CN105343582A - 一种治疗破伤风的药物及其制备方法 - Google Patents

一种治疗破伤风的药物及其制备方法 Download PDF

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CN105343582A
CN105343582A CN201510945726.7A CN201510945726A CN105343582A CN 105343582 A CN105343582 A CN 105343582A CN 201510945726 A CN201510945726 A CN 201510945726A CN 105343582 A CN105343582 A CN 105343582A
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徐士魁
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徐士魁
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Abstract

本发明公开了一种治疗破伤风的药物及其制备方法,其主要是由蝉蜕、金银花、钩藤、天麻、全蝎、桑叶、连翘、天南星、桂枝、麦冬、防风、羌活、大黄、赤芍、刺蒺藜、吴茱萸、滑石、甘草、白芷、川芎、半夏、栀子、苍耳子、红花、桃仁、瓜蒌、藁本、黄芩、地榆。按一定重量配比制备而成。本发明药物具有清热解毒,止痉,通络,祛风燥湿,活血止痛,行气开郁的功能,用于治疗破伤风见效快、疗效好,不复发。

Description

-种治疗破伤风的药物及其制备方法
技术领域
[0001] 本发明设及一种治疗破伤风的药物及其制备方法,属中药领域。
背景技术
[0002] 破伤风破伤风杆菌经由皮肤或黏膜伤口侵入人体,在缺氧环境下生长繁殖,产生 毒素而引起阵发性肌疫李的一种特异性感染。中医则认为破伤风与风毒之邪,外邪入侵,气 血不杨,经络拘急有关。由于西药治疗副作用大,因此人们对有效治疗破伤风的中药药物存 在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
[0003] 本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗破伤 风的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种有效治疗破伤风的中药组合药物。
[0005] 本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006] 本发明药物是选择赠蚁、金银花、钩藤、天麻、全蜗、桑叶、连翅、天南星、桂枝、麦 冬、防风、弟活、大黄、赤巧、刺裝襲、吴荣英、滑石、甘草、白芯川号、半夏、檐子、苍耳子、红 花、桃仁、瓜萎、蔓本、黄琴、地愉、±荆芥、马齿宽、下香药物进行组合制备的,将运些药物组 合使得各药物功效产生协同作用,从而能够有效治疗破伤风。其中,选用赠蚁是因为其性味 甘咸,凉,入肺、肝经,有散风热,宣肺,定疫的功能,治外感风热,咳嗽音哑,麻疹透发不杨, 风疹痊痒,小儿惊癖,目赤,繫障,疗疮肿毒,破伤风。选用金银花是因为其性味甘,寒,入 肺、胃经,有清热,解毒的功能,治溫病发热,热毒血频,痴瘍,肿毒,療痛,持漏。选用钩藤是 因为其性味苦,凉,入肝、屯、经,有清热平肝,焰风定惊的功能,治小儿惊癖瘦疵,大人血压偏 高,头晕、目眩,妇人子癖。选用天麻是因为其性味甘,平,入肝经,有息风,定惊的功能,治眩 晕眼黑,头风头痛,肢体麻木,半身不遂,语言蹇涩,小儿惊癖动风。选用全蜗是因为其性味 咸辛,平,有毒,有桂风,止疫,通络,解毒的功能,治惊风抽摇,癒癖,中风,半身不遂,口眼喝 斜,偏头痛,风湿搏痛,破伤风,淋己结结核,风疹疮肿。选用桑叶是因为其性味苦甘,寒,入 肺、肝经,有桂风清热,凉血明目的功能,治风湿发热,头痛,目赤,口渴,肺热咳嗽,风搏,癒 疹,下肢象皮肿。选用连翅是因为其性味苦,凉,入屯、、肝、胆经,有清热,解毒,散结,消肿的 功能,治溫热,丹毒,斑疹,痴瘍肿毒,療痛,小便淋闭。