CN1077888C - 苯并吡喃类化合物和含有它们的药物组合物 - Google Patents

苯并吡喃类化合物和含有它们的药物组合物 Download PDF

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Publication number
CN1077888C
CN1077888C CN96194146A CN96194146A CN1077888C CN 1077888 C CN1077888 C CN 1077888C CN 96194146 A CN96194146 A CN 96194146A CN 96194146 A CN96194146 A CN 96194146A CN 1077888 C CN1077888 C CN 1077888C
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CN
China
Prior art keywords
chromene
dihydro
dimethyl
hydroxyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN96194146A
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English (en)
Chinese (zh)
Other versions
CN1185153A (zh
Inventor
P·W·曼利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10774940&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1077888(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN1185153A publication Critical patent/CN1185153A/zh
Application granted granted Critical
Publication of CN1077888C publication Critical patent/CN1077888C/zh
Anticipated expiration legal-status Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN96194146A 1995-05-24 1996-05-24 苯并吡喃类化合物和含有它们的药物组合物 Expired - Fee Related CN1077888C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9510477.4 1995-05-24
GBGB9510477.4A GB9510477D0 (en) 1995-05-24 1995-05-24 Organic compounds

Publications (2)

Publication Number Publication Date
CN1185153A CN1185153A (zh) 1998-06-17
CN1077888C true CN1077888C (zh) 2002-01-16

Family

ID=10774940

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96194146A Expired - Fee Related CN1077888C (zh) 1995-05-24 1996-05-24 苯并吡喃类化合物和含有它们的药物组合物

Country Status (30)

Country Link
US (1) US5905156A (https=)
EP (1) EP0828733B1 (https=)
JP (1) JPH11505820A (https=)
KR (1) KR100437981B1 (https=)
CN (1) CN1077888C (https=)
AR (1) AR004489A1 (https=)
AT (1) ATE205204T1 (https=)
AU (1) AU703276B2 (https=)
BR (1) BR9609048A (https=)
CA (1) CA2217821C (https=)
CO (1) CO4700520A1 (https=)
CZ (1) CZ294474B6 (https=)
DE (1) DE69615019T2 (https=)
DK (1) DK0828733T3 (https=)
ES (1) ES2163634T3 (https=)
FI (1) FI973992A7 (https=)
GB (1) GB9510477D0 (https=)
HU (1) HU222772B1 (https=)
IL (1) IL118382A (https=)
MY (1) MY114924A (https=)
NO (1) NO314846B1 (https=)
NZ (1) NZ309765A (https=)
PL (1) PL184144B1 (https=)
PT (1) PT828733E (https=)
RU (1) RU2160735C2 (https=)
SK (1) SK283215B6 (https=)
TR (1) TR199701417T1 (https=)
TW (1) TW421646B (https=)
WO (1) WO1996037490A1 (https=)
ZA (1) ZA964209B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106008288A (zh) * 2016-06-15 2016-10-12 西北农林科技大学 一种苯磺酰胺类化合物及其用途

