CN106943507A - 一种治疗老年性黄斑变性的药物及其制备方法 - Google Patents
一种治疗老年性黄斑变性的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗老年性黄斑变性的药物及其制备方法,其主要是由丹参、生地黄、党参、茯苓、黄芪、山药、当归、菊花、柴胡、女贞子、枸杞子、蔓荆子、夏枯草、赤芍、泽泻、茺蔚子、夜明砂、车前子、墨旱莲、桃仁、牛膝、桔梗、僵蚕、何首乌、山茱萸按一定重量配比制备而成,本发明药物具有清热凉血,清肝散结,散血消积,补肝肾,补中益气,养阴生津的功能,用于治疗老年性黄斑变性见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗老年性黄斑变性的药物及其制备方法,属中药领域。
背景技术
老年性黄斑变性又称年龄相关性黄斑变性(AMD),为黄斑区结构的衰老性改变。中医则认为老年性黄斑变性与肝郁化火,脾肾亏虚,气虚血瘀有关。由于西药治疗副作用大,因此人们对有效治疗老年性黄斑变性的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗老年性黄斑变性的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗老年性黄斑变性的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择丹参、生地黄、党参、茯苓、黄芪、山药、当归、菊花、柴胡、女贞子、枸杞子、蔓荆子、夏枯草、赤芍、泽泻、茺蔚子、夜明砂、车前子、墨旱莲、桃仁、牛膝、桔梗、僵蚕、何首乌、山茱萸进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗老年性黄斑变性。其中选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用生地黄是因为其性味甘,寒,归心、肝、肾经,有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内热消渴,吐血,衄血,发斑发疹。选用党参是因为其性味甘,平,入手、足太阴经气分,有补中益气,生津的功能,治脾胃虚弱,气血两亏,体倦无力,食少,口渴,久泻,脱肛。选用茯苓是因为其性味甘淡,平,入心、脾、肺经,有渗湿利水,益脾和胃,宁心安神的功能,治小便不利水肿胀痛,痰饮咳逆,呕哕,泄泻,遗精,淋浊,惊悸,健忘。选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用山药是因为其性味甘,平,入肺、脾、肾经,有健脾,补肺,固肾,益精的功能,治脾虚泄泻,久痢,虚劳咳嗽,消渴,遗精、带下,小便频数。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用菊花是因为其性味甘苦,凉,入肺,肝经,有疏风,消热,明目,解毒的功能,治头痛,眩晕,目赤,心胸烦热,疔疮,肿毒。选用柴胡是因为其性味苦,凉,入肝、胆经,有和解表里,疏肝,升阳的功能,治寒热往来,胸满胁痛,口苦耳聋,头痛目眩,疟疾,下利脱肛,月经不调,子宫下垂。选用女贞子是因为其性味苦甘,平,入肝、肾经,有补肝肾,强腰膝的功能,治阴虚内热,头晕,目花耳鸣,腰膝酸软,须发早白。选用枸杞子是因为其性味甘,平,有滋肾,润肺,补肝,明目的功能,治肝肾阴亏,腰膝酸软,头晕目眩,目昏多泪,虚劳咳嗽,消渴,遗精。选用蔓荆子是因为其性味苦辛,凉,入肝、胃,膀胱经,有疏散风热,清利头目的功能,治风热感冒,正、偏头痛,齿痛,目睛内痛。选用夏枯草是因为其性味苦辛,寒,入肝、胆经,有清肝,散结的功能,治瘰疬,瘿瘤,乳痈,乳癌,目珠夜痛,羞明流泪,头目眩晕,口眼歪斜,筋骨疼痛,肺结核,急性黄疸型传染性肝炎,血崩,带下。选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用泽泻是因为其性味甘,寒,入膀胱经,有利水,渗湿,泄热的功能,治小便不利,水肿肛满,呕吐,泻痢,痰饮,脚气,淋病,尿血。选用茺蔚子是因为其性味甘辛,凉,入心胞、肝经,有活血调经,疏风清热的功能,治妇女月经不调,崩中带下,产后瘀血作痛,肝热头痛,目赤肿痛,或生翳膜。选用夜明砂是因为其性味辛,寒,入肝经,有清热明目,散血消积的功能,治青盲雀目,内外障翳,瘰疬,疳积,疟疾。选用车前子是因为其性味甘,寒,入肾、膀胱经,有利水,清热,明目,祛痰的功能,治小便不通,淋浊,带下,尿血,暑湿泻痢,咳嗽多痰,湿痹,目赤障翳。选用墨旱莲是因为其性味苦酸,凉,入肝、肾经,有凉血,止血,补肾,益阴的功能,治吐血,咳血,衄血,尿血,便血,血痢,刀伤出血,须发早白,白喉,淋浊,滞下,阴部湿痒。选用桃仁是因为其性味苦甘,平,入心、肝、大肠经,有破血行瘀,润燥滑经功能,治经闭,癥瘕,热病蓄血,血痹,疟疾,跌打损伤,瘀血肿痛,血燥便秘的。选用牛膝是因为其性味甘苦酸,平,入肝、肾经,生用散瘀血,消痈肿,治淋病,尿血,经闭,癥瘕,难产,胞衣不下,产后瘀血腹痛,喉痹,痈肿,跌打损伤,熟用补肝肾,强筋骨,治腰膝骨痛,四肥拘挛,痿痹。选用桔梗是因为其性味苦辛,平,入肺、胃经,有开宣肺气,祛痰排脓的功能,治外感咳嗽,咽喉肿痛,肺痈吐脓,胸满胁痛,痢疾腹痛。选用僵蚕是因为其性味辛、咸,平,归肝,肺经。祛风解痉,化痰散结。用于中风口眼歪斜,惊痫抽搐,头赐,喉痹,瘰疠结核,风疹丹毒。选用何首乌是因为其性味苦甘涩,微温,入肝、肾经,有补肝,益肾,养血,祛风的功能,治肝肾阴亏,发须早白,血虚头晕,腰膝软弱,筋骨酸痛,遗精,崩带,久疟,久痢,慢性肝炎,痈肿,瘰疬,肠风,痔疾。选用山茱萸是因为其性味酸,微温,入肝、肾经,有补肝肾,涩精气,固虚脱的功能,治腰膝酸痛,眩晕,耳鸣,阳痿,遗精,小便频数,肝虚寒热,虚汗不止,心摇脉散。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
