CN108743902A - 一种治疗低血压的药物及其制备方法 - Google Patents
一种治疗低血压的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗低血压的药物及其制备方法,其主要是由补骨脂、当归、泽泻、桂枝、人参、干姜、黄芪、黄精、五味子、党参、肉桂、甘草、山茱萸、阿胶、酸枣仁、茯苓、麦冬、枳壳、附子、巴戟天、紫河车、升麻、川芎、红参、大枣按一定重量配比制备而成,本发明药物具有补血和血、润燥滑肠、利水渗湿、补中益气、补脾益胃、调营卫的功能,用于治疗低血压见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗低血压的药物及其制备方法,属中药领域。
技术背景
低血压是指体循环动脉压力低于正常的状态。由于高血压在临床上常常引起心、脑、肾等重要脏器的损害而备受重视,世界卫生组织也对高血压的诊断标准有明确规定,但低血压的诊断尚无统一标准。一般认为成年人上肢动脉血压低于12/8 kPa(90/60mmHg)即为低血压。中医则认为低血压与气血两虚、气阴两虚、肾阴不足、湿困中焦有关。由于西药治疗副作用大,因此人们对有效治疗低血压的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗低血压的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗低血压的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明是选择补骨脂、当归、泽泻、桂枝、人参、干姜、黄芪、黄精、五味子、党参、肉桂、甘草、山茱萸、阿胶、酸枣仁、茯苓、麦冬、枳壳、附子、巴戟天、紫河车、升麻、川芎、红参、大枣、生地黄、淫羊藿、枸杞子、石菖蒲药物进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗低血压。其中选用补骨脂是因为其性味辛,温。入肾经。补肾。治肾虚冷泻,遗尿,滑精,小便频数,阳瘘,腰膝冷痛,虚寒喘嗽。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用泽泻是因为其性味甘,寒,入膀胱经,有利水,渗湿,泄热的功能,治小便不利,水肿肛满,呕吐,泻痢,痰饮,脚气,淋病,尿血。选用桂枝是因为其性味辛甘,温,入膀胱、心、肺经,有发汗解肌,温经通脉的功能,治风寒表证,肩背肢节酸疼,胸痹痰饮,经闭癥瘕。选用人参是因为其性味甘微甘,温,入脾、肺经,有大补元气,固脱生津,安神的功能,治劳伤虚损,食少,倦怠,反胃吐食,大便滑泄,虚咳喘促,自汗暴脱,惊悸,健忘,眩晕头痛,阳萎,尿频,消渴,妇女崩漏,小儿慢惊及久虚不复,一切气血津液不足之症。选用干姜是因为其性味辛,热,入脾、胃、肺经,有温中逐寒,回阳通脉的功能,治心腹冷痛,吐泻,肢冷脉微,寒饮喘咳,风寒湿痹,阳虚吐、衄、下血。选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用黄精是因为其性味甘平,入脾、肺、肾经,有补中益气,润心肺,强筋骨的功能,治虚损寒热,肺痨咳血,病后体虚食少,筋骨软弱,风湿疼痛,风癞癣疾。选用五味子是因为其性味酸,温,入肺、肾经,有敛肺,滋肾,生津,收汗,涩精的功能,治肺虚喘咳,口干作渴,自汗,盗汗,劳伤羸瘦,梦遗滑精,久泻久痢。选用党参是因为其性味甘,平,入手、足太阴经气分,有补中益气,生津的功能,治脾胃虚弱,气血两亏,体倦无力,食少,口渴,久泻,脱肛。选用肉桂是因为其性味辛甘,热,入肾、脾、膀胱经,有补元阳,暖脾胃,除积冷,通血脉的功能,治命门火衰,肢冷脉微,亡阳虚脱,腹痛泄泻,寒疝奔豚,腰膝冷痛,经闭癥瘕,阴疽,流注,及虚阳浮越,上热下寒。选用甘草是因为其性味甘平,归脾、胃肺经,有润肺,解毒的功能,炙用治脾胃虚弱,食少,腹痛,便溏,劳倦发热,肺痿咳嗽。选用山茱萸是因为其性味酸,微温,入肝、肾经,有补肝肾,涩精气,固虚脱的功能,治腰膝酸痛,眩晕,耳鸣,阳痿,遗精,小便频数,肝虚寒热,虚汗不止,心摇脉散。选用阿胶是因为其性味甘平,入肺、肝、肾经,有滋阴补血,安胎的功能,治血虚,虚劳咳嗽,吐血、衄血、便血,妇女月经不调,崩中,治漏。