CN106880779A - 一种治疗糖尿病视网膜病变的药物及其制备方法 - Google Patents

一种治疗糖尿病视网膜病变的药物及其制备方法 Download PDF

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CN106880779A
CN106880779A CN201710144992.9A CN201710144992A CN106880779A CN 106880779 A CN106880779 A CN 106880779A CN 201710144992 A CN201710144992 A CN 201710144992A CN 106880779 A CN106880779 A CN 106880779A
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李子义
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Abstract

本发明公开了一种治疗糖尿病视网膜病变的药物及其制备方法,其主要是由生地黄、决明子、麦冬、牡丹皮、玉竹、玉米须、山药、枸杞、玄参、黄芪、葛根、五味子、白芍、何首乌、白茅根、茯苓、茺蔚子、柴胡、甘草、三七、蝉蜕等按一定重量配比制备而成,本发明药物具有清肝明目,利水,活血调经,养阴润燥,疏风清热,养血柔肝,益卫固表,补中益的功能,用于治疗糖尿病视网膜病变见效快、疗效好,不复发。

Description

一种治疗糖尿病视网膜病变的药物及其制备方法
技术领域
本发明涉及一种治疗糖尿病视网膜病变的药物及其制备方法,属中药领域。
背景技术
糖尿病视网膜病变是糖尿病性微血管病变中最重要的表现,是一种具有特异性改变的眼底病变,是糖尿病的严重并发证之一。中医则认为糖尿病视网膜病变与气阴两虚,湿热中阻,瘀血阻滞有关。由于西药治疗副作用大,因此人们对有效治疗糖尿病视网膜病变的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗糖尿病视网膜病变的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗糖尿病视网膜病变的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择生地黄、决明子、麦冬、牡丹皮、玉竹、玉米须、山药、枸杞、玄参、黄芪、葛根、五味子、白芍、何首乌、白茅根、茯苓、茺蔚子、柴胡、甘草、三七、蝉蜕、泽泻、密蒙花、浙贝母进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗糖尿病视网膜病变。其中选用生地黄是因为其性味甘,寒,归心、肝、肾经,有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内热消渴,吐血,衄血,发斑发疹。选用决明子是因为其性味苦甘,凉,入肝、肾经,有清肝,明目,利水,通便的功能,治风热赤眼,青盲,雀目,高血压,肝炎,肝硬化腹化,习惯性便秘。选用麦冬是因为其性味甘微苦,寒,入肺、胃、心经,有养阴润肺,清心除烦,益胃生津的功能,治肺燥干咳,吐血,咯血,肺痿,肺痈,虚劳烦热,清渴,热病津伤,咽干口燥,便秘。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。选用玉竹是因为其性味甘,平,入肺,胃经,有养阴,润燥,除烦,止渴的功能,治热病阳伤,咳嗽,烦渴,虚劳发热,消谷易饥,小便频数。选用玉米须是因为其性味甘,平,有利尿,泄热,平肝,利胆的功能,治肾炎水肿,脚气,黄疸肝炎,高血压,胆囊炎,胆结石,糖尿病,吐血衄血,鼻渊,乳痈。选用山药是因为其性味甘,平,入肺、脾、肾经,有健脾,补肺,固肾,益精的功能,治脾虚泄泻,久痢,虚劳咳嗽,消渴,遗精、带下,小便频数。选用枸杞是因为其性味甘,平,有滋肾,润肺,补肝,明目的功能,治肝肾阴亏,腰膝酸软,头晕目眩,目昏多泪,虚劳咳嗽,消渴,遗清。选用玄参是因为其性味苦咸,凉,入肺、肾经,有滋阴,降火,除烦,解毒的功能,治热病烦渴,发斑,骨蒸劳热,夜寐不宁,自汗盗汗,津伤便秘,吐血衄血,咽喉肿痛,痈肿,瘰疬。选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用葛根是因为其性味甘辛,平,入脾、胃经,有升阳解肌,透疹止泻,除烦止渴的功能,治伤寒,温热,头痛,项强,烦热消喝,泄泻,痢疾,癍诊不透,高血压,心绞痛,耳聋。选用五味子是因为其性味酸,温,入肺、肾经,有敛肺,滋肾,生津,收汗,涩精的功能,治肺虚喘咳,口干作渴,自汗,盗汗,劳伤羸瘦,梦遗滑精,久泻久痢;选用白芍是因为其性味苦酸,凉,入肝、脾经,有养血柔肝,缓中止痛,敛阴收汗的功能,治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热,月经不调,崩漏,带下。选用何首乌是因为其性味苦甘涩,微温,入肝、肾经,有补肝,益肾,养血,祛风的功能,治肝肾阴亏,发须早白,血虚头晕,腰膝软弱,筋骨酸痛,遗精,崩带,久疟,久痢,慢性肝炎,痈肿,瘰疬,肠风,痔疾。选用白茅根是因为其性味甘、寒,入肺、胃、小肠经,有凉血,止血,清热,利尿的功能,治热病烦渴,吐血,衄血,肺热喘急,胃热哕逆,淋病,小便不利,水肿,黄疸。选用茯苓是因为其性味甘淡,平,入心、脾、肺经,有渗湿利水,益脾和胃,宁心安神的功能,治小便不利水肿胀痛,痰饮咳逆,呕哕,泄泻,遗精,淋浊,惊悸,健忘。选用茺蔚子是因为其性味甘辛,凉,入心胞、肝经,有活血调经,疏风清热的功能,治妇女月经不调,崩中带下,产后瘀血作痛,肝热头痛,目赤肿痛,或生翳膜。选用柴胡是因为其性味苦,凉,入肝、胆经,有和解表里,疏肝,升阳的功能,治寒热往来,胸满胁痛,口苦耳聋,头痛目眩,疟疾,下利脱肛,月经不调,子宫下垂。选用甘草是因为其性味甘,平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能;炙用,治脾胃食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊癎;生用,治咽喉肿痛,消化性溃疡,痈疸疮疡,解药毒及食物中毒。选用三七是因为其性味甘微苦,温,入肝、胃、大肠经,有止血,散瘀,消肿,定痛的功能,治吐血,咳血,衄血,便血,血痢,崩漏,癥瘕,产后血晕,恶露不下,跌扑瘀血,外伤出血,痈肿疼痛。选用蝉蜕是因为其性味甘咸,凉,入肺、肝经,有散风热,宣肺,定痉的功能,治外感风热,咳嗽音哑,麻疹透发不畅,风疹瘙痒,小儿惊癎,目赤,翳障,疔疮肿毒,破伤风。选用泽泻是因为其性味甘,寒,入膀胱经,有利水,渗湿,泄热的功能,治小便不利,水肿肛满,呕吐,泻痢,痰饮,脚气,淋病,尿血。选用密蒙花是因为其性味甘,凉,入肝经,有祛风,凉血,润肝,明目的功能,治目赤肿痛,多泪羞明,青盲翳障,风弦烂眼。选用浙贝母是因为其性味苦,微寒,归肺、心经,有清热散结,化痰止咳的功能,治风热犯肺,痰火咳嗽,肺痈,乳痈,瘰疬,疮毒,心胸郁闷。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
