CN105343582A - 一种治疗破伤风的药物及其制备方法 - Google Patents

一种治疗破伤风的药物及其制备方法 Download PDF

Info

Publication number
CN105343582A
CN105343582A CN201510945726.7A CN201510945726A CN105343582A CN 105343582 A CN105343582 A CN 105343582A CN 201510945726 A CN201510945726 A CN 201510945726A CN 105343582 A CN105343582 A CN 105343582A
Authority
CN
China
Prior art keywords
grams
gram
radix
rhizoma
fructus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201510945726.7A
Other languages
English (en)
Inventor
徐士魁
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201510945726.7A priority Critical patent/CN105343582A/zh
Publication of CN105343582A publication Critical patent/CN105343582A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/12Magnesium silicate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/646Arachnids, e.g. spiders, scorpions, ticks or mites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237Notopterygium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238Saposhnikovia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • A61K36/428Trichosanthes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605Morus (mulberry)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/61Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634Forsythia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/739Sanguisorba (burnet)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/744Gardenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/754Evodia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8884Arisaema, e.g. Jack in the pulpit
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888Pinellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968Ophiopogon (Lilyturf)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • A61K36/8988Gastrodia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

本发明公开了一种治疗破伤风的药物及其制备方法,其主要是由蝉蜕、金银花、钩藤、天麻、全蝎、桑叶、连翘、天南星、桂枝、麦冬、防风、羌活、大黄、赤芍、刺蒺藜、吴茱萸、滑石、甘草、白芷、川芎、半夏、栀子、苍耳子、红花、桃仁、瓜蒌、藁本、黄芩、地榆。按一定重量配比制备而成。本发明药物具有清热解毒,止痉,通络,祛风燥湿,活血止痛,行气开郁的功能,用于治疗破伤风见效快、疗效好,不复发。