选用天南星是因为其性味苦辛,溫,有 毒,入肺、肝、脾经,有燥湿化疲,桂风定惊,消肿散结的功能,治中风疲塞,口眼喝斜,半身不 遂,癒癖,惊风,破伤风,风疲眩晕,喉搏,療痛,痴肿,跌扑折伤,蛇虫咬伤。选用桂枝是因为 其性味辛甘,溫,入膀脫、屯、、肺经,有发汗解肌,溫经通脉的功能,治风寒表证,肩背肢节酸 疼,胸搏疲饮,经闭瘤瘤。选用麦冬是因为其性味甘微苦,寒,入肺、胃、屯、经,有养阴润肺,清 屯、除烦,益胃生津的功能,治肺燥干咳,吐血,咯血,肺瘦,肺痴,虚劳烦热,清渴,热病津伤, 咽干口燥,便秘。选用防风是因为其性味辛甘,溫,入膀脫、肺、脾经,有发表,桂风,胜湿,止 痛的功能,治外感风寒,头痛,目眩,项强,风寒湿搏,骨节酸痛,四肢李急,破伤风。选用弟活 是因为其性味辛苦,溫,入膀脫、肾经,有散表寒,桂风湿,利关节的功能,治感冒风寒,头痛 无汗,风寒湿搏,项强筋急,骨节酸疼,风水浮肿,痴痘疮毒。选用大黄是因为其性味苦、寒, 入胃、大肠、肝径,有泻热毒,破积滞,行疲血的功能,治实热便秘,檐语发狂,食积瘡满,频疾 初起,里急后重,疲停经闭,瘤瘤积聚,时行热疫,暴眼赤痛,吐血,赃血,阳黄,水肿,淋浊,瘦 赤,痴瘍肿毒,疗疮,汤火伤。选用赤巧是因为其性味苦,微寒,归肝经,有清热凉血,散疲止 痛的功能,治溫毒发狂,吐血赃血,目赤肿痛,肝郁胁痛,经闭痛经,癖瘤腹痛,跌扑损伤,痴 肿疮瘍。选用刺裝襲是因为其性味苦辛,溫,入肝、肺经,有散风,明目,下气,行血的功能,治 头痛,身痒,目赤肿繫,胸满,咳逆,瘤瘤,乳难,痴痘,療痛。选用吴荣英是因为其性味辛苦, 溫,有毒,入肝、胃经,有溫中,止痛,理气,燥湿的功能,治呕逆吞酸,厥阴头痛,脏寒吐泻,腕 腹胀痛,脚气,痛气,口疮溃瘍,齿痛,湿疹,黄水疮。选用滑石是因为其性味甘、淡,寒,归膀 脫、肺、胃经,有利尿通淋,清热解毒,桂湿解暑的功能,治热淋、石淋,尿热涩痛,暑湿烦渴, 湿热水泻,外治湿疹,湿疮,萍子。选用甘草是因为其性味甘,平,入脾、胃、肺经,有和中缓 急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便漉,劳倦发热,肺瘦咳嗽,屯、 惇,惊癖;生用治咽喉肿痛,消化性溃瘍,痴痘疮瘍,解药毒及食物中毒。选用白巧是因为其 性味辛,溫,入肺、脾、胃经,有桂风,燥湿,消肿,止痛的功能,治头痛,眉棱骨痛,齿痛,鼻渊, 寒湿腹痛,肠风持漏,赤白带下,痴痘疮瘍,皮肤燥痒,巧癖。选用川号是因为其性味辛,溫, 入肝、胆经,有行气开郁,桂风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒搏筋 李,经闭,难产,产后疲阻块痛,痴痘疮瘍。选用半夏是因为其性味辛,溫,有毒,入脾、胃经, 有燥湿化疲,降逆止呕,清瘡散结的功能,治湿疲冷饮呕吐,反胃,咳喘疲多,我隔胀满,疲厥 头痛,头晕不眠,外消痴肿。选用檐子是因为其性味苦,寒,入屯、、肝、肺、胃经,有清热,泻火, 凉血的功能,治热病虚烦不眠,黄痘,淋病,消渴,目赤,咽痛,吐血,赃血,血频,尿血,热毒疮 瘍,扭伤肿痛。选用苍耳子是因为其性味甘,溫,有毒,入肺、肝经,有散风,止痛,桂湿,杀虫 的功能,治风寒头痛,鼻渊,齿痛,风寒湿搏,四脚李痛,巧癒,痊痒。选用红花是因为其性味 甘,平,入屯、、肝经,有活血化疲,散郁开结的功能,治忧思郁结,胸隔瘡闷,吐血,伤寒发狂, 惊怖恍惚,妇女经闭,产后疲血腹痛,跌扑肿痛。选用桃仁是因为其性味苦甘,平,入屯、、肝、 大肠经,有破血行疲,润燥滑经的功能,治经闭,瘤瘤,热病蓄血,血搏,追疾,跌打损伤,疲血 肿痛,血燥便秘。选用瓜萎是因为其性味甘、微苦,寒,归肺、胃、大肠经,有清热涂疲,宽胸散 结,润燥滑肠的功能,治肺热咳嗽,疲浊黄稠,胸搏屯、痛,结胸瘡满,乳痴,肠痴,大便秘结。选 用蔓本是因为其性味辛,溫,归膀脫经,有散寒桂风,除湿止痛的功能,用于风寒感冒,颤顶 疼痛。选用黄琴是因为其性味苦寒,入屯、肺、胆、大肠经,有泻实火,除湿热,止血安胎的功 能,治壮热烦渴,肺热咳嗽。选用地愉是因为其性味苦酸、寒。入肝、大肠经。凉血止血,清 热解毒。治吐血,赃血,血频,崩溃,肠风,持漏,痴肿,湿疹,金疮,烧伤。选用±荆芥是因为 其性味辛,溫,有毒,有桂风,杀虫,通经,止痛的功能,治皮肤风湿搏痛,钩虫,咖虫,痛经,经 闭,皮肤湿疹,蛇虫咬伤。选用马齿宽是因为其性味酸,寒,入大肠、肝、脾经,有清热解毒,散 血消肿的功能,治热频脈血,热淋,血淋,带下,痴肿恶疮,丹毒,療痛。选用下香是因为其性 味辛,溫,入胃、脾、肾经,有溫中,暖肾,降逆的功能,治呢逆,呕吐,反胃,泻频,屯、腹冷痛,疫 癖,痛气,癖疾。
