CN107382860A - 脯氨酰羟化酶抑制剂的晶体形态 - Google Patents

脯氨酰羟化酶抑制剂的晶体形态 Download PDF

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Publication number
CN107382860A
CN107382860A CN201710546619.6A CN201710546619A CN107382860A CN 107382860 A CN107382860 A CN 107382860A CN 201710546619 A CN201710546619 A CN 201710546619A CN 107382860 A CN107382860 A CN 107382860A
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compound
salt
item
amino
methyl
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Chinese (zh)
Inventor
克劳迪娅·维兹
朴贞玟
迈克尔·道格拉斯·汤普森
迈克尔·约翰·马蒂内利
大卫·A·尤为尔
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Fibrogen Inc
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Fibrogen Inc
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Application filed by Fibrogen Inc filed Critical Fibrogen Inc
Publication of CN107382860A publication Critical patent/CN107382860A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P39/00—General protective or antinoxious agents
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • AIDS & HIV (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
CN201710546619.6A 2012-07-16 2013-07-15 脯氨酰羟化酶抑制剂的晶体形态 Pending CN107382860A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261672191P 2012-07-16 2012-07-16
US61/672,191 2012-07-16
US201361768297P 2013-02-22 2013-02-22
US61/768,297 2013-02-22
US201361832566P 2013-06-07 2013-06-07
US61/832,566 2013-06-07
CN201310302481.7A CN103539735B (zh) 2012-07-16 2013-07-15 脯氨酰羟化酶抑制剂的晶体形态

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CN107382860A true CN107382860A (zh) 2017-11-24

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CN201710546191.5A Active CN107501177B (zh) 2012-07-16 2013-07-15 脯氨酰羟化酶抑制剂的晶体形态
CN202111361393.5A Pending CN114409596A (zh) 2012-07-16 2013-07-15 脯氨酰羟化酶抑制剂的晶体形态
CN201710546643.XA Pending CN107540607A (zh) 2012-07-16 2013-07-15 脯氨酰羟化酶抑制剂的晶体形态
CN201380037479.XA Pending CN104684897A (zh) 2012-07-16 2013-07-15 脯氨酰羟化酶抑制剂的晶体形态
CN201710546619.6A Pending CN107382860A (zh) 2012-07-16 2013-07-15 脯氨酰羟化酶抑制剂的晶体形态
CN201810750543.3A Pending CN109369524A (zh) 2012-07-16 2013-07-15 脯氨酰羟化酶抑制剂的晶体形态
CN202210791828.8A Pending CN115093370A (zh) 2012-07-16 2013-07-15 脯氨酰羟化酶抑制剂的晶体形态
CN201310302481.7A Active CN103539735B (zh) 2012-07-16 2013-07-15 脯氨酰羟化酶抑制剂的晶体形态
CN201710546354.XA Active CN107382859B (zh) 2012-07-16 2013-07-15 脯氨酰羟化酶抑制剂的晶体形态

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CN201710546191.5A Active CN107501177B (zh) 2012-07-16 2013-07-15 脯氨酰羟化酶抑制剂的晶体形态
CN202111361393.5A Pending CN114409596A (zh) 2012-07-16 2013-07-15 脯氨酰羟化酶抑制剂的晶体形态
CN201710546643.XA Pending CN107540607A (zh) 2012-07-16 2013-07-15 脯氨酰羟化酶抑制剂的晶体形态
CN201380037479.XA Pending CN104684897A (zh) 2012-07-16 2013-07-15 脯氨酰羟化酶抑制剂的晶体形态

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CN201810750543.3A Pending CN109369524A (zh) 2012-07-16 2013-07-15 脯氨酰羟化酶抑制剂的晶体形态
CN202210791828.8A Pending CN115093370A (zh) 2012-07-16 2013-07-15 脯氨酰羟化酶抑制剂的晶体形态
CN201310302481.7A Active CN103539735B (zh) 2012-07-16 2013-07-15 脯氨酰羟化酶抑制剂的晶体形态
CN201710546354.XA Active CN107382859B (zh) 2012-07-16 2013-07-15 脯氨酰羟化酶抑制剂的晶体形态

