CN106110184A - 一种治疗脂肪肝的药物及其制备方法 - Google Patents

一种治疗脂肪肝的药物及其制备方法 Download PDF

Info

Publication number
CN106110184A
CN106110184A CN201610564169.9A CN201610564169A CN106110184A CN 106110184 A CN106110184 A CN 106110184A CN 201610564169 A CN201610564169 A CN 201610564169A CN 106110184 A CN106110184 A CN 106110184A
Authority
CN
China
Prior art keywords
radix
gram
grams
rhizoma
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201610564169.9A
Other languages
English (en)
Inventor
甄建民
Original Assignee
甄建民
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 甄建民 filed Critical 甄建民
Priority to CN201610564169.9A priority Critical patent/CN106110184A/zh
Publication of CN106110184A publication Critical patent/CN106110184A/zh
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/57Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/58Reptiles
    • A61K35/586Turtles; Tortoises, e.g. terrapins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/19Acanthaceae (Acanthus family)
    • A61K36/195Strobilanthes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315Isatis, e.g. Dyer's woad
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • A61K36/424Gynostemma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482Cassia, e.g. golden shower tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/51Gentianaceae (Gentian family)
    • A61K36/515Gentiana
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
    • A61K36/575Magnolia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/58Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/62Nymphaeaceae (Water-lily family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/884Alismataceae (Water-plantain family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994Coix (Job's tears)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9066Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

本发明公开了一种治疗脂肪肝的药物及其制备方法,其主要是由茵陈蒿、丹参、黄芪、泽泻、山楂、厚朴、鳖甲、泽兰、鸡内金、郁金、青皮、龙胆、何首乌、决明子、大黄、柴胡、川楝子、荷叶、青黛、重楼、虎杖、枳壳按一定重量配比制备而成,本发明药物具有健脾,燥湿解郁,泻肝实火,除下焦湿热,疏肝破气,散结消痰的功能,用于治疗脂肪肝见效快、疗效好,不复发。