Description

一种治疗破伤风的药物及其制备方法
技术领域
本发明涉及一种治疗破伤风的药物及其制备方法,属中药领域。
背景技术
破伤风破伤风杆菌经由皮肤或黏膜伤口侵入人体,在缺氧环境下生长繁殖,产生毒素而引起阵发性肌痉挛的一种特异性感染。中医则认为破伤风与风毒之邪,外邪入侵,气血不畅,经络拘急有关。由于西药治疗副作用大,因此人们对有效治疗破伤风的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗破伤风的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗破伤风的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择蝉蜕、金银花、钩藤、天麻、全蝎、桑叶、连翘、天南星、桂枝、麦冬、防风、羌活、大黄、赤芍、刺蒺藜、吴茱萸、滑石、甘草、白芷、川芎、半夏、栀子、苍耳子、红花、桃仁、瓜蒌、藁本、黄芩、地榆、土荆芥、马齿苋、丁香药物进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗破伤风。其中,选用蝉蜕是因为其性味甘咸,凉,入肺、肝经,有散风热,宣肺,定痉的功能,治外感风热,咳嗽音哑,麻疹透发不畅,风疹瘙痒,小儿惊癎,目赤,翳障,疔疮肿毒,破伤风。选用金银花是因为其性味甘,寒,入肺、胃经,有清热,解毒的功能,治温病发热,热毒血痢,痈疡,肿毒,瘰疬,痔漏。选用钩藤是因为其性味苦,凉,入肝、心经,有清热平肝,熄风定惊的功能,治小儿惊癎瘈瘲,大人血压偏高,头晕、目眩,妇人子癎。选用天麻是因为其性味甘,平,入肝经,有息风,定惊的功能,治眩晕眼黑,头风头痛,肢体麻木,半身不遂,语言蹇涩,小儿惊癎动风。选用全蝎是因为其性味咸辛,平,有毒,有祛风,止痉,通络,解毒的功能,治惊风抽搐,癫癎,中风,半身不遂,口眼斜,偏头痛,风湿痹痛,破伤风,淋巴结结核,风疹疮肿。选用桑叶是因为其性味苦甘,寒,入肺、肝经,有祛风清热,凉血明目的功能,治风湿发热,头痛,目赤,口渴,肺热咳嗽,风痹,瘾疹,下肢象皮肿。选用连翘是因为其性味苦,凉,入心、肝、胆经,有清热,解毒,散结,消肿的功能,治温热,丹毒,斑疹,痈疡肿毒,瘰疬,小便淋闭。选用天南星是因为其性味苦辛,温,有毒,入肺、肝、脾经,有燥湿化痰,祛风定惊,消肿散结的功能,治中风痰壅,口眼斜,半身不遂,癫癎,惊风,破伤风,风痰眩晕,喉痹,瘰疬,痈肿,跌扑折伤,蛇虫咬伤。选用桂枝是因为其性味辛甘,温,入膀胱、心、肺经,有发汗解肌,温经通脉的功能,治风寒表证,肩背肢节酸疼,胸痹痰饮,经闭癥瘕。选用麦冬是因为其性味甘微苦,寒,入肺、胃、心经,有养阴润肺,清心除烦,益胃生津的功能,治肺燥干咳,吐血,咯血,肺痿,肺痈,虚劳烦热,清渴,热病津伤,咽干口燥,便秘。选用防风是因为其性味辛甘,温,入膀胱、肺、脾经,有发表,祛风,胜湿,止痛的功能,治外感风寒,头痛,目眩,项强,风寒湿痹,骨节酸痛,四肢挛急,破伤风。选用羌活是因为其性味辛苦,温,入膀胱、肾经,有散表寒,祛风湿,利关节的功能,治感冒风寒,头痛无汗,风寒湿痹,项强筋急,骨节酸疼,风水浮肿,痈疽疮毒。选用大黄是因为其性味苦、寒,入胃、大肠、肝径,有泻热毒,破积滞,行瘀血的功能,治实热便秘,谵语发狂,食积痞满,痢疾初起,里急后重,瘀停经闭,癥瘕积聚,时行热疫,暴眼赤痛,吐血,衄血,阳黄,水肿,淋浊,溲赤,痈疡肿毒,疔疮,汤火伤。选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用刺蒺藜是因为其性味苦辛,温,入肝、肺经,有散风,明目,下气,行血的功能,治头痛,身痒,目赤肿翳,胸满,咳逆,癥瘕,乳难,痈疽,瘰疬。选用吴茱萸是因为其性味辛苦,温,有毒,入肝、胃经,有温中,止痛,理气,燥湿的功能,治呕逆吞酸,厥阴头痛,脏寒吐泻,脘腹胀痛,脚气,疝气,口疮溃疡,齿痛,湿疹,黄水疮。选用滑石是因为其性味甘、淡,寒,归膀胱、肺、胃经,有利尿通淋,清热解毒,祛湿解暑的功能,治热淋、石淋,尿热涩痛,暑湿烦渴,湿热水泻,外治湿疹,湿疮,痱子。