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US (5) US9115085B2 (enExample)
EP (3) EP4029854A1 (enExample)
JP (2) JP6491093B2 (enExample)
KR (4) KR20220164068A (enExample)
CN (9) CN107501177B (enExample)
AU (1) AU2013290438C1 (enExample)
BR (1) BR112015001101A2 (enExample)
CA (1) CA2879242C (enExample)
CY (2) CY1120805T1 (enExample)
DK (2) DK2872488T3 (enExample)
ES (2) ES2905898T3 (enExample)
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HK (1) HK1243409A1 (enExample)
HR (2) HRP20220182T1 (enExample)
HU (2) HUE057925T2 (enExample)
IL (1) IL236626B (enExample)
IN (1) IN2015KN00262A (enExample)
LT (3) LT3470397T (enExample)
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NZ (1) NZ704662A (enExample)
PL (2) PL2872488T3 (enExample)
PT (2) PT2872488T (enExample)
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SG (3) SG10201700873UA (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
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CN107382859A (zh) * 2012-07-16 2017-11-24 菲布罗根有限公司 脯氨酰羟化酶抑制剂的晶体形态

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CN102718708A (zh) 2003-06-06 2012-10-10 菲布罗根有限公司 含氮杂芳基化合物及其在增加内源性促红细胞生成素中的用途
CN105037323A (zh) 2008-11-14 2015-11-11 菲布罗根有限公司 作为hif羟化酶抑制剂的苯并噻喃衍生物
CN103608346B (zh) 2011-02-02 2016-06-15 菲布罗根有限公司 作为缺氧诱导因子(hif)羟化酶抑制剂的萘啶衍生物
ES2631655T3 (es) 2012-07-16 2017-09-01 Fibrogen, Inc. Procedimiento para fabricar compuestos de isoquinolina
US8883823B2 (en) 2012-07-16 2014-11-11 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
LT3003284T (lt) 2013-06-06 2020-04-27 Fibrogen, Inc. Hif hidroksilazės inhibitoriaus farmacinės kompozicijos
CN103694172A (zh) * 2013-12-26 2014-04-02 辽宁亿灵科创生物医药科技有限公司 含氮杂芳基化合物的衍生物
WO2016045125A1 (en) 2014-09-28 2016-03-31 Merck Sharp & Dohme Corp. Inhibitors of hif prolyl hydroxylase
CN104892509B (zh) * 2015-06-04 2018-03-09 苏州明锐医药科技有限公司 诺得司他的制备方法
CN106916105A (zh) * 2015-12-28 2017-07-04 徐州万邦金桥制药有限公司 一种纯化可博美的方法
US11510917B2 (en) 2016-02-19 2022-11-29 Cornell University HIF-stabilization and prevention of hyperoxia-induced neonatal lung disease
CN106187888A (zh) * 2016-07-18 2016-12-07 江苏德源药业股份有限公司 Fg‑4592单晶及其制备方法
CN108017583B (zh) * 2016-11-01 2021-04-06 徐州万邦金桥制药有限公司 一种可博美的制备方法
CN107382986B (zh) * 2017-08-02 2022-09-20 江苏艾立康医药科技有限公司 4-羟基-1-甲基异喹啉衍生物及其在增加内源性促红细胞生成素中的用途
WO2019030711A1 (en) * 2017-08-11 2019-02-14 Dr. Reddy’S Laboratories Limited POLYMORPHS AND CO-CRYSTALS OF ROXADUSTAT
WO2019042485A1 (en) 2017-08-30 2019-03-07 Zentiva, K.S. FORMS IN THE STRONG STATE OF ROXADUSTAT
JP7144510B2 (ja) * 2017-09-04 2022-09-29 サンド・アクチエンゲゼルシヤフト 経口投与可能なｈｉｆプロリルヒドロキシラーゼ阻害剤の共結晶
CN112166105B (zh) 2018-06-05 2022-03-04 沈阳化工大学 一种三氟乙基硫醚(亚砜)取代苯类化合物及其用途
CN111320583A (zh) * 2018-12-14 2020-06-23 广东东阳光药业有限公司 诺德司他新晶型及其制备方法
CN109369525A (zh) * 2018-12-29 2019-02-22 安礼特（上海）医药科技有限公司 罗沙司它的新晶型及其制备方法
WO2020217190A1 (en) * 2019-04-26 2020-10-29 Dr. Reddy’S Laboratories Limited Process for the purification of roxadustat
CN112679428A (zh) * 2019-10-17 2021-04-20 罗欣药业(上海)有限公司 罗沙司他新晶型及其制备方法
CN113015722B (zh) * 2019-10-22 2022-02-11 苏州科睿思制药有限公司 一种低氧诱导因子脯氨酰羟化酶抑制剂晶型
CN110721185B (zh) * 2019-11-13 2022-04-12 南京市儿童医院 罗沙司他用于心肌保护的用途
CN112961107B (zh) * 2019-12-13 2024-06-25 罗欣药业(上海)有限公司 罗沙司他的晶型及其制备方法
US20230190731A1 (en) * 2020-03-17 2023-06-22 Zydus Lifesciences Limited Formulation comprising hif prolyl hydroxylase inhibitors
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