CN107208138A - 用于癌症预后和治疗的方法和组合物 - Google Patents
用于癌症预后和治疗的方法和组合物 Download PDFInfo
- Publication number
- CN107208138A CN107208138A CN201580070110.8A CN201580070110A CN107208138A CN 107208138 A CN107208138 A CN 107208138A CN 201580070110 A CN201580070110 A CN 201580070110A CN 107208138 A CN107208138 A CN 107208138A
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- cancer
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- immunotherapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462098055P | 2014-12-30 | 2014-12-30 | |
| US62/098,055 | 2014-12-30 | ||
| PCT/US2015/067878 WO2016109546A2 (en) | 2014-12-30 | 2015-12-29 | Methods and compositions for prognosis and treatment of cancers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107208138A true CN107208138A (zh) | 2017-09-26 |
Family
ID=55315702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580070110.8A Pending CN107208138A (zh) | 2014-12-30 | 2015-12-29 | 用于癌症预后和治疗的方法和组合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11236394B2 (enExample) |
| EP (1) | EP3240908A2 (enExample) |
| JP (2) | JP2018503373A (enExample) |
| CN (1) | CN107208138A (enExample) |
| WO (1) | WO2016109546A2 (enExample) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108823309A (zh) * | 2018-06-11 | 2018-11-16 | 北京大学人民医院 | 检测kiaa0125基因表达水平的物质在辅助鉴定急性淋巴细胞白血病中的应用 |
| CN109880894A (zh) * | 2019-03-05 | 2019-06-14 | 杭州西合森医学检验实验室有限公司 | 基于RNAseq的肿瘤免疫微环境预测模型的构建方法 |
| CN110804642A (zh) * | 2019-09-10 | 2020-02-18 | 清华大学 | Gpr174免疫学功能及其用途 |
| CN111500733A (zh) * | 2020-05-27 | 2020-08-07 | 中国人民解放军军事科学院军事医学研究院 | 外周血单核细胞中用于非小细胞肺癌早期诊断的分子标记物 |
| CN112530581A (zh) * | 2020-12-03 | 2021-03-19 | 安徽医科大学第一附属医院 | 一种前列腺癌患者的免疫分子分类系统及其应用 |
| CN112567052A (zh) * | 2018-06-21 | 2021-03-26 | 癌症研究技术有限公司 | 预后和治疗响应预测方法 |
| CN112639479A (zh) * | 2018-08-29 | 2021-04-09 | 延世大学校产学协力团 | 提供关于对癌症免疫疗法的治疗反应的信息的方法和使用其的试剂盒 |
| CN112739314A (zh) * | 2018-08-08 | 2021-04-30 | 雪松-西奈医学中心 | 用于治疗癌症和自体免疫疾病的组合物和方法 |
| CN112831562A (zh) * | 2021-01-25 | 2021-05-25 | 浙江科技学院 | 一种用于预测肝癌患者切除术后复发风险的生物标志物组合、试剂盒 |
| WO2022053065A1 (zh) * | 2020-09-14 | 2022-03-17 | 信达生物制药(苏州)有限公司 | 用于预测或评估肺癌患者的生物标志物、检测方法及应用 |
| WO2024234348A1 (en) * | 2023-05-17 | 2024-11-21 | Yanjun Wang | Biomarker for immune checkpoint blockade therapy in nsclc |
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|---|---|---|---|---|
| TWI715587B (zh) | 2015-05-28 | 2021-01-11 | 美商安可美德藥物股份有限公司 | Tigit結合劑和彼之用途 |
| US12241053B2 (en) | 2015-10-09 | 2025-03-04 | The Brigham And Women's Hospital, Inc. | Modulation of novel immune checkpoint targets |
| EP3400246B1 (en) | 2016-01-08 | 2020-10-21 | H. Hoffnabb-La Roche Ag | Methods of treating cea-positive cancers using pd-1 axis binding antagonists and anti-cea/anti-cd3 bispecific antibodies |
| WO2018029124A1 (en) * | 2016-08-08 | 2018-02-15 | F. Hoffmann-La Roche Ag | Therapeutic and diagnostic methods for cancer |
| JP7235508B2 (ja) * | 2016-11-24 | 2023-03-08 | 第一三共株式会社 | Pd-1免疫チェックポイント阻害剤による治療に対するがんの感受性を予測する方法 |
| CN110662552A (zh) | 2016-11-30 | 2020-01-07 | 昂科梅德制药有限公司 | 包含tigit结合剂的癌症治疗方法 |
| EP3333268A1 (en) * | 2016-12-09 | 2018-06-13 | Institut Paoli Calmettes | Biomarker panel for prognosis of bladder cancer |