选用甘草是因为其性味甘,平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊癎;生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用白芷是因为其性味辛,温,入肺、脾、胃经,有祛风,燥湿,消肿,止痛的功能,治头痛,眉棱骨痛,齿痛,鼻渊,寒湿腹痛,肠风痔漏,赤白带下,痈疽疮疡,皮肤燥痒,疥癣。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用半夏是因为其性味辛,温,有毒,入脾、胃经,有燥湿化痰,降逆止呕,清痞散结的功能,治湿痰冷饮呕吐,反胃,咳喘痰多,我膈胀满,痰厥头痛,头晕不眠,外消痈肿。选用栀子是因为其性味苦,寒,入心、肝、肺、胃经,有清热,泻火,凉血的功能,治热病虚烦不眠,黄疸,淋病,消渴,目赤,咽痛,吐血,衄血,血痢,尿血,热毒疮疡,扭伤肿痛。选用苍耳子是因为其性味甘,温,有毒,入肺、肝经,有散风,止痛,祛湿,杀虫的功能,治风寒头痛,鼻渊,齿痛,风寒湿痹,四脚挛痛,疥癞,瘙痒。选用红花是因为其性味甘,平,入心、肝经,有活血化瘀,散郁开结的功能,治忧思郁结,胸膈痞闷,吐血,伤寒发狂,惊怖恍惚,妇女经闭,产后瘀血腹痛,跌扑肿痛。选用桃仁是因为其性味苦甘,平,入心、肝、大肠经,有破血行瘀,润燥滑经的功能,治经闭,癥瘕,热病蓄血,血痹,疟疾,跌打损伤,瘀血肿痛,血燥便秘。选用瓜蒌是因为其性味甘、微苦,寒,归肺、胃、大肠经,有清热涤痰,宽胸散结,润燥滑肠的功能,治肺热咳嗽,痰浊黄稠,胸痹心痛,结胸痞满,乳痈,肠痈,大便秘结。选用藁本是因为其性味辛,温,归膀胱经,有散寒祛风,除湿止痛的功能,用于风寒感冒,巅顶疼痛。选用黄芩是因为其性味苦寒,入心肺、胆、大肠经,有泻实火,除湿热,止血安胎的功能,治壮热烦渴,肺热咳嗽。选用地榆是因为其性味苦酸、寒。入肝、大肠经。凉血止血,清热解毒。治吐血,衄血,血痢,崩溃,肠风,痔漏,痈肿,湿疹,金疮,烧伤。选用土荆芥是因为其性味辛,温,有毒,有祛风,杀虫,通经,止痛的功能,治皮肤风湿痹痛,钩虫,蛔虫,痛经,经闭,皮肤湿疹,蛇虫咬伤。选用马齿苋是因为其性味酸,寒,入大肠、肝、脾经,有清热解毒,散血消肿的功能,治热痢脓血,热淋,血淋,带下,痈肿恶疮,丹毒,瘰疬。选用丁香是因为其性味辛,温,入胃、脾、肾经,有温中,暖肾,降逆的功能,治呃逆,呕吐,反胃,泻痢,心腹冷痛,痃癖,疝气,癣疾。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
蝉蜕10-20克,金银花10-20克,钩藤5-15克,天麻7-12克,全蝎5-10克,桑叶10-20克,连翘15-25克,天南星5-15克,桂枝5-10克,麦冬5-15克,防风10-20克,羌活5-15克,大黄7-12克,赤芍5-15克,刺蒺藜5-15克,吴茱萸10-15克,滑石5-15克,甘草7-12克,白芷5-15克,川芎5-15克,半夏10-15克,栀子10-20克,苍耳子10-15克,红花5-15克,桃仁5-15克,瓜蒌10-20克,藁本5-15克,黄芩5-10克,地榆10-20克,土荆芥10-15克,马齿苋10-20克,丁香5-8克。
优选为:
蝉蜕15克,金银花15克,钩藤10克,天麻9克,全蝎8克,桑叶15克,连翘20克,天南星10克,桂枝8克,麦冬10克,防风15克,羌活10克,大黄9克,赤芍10克,刺蒺藜10克,吴茱萸12克,滑石10克,甘草9克,白芷10克,川芎10克,半夏12克,栀子15克,苍耳子12克,红花10克,桃仁10克,瓜蒌15克,藁本10克,黄芩8克,地榆15克,土荆芥12克,马齿苋15克,丁香6克。
本发明药物的制备方法如下
一、备料
1、蝉蜕:拣去杂质,洗净晒干;
2、金银花:筛去泥沙,拣净杂质;
3、钩藤:拣去老梗、杂质,洗净,晒干;
4、天麻:将天麻片平铺于喷过水的表芯纸上,置锅内,用文火烧至纸色焦黄,不断将药片翻动至两面老黄色为止;
5、全蝎:清水漂去盐质,晒干,或微火焙用;
6、桑叶:拣去杂质,搓碎,簸去梗,筛去泥屑;
7、连翘:拣净杂质,搓开,除去枝梗;
8、天南星:拣去杂质,洗净灰屑,晒干;
9、桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
10、麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干;