具体实施方式
[0007] 本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下 述重量范围内都具有较好的疗效: 赠蚁10-20克,金银花10-20克,钩藤5-15克,天麻7-12克,全蜗5-10克,桑叶10-20 克,连翅15-25克,天南星5-15克,桂枝5-10克,麦冬5-15克,防风10-20克,弟活5-15克, 大黄7-12克,赤巧5-15克,刺裝襲5-15克,吴荣英10-15克,滑石5-15克,甘草7-12克, 白巧5-15克,川号5-15克,半夏10-15克,檐子10-20克,苍耳子10-15克,红花5-15克, 桃仁5-15克,瓜萎10-20克,蔓本5-15克,黄琴5-10克,地愉10-20克,±荆芥10-15克, 马齿宽10-20克,下香5-8克。
[000引优选为: 赠蚁15克,金银花15克,钩藤10克,天麻9克,全蜗8克,桑叶15克,连翅20克,天南 星10克,桂枝8克,麦冬10克,防风15克,弟活10克,大黄9克,赤巧10克,刺裝襲10克, 吴荣英12克,滑石10克,甘草9克,白巧10克,川号10克,半夏12克,檐子15克,苍耳子 12克,红花10克,桃仁10克,瓜萎15克,蔓本10克,黄琴8克,地愉15克,±荆芥12克,马 齿宽15克,下香6克。
[0009] 本发明药物的制备方法如下 一、备料 1、 赠蚁:炼去杂质,洗净晒干; 2、 金银花:筛去泥沙,炼净杂质; 3、 钩藤:炼去老梗、杂质,洗净,晒干; 4、 天麻:将天麻片平铺于喷过水的表忍纸上,置锅内,用文火烧至纸色焦黄,不断将药 片翻动至两面老黄色为止; 5、 全蜗:清水漂去盐质,晒干,或微火赔用; 6、 桑叶:炼去杂质,磋砕,鑛去梗,筛去泥屑; 7、 连翅:炼净杂质,磋开,除去枝梗; 8、 天南星:炼去杂质,洗净灰屑,晒干; 9、 桂枝:用水稍浸泡,拱出,闷润至透,切片,惊干,筛去屑; 10、 麦冬:炼净杂质,用水浸泡,拱出,润透后抽去屯、,再洗净晒干; 11、 防风:除去残茎,用水浸泡,拱出,润透切片,晒干; 12、 弟活:炼去杂质,洗净,润透,切片,惊干; 13、 大黄:炼净杂质,大小分档,炯润至内外湿度均匀,切片或切成小块、晒干; 14、 赤巧:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑; 15、 刺裝襲:漂去泥沙,除净残留的硬刺; 16、 吴荣英:取原药材,除去果柄、枝及杂质,筛去碎屑; 17、 滑石:取原药材,除去杂质,洗净,干燥; 18、 甘草:炼去杂质,洗净,用水浸泡至八成透时,拱出,润透切片,惊干; 19、 白巧:炼净杂质,用水洗净,浸泡,拱出润透,略晒至外皮无滑腻感时,再闷润后,切 片干燥; 20、 川号:炼去杂质,分开大、小个,用水浸泡,晒惊,闷润后切化干燥; 21、 半夏:炼去杂质,筛去灰屑; 22、 檐子:筛去灰屑,炼去杂质,娠碎过筛或剪去两端; 23、 苍耳子:炼尽杂质,去刺,筛去灰屑,微炒至黄色,取出放凉; 24、 红花:炼净杂质,除去茎叶、蒂头,晒干; 25、 桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,拱出,浸入凉水中,磋去种皮,晒 干,鑛净; 26、 瓜萎:取原药材,除去杂质及果柄,洗净,压扁,切丝或小块,干燥; 27、 蔓本:取原药材,除去杂质,大小分档,抢水洗净,润透,切片,晒干; 28、 黄琴:炼去杂质,除去残茎,用凉水浸润或置开水中稍浸拱出,切片,晒干; 29、 地愉:炼去杂质,用水洗净,稍浸泡,润透,切成厚片,晒干; 30、 ±荆芥:炼净杂质,用水略泡,拱出切段,晒干; 31、 马齿宽:炼净杂质,除去残根,W水稍润,切段晒干; 32、 下香:炼去杂质、花梗,筛去灰屑,用时捣碎。
