CN108137706A - 药物缀合的双特异性抗原结合构建体 - Google Patents

药物缀合的双特异性抗原结合构建体 Download PDF

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Publication number
CN108137706A
CN108137706A CN201680053451.9A CN201680053451A CN108137706A CN 108137706 A CN108137706 A CN 108137706A CN 201680053451 A CN201680053451 A CN 201680053451A CN 108137706 A CN108137706 A CN 108137706A
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China
Prior art keywords
antigen
binding
composition
construct
cell
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CN201680053451.9A
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Chinese (zh)
Inventor
G·Y·K·恩格
L·G·普雷斯塔
T·斯普雷特冯克罗登斯泰恩
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Zymeworks BC Inc
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Zymeworks BC Inc
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Publication of CN108137706A publication Critical patent/CN108137706A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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