| WO2018122249A1 (en) * | 2016-12-28 | 2018-07-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival time of patients suffering from a microsatellite stable colorectal cancer |
| EP3580349A1 (en) * | 2017-02-07 | 2019-12-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Tim-3 for assessing the severity of cancer |
| CN106950371B (zh) * | 2017-02-17 | 2019-03-08 | 张灏 | Pd-l1、cdk5和ctla4中的至少一种在制备肿瘤诊断试剂盒中的用途 |
| EP3589754B1 (en) | 2017-03-01 | 2023-06-28 | F. Hoffmann-La Roche AG | Diagnostic and therapeutic methods for cancer |
| US10340030B2 (en) | 2017-06-13 | 2019-07-02 | Bostongene Corporation | Systems and methods for identifying cancer treatments from normalized biomarker scores |
| KR102348291B1 (ko) * | 2017-06-14 | 2022-01-07 | 연세대학교 산학협력단 | 암 환자의 치료 반응성을 예측하는 방법 |
| WO2018232142A1 (en) * | 2017-06-14 | 2018-12-20 | Icahn School Of Medicine At Mount Sinai | Methods for the detection and treatment of classes of hepatocellular carcinoma responsive to immunotherapy |
| CN111164700B (zh) * | 2017-07-14 | 2024-10-29 | 余因子基因组学公司 | 使用下一代测序的免疫-肿瘤学应用 |
| JP7304558B2 (ja) * | 2017-12-12 | 2023-07-07 | 地方独立行政法人神奈川県立病院機構 | がん免疫療法の予後予測のためのバイオマーカー |
| CN112771177A (zh) * | 2018-05-21 | 2021-05-07 | 纳米线科技公司 | 分子基因标签及其使用方法 |
| US20210338727A1 (en) * | 2018-09-13 | 2021-11-04 | Nkarta, Inc. | Natural killer cell compositions and immunotherapy methods for treating tumors |
| KR20210100656A (ko) * | 2018-12-05 | 2021-08-17 | 제넨테크, 인크. | 암 면역요법을 위한 진단 방법 및 조성물 |
| CA3131533A1 (en) | 2019-03-05 | 2020-09-10 | Nkarta, Inc. | Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| WO2020201362A2 (en) * | 2019-04-02 | 2020-10-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
| EP3953712A1 (en) * | 2019-04-10 | 2022-02-16 | Universität Zürich | A method for determining the likelihood of a patient being responsive to cancer immunotherapy |
| JP2022534967A (ja) * | 2019-05-30 | 2022-08-04 | ブリストル-マイヤーズ スクイブ カンパニー | 多腫瘍遺伝子シグネチャーおよびその使用 |
| EP3976040A1 (en) * | 2019-06-01 | 2022-04-06 | Ares Trading S.A. | Pd-1 axis binding antagonist to treat cancer with genetic mutations in specific genes |
| KR102042710B1 (ko) * | 2019-07-02 | 2019-11-08 | 의료법인 성광의료재단 | 면역체크 포인트와 관련된, 난소암 진단용 바이오마커 |
| KR20210068304A (ko) * | 2019-11-29 | 2021-06-09 | 의료법인 성광의료재단 | 면역 세포 치료제에 대한 치료 반응성 예측용 바이오마커 |
| US20210181200A1 (en) * | 2019-12-17 | 2021-06-17 | Women's College Hospital | Ovarian cancer biomarker and methods of using same |
| GB202007099D0 (en) | 2020-05-14 | 2020-07-01 | Kymab Ltd | Tumour biomarkers for immunotherapy |
| KR20230012559A (ko) | 2020-05-19 | 2023-01-26 | 베링거 인겔하임 인터내셔날 게엠베하 | 암 치료를 위한 결합 분자 |
| AU2021293507A1 (en) | 2020-06-18 | 2023-02-02 | F. Hoffmann-La Roche Ag | Treatment with anti-TIGIT antibodies and PD-1 axis binding antagonists |
| KR102647295B1 (ko) * | 2020-09-03 | 2024-03-14 | 한국과학기술연구원 | 암 면역 치료의 효능 예측을 위한 바이오마커 및 이의 용도 |
| WO2022109607A2 (en) * | 2020-11-19 | 2022-05-27 | Tempus Labs, Inc. | Determination of cytotoxic gene signature and associated systems and methods for response prediction and treatment |
