substituted
unsubstituted
compound
alkyl
aryl
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Pending
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CN201710885364.6A
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English (en)
Chinese (zh)
Inventor
邵黎明
王凤江
S·C·玛尔科姆
M·C·赫维特
马建国
S·莱布
M·A·瓦尼
U·坎贝尔
S·R·恩格尔
L·W·哈迪
P·科克
R·施雷伯
K·L·斯皮尔
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Sumitomo Pharma America Inc
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Sepracor Inc
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Publication of CN108178733A publication Critical patent/CN108178733A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/76—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and etherified hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201710885364.6A 2007-05-31 2008-06-02 苯基取代的环烷胺作为一元胺再摄取抑制剂 Pending CN108178733A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94124207P 2007-05-31 2007-05-31
US60/941,242 2007-05-31
CN200880018324A CN101686672A (zh) 2007-05-31 2008-06-02 苯基取代的环烷胺作为一元胺再摄取抑制剂

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200880018324A Division CN101686672A (zh) 2007-05-31 2008-06-02 苯基取代的环烷胺作为一元胺再摄取抑制剂

Publications (1)

Publication Number Publication Date
CN108178733A true CN108178733A (zh) 2018-06-19

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
CN201710885364.6A Pending CN108178733A (zh) 2007-05-31 2008-06-02 苯基取代的环烷胺作为一元胺再摄取抑制剂
CN201410016299.XA Expired - Fee Related CN103936605B (zh) 2007-05-31 2008-06-02 苯基取代的环烷胺作为一元胺再摄取抑制剂
CN200880018324A Pending CN101686672A (zh) 2007-05-31 2008-06-02 苯基取代的环烷胺作为一元胺再摄取抑制剂

Family Applications After (2)

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CN201410016299.XA Expired - Fee Related CN103936605B (zh) 2007-05-31 2008-06-02 苯基取代的环烷胺作为一元胺再摄取抑制剂
CN200880018324A Pending CN101686672A (zh) 2007-05-31 2008-06-02 苯基取代的环烷胺作为一元胺再摄取抑制剂

Country Status (14)

Country Link
US (3) US8669291B2 (enExample)
EP (3) EP2154962A4 (enExample)
JP (3) JP5420534B2 (enExample)
KR (1) KR101581289B1 (enExample)
CN (3) CN108178733A (enExample)
AU (1) AU2008259841B2 (enExample)
BR (1) BRPI0811639A2 (enExample)
CA (1) CA2688493C (enExample)
IL (1) IL202405A (enExample)
MX (1) MX2009012685A (enExample)
NZ (1) NZ580429A (enExample)
RU (1) RU2470011C2 (enExample)
WO (1) WO2008151156A1 (enExample)
ZA (1) ZA200907171B (enExample)

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WO2010017418A1 (en) * 2008-08-07 2010-02-11 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
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WO2011017634A2 (en) * 2009-08-07 2011-02-10 Sepracore Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
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US9283196B1 (en) * 2013-01-30 2016-03-15 MediSynergics, LLC Cycloalkyl-diamines for CNS disorders
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WO2017197101A1 (en) * 2016-05-12 2017-11-16 Research Triangle Institute Vinylogous phenethylamines as neurotransmitter releasers
WO2021241875A1 (ko) 2020-05-29 2021-12-02 재단법인 대구경북첨단의료산업진흥재단 설폰아미드 유도체 및 이를 유효성분으로 함유하는 정신질환의 예방 또는 치료용 약학적 조성물
KR102397705B1 (ko) 2020-05-29 2022-05-13 재단법인 대구경북첨단의료산업진흥재단 N을 하나 이상 포함하는 5원자의 헤테로아릴 유도체 및 이를 유효성분으로 함유하는 정신질환의 예방 또는 치료용 약학적 조성물
JP2023528546A (ja) 2020-05-29 2023-07-04 テグ－キョンプク メディカル イノベーション ファウンデーション カルボキサミド誘導体およびそれを有効成分とする精神病の予防または治療に使用するための医薬組成物
WO2025232878A1 (zh) * 2024-05-09 2025-11-13 苏州旺山旺水生物医药股份有限公司 一类含取代的苯基的胺类化合物、其制备方法和用途

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