Description

一种治疗脂肪肝的药物及其制备方法
技术领域
[0001] 本发明涉及一种治疗脂肪肝的药物及其制备方法,属中药领域。
背景技术
[0002] 脂肪肝是指由于各种原因引起的肝细胞内脂肪堆积过多的病变,轻者无症状,重 者病情凶猛。一般而言,脂肪肝属可逆性疾病。中医则认为脂肪肝与肝郁气滞,肝胆湿热,脾 虚湿盛,痰瘀阻络有关。由于西药治疗副作用大,因此人们对有效治疗脂肪肝的中药药物存 在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
[0003] 本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗脂肪 肝的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种有效治疗脂肪肝的中药组合药物。
[0005] 本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006] 本发明药物是选择茵陈蒿、丹参、黄芪、泽泻、山楂、厚朴、鳖甲、泽兰、鸡内金、郁 金、青皮、龙胆、何首乌、决明子、大黄、柴胡、川楝子、荷叶、青黛、重楼、虎杖、枳壳、苍术、茯 苓、绞股蓝、枸杞子、白术、川芎、莪术、薏苡仁、仙鹤草、甘草、姜黄药物进行组合制备的,将 这些药物组合使得各药物功效产生协同作用,从而能够有效治疗脂肪肝。其中,选用茵陈蒿 是因为其性味苦辛,凉,入肝、脾、膀胱经,有清热利湿的功能,治湿热黄疸,小便不利,风痒 疮疥。选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功 能,治心绞痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠, 恶疮肿毒。选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒, 生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益的功能,治内伤劳 倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用山楂是因为其性味酸甘,微 温,入脾、胃、肝经,有消食积,散瘀血,驱缘虫的功能,治肉积,癥瘕,痰饮,痞满,吞酸,泻痢, 肠风,腰痛,疝气,产后儿枕痛,恶露不尽,小儿也食停滞。选用厚朴是因为其性味苦辛,温, 入脾、胃、大肠经,有温中,下气,燥湿,消痰的功能,治胸腹痞满胀痛,反胃、呕吐,宿食不消, 痰饮喘咳,寒湿泻痢。选用鳖甲是因为其性味咸,平,入肝、脾经,有养阴清热,平肝熄风,软 坚散结的功能,治劳热骨蒸,阴虚风动,劳疟疟母,癥瘕痃癖,经闭经漏,小儿惊癎。选用泽兰 是因为其性味苦辛,微温,入肝、脾经,有活血,行水的功能,治经闭,癥瘕,产后瘀滞腹痛,身 面浮肿,跌扑损伤,金疮,痈肿。选用鸡内金是因为其性味甘,平,入脾、胃经,有消积滞,健脾 胃的功能,治食积胀满,呕吐反胃,泻痢,疳积,消渴,遗溺,喉痹乳蛾,牙疳口疮。选用郁金是 因为其性味辛苦,凉,入心、肺、肝经,有行气解随,凉血破瘀的功能,治胸腹胁肋诸痛,失心 癫狂,热病神昏,吐血,衄血,尿血,血淋,妇女倒经,黄疸。选用青皮是因为其性味苦辛,微 温,入肝、胆经,有疏肝破气,散结消痰的功能,治胸胁胃脘疼痛,疝气,食积,乳肿,乳核,久 疟癖块。选用龙胆是因为其性味苦,寒,入肝、胆经,有泻肝实火,除下焦湿热的功能,治肝经 热盛,惊癎狂躁,乙型脑炎,头痛,目赤,咽痛,黄疸,热痢,痈肿疮疡,阴囊肿痛,阴部湿痒。选 用何首乌是因为其性味苦甘涩,微温,入肝、肾经,有补肝,益肾,养血,祛风的功能,治肝肾 阴亏,发须早白,血虚头晕,腰膝软弱,筋骨酸痛,遗精,崩带,久疟,久痢,慢性肝炎,痈肿,瘰 疬,肠风,痔疾。选用决明子是因为其性味苦甘,凉,入肝、肾经,有清肝,明目,利水,通便的 功能,治风热赤眼,青盲,雀目,高血压,肝炎,肝硬化腹化,习惯性便秘。选用大黄是因为其 性味苦、寒,入胃、大肠、肝径,有泻热毒,破积滞,行瘀血的功能,治实热便秘,谵语发狂,食 积痞满,痢疾初起,里急后重,瘀停经闭,癥瘕积聚,时行热疫,暴眼赤痛,吐血,衄血,阳黄, 水肿,淋浊,溲赤,痈疡肿毒,疔疮,汤火伤。选用柴胡是因为其性味苦,凉,入肝、胆经,有和 解表里,疏肝,升阳的功能,治寒热往来,胸满胁痛,口苦耳聋,头痛目眩,疟疾,下利脱肛,月 经不调,子宫下垂。选用川楝子是因为其性味苦,寒,有毒,入肝、胃、小肠经,有降湿热,清肝 火,止痛,杀虫的功能,治热厥心痛,胁痛,疝痛,虫积腹痛。选用荷叶是因为其性味苦涩,平, 入心、肝、脾经,有清暑利湿,升发清阳,止血的功能,治暑湿泄泻、眩晕,水气浮肿,雷头风, 吐血,衄血,崩漏,便血,产后血晕。选用青黛是因为其性味咸,寒,入肝、肺、胃经,有清热,凉 血,解毒的功能,治温病热盛,斑疹,吐血、略血,小儿惊癎,疮肿,丹毒,蛇虫咬伤。选用重楼 是因为其性味苦,微寒,有小毒,归肝经,有清热解毒,消肿止痛,凉肝定惊的功能,治疔疮痈 月中,咽喉肿痛,毒蛇咬伤,跌扑伤痛,惊风抽搐。