生地黄15-25克,决明子10-20克,麦冬10-20克,牡丹皮10-15克,玉竹15-25克,玉米须20-30克,山药10-20克,枸杞10-20克,玄参10-15克,黄芪15-20克,葛根10-20克,五味子5-15克,白芍10-15克,何首乌15-20克,白茅根15-25克,茯苓10-20克,茺蔚子10-20克,柴胡5-15克,甘草5-15克,三七5-10克,蝉蜕5-15克,泽泻10-15克,密蒙花10-20克,浙贝母5-10克。
优选为:
生地黄20克,决明子15克,麦冬15克,牡丹皮12克,玉竹20克,玉米须25克,山药15克,枸杞15克,玄参12克,黄芪18克,葛根15克,五味子10克,白芍12克,何首乌18克,白茅根20克,茯苓15克,茺蔚子15克,柴胡10克,甘草10克,三七8克,蝉蜕10克,泽泻12克,密蒙花15克,浙贝母8克。
本发明药物的制备方法如下
一、备料
1、生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
2、决明子:取净决明子,置锅内炒至微有香气,取出,放凉;
3、麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干;
4、牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
5、玉竹:除去杂质,洗净泥土,闷润至内外湿度均匀,切片,晒干;
6、玉米须:取原药材,除去杂质,筛去灰屑;
7、山药:拣净杂质,用水浸泡至山药中心部软化为止,捞出稍晾,切片晒干或烘干;
8、枸杞:簸净杂质,摘去残留的梗和蒂;
9、玄参:拣净杂质,除去芦头,洗净润透,切片,晾干;
10、黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切片,晒干;
11、葛根:拣去杂质,洗净,用水浸泡,捞出,润透,及时切片,晒干;
12、五味子:筛去灰屑,除去杂质,置蒸笼内蒸透,取出晒干;
13、白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
14、何首乌:拣去杂质,洗净,用水泡至八成透,捞出,润至内外湿度均匀,切片或切成方块,晒干;
15、白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎屑;
16、茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干;
17、茺蔚子:果实成熟时割取全株,晒干,打下果实,拣去枝叶,筛净杂质;
18、、柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,晒干;
19、甘草:取甘草片,加炼热的蜂蜜与开水少许,拌匀,稍闷,置锅内用文火炒至变深黄色,不粘手为止,取出放凉,每甘草100斤,用炼熟蜂蜜25—30斤;
20、三七:拣净杂质,捣碎,研末或润透后切片晒干;
21、蝉蜕:拣去杂质,洗净晒干;
22、泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
23、密蒙花:拣去杂质,筛净灰土;
24、浙贝母:除去杂质,大小分档,洗净,润透,切厚片,干燥,街去碎屑,或打碎。
二、制备
1、将所述重量的生地黄、决明子、麦冬、牡丹皮、玉竹、玉米须、山药、枸杞、玄参、黄芪、葛根、五味子、白芍、何首乌、白茅根、茯苓、茺蔚子、柴胡、甘草、三七、蝉蜕、泽泻、密蒙花、浙贝母放入煎药容器内,第一次加水6倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水4倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为2剂服用。
组方中决明子有清肝,明目,利水,通便的功能为君药;玉竹养阴,润燥,除烦,止渴;茺蔚子活血调经,疏风清热二者为臣药,三味药共同发挥清肝明目,利水,养阴润燥,除烦止渴,活血调经,疏风清热的作用,治疗糖尿病视网膜病变效力全面,且以清肝明目,利水,活血调经,养阴润燥,疏风清热为主可治本,白芍有养血柔肝,缓中止痛,敛阴收汗的功能为佐药,黄芪有益卫固表,利水消肿,托毒生肌,补中益,治气虚血脱及一切气衰血虚之症的功能为使药,与下余诸药是治标。
本发明药物具有清肝明目,利水,活血调经,养阴润燥,疏风清热,养血柔肝,益卫固表,补中益的功能,用于治疗糖尿病视网膜病变,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治糖尿病视网膜病变门诊患者共17例。
2、诊断标准
典型症状为眼前闪光感、黄斑水肿、缺血或渗出累及中心凹,可引起不同程度的视力减退或视物变形。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,30天为一个疗程,连续服用2个疗程。
4、疗效评定标准
显效:糖尿病视网膜病变症状消失,恢复正常,痊愈;
好转:患者闪光感、黄斑水肿、缺血,视力减退症状明显好转,逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗糖尿病视网膜病变患者17例,结果显效14例,显效率为82.35%,好转2例,好转率为11.77%,无效1例,总有效率为94.12%。