[0010] 二、制备 1、将炮制后的赠蚁、金银花、钩藤、天麻、全蜗、桑叶、连翅、天南星、桂枝、麦冬、防风、弟 活、大黄、赤巧、刺裝襲、吴荣英、滑石、甘草、白巧、川号、半夏、檐子、苍耳子、红花、桃仁、瓜 萎、蔓本、黄琴、地愉、±荆芥、马齿宽、下香放入煎药容器内,其中滑石装入布袋第一次加水 8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第 一次煎煮液倒入容器内。
[0011] 2、将过滤的药渣加6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮 液。
[0012] 3、将两次煎煮液混合揽拌均匀即得,分为4剂服用。
[0013] 组方中金银花有清热解毒,治溫病发热的功能为君药;全蜗桂风,止疫,通络,解 毒;川号有行气开郁,桂风燥湿,活血止痛的功能,二者为臣药,=味药共同发挥清热解毒, 止疫,通络,桂风燥湿,活血止痛,行气开郁的作用,治疗破伤风效力全面,且W清热解毒,止 疫,通络,桂风,活血为主可治本,藏红花有活血化疲,散郁开结的功能为佐药,甘草有和中 缓急,解毒,调和诸药,治脾胃虚弱,解药毒及食物中毒的功能为使药,与余下诸药是治标。
[0014] 本发明药物具有清热解毒,止疫,通络,桂风燥湿,活血止痛,行气开郁的功能,用 于治疗破伤风,疗程短、见效快、治愈后不复发。
[0015]
具体实施方式: W下通过试验例来进一步阐述本发明所述药物的有益效果,运些试验例包括本发明药 物的动物毒性试验报告和临床疗效观察资料。
[0016] [试验例1]本发明药物的动物毒性试验报告: 取家兔30只,雌雄兼用,体重2. 0-2.化g,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。服用药液超常量组为20ml/kg,正常量为lOml/kg,给药方式为 灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常, 药物无不良毒副作用。
[0017] [试验例2]本发明药物的临床疗效观察 1、一般资料 收治破伤风口诊患者共33例。
[001引 2、诊断标准 典型症状为全身乏力、头晕、头痛、巧嚼无力、局部肌肉发紧、化痛、反射亢进全身肌肉 强直性疫李,阵发性抽摇,抽摇间歇期全身肌肉仍紧张强直,伴有发热,但神志清醒,多因并 发症而死亡。
[001引 3、治疗方法 选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续 服用3个疗程。
[0020] 4、疗效评定标准 显效:破伤风症状消失,体质恢复正常,痊愈; 好转:患者乏力,肌肉疫李,发热,局部肌肉反射亢进症状减轻,破伤风症状明显好转, 体质逐步恢复; 无效:达不到好转标准者。
[0021] 5、治疗结果(见下表)
Figure CN105343582AD00081
在上述治疗中,用本发明药物治疗破伤风患者33例,结果显效26例,显效率为78. 79%, 好转5例,好转率为15. 15%,无效2例,总有效率为93. 94%。

Claims (3)

1. 一种治疗破伤风的药物,其特征在于:它是由下列重量范围内的原料药制成: 蝉蜕10-20克,金银花10-20克,钩藤5-15克,天麻7-12克,全蝎5-10克,桑叶10-20 克,连翘15-25克,天南星5-15克,桂枝5-10克,麦冬5-15克,防风10-20克,羌活5-15克, 大黄7-12克,赤芍5-15克,刺蒺藜5-15克,吴茱萸10-15克,滑石5-15克,甘草7-12克, 白芷5-15克,川芎5-15克,半夏10-15克,栀子10-20克,苍耳子10-15克,红花5-15克, 桃仁5-15克,瓜蒌10-20克,藁本5-15克,黄芩5-10克,地榆10-20克,土荆芥10-15克, 马齿苋10-20克,丁香5-8克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 