选用虎杖是因为其性味苦,平,有祛风,利湿, 破瘀,通经的功能,治风湿筋骨疼痛,湿热黄疸,淋浊带下,妇女经闭,产后恶露不下,癥瘕积 聚,痔漏下血,跌扑损伤,烫伤,恶疮癣疾。选用枳壳是因为其性味苦辛,凉,入肺、脾、大肠 经,有破气,行痰,消积的功能,治胸膈痰滞,胸痞,胁胀,食积,噫气,呕逆,下痢后重,脱肛, 子宫脱垂。选用苍术是因为其性味辛苦,温,入脾、胃经,有健脾,燥湿,解郁,辟秽的功能,治 湿盛困脾,倦怠嗜卧,脘痞腹胀,食欲不振,呕吐,泄泻,痢疾,疟疾,痰饮,水肿,时气感冒,风 寒湿痹,足痿,夜盲。选用茯苓是因为其性味甘淡,平,入心、脾、肺经,有渗湿利水,益脾和 胃,宁心安神的功能,治小便不利水肿胀痛,痰饮咳逆,呕哕,泄泻,遗精,淋浊,惊悸,健忘。 选用绞股蓝是因为其性味苦,寒,归肺、脾、肾经,有清热解毒,止咳祛痰,生津安神的功能, 治慢性支气管炎,传染性肝炎,肾盂肾炎,胃肠炎,心血管病。选用枸杞子是因为其性味甘, 平,有滋肾,润肺,补肝,明目的功能,治肝肾阴亏,腰膝酸软,头晕目眩,目昏多泪,虚劳咳 嗽,消渴,遗精。选用白术是因为其性味苦甘,温,入脾、胃经,有补脾,益胃,燥湿,和中的功 能,治脾胃气弱,不思饮食,倦怠少气,虚胀,泄泻,痰饮,水肿,黄疸,湿痹,小便不利,头晕, 自汗,胎气不安。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止 痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选 用莪术是因为其性味辛、苦,温,归肝、脾经,有行气破血,消积止痛的功能,治癥瘕痞块,瘀 血经闭,食积肛痛,跌打肿痛,早期宫颈癌。选用薏苡仁是因为其性味甘淡,凉,入脾、肺、肾 经,有健脾,补肺,清热,利湿的功能,治泄泻,湿痹,筋脉拘挛,屈伸不利,水肿,脚气,肺痿, 肺痈,肠痈,淋池,白带。选用仙鹤草是因为其性味苦辛、平。入肺、肝、脾经。止血,健胃。治咯 血,吐血,尿血,便血,赤白痢疾,崩漏带下,劳伤脱力,痈肿,跌打、创伤出血。选用甘草是因 为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱, 食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡, 解药毒及食物中毒。选用姜黄是因为其性味辛苦,温,入脾、肝经,有破血,行气,通经,止痛 的功能,治心腹痞满胀痛,臂痛,癥瘕,妇女血瘀经闭,产后瘀停腹痛,跌扑损伤,痈肿。
具体实施方式
[0007] 本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下 述重量范围内都具有较好的疗效: 茵陈蒿15-25克,丹参10-20克,黄芪10-20克,泽泻10-20克,山楂15-25克,厚朴5-15克, 鳖甲5-15克,泽兰10-20克,鸡内金10-20克,郁金10-20克,青皮5-15克,龙胆5-15克,何首乌 10-20克,决明子5-15克,大黄10-20克,柴胡10-20克,川楝子5-10克,荷叶15-25克,青黛10-20克,重楼5-15克,虎杖10-20克,枳壳5-15克,苍术5-15克,茯苓5-15克,绞股蓝10-20克,枸 杞子10-20克,白术5-15克,川芎5-15克,莪术10-15克,薏苡仁15-25克,仙鹤草5-15克,甘草 5-15克,姜黄10-20克。
[0008] 优选为: 茵陈蒿20克,丹参15克,黄芪15克,泽泻15克,山楂20克,厚朴10克,鳖甲10克,泽兰15 克,鸡内金15克,郁金15克,青皮10克,龙胆10克,何首乌15克,决明子10克,大黄15克,柴胡 15克,川楝子8克,荷叶20克,青黛15克,重楼10克,虎杖15克,枳壳10克,苍术10克,茯苓10 克,绞股蓝15克,枸杞子15克,白术10克,川芎10克,莪术12克,薏苡仁20克,仙鹤草10克,甘 草10克,姜黄15克。
[0009] 本发明药物的制备方法如下 一、备料 1、 茵陈蒿:过筛,拣去杂质,除去残根,碾碎,再过箩去净泥肩; 2、 丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干; 3、 黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切片, 晒干; 4、 泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切 片,晒干; 5、 山楂:拣净杂质,筛去核; 6、 厚朴:用水浸泡捞出,润透后刮去粗皮,洗净,切丝,晾干; 7、 鳖甲:用水浸泡,去净皮肉,洗净,晒干; 8、 泽兰:拣去杂质,除去残根,喷水稍润,切段晒干; 9、 鸡内金:拣去杂质,漂净晒干; 10、 郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干; 11、 青皮:拣净杂质,用水浸泡,捞出,润透,切片,晒干; 12、 龙胆:拣去杂质,除去残茎,洗净,润透后切段,晒干; 13、 