Claims (3)

1.一种治疗糖尿病视网膜病变的药物,其特征在于:它是由下列重量范围内的原料药制成:
生地黄15-25克,决明子10-20克,麦冬10-20克,牡丹皮10-15克,玉竹15-25克,玉米须20-30克,山药10-20克,枸杞10-20克,玄参10-15克,黄芪15-20克,葛根10-20克 ,五味子5-15克,白芍10-15克,何首乌15-20克,白茅根15-25克,茯苓10-20克,茺蔚子10-20克,柴胡5-15克,甘草5-15克,三七5-10克,蝉蜕5-15克,泽泻10-15克,密蒙花10-20克,浙贝母5-10克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
生地黄20克,决明子15克,麦冬15克,牡丹皮12克,玉竹20克,玉米须25克,山药15克,枸杞15克,玄参12克,黄芪18克,葛根15克,五味子10克,白芍12克,何首乌18克,白茅根20克,茯苓15克,茺蔚子15克,柴胡10克,甘草10克,三七8克,蝉蜕10克,泽泻12克,密蒙花15克,浙贝母8克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
(2)决明子:取净决明子,置锅内炒至微有香气,取出,放凉;
(3)麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干;
(4)牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
(5)玉竹:除去杂质,洗净泥土,闷润至内外湿度均匀,切片,晒干;
(6)玉米须:取原药材,除去杂质,筛去灰屑;
(7)山药:拣净杂质,用水浸泡至山药中心部软化为止,捞出稍晾,切片晒干或烘干;
(8)枸杞:簸净杂质,摘去残留的梗和蒂;
(9)玄参:拣净杂质,除去芦头,洗净润透,切片,晾干;
(10)黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切片,晒干;
(11)葛根:拣去杂质,洗净,用水浸泡,捞出,润透,及时切片,晒干;
(12)五味子:筛去灰屑,除去杂质,置蒸笼内蒸透,取出晒干;
(13)白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
(14)何首乌:拣去杂质,洗净,用水泡至八成透,捞出,润至内外湿度均匀,切片或切成方块,晒干;
(15)白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎屑;
(16)茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干;
(17)茺蔚子:果实成熟时割取全株,晒干,打下果实,拣去枝叶,筛净杂质;
(18)柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,晒干;
(19)甘草:取甘草片,加炼热的蜂蜜与开水少许,拌匀,稍闷,置锅内用文火炒至变深黄色,不粘手为止,取出放凉,每甘草100斤,用炼熟蜂蜜25—30斤;
(20)三七:拣净杂质,捣碎,研末或润透后切片晒干;
(21)蝉蜕:拣去杂质,洗净晒干;
(22)泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
(23)密蒙花:拣去杂质,筛净灰土;
(24)浙贝母:除去杂质,大小分档,洗净,润透,切厚片,干燥,街去碎屑,或打碎;
(二)制备
(1)将所述重量的生地黄、决明子、麦冬、牡丹皮、玉竹、玉米须、山药、枸杞、玄参、黄芪、葛根、五味子、白芍、何首乌、白茅根、茯苓、茺蔚子、柴胡、甘草、三七、蝉蜕、泽泻、密蒙花、浙贝母放入煎药容器内,加水6倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水4倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为2剂服用。
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