选用酸枣仁是因为其性味甘,平,入心、脾、肝、胆经,有养肝,宁心,安神,敛汗的功能,治虚烦不眠,惊悸怔忡,烦渴,虚汗。选用茯苓是因为其性味甘淡,平,入心、脾、肺经,有渗湿利水,益脾和胃,宁心安神的功能,治小便不利水肿胀痛,痰饮咳逆,呕哕,泄泻,遗精,淋浊,惊悸,健忘。选用麦冬是因为其性味甘微苦,寒,入肺、胃、心经,有养阴润肺,清心除烦,益胃生津的功能,治肺燥干咳,吐血,咯血,肺痿,肺痈,虚劳烦热,清渴,热病津伤,咽干口燥,便秘。选用枳壳是因为其性味苦辛,凉,入肺、脾、大肠经,有破气,行痰,消积的功能,治胸膈痰滞,胸痞,胁胀,食积,噫气,呕逆,下痢后重,脱肛,子宫脱垂。选用附子是因为其性味辛甘,热,有毒,入心、脾、肾经,有回阳补火,散寒除湿的功能,治阴盛格阳,大汗亡阳,吐利厥逆,心腹冷痛,脾泄冷痢,脚气水肿,小儿慢惊,风寒湿痹,踒躄拘挛,阴疽疮漏及一切沉寒痼冷之疾。选用巴戟天是因为其性味辛甘,温,入肝、肾经,有补肾阳,壮筋骨,祛风湿的功能,治阳痿,少腹冷痛,小便不禁,子宫虚冷,风寒湿痹,腰膝酸痛。选用紫河车是因为其性味甘咸,温,入肺、肝、肾经,有补气,养血,益精的功能,治虚损,羸瘦,劳热骨蒸,咳喘,咯血,盗汗,遗精,阳痿,妇女血气不足,不孕或乳少。选用升麻是因为其性味甘辛微苦,凉,入肺、脾、胃经,有升阳,发表,透疹,解毒的功能,治时气疫劳,头痛寒热,喉痛,口疮疤,斑疹不透,中气下陷,久泻久痢,脱肛,妇女崩带,子宫下坠,痈肿疮毒。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用红参是因为其性味甘、微苦,温,入脾、肺、心经,有大补元气,复脉固脱,益气摄血的功能,治体虚欲脱,肢冷脉微,气不摄血,崩漏下知,心力衰竭,心源性休克。选用大枣是因为其性味甘,温,入脾、胃经,有补脾和胃,益气生津,调营卫,解药毒的功能,治胃虚食少,脾弱便溏,气血津液不足,营卫不和,心悸怔忡,妇人脏躁。选用生地黄是因为其性味甘,寒,归心、肝、肾经,有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内热消渴,吐血,衄血,发斑发疹。选用淫羊藿是因为其性味辛甘,温,入肝、肾经,有补肾壮阳,祛风除湿的功能,治阳痿不举,小便淋沥,筋骨挛急,半身不遂,腰膝无力,风湿痹痛,四脚不仁。选用枸杞子是因为其性味甘,平,有滋肾,润肺,补肝,明目的功能,治肝肾阴亏,腰膝酸软,头晕目眩,目昏多泪,虚劳咳嗽,消渴,遗清。选用石菖蒲是因为其性味辛苦,微温,入心、肝、脾经,有开窍,豁痰,理气,活血,散风,去湿的功能,治癫癎,痰厥,热病神昏,健忘,气闭耳聋,心胸烦闷,胃痛,腹痛,风寒湿痹,痈疽肿毒,跌打损伤。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
补骨脂15-20克、当归10-15克、泽泻10-20克、桂枝5-15克、人参10-15克、干姜5-10克、黄芪15-20克、黄精10-20克、五味子10-15克、党参10-20克、肉桂5-15克、甘草5-15克、山茱萸5-10克、阿胶5-15克、酸枣仁5-15克、茯苓10-15克、麦冬5-15克、枳壳5-15克、附子5-10克、巴戟天10-15克、紫河车5-15克、升麻5-10克、川芎10-20克、红参10-20克、大枣15-20克、生地黄10-15克、淫羊藿5-10克、枸杞子5-15克、石菖蒲10-15克。
优选为
补骨脂18克、当归12克、泽泻15克、桂枝10克、人参12克、干姜8克、黄芪18克、黄精15克、五味子12克、党参15克、肉桂10克、甘草10克、山茱萸8克、阿胶10克、酸枣仁10克、茯苓12克、麦冬10克、枳壳10克、附子8克、巴戟天12克、紫河车10克、升麻8克、川芎15克、红参15克、大枣18克、生地黄12克、淫羊藿8克、枸杞子10克、石菖蒲12克。
本发明药物的制备方法如下
一、备料
1、补骨脂:簸尽杂质,洗净,晒干;
2、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
3、泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
4、桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
