CN107056936B - 免疫球蛋白基因多样性的操纵及多抗体治疗剂 - Google Patents

免疫球蛋白基因多样性的操纵及多抗体治疗剂 Download PDF

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CN107056936B
CN107056936B CN201610821299.6A CN201610821299A CN107056936B CN 107056936 B CN107056936 B CN 107056936B CN 201610821299 A CN201610821299 A CN 201610821299A CN 107056936 B CN107056936 B CN 107056936B
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human
antibody
gene segments
gene
heavy chain
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CN107056936A (zh
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G·弗里德里克
E-C·李
J·克拉贝
N·英格兰
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Kymab Ltd
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Priority claimed from GB201116120A external-priority patent/GB201116120D0/en
Priority claimed from GB201116122A external-priority patent/GB201116122D0/en
Priority claimed from GBGB1203257.9A external-priority patent/GB201203257D0/en
Priority claimed from GBGB1204592.8A external-priority patent/GB201204592D0/en
Priority claimed from GBGB1205702.2A external-priority patent/GB201205702D0/en
Priority claimed from GBGB1208749.0A external-priority patent/GB201208749D0/en
Priority claimed from GB201211692A external-priority patent/GB201211692D0/en
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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CN201610821299.6A 2011-09-19 2012-09-18 免疫球蛋白基因多样性的操纵及多抗体治疗剂 Active CN107056936B (zh)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
GB201116120A GB201116120D0 (en) 2011-09-19 2011-09-19 Manipulation of immunoglobulin gene diversity and multi antibody therapeutics, especially for infectious diseases
GB1116120.5 2011-09-19
GB1116122.1 2011-09-19
GB201116122A GB201116122D0 (en) 2011-09-19 2011-09-19 Synthetically-extended & ethnically diverse superhuman immunoglobulin gene repertoires
GBGB1203257.9A GB201203257D0 (en) 2012-02-24 2012-02-24 Animals, repertoires & methods
GB1203257.9 2012-02-24
GB1204592.8 2012-03-15
GBGB1204592.8A GB201204592D0 (en) 2012-03-15 2012-03-15 Animals, repertoires & methods
GBGB1205702.2A GB201205702D0 (en) 2012-03-29 2012-03-29 Animals,repertoires & methods
GB1205702.2 2012-03-29
GB1208749.0 2012-05-18
GBGB1208749.0A GB201208749D0 (en) 2012-05-18 2012-05-18 Synthetically-extended & ethnically-diverse superhuman immunoglobulin gene repertoires
GB1211692.7 2012-07-02
GB201211692A GB201211692D0 (en) 2012-07-02 2012-07-02 Animals, repertories & methods
CN201280056528.XA CN103945689B (zh) 2011-09-19 2012-09-18 免疫球蛋白基因多样性的操纵及多抗体治疗剂

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CN107056936B true CN107056936B (zh) 2021-09-03

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CN201280056727.0A Pending CN104080916A (zh) 2011-09-19 2012-09-18 定制供人类使用的抗体、可变结构域和链
CN201280056528.XA Active CN103945689B (zh) 2011-09-19 2012-09-18 免疫球蛋白基因多样性的操纵及多抗体治疗剂
CN201610883894.2A Expired - Fee Related CN106995822B (zh) 2011-09-19 2012-09-18 定制供人类使用的抗体、可变结构域和链

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CN201280056528.XA Active CN103945689B (zh) 2011-09-19 2012-09-18 免疫球蛋白基因多样性的操纵及多抗体治疗剂
CN201610883894.2A Expired - Fee Related CN106995822B (zh) 2011-09-19 2012-09-18 定制供人类使用的抗体、可变结构域和链

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AU (3) AU2012311286B2 (enExample)
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US9445581B2 (en) 2012-03-28 2016-09-20 Kymab Limited Animal models and therapeutic molecules
CA3250882A1 (en) 2010-08-02 2025-11-29 Regeneron Pharamaceuticals, Inc. Mice that Make Binding Proteins Comprising VL Domains
MY172718A (en) 2011-08-05 2019-12-11 Regeneron Pharma Humanized universal light chain mice
WO2013041844A2 (en) 2011-09-19 2013-03-28 Kymab Limited Antibodies, variable domains & chains tailored for human use
WO2013045916A1 (en) 2011-09-26 2013-04-04 Kymab Limited Chimaeric surrogate light chains (slc) comprising human vpreb
MY172946A (en) * 2011-10-17 2019-12-16 Regeneron Pharma Restricted immunoglobulin heavy chain mice
US9253965B2 (en) 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
KR102081657B1 (ko) 2011-12-20 2020-02-26 리제너론 파마슈티칼스 인코포레이티드 인간화 경쇄 마우스
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
GB2502127A (en) 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
HUE055617T2 (hu) 2012-06-12 2021-12-28 Regeneron Pharma Korlátozott immunglobulin nehézlánc lókuszokkal rendelkezõ, humanizált, nem humán élõlények
ES2678221T3 (es) 2013-02-20 2018-08-09 Regeneron Pharmaceuticals, Inc. Animales no humanos con secuencias de cadena pesada de inmunoglobulina modificadas
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
US9783618B2 (en) 2013-05-01 2017-10-10 Kymab Limited Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
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