蝉蜕15克,金银花15克,钩藤10克,天麻9克,全蝎8克,桑叶15克,连翘20克,天南 星10克,桂枝8克,麦冬10克,防风15克,羌活10克,大黄9克,赤芍10克,刺蒺藜10克, 吴茱萸12克,滑石10克,甘草9克,白芷10克,川芎10克,半夏12克,栀子15克,苍耳子 12克,红花10克,桃仁10克,瓜蒌15克,藁本10克,黄芩8克,地榆15克,土荆芥12克,马 齿苋15克,丁香6克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (一)备料 (1) 蝉蜕:拣去杂质,洗净晒干; (2) 金银花:筛去泥沙,拣净杂质; (3) 钩藤:拣去老梗、杂质,洗净,晒干; (4) 天麻:将天麻片平铺于喷过水的表芯纸上,置锅内,用文火烧至纸色焦黄,不断将药 片翻动至两面老黄色为止; (5) 全蝎:清水漂去盐质,晒干,或微火焙用; (6) 桑叶:拣去杂质,搓碎,鑛去梗,筛去泥肩; (7) 连翘:拣净杂质,搓开,除去枝梗; (8) 天南星:拣去杂质,洗净灰肩,晒干; (9) 桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去肩; (10) 麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干; (11) 防风:除去残茎,用水浸泡,捞出,润透切片,晒干; (12) 羌活:拣去杂质,洗净,润透,切片,晾干; (13) 大黄:拣净杂质,大小分档,闷润至内外湿度均匀,切片或切成小块、晒干; (14) 赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎肩; (15) 刺蒺藜:漂去泥沙,除净残留的硬刺; (16) 吴朱英:取原药材,除去果柄、枝及杂质,师去碎肩; (17) 滑石:取原药材,除去杂质,洗净,干燥; (18) 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晾干; (19) 白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切 片干燥; (20) 川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥; (21) 半夏:拣去杂质,筛去灰肩; (22) 栀子:筛去灰肩,拣去杂质,碾碎过筛或剪去两端; (23)苍耳子:拣尽杂质,去刺,筛去灰肩,微炒至黄色,取出放凉; (24)红花:拣净杂质,除去茎叶、蒂头,晒干; (25)桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒 干,簸净; (26) 瓜蒌:取原药材,除去杂质及果柄,洗净,压扁,切丝或小块,干燥; (27)藁本:取原药材,除去杂质,大小分档,抢水洗净,润透,切片,晒干; (28)黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干; (29)地榆:拣去杂质,用水洗净,稍浸泡,润透,切成厚片,晒干; (30) 土荆芥:拣净杂质,用水略泡,捞出切段,晒干; (31)马齿苋:拣净杂质,除去残根,以水稍润,切段晒干; (32) 丁香:拣去杂质、花梗,筛去灰肩,用时捣碎; (二)制备 (1) 将炮制好的蝉蜕、金银花、钩藤、天麻、全蝎、桑叶、连翘、天南星、桂枝、麦冬、防风、 羌活、大黄、赤芍、刺蒺藜、吴茱萸、滑石、甘草、白芷、川芎、半夏、栀子、苍耳子、红花、桃仁、 瓜蒌、藁本、黄芩、地榆、土荆芥、马齿苋、丁香放入煎药容器内,其中滑石装布袋加水8倍 量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次 煎煮液倒入容器内; (2) 将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮 液; (3)将两次煎煮液混合搅拌均匀即得,分为4剂服用。
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