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972894A (en) * 1997-08-07 1999-10-26 Cytran, Inc. Peptides having potassium channel opener activity
GB9822024D0 (en) * 1998-10-09 1998-12-02 Novartis Ag Organic compounds
GB9909792D0 (en) * 1998-12-04 1999-06-23 Cambridge Bioclinical Limited Potassium channel activators and their use
US6384244B2 (en) 2000-05-18 2002-05-07 Merck & Co., Inc. Process for preparing cis- aminochromanols
KR101078357B1 (ko) * 2002-08-29 2011-10-31 닛산 가가쿠 고교 가부시키 가이샤 아미노벤조피란 화합물의 제조방법
US7098340B2 (en) 2003-05-14 2006-08-29 Warner Lambert Company Llc Benzyl sulfonamide derivatives
KR100704009B1 (ko) * 2005-08-30 2007-04-04 한국화학연구원 염증억제 활성을 가지는6-알킬아미노-2-메틸-2'-(ｎ-메틸치환술폰아미도)메틸-2ｈ-1-벤조피란 유도체
CA2999769A1 (en) 2015-09-28 2017-04-06 Genentech, Inc. Therapeutic compounds and methods of use thereof
JP2020511511A (ja) * 2017-03-24 2020-04-16 ジェネンテック， インコーポレイテッド ナトリウムチャネル阻害剤としての４−ピペリジン−ｎ−（ピリミジン−４−イル）クロマン−７−スルホンアミド誘導体
TW202003490A (zh) 2018-05-22 2020-01-16 瑞士商赫孚孟拉羅股份公司 治療性化合物及其使用方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0514942A1 (en) * 1991-05-22 1992-11-25 Korea Research Institute Of Chemical Technology Novel benzopyran derivatives and processes for the preparation thereof
US5236935A (en) * 1992-05-21 1993-08-17 Korea Research Institute Of Chemical Technology Benzopyran derivatives and processes for the preparation thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4971982A (en) * 1987-07-06 1990-11-20 Hoffmann-La Roche Inc. Benzopyran derivatives
ES2030627A6 (es) * 1990-11-28 1992-11-01 Uriach & Cia Sa J Procedimiento para la obtencion de compuestos benzopiranicos.
GB9102803D0 (en) * 1991-02-11 1991-03-27 Ici Plc Pyridine compounds
TW244350B (https=) * 1991-12-14 1995-04-01 Hoechst Ag

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0514942A1 (en) * 1991-05-22 1992-11-25 Korea Research Institute Of Chemical Technology Novel benzopyran derivatives and processes for the preparation thereof
US5236935A (en) * 1992-05-21 1993-08-17 Korea Research Institute Of Chemical Technology Benzopyran derivatives and processes for the preparation thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106008288A (zh) * 2016-06-15 2016-10-12 西北农林科技大学 一种苯磺酰胺类化合物及其用途

Also Published As

Publication number Publication date
CN1185153A (zh) 1998-06-17
AR004489A1 (es) 1998-12-16
NZ309765A (en) 2000-01-28
DE69615019D1 (de) 2001-10-11
IL118382A (en) 2000-01-31
PL184144B1 (pl) 2002-09-30
CO4700520A1 (es) 1998-12-29
SK283215B6 (sk) 2003-03-04
CA2217821A1 (en) 1996-11-28
TW421646B (en) 2001-02-11
CZ368897A3 (cs) 1998-02-18
CZ294474B6 (cs) 2005-01-12
IL118382A0 (en) 1996-09-12
HUP9801751A2 (hu) 1999-06-28
NO314846B1 (no) 2003-06-02
KR19990021925A (ko) 1999-03-25
GB9510477D0 (en) 1995-07-19
NO975365D0 (no) 1997-11-21
TR199701417T1 (xx) 1998-02-21
HK1014137A1 (en) 1999-09-24
ATE205204T1 (de) 2001-09-15
DE69615019T2 (de) 2002-06-06
JPH11505820A (ja) 1999-05-25
MX9709004A (es) 1998-03-31
FI973992L (fi) 1997-12-09
SK157797A3 (en) 1998-05-06
EP0828733A1 (en) 1998-03-18
FI973992A7 (fi) 1997-12-09
CA2217821C (en) 2008-05-06
US5905156A (en) 1999-05-18
DK0828733T3 (da) 2001-12-17
BR9609048A (pt) 1999-02-23
ZA964209B (en) 1997-11-24
MY114924A (en) 2003-02-28
HUP9801751A3 (en) 1999-08-30
KR100437981B1 (ko) 2004-07-16
PT828733E (pt) 2002-02-28
ES2163634T3 (es) 2002-02-01
AU6000896A (en) 1996-12-11
FI973992A0 (fi) 1997-10-17
NO975365L (no) 1998-01-15
EP0828733B1 (en) 2001-09-05
RU2160735C2 (ru) 2000-12-20
HU222772B1 (hu) 2003-10-28
AU703276B2 (en) 1999-03-25
PL324042A1 (en) 1998-05-11
WO1996037490A1 (en) 1996-11-28

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20020116

Termination date: 20130524