| EP4026918A1 (en) | 2021-01-12 | 2022-07-13 | Koninklijke Philips N.V. | Prediction of an outcome of a colorectal cancer subject |
| IL306090A (en) * | 2021-03-25 | 2023-11-01 | Oncxerna Therapeutics Inc | Targeted cancer treatments |
| WO2022211620A1 (en) * | 2021-04-01 | 2022-10-06 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Cd4/il-2 biomarker. |
| EP4370713A1 (en) | 2021-07-15 | 2024-05-22 | Vib Vzw | Biomarkers predicting response of breast cancer to immunotherapy |
| JP7480754B2 (ja) | 2021-07-19 | 2024-05-10 | トヨタ自動車株式会社 | 蓄電装置 |
| CN118871463A (zh) | 2021-07-28 | 2024-10-29 | 基因泰克公司 | 用于治疗癌症的方法和组合物 |
| TW202321308A (zh) | 2021-09-30 | 2023-06-01 | 美商建南德克公司 | 使用抗tigit抗體、抗cd38抗體及pd—1軸結合拮抗劑治療血液癌症的方法 |
| EP4526470A1 (en) * | 2022-05-19 | 2025-03-26 | Agendia N.V. | Prediction of response to immune therapy in breast cancer patients |
| IL317449A (en) | 2022-06-07 | 2025-02-01 | Genentech Inc | Method for determining the efficacy of a lung cancer treatment comprising an anti-PD-L1 antagonist and an anti-TIGIT antibody-antagonist |
| KR20240051492A (ko) * | 2022-10-13 | 2024-04-22 | 주식회사 네오셀라 | 대식세포 분화 및 분포에 따른 면역세포 치료제의 치료 반응성 예측 방법 |
| AU2024230918A1 (en) | 2023-03-06 | 2025-10-16 | Genentech, Inc. | Prognostic and therapeutic methods for non-small cell lung cancer |
| WO2024225488A1 (ja) * | 2023-04-27 | 2024-10-31 | 株式会社リプロセル | 抗pd-1抗体療法に応答性である候補がん患者を同定する方法 |
| WO2025174933A1 (en) | 2024-02-14 | 2025-08-21 | Genentech, Inc. | Methods for treatment of pancreatic cancer with anti-pd-l1 ab, anti-tigit ab, gemcitabine and nab-placlitaxel |
Citations (3)
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| EP2484762A1 (en) * | 2009-10-02 | 2012-08-08 | Kurume University | Method for predicting therapeutic effect of immunotherapy on cancer patient and/or prognosis after immunotherapy, and gene set and kit to be used therein |
| WO2014023706A1 (en) * | 2012-08-06 | 2014-02-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for screening patients with a cancer |
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-
2015
- 2015-12-29 CN CN201580070110.8A patent/CN107208138A/zh active Pending
- 2015-12-29 WO PCT/US2015/067878 patent/WO2016109546A2/en not_active Ceased
- 2015-12-29 EP EP15832855.9A patent/EP3240908A2/en active Pending
- 2015-12-29 JP JP2017534648A patent/JP2018503373A/ja active Pending
-
2017
- 2017-05-31 US US15/609,473 patent/US11236394B2/en active Active
-
2021
- 2021-03-01 JP JP2021031306A patent/JP7325463B2/ja active Active
- 2021-12-17 US US17/554,966 patent/US12385098B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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Also Published As
| Publication number | Publication date |
|---|---|
| EP3240908A2 (en) | 2017-11-08 |
| US12385098B2 (en) | 2025-08-12 |
| US20170260594A1 (en) | 2017-09-14 |
| JP2018503373A (ja) | 2018-02-08 |
| WO2016109546A3 (en) | 2016-09-01 |
| US20220298576A1 (en) | 2022-09-22 |
| JP7325463B2 (ja) | 2023-08-14 |
| US11236394B2 (en) | 2022-02-01 |
| JP2021118684A (ja) | 2021-08-12 |
| WO2016109546A2 (en) | 2016-07-07 |
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