何首乌:拣去杂质,洗净,用水泡至八成透,捞出,润至内外湿度均匀,切片或切成方 块,晒干; 14、 决明子:取净决明子,置锅内炒至微有香气,取出,放凉; 15、 大黄:取切成小块的生大黄,用黄酒拌匀,放蒸笼内蒸制,或置罐内密封,坐水锅中, 隔水蒸透,取出晒干,大黄块100斤,用黄酒40斤; 16、 柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,随即晒干; 17、 川楝子:拣去杂质,洗净,烘干,乳碎或劈成两半; 18、 荷叶:以水洗净,剪去蒂与边缘,切丝,晒干; 19、 青黛:拣去杂质,过箩; 20、 重楼:除去须根,洗净,干燥; 21、 虎杖:米得后,细挫,晒干; 22、 枳壳:除去瓤、核,冼净,稍浸,捞出,润软,以手能捏对折为止,切片,晾干; 23、 苍术:拣去杂质,用水泡至七、八成透,捞出,润透后切片,晒干; 24、 茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干; 25、 绞股蓝:取原药材,除去杂质,洗净,稍晾,切段,干燥; 26、 枸杞子:簸净杂质,摘去残留的梗和蒂; 27、 白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干; 28、 川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥; 29、 莪术:取原药材,除去杂质,大小分档,洗净,略浸泡,取出,润透,切薄片,干燥,筛去 碎肩; 30、 意该仁:取原药材,除去残留皮壳、杂质; 31、 仙鹤草:除去杂质残根,洗净,润透,切断,晒干 32、 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干; 33、 姜黄:拣去杂质,用水浸泡,捞起,润透后切片,晒干。
[0010] 二、制备 1、将炮制后的茵陈蒿、丹参、黄芪、泽泻、山楂、厚朴、鳖甲、泽兰、鸡内金、郁金、青皮、龙 胆、何首乌、决明子、大黄、柴胡、川楝子、荷叶、青黛、重楼、虎杖、枳壳、苍术、茯苓、绞股蓝、 枸杞子、白术、川芎、莪术、薏苡仁、仙鹤草、甘草、姜黄放入煎药容器内,第一次加水8倍量, 浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮 液倒入容器内。
[0011] 2、将过滤的药渣加6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液。
[0012] 3、将两次煎煮液混合搅拌均匀,分为4剂服用。
[0013] 组方中苍术有健脾,燥湿,解郁,辟秽,治湿盛困脾的功能为君药;厚朴温中,下气, 燥湿,消痰;龙胆有泻肝实火,除下焦湿热的功能,二者为臣药,三味药共同发挥健脾,燥湿, 解郁,辟秽,消痰,泻肝实火,除下焦湿热的作用,治疗脂肪肝效力全面,且以健脾,燥湿,解 郁,消痰,泻肝实火,除下焦湿热为主可治本,甘草有和中缓急,润肺,解毒,调和诸药,解药 毒及食物中毒的功能为佐药,青皮有疏肝破气,散结消痰的功能为使药,与余下诸药是治 标。
[0014] 本发明药物具有健脾,燥湿解郁,泻肝实火,除下焦湿热,疏肝破气,散结消痰的功 能,用于治疗脂肪肝,疗程短、见效快、治愈后不复发。
[0015]
具体实施方式: 以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药 物的动物毒性试验报告和临床疗效观察资料。
[0016] [试验例1]本发明药物的动物毒性试验报告: 取家兔30只,雌雄兼用,体重2.0-2.5kg,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给 药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良 毒副作用。
[0017] [试验例2 ]本发明药物的临床疗效观察 1、一般资料 收治脂肪肝门诊患者共39例。
[0018] 2、诊断标准 典型症状为有食欲不振、疲倦乏力、恶心、呕吐、肝区或右上腹隐痛,脂肪肝病人也常有 舌炎、口角炎、皮肤淤斑、四肢麻木、四肢感觉异常等末梢神经炎的改变。少数病人也可有消 化道出血、牙龈出血、鼻衄等。重度脂肪肝患者可以有腹腔积液和下肢水肿、电解质紊乱如 低钠、低钾血症等等症状。
[0019] 3、治疗方法 选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,10天为一个疗程,连续 服用3个疗程。
[0020] 4、疗效评定标准 显效:脂肪肝症状消失,体质恢复正常,痊愈; 好转:患者食欲不振,疲倦乏力,恶心呕吐和上腹隐痛的症状减轻,脂肪肝症状明显好 转,体质逐步恢复; 无效:达不到好转标准者。
[0021] 5、治疗结果(见下表)
Figure CN106110184AD00081
在上述治疗中,用本发明药物治疗脂肪肝患者39例,结果显效33例,显效率为84.61%, 好转5例,好转率为12.82%,无效1例,总有效率为97.43%。