11、防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
12、羌活:拣去杂质,洗净,润透,切片,晾干;
13、大黄:拣净杂质,大小分档,焖润至内外湿度均匀,切片或切成小块、晒干;
14、赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
15、刺蒺藜:漂去泥沙,除净残留的硬刺;
16、吴茱萸:取原药材,除去果柄、枝及杂质,筛去碎屑;
17、滑石:取原药材,除去杂质,洗净,干燥;
18、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晾干;
19、白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切片干燥;
20、川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
21、半夏:拣去杂质,筛去灰屑;
22、栀子:筛去灰屑,拣去杂质,碾碎过筛或剪去两端;
23、苍耳子:拣尽杂质,去刺,筛去灰屑,微炒至黄色,取出放凉;
24、红花:拣净杂质,除去茎叶、蒂头,晒干;
25、桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
26、瓜蒌:取原药材,除去杂质及果柄,洗净,压扁,切丝或小块,干燥;
27、藁本:取原药材,除去杂质,大小分档,抢水洗净,润透,切片,晒干;
28、黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干;
29、地榆:拣去杂质,用水洗净,稍浸泡,润透,切成厚片,晒干;
30、土荆芥:拣净杂质,用水略泡,捞出切段,晒干;
31、马齿苋:拣净杂质,除去残根,以水稍润,切段晒干;
32、丁香:拣去杂质、花梗,筛去灰屑,用时捣碎。
二、制备
1、将炮制后的蝉蜕、金银花、钩藤、天麻、全蝎、桑叶、连翘、天南星、桂枝、麦冬、防风、羌活、大黄、赤芍、刺蒺藜、吴茱萸、滑石、甘草、白芷、川芎、半夏、栀子、苍耳子、红花、桃仁、瓜蒌、藁本、黄芩、地榆、土荆芥、马齿苋、丁香放入煎药容器内,其中滑石装入布袋第一次加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内。
2、将过滤的药渣加6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液。
3、将两次煎煮液混合搅拌均匀即得,分为4剂服用。
组方中金银花有清热解毒,治温病发热的功能为君药;全蝎祛风,止痉,通络,解毒;川芎有行气开郁,祛风燥湿,活血止痛的功能,二者为臣药,三味药共同发挥清热解毒,止痉,通络,祛风燥湿,活血止痛,行气开郁的作用,治疗破伤风效力全面,且以清热解毒,止痉,通络,祛风,活血为主可治本,藏红花有活血化瘀,散郁开结的功能为佐药,甘草有和中缓急,解毒,调和诸药,治脾胃虚弱,解药毒及食物中毒的功能为使药,与余下诸药是治标。
本发明药物具有清热解毒,止痉,通络,祛风燥湿,活血止痛,行气开郁的功能,用于治疗破伤风,疗程短、见效快、治愈后不复发。
具体实施方式:
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。服用药液超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治破伤风门诊患者共33例。
2、诊断标准
典型症状为全身乏力、头晕、头痛、咀嚼无力、局部肌肉发紧、扯痛、反射亢进全身肌肉强直性痉挛,阵发性抽搐,抽搐间歇期全身肌肉仍紧张强直,伴有发热,但神志清醒,多因并发症而死亡。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:破伤风症状消失,体质恢复正常,痊愈;
好转:患者乏力,肌肉痉挛,发热,局部肌肉反射亢进症状减轻,破伤风症状明显好转,体质逐步恢复;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗破伤风患者33例,结果显效26例,显效率为78.79%,好转5例,好转率为15.15%,无效2例,总有效率为93.94%。