5、人参:除去芦头,切段;
6、干姜:拣净杂质,用水浸泡3—6小时,捞出,闷润后切片或切成小方块,晒干;
7、黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切片,晒干;
8、黄精:洗净泥土,略润,切片,晒干;
9、五味子:筛去灰屑,除去杂质,置蒸笼内蒸透,取出晒干;
10、党参:洗净泥沙后润透去芦,切片或切段,晒干;
11、肉桂:拣净杂质,刮去粗皮,用时打碎,或刮去粗皮,用温开水浸润片刻,切片,晾干;
12、甘草:取甘草片,加炼热的蜂蜜与开水少许,拌匀,稍闷,置锅内用文火炒至变深黄色,不粘手为止,取出放凉,每甘草100斤,用炼熟蜂蜜25—30斤;
13、山茱萸:洗净,除去果核及杂质,晒干;
14、阿胶:捣碎用;
15、酸枣仁:原药放入竹箩内,沉入清水缸中,使仁浮在水面,壳沉水底,将刺仁捞出,晒干;
16、茯苓:用水浸泡,洗净,捞出,闷透后,切片,晒干;
17、麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干;
18、枳壳:除去瓤、核,冼净,稍浸,捞出,润软,以手能捏对折为止,切片,晾干;
19、附子:用水浸泡,捞出,切片,晾干;
20、巴戟天:拣去杂质,用热水泡透后,趁热抽去木心,切段,晒干;
21、紫河车:用新鲜的紫河车,横直割开血管,用水反复洗漂干净;
22、升麻:拣去杂质,略泡洗净,捞出,润透,切片,晒干;
23、川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
24、红参:取原药材,润透,切薄片,干燥;
25、大枣:拣净杂质,晒干;
26、生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
27、淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
28、枸杞子:簸净杂质,摘去残留的梗和蒂;
29、石菖蒲:拣去杂质,洗净,稍浸泡,润透,切片,晒干。
二、制备
1、将所述重量的补骨脂、当归、泽泻、桂枝、人参、干姜、黄芪、黄精、五味子、党参、肉桂、甘草、山茱萸、阿胶、酸枣仁、茯苓、麦冬、枳壳、附子、巴戟天、紫河车、升麻、川芎、红参、大枣、生地黄、淫羊藿、枸杞子、石菖蒲放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为3剂服用。
组方中补骨脂补肾,当归有补血和血,调经止痛,润燥滑肠的功能二者为君药;泽泻利水,渗湿,泄热,桂枝有发汗解肌,温经通脉的功能,与人参、五味子为臣药,6味药共同发挥补血和血、润燥滑肠、利水渗湿、温经通脉、发汗解肌的作用,治疗低血压效力全面,且以补血和血、润燥滑肠、利水渗湿为主,可治本;党参补中益气,生津的功能与肉桂、巴戟天、紫河车、升麻、川芎、红参为佐药;大枣有补脾和胃,益气生津,调营卫,解药毒的功能与余下诸药为使药,是治标。
本发明药物具有补血和血、润燥滑肠、利水渗湿、补中益气、补脾益胃、调营卫的功能,用于治疗低血压,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治低血压门诊患者共30例。
2、诊断标准
典型症状为:疲乏无力、头晕、神经功能障碍、食欲不振、腹部不适、消化不良,以及血增多、减少、抵抗力降低易引起感染等。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,15天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:低血压症状消失,体质恢复正常,痊愈;
好转:患者疲乏无力、头晕、神经功能障碍、食欲不振、腹部不适、消化不良,以及抵抗力降低易引起感染的现象减轻,低血压症状明显好转,逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗低血压患者30例,结果显效22例,显效率为73.33%,好转6例,好转率为20%,无效2例,总有效率为93.33%。
Claims (3)
1.一种治疗低血压的药物,其特征在于:它是由下列重量范围内的原料药制成:
补骨脂15-20克、当归10-15克、泽泻10-20克、桂枝5-15克、人参10-15克、干姜5-10克、黄芪15-20克、黄精10-20克、五味子10-15克、党参10-20克、肉桂5-15克、甘草5-15克、山茱萸5-10克、阿胶5-15克、酸枣仁5-15克、茯苓10-15克、麦冬5-15克、枳壳5-15克、附子5-10克、巴戟天10-15克、紫河车5-15克、升麻5-10克、川芎10-20克、红参10-20克、大枣15-20克、生地黄10-15克、淫羊藿5-10克、枸杞子5-15克、石菖蒲10-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
补骨脂18克、当归12克、泽泻15克、桂枝10克、人参12克、干姜8克、黄芪18克、黄精15克、五味子12克、党参15克、肉桂10克、甘草10克、山茱萸8克、阿胶10克、酸枣仁10克、茯苓12克、麦冬10克、枳壳10克、附子8克、巴戟天12克、紫河车10克、升麻8克、川芎15克、红参15克、大枣18克、生地黄12克、淫羊藿8克、枸杞子10克、石菖蒲12克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)补骨脂:簸尽杂质,洗净,晒干;
(2)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(3)泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
(4)桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
(5)人参:除去芦头,切段;
(6)干姜:拣净杂质,用水浸泡3—6小时,捞出,闷润后切片或切成小方块,晒干;
(7)黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切片,晒干;
(8)黄精:洗净泥土,略润,切片,晒干;
(9)五味子:筛去灰屑,除去杂质,置蒸笼内蒸透,取出晒干;
(10)党参:洗净泥沙后润透去芦,切片或切段,晒干;
(11)肉桂:拣净杂质,刮去粗皮,用时打碎,或刮去粗皮,用温开水浸润片刻,切片,晾干;
(12)甘草:取甘草片,加炼热的蜂蜜与开水少许,拌匀,稍闷,置锅内用文火炒至变深黄色,不粘手为止,取出放凉,每甘草100斤,用炼熟蜂蜜25—30斤;
(13)山茱萸:洗净,除去果核及杂质,晒干;
(14)阿胶:捣碎用;
(15)酸枣仁:原药放入竹箩内,沉入清水缸中,使仁浮在水面,壳沉水底,将刺仁捞出,晒干;
(16)茯苓:用水浸泡,洗净,捞出,闷透后,切片,晒干;
(17)麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干;
(18)枳壳:除去瓤、核,冼净,稍浸,捞出,润软,以手能捏对折为止,切片,晾干;
(19)附子:用水浸泡,捞出,切片,晾干;
(20)巴戟天:拣去杂质,用热水泡透后,趁热抽去木心,切段,晒干;
(21)紫河车:用新鲜的紫河车,横直割开血管,用水反复洗漂干净;
(22)升麻:拣去杂质,略泡洗净,捞出,润透,切片,晒干;
(23)川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
(24)红参:取原药材,润透,切薄片,干燥;
(25)大枣:拣净杂质,晒干;
(26)生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
(27)淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
(28)枸杞子:簸净杂质,摘去残留的梗和蒂;
(29)石菖蒲:拣去杂质,洗净,稍浸泡,润透,切片,晒干;
(二)制备
(1)将所述重量的补骨脂、当归、泽泻、桂枝、人参、干姜、黄芪、黄精、五味子、党参、肉桂、甘草、山茱萸、阿胶、酸枣仁、茯苓、麦冬、枳壳、附子、巴戟天、紫河车、升麻、川芎、红参、大枣、生地黄、淫羊藿、枸杞子、石菖蒲放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为3剂服用。
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