Claims (3)

1. 一种治疗脂肪肝的药物,其特征在于:它是由下列重量范围内的原料药制成: 茵陈蒿15-25克,丹参10-20克,黄芪10-20克,泽泻10-20克,山楂15-25克,厚朴5-15克, 鳖甲5-15克,泽兰10-20克,鸡内金10-20克,郁金10-20克,青皮5-15克,龙胆5-15克,何首乌 10-20克,决明子5-15克,大黄10-20克,柴胡10-20克,川楝子5-10克,荷叶15-25克,青黛10-20克,重楼5-15克,虎杖10-20克,枳壳5-15克,苍术5-15克,茯苓5-15克,绞股蓝10-20克,枸 杞子10-20克,白术5-15克,川芎5-15克,莪术10-15克,薏苡仁15-25克,仙鹤草5-15克,甘草 5-15克,姜黄10-20克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 茵陈蒿20克,丹参15克,黄芪15克,泽泻15克,山楂20克,厚朴10克,鳖甲10克,泽兰15 克,鸡内金15克,郁金15克,青皮10克,龙胆10克,何首乌15克,决明子10克,大黄15克,柴胡 15克,川楝子8克,荷叶20克,青黛15克,重楼10克,虎杖15克,枳壳10克,苍术10克,茯苓10 克,绞股蓝15克,枸杞子15克,白术10克,川芎10克,莪术12克,薏苡仁20克,仙鹤草10克,甘 草10克,姜黄15克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (一)备料 (1) 茵陈蒿:过筛,拣去杂质,除去残根,碾碎,再过箩去净泥肩; (2) 丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干; (3) 黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切片, 晒干; (4) 泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀, 切片,晒干; (5 )山楂:拣净杂质,筛去核; (6)厚朴:用水浸泡捞出,润透后刮去粗皮,洗净,切丝,晾干; (7 )鳖甲:用水浸泡,去净皮肉,洗净,晒干; (8) 泽兰:拣去杂质,除去残根,喷水稍润,切段晒干; (9) 鸡内金:拣去杂质,漂净晒干; (10) 郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干; (11) 青皮:拣净杂质,用水浸泡,捞出,润透,切片,晒干; (12) 龙胆:拣去杂质,除去残茎,洗净,润透后切段,晒干; (13) 何首乌:拣去杂质,洗净,用水泡至八成透,捞出,润至内外湿度均匀,切片或切成 方块,晒干; (14) 决明子:取净决明子,置锅内炒至微有香气,取出,放凉; (15) 大黄:取切成小块的生大黄,用黄酒拌匀,放蒸笼内蒸制,或置罐内密封,坐水锅 中,隔水蒸透,取出晒干,大黄块100斤,用黄酒40斤; (16) 柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,随即晒干; (17) 川楝子:拣去杂质,洗净,烘干,乳碎或劈成两半; (18) 荷叶:以水洗净,剪去蒂与边缘,切丝,晒干; (19) 青黛:拣去杂质,过箩; (20 )重楼:除去须根,洗净,干燥; (21) 虎杖:米得后,细挫,晒干; (22) 枳壳:除去瓤、核,冼净,稍浸,捞出,润软,以手能捏对折为止,切片,晾干; (23) 苍术:拣去杂质,用水泡至七、八成透,捞出,润透后切片,晒干; (24) 茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干; (25 )绞股蓝:取原药材,除去杂质,洗净,稍晾,切段,干燥; (26) 枸杞子:簸净杂质,摘去残留的梗和蒂; (27) 白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干; (28) 川考:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥; (29) 莪术:取原药材,除去杂质,大小分档,洗净,略浸泡,取出,润透,切薄片,干燥,筛 去碎肩; (30) 意该仁:取原药材,除去残留皮壳、杂质; (31) 仙鹤草:除去杂质残根,洗净,润透,切断,晒干 (32) 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干; (33 )姜黄:拣去杂质,用水浸泡,捞起,润透后切片,晒干; (二)制备 (1) 将炮制后的茵陈蒿、丹参、黄芪、泽泻、山楂、厚朴、鳖甲、泽兰、鸡内金、郁金、青皮、 龙胆、何首乌、决明子、大黄、柴胡、川楝子、荷叶、青黛、重楼、虎杖、枳壳、苍术、茯苓、绞股 蓝、枸杞子、白术、川芎、莪术、薏苡仁、仙鹤草、甘草、姜黄放入煎药容器内,加水8倍量,浸泡 100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒 入容器内; (2) 将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液; (3) 将两次煎煮液混合搅拌均匀,分为4剂服用。
CN201610564169.9A 2016-07-18 2016-07-18 一种治疗脂肪肝的药物及其制备方法 Withdrawn CN106110184A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610564169.9A CN106110184A (zh) 2016-07-18 2016-07-18 一种治疗脂肪肝的药物及其制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610564169.9A CN106110184A (zh) 2016-07-18 2016-07-18 一种治疗脂肪肝的药物及其制备方法