Claims (3)

1.一种治疗破伤风的药物,其特征在于:它是由下列重量范围内的原料药制成:
蝉蜕10-20克,金银花10-20克,钩藤5-15克,天麻7-12克,全蝎5-10克,桑叶10-20克,连翘15-25克,天南星5-15克,桂枝5-10克,麦冬5-15克,防风10-20克,羌活5-15克,大黄7-12克,赤芍5-15克,刺蒺藜5-15克,吴茱萸10-15克,滑石5-15克,甘草7-12克,白芷5-15克,川芎5-15克,半夏10-15克,栀子10-20克,苍耳子10-15克,红花5-15克,桃仁5-15克,瓜蒌10-20克,藁本5-15克,黄芩5-10克,地榆10-20克,土荆芥10-15克,马齿苋10-20克,丁香5-8克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
蝉蜕15克,金银花15克,钩藤10克,天麻9克,全蝎8克,桑叶15克,连翘20克,天南星10克,桂枝8克,麦冬10克,防风15克,羌活10克,大黄9克,赤芍10克,刺蒺藜10克,吴茱萸12克,滑石10克,甘草9克,白芷10克,川芎10克,半夏12克,栀子15克,苍耳子12克,红花10克,桃仁10克,瓜蒌15克,藁本10克,黄芩8克,地榆15克,土荆芥12克,马齿苋15克,丁香6克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)蝉蜕:拣去杂质,洗净晒干;
(2)金银花:筛去泥沙,拣净杂质;
(3)钩藤:拣去老梗、杂质,洗净,晒干;
(4)天麻:将天麻片平铺于喷过水的表芯纸上,置锅内,用文火烧至纸色焦黄,不断将药片翻动至两面老黄色为止;
(5)全蝎:清水漂去盐质,晒干,或微火焙用;
(6)桑叶:拣去杂质,搓碎,簸去梗,筛去泥屑;
(7)连翘:拣净杂质,搓开,除去枝梗;
(8)天南星:拣去杂质,洗净灰屑,晒干;
(9)桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
(10)麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干;
(11)防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
(12)羌活:拣去杂质,洗净,润透,切片,晾干;
(13)大黄:拣净杂质,大小分档,闷润至内外湿度均匀,切片或切成小块、晒干;
(14)赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
(15)刺蒺藜:漂去泥沙,除净残留的硬刺;
(16)吴茱萸:取原药材,除去果柄、枝及杂质,筛去碎屑;
(17)滑石:取原药材,除去杂质,洗净,干燥;
(18)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晾干;
(19)白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切片干燥;
(20)川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
(21)半夏:拣去杂质,筛去灰屑;
(22)栀子:筛去灰屑,拣去杂质,碾碎过筛或剪去两端;
(23)苍耳子:拣尽杂质,去刺,筛去灰屑,微炒至黄色,取出放凉;
(24)红花:拣净杂质,除去茎叶、蒂头,晒干;
(25)桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
(26)瓜蒌:取原药材,除去杂质及果柄,洗净,压扁,切丝或小块,干燥;
(27)藁本:取原药材,除去杂质,大小分档,抢水洗净,润透,切片,晒干;
(28)黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干;
(29)地榆:拣去杂质,用水洗净,稍浸泡,润透,切成厚片,晒干;
(30)土荆芥:拣净杂质,用水略泡,捞出切段,晒干;
(31)马齿苋:拣净杂质,除去残根,以水稍润,切段晒干;
(32)丁香:拣去杂质、花梗,筛去灰屑,用时捣碎;
(二)制备
(1)将炮制好的蝉蜕、金银花、钩藤、天麻、全蝎、桑叶、连翘、天南星、桂枝、麦冬、防风、羌活、大黄、赤芍、刺蒺藜、吴茱萸、滑石、甘草、白芷、川芎、半夏、栀子、苍耳子、红花、桃仁、瓜蒌、藁本、黄芩、地榆、土荆芥、马齿苋、丁香放入煎药容器内,其中滑石装布袋加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀即得,分为4剂服用。
CN201510945726.7A 2015-12-17 2015-12-17 一种治疗破伤风的药物及其制备方法 Pending CN105343582A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510945726.7A CN105343582A (zh) 2015-12-17 2015-12-17 一种治疗破伤风的药物及其制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510945726.7A CN105343582A (zh) 2015-12-17 2015-12-17 一种治疗破伤风的药物及其制备方法