丹参10-20克,生地黄10-20克,党参10-15克,茯苓10-20克,黄芪10-20克,山药10-20克,当归5-15克,菊花10-15克,柴胡5-15克,女贞子10-15克,枸杞子10-20克,蔓荆子5-15克,夏枯草5-15克,赤芍5-15克,泽泻10-15克,茺蔚子5-15克,夜明砂5-10克,车前子5-15克,墨旱莲5-15克,桃仁5-10克,牛膝5-15克,桔梗10-15克,僵蚕5-15克,何首乌5-15克,山茱萸10-20克。
优选为:
丹参15克,生地黄15克,党参12克,茯苓15克,黄芪15克,山药15克,当归10克,菊花12克,柴胡10克,女贞子12克,枸杞子15克,蔓荆子10克,夏枯草10克,赤芍10克,泽泻12克,茺蔚子10克,夜明砂8克,车前子10克,墨旱莲10克,桃仁8克,牛膝10克,桔梗12克,僵蚕10克,何首乌10克,山茱萸15克。
本发明药物的制备方法如下
一、备料
1、丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
2、生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
3、党参:洗净泥沙后润透去芦,切片或切段,晒干;
4、茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干;
5、黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切片,晒干;
6、山药:拣净杂质,用水浸泡至山药中心部软化为止,捞出稍晾,切片晒干或烘干;
7、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
8、菊花:拣净叶梗、花柄及泥屑杂质;
9、柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,随即晒干;
10、女贞子:拣去杂质,洗净,晒干;
11、枸杞子:簸净杂质,摘去残留的梗和蒂;
12、蔓荆子:筛净灰屑,除去残存萼片,置锅内用武火炒至焦黄色,略喷清水,放凉;
13、夏枯草:取原药材,除去枝梗、叶片及杂质,筛去灰屑;
14、赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
15、泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
16、茺蔚子:果实成熟时割取全株,晒干,打下果实,拣去枝叶,筛净杂质;
17、夜明砂:拣净杂质,簸去泥砂,漂洗后晒干;
18、车前子:拣去杂质,筛去泥屑,空粒;
19、墨旱莲:拣净杂质,除去残根,洗净闷透,切段晒干;
20、桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
21、牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
22、桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干;
23、僵蚕:取原药材,除去残丝,杂质;
24、何首乌:拣去杂质,洗净,用水泡至八成透,捞出,润至内外湿度均匀,切片或切成方块,晒干;
25、山茱萸:洗净,除去果核及杂质,晒干。
二、制备
1、将所述重量的丹参、生地黄、党参、茯苓、黄芪、山药、当归、菊花、柴胡、女贞子、枸杞子、蔓荆子、夏枯草、赤芍、泽泻、茺蔚子、夜明砂、车前子、墨旱莲、桃仁、牛膝、桔梗、僵蚕、何首乌、山茱萸放入煎药容器内,第一次加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为3剂服用。
组方中生地黄有清热凉血,养阴,生津的功能为君药;夏枯草清肝,散结;夜明砂有清热明目,散血消积的功能,二者为臣药,三味药共同发挥清热凉血,养阴生津,清肝散结,散血消积,清热明目的作用,治疗老年性黄斑变性效力全面,且以清热凉血,清肝散结,散血消积,清热明目为主可治本,党参是因为其性味甘,平,入手、足太阴经气分,有补中益气,生津功能为佐药,女贞子有补肝肾,强腰膝的功能为使药,与下余诸药是治标。
本发明药物具有清热凉血,清肝散结,散血消积,补肝肾,补中益气,养阴生津的功能,用于治疗老年性黄斑变性,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治老年性黄斑变性门诊患者共29例。
2、诊断标准
典型症状为中心视力下降,视物变形,视物对比度下降等。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、中、晚各服1次,7天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:老年性黄斑变性症状消失,恢复正常,痊愈;
好转:患者中心视力下降,视物变形,视物对比度下降的现象减轻,老年性黄斑变性症状明显好转,逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗老年性黄斑变性患者29例,结果显效24例,显效率为82.76%,好转4例,好转率为13.79%,无效1例,总有效率为96.55%。
Claims (3)
1.一种治疗老年性黄斑变性的药物,其特征在于:它是由下列重量范围内的原料药制成:
丹参10-20克,生地黄10-20克,党参10-15克,茯苓10-20克,黄芪10-20克,山药10-20克,当归5-15克,菊花10-15克,柴胡5-15克,女贞子10-15克,枸杞子10-20克,蔓荆子5-15克,夏枯草5-15克,赤芍5-15克,泽泻10-15克,茺蔚子5-15克,夜明砂5-10克,车前子5-15克,墨旱莲5-15克,桃仁5-10克,牛膝5-15克,桔梗10-15克,僵蚕5-15克,何首乌5-15克,山茱萸10-20克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
丹参15克,生地黄15克,党参12克,茯苓15克,黄芪15克,山药15克,当归10克,菊花12克,柴胡10克,女贞子12克,枸杞子15克,蔓荆子10克,夏枯草10克,赤芍10克,泽泻12克,茺蔚子10克,夜明砂8克,车前子10克,墨旱莲10克,桃仁8克,牛膝10克,桔梗12克,僵蚕10克,何首乌10克,山茱萸15克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
(2)生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
(3)党参:洗净泥沙后润透去芦,切片或切段,晒干;
(4)茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干;
(5)黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切片,晒干;
(6)山药:拣净杂质,用水浸泡至山药中心部软化为止,捞出稍晾,切片晒干或烘干;
(7)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(8)菊花:拣净叶梗、花柄及泥屑杂质;
(9)柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,随即晒干;
(10)女贞子:拣去杂质,洗净,晒干;
(11)枸杞子:簸净杂质,摘去残留的梗和蒂;
(12)蔓荆子:筛净灰屑,除去残存萼片,置锅内用武火炒至焦黄色,略喷清水,放凉;
(13)夏枯草:取原药材,除去枝梗、叶片及杂质,筛去灰屑;
(14)赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
(15)泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
(16)茺蔚子:果实成熟时割取全株,晒干,打下果实,拣去枝叶,筛净杂质;
(17)夜明砂:拣净杂质,簸去泥砂,漂洗后晒干;
(18)车前子:拣去杂质,筛去泥屑,空粒;
(19)墨旱莲:拣净杂质,除去残根,洗净闷透,切段晒干;
(20)桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
(21)牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
(22)桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干;
(23)僵蚕:取原药材,除去残丝,杂质;
(24)何首乌:拣去杂质,洗净,用水泡至八成透,捞出,润至内外湿度均匀,切片或切成方块,晒干;
(25)山茱萸:洗净,除去果核及杂质,晒干;
(二)制备
(1)将所述重量的丹参、生地黄、党参、茯苓、黄芪、山药、当归、菊花、柴胡、女贞子、枸杞子、蔓荆子、夏枯草、赤芍、泽泻、茺蔚子、夜明砂、车前子、墨旱莲、桃仁、牛膝、桔梗、僵蚕、何首乌、山茱萸放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为3剂服用。
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CN110227122A (zh) * | 2019-07-31 | 2019-09-13 | 郑州巨人生化集团有限公司 | 一种消除眼底黄斑变性的中药外用组合物及其制备方法 |
KR20190133978A (ko) * | 2018-05-24 | 2019-12-04 | 종근당건강 주식회사 | 하고초 추출물을 유효성분으로 함유하는 황반변성의 예방 또는 치료용 약학 조성물 |
WO2021100940A1 (ko) * | 2019-11-22 | 2021-05-27 | 종근당건강 주식회사 | 하고초 추출물을 유효성분으로 함유하는 황반변성의 예방 또는 치료용 약학 조성물 |
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KR20190133978A (ko) * | 2018-05-24 | 2019-12-04 | 종근당건강 주식회사 | 하고초 추출물을 유효성분으로 함유하는 황반변성의 예방 또는 치료용 약학 조성물 |
KR102120483B1 (ko) | 2018-05-24 | 2020-06-08 | 종근당건강 주식회사 | 하고초 추출물을 유효성분으로 함유하는 황반변성의 예방 또는 치료용 약학 조성물 |
CN110227122A (zh) * | 2019-07-31 | 2019-09-13 | 郑州巨人生化集团有限公司 | 一种消除眼底黄斑变性的中药外用组合物及其制备方法 |
WO2021100940A1 (ko) * | 2019-11-22 | 2021-05-27 | 종근당건강 주식회사 | 하고초 추출물을 유효성분으로 함유하는 황반변성의 예방 또는 치료용 약학 조성물 |
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