Publications (1)

Publication Number Publication Date
CN106110184A true CN106110184A (zh) 2016-11-16

Family

ID=57283902

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610564169.9A Withdrawn CN106110184A (zh) 2016-07-18 2016-07-18 一种治疗脂肪肝的药物及其制备方法

Country Status (1)

Country Link
CN (1) CN106110184A (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107224558A (zh) * 2017-06-13 2017-10-03 江苏黄河药业股份有限公司 一种治疗脂肪肝的参芪制剂及其制备方法
CN107281441A (zh) * 2017-06-13 2017-10-24 江苏黄河药业股份有限公司 一种参芪补肝健胃健脾的制剂及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103736036A (zh) * 2014-01-28 2014-04-23 张怀胜 一种治疗非酒精性脂肪性肝病的药物及其制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103736036A (zh) * 2014-01-28 2014-04-23 张怀胜 一种治疗非酒精性脂肪性肝病的药物及其制备方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107224558A (zh) * 2017-06-13 2017-10-03 江苏黄河药业股份有限公司 一种治疗脂肪肝的参芪制剂及其制备方法
CN107281441A (zh) * 2017-06-13 2017-10-24 江苏黄河药业股份有限公司 一种参芪补肝健胃健脾的制剂及其制备方法

Similar Documents

Publication Publication Date Title
CN103550733A (zh) 一种治疗滑胎的药物及其制备方法
CN103432390B (zh) 一种治疗冠心病的药物及其制备方法
CN105477487A (zh) 一种治疗慢性咽炎的药物及其制备方法
CN103977306A (zh) 一种治疗乙型肝炎的药物及其制备方法
CN105362889A (zh) 一种治疗耳鸣的药物及其制备方法
CN106110184A (zh) 一种治疗脂肪肝的药物及其制备方法
CN104352758A (zh) 一种治疗高血压的药物及其制备方法
CN103550694A (zh) 一种治疗脱发的药物及其制备方法
CN103735916B (zh) 一种治疗肾病综合症的药物及其制备方法
CN105343490A (zh) 一种治疗痔疮的药物及其制备方法
CN103263575B (zh) 一种治疗头痛的药物及其制备方法
CN105343757A (zh) 一种治疗腹胀的药物及其制备方法
CN102805825B (zh) 一种治疗皮肤瘙痒症的药物及其制备方法
CN104435684A (zh) 一种治疗口腔溃疡的药物及其制备方法
CN104056224A (zh) 一种治疗习惯性流产的药物及其制备方法
CN103623297B (zh) 一种治疗急性乳腺炎的药物及其制备方法
CN105477545A (zh) 一种治疗脑血栓的药物及其制备方法
CN106692858A (zh) 一种治疗胎动不安的药物及其制备方法
CN106511806A (zh) 一种治疗癔症的药物及其制备方法
CN105343582A (zh) 一种治疗破伤风的药物及其制备方法
CN105943894A (zh) 一种治疗急性卡他性结膜炎的药物及其制备方法
CN105412825A (zh) 一种治疗高脂血症的药物及其制备方法
CN105412830A (zh) 一种治疗急性黄疸型肝炎的药物及其制备方法
CN105435187A (zh) 一种治疗干燥病的药物及其制备方法
CN105343859A (zh) 一种治疗眩晕症的药物及其制备方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WW01 Invention patent application withdrawn after publication
WW01 Invention patent application withdrawn after publication

Application publication date: 20161116