Publications (1)

Publication Number Publication Date
CN105343582A true CN105343582A (zh) 2016-02-24

Family

ID=55319741

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201510945726.7A Pending CN105343582A (zh) 2015-12-17 2015-12-17 一种治疗破伤风的药物及其制备方法

Country Status (1)

Country Link
CN (1) CN105343582A (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109966423A (zh) * 2019-03-26 2019-07-05 内蒙古艾鲁维农牧业开发有限责任公司 治疗破伤风的中药制剂

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101181534A (zh) * 2007-12-04 2008-05-21 朱惠芬 一种治疗破伤风的中药制剂
JP2010254695A (ja) * 2009-03-29 2010-11-11 Yasuo Kanamaru 人間、犬猫動物のすべて畜産のすべてミツバチ益虫のすべて鳥類のすべて樹木のすべて植物のすべての病気快復の液体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101181534A (zh) * 2007-12-04 2008-05-21 朱惠芬 一种治疗破伤风的中药制剂
JP2010254695A (ja) * 2009-03-29 2010-11-11 Yasuo Kanamaru 人間、犬猫動物のすべて畜産のすべてミツバチ益虫のすべて鳥類のすべて樹木のすべて植物のすべての病気快復の液体

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
吴滨等: "破伤风验案二则", 《黑龙江中医药》 *
杨光伦: "中药为主治疗破伤风23例", 《湖北中医杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109966423A (zh) * 2019-03-26 2019-07-05 内蒙古艾鲁维农牧业开发有限责任公司 治疗破伤风的中药制剂

Similar Documents

Publication Publication Date Title
CN103550439B (zh) 一种治疗带状疱疹的药物及其制备方法
CN102772711A (zh) 一种治疗痔疮的药物及其制备方法
CN105477487A (zh) 一种治疗慢性咽炎的药物及其制备方法
CN105412622A (zh) 一种治疗面瘫的药物及其制备方法
CN105362822A (zh) 一种治疗痤疮的药物及其制备方法
CN103977306A (zh) 一种治疗乙型肝炎的药物及其制备方法
CN103735934B (zh) 一种治疗腰部疼痛的药物及其制备方法
CN105343490A (zh) 一种治疗痔疮的药物及其制备方法
CN105362889A (zh) 一种治疗耳鸣的药物及其制备方法
CN104398925A (zh) 一种治疗皮肤病的药物及其制备方法
CN106110184A (zh) 一种治疗脂肪肝的药物及其制备方法
CN103263575B (zh) 一种治疗头痛的药物及其制备方法
CN105457001A (zh) 一种治疗小儿多动症的药物及其制备方法
CN105521473A (zh) 一种治疗小儿麻痹后遗症的药物及其制备方法
CN105343582A (zh) 一种治疗破伤风的药物及其制备方法
CN103656589B (zh) 一种治疗病毒性心肌炎的药物及其制备方法
CN103751752B (zh) 一种治疗痢疾的药物及其制备方法
CN103830698B (zh) 一种治疗儿童腹股沟疝的药物及其制备方法
CN105412825A (zh) 一种治疗高脂血症的药物及其制备方法
CN105311518A (zh) 一种治疗哮喘的药物及其制备方法
CN105456928A (zh) 一种治疗类风湿性关节炎的药物及其制备方法
CN105943894A (zh) 一种治疗急性卡他性结膜炎的药物及其制备方法
CN105343854A (zh) 一种治疗胃脘痛的药物及其制备方法
CN105381317A (zh) 一种治疗头痛的药物及其制备方法
CN105477545A (zh) 一种治疗脑血栓的药物及其制备方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20160224