CN109966423A - 治疗破伤风的中药制剂 - Google Patents
治疗破伤风的中药制剂 Download PDFInfo
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- CN109966423A CN109966423A CN201910234410.5A CN201910234410A CN109966423A CN 109966423 A CN109966423 A CN 109966423A CN 201910234410 A CN201910234410 A CN 201910234410A CN 109966423 A CN109966423 A CN 109966423A
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Abstract
本发明提供了治疗破伤风的中药制剂,涉及中药制药技术领域,包括用于破伤风治疗初期的中药制剂A和用于破伤风治疗恢复期的中药制剂B。两种中药制剂分别用于破伤风治疗的不同时期,前者以治疗为主,功效快速,后者以调理恢复为主,用药温和,二者相互结合使用能够提高中药制剂中药物的利用率,对发病期为前、中、后期的破伤风患者均有治疗效果,同时两种中药制剂均无毒副作用、成本低且制备过程简单,同时避免了破伤风治疗过程进行伤口或手术处理给病人造成的痛苦。
Description
技术领域
本发明涉及中药制药技术领域,具体涉及治疗破伤风的中药制剂。
背景技术
破伤风是破伤风杆菌从伤口浸入而引发的一种人畜共患的传染病,破伤风杆菌通常存在于人畜肠道,随粪便排出体外,进而广泛存在于泥土和人畜粪便中。于人而言,开放性损伤,如开放性骨折、烧伤,甚至林刺或锈钉刺伤导致的细小伤口,均可能发生破伤风;于牲畜而言,伤劳太过、畜养失调、鞧皮磨破尾根、肚带擦损肘、耳根磨破、蹄壁刺伤以及鄯后伤口处理不当等,也均为此病发生的原因。破伤风前期主要表现为浑身发痒、频频揩擦、头项不灵活、四肢稍僵、眼神较急、走路不便以及食草较慢;中期主要表现为眼急惶恐、口紧涎生咀嚼缓慢、闪骨外露、呼吸急迫、伸头直项、四肢腰脊僵硬以及耳紧尾揭;后期主要表现为皮肉紧硬、腰板如椽、行如木马、鼻搧气喘、牙关紧闭、口流涎沫、不食水草、肉颤出汗、伸头直项以及行走艰难。
破伤风发病快、治疗困难且死亡率高,因此需要采取积极的综合治疗措施,如清除毒素来源、控制并解除痉挛、保持患者呼吸顺畅以及中和游离毒素等,但此类方法仅能做到预防,难以真正起到治疗作用。目前为止,通常使用破伤风抗毒素及破伤风抗毒血清进行静脉滴注,以达到治愈的目的,但此类方法存在医疗条件要求高、伤口处理增加病人的痛苦以及毒副作用大的问题,而手术治疗则存在费用高以及风险大等缺点。近年来,更多人寻找中药药方治疗破伤风的方式,并取得了良好的进展,中国专利200710114846.8公开了一种治疗破伤风的中药制剂,该中药制剂的配方由地龙、蝉蜕、天麻、羌活、防风、荆芥、天南星、钩藤、赤勺、明矾、麦门冬、丹皮、茯神、蜈蚣、全虫、败酱、金银花、川芎、连翘、红花、桃仁以及当归组成,制备工艺简单、治疗费用低,防治破伤风效果显著,且对人体无毒副作用。该发明更多地注重调节,以预防破伤风为主,降低了起治疗作用药物的比重,影响了药物功能的正常发挥,从而功效较慢且治疗时间较长。中国专利201310740571.4公开了一种治疗破伤风的中药组合物,该中药制剂的配方由铁线草、一点红和扶芳藤组成,药物简单易得,成本低,组方合理、配伍精简,适用于不能及时注射疫苗的破伤风患者。但该发明更注重治疗而非调理,在患者恢复期时使用可能会存在用药过重的问题。中国专利201610621754.8公开了一种治疗破伤风的中药制剂及制备方法,该中药制剂的有效成分的原料包括:琴叶榕、青箭、肝风草、桑沥、天麻、大金刀、地黄瓜、瓦草、单条草、窃衣、梵天花、香橼、蒟酱叶、小铜锤、山药和人中白,具有消炎止痛、活血通脉、镇静安神及清热解毒的功效,疗效显著,治愈后不复发,安全无毒副作用,能够达到标本兼治的目的,同时成本较低,但该中药制剂需要经过原材料的多次蒸煮及提取,制备过程较为复杂。上述三项专利中的中药制剂作用于破伤风的整个过程,而诸如破伤风等类型的病症,不同时期如初期及恢复期等所需要的药物成分及含量各不相同。因此,同样的制剂在治疗的不同时期使用并无针对性,存在着制剂难以充分发挥功效以及治疗效率低等问题。
因此,针对现有治疗破伤风的药剂或手术等存在的医疗条件要求高、伤口处理增加病人的痛苦、毒副作用大、费用高、风险大、无针对性以及功效慢等问题,应当找寻用于破伤风治疗的中药制剂,使得该中药制剂能够有针对性地对破伤风特定的时期进行治疗,同时该中药应具有制备过程简单、疗效显著、无毒副作用及成本低等优点。
发明内容
本发明针对现有技术存在的问题,提供了治疗破伤风的中药制剂,包括用于破伤风治疗初期的中药制剂A和用于破伤风治疗恢复期的中药制剂B。两种中药制剂分别用于破伤风治疗的不同时期,前者以治疗为主,功效快速,后者以调理恢复为主,用药温和,二者相互结合使用能够提高中药制剂中药物的利用率,对发病期为前、中、后期的破伤风患者均有治疗效果,同时两种中药制剂均无毒副作用、成本低且制备过程简单,同时避免了破伤风治疗过程进行伤口或手术处理给病人造成的痛苦。
为实现上述目的,本发明采用的技术方案如下:
本发明提供治疗破伤风的中药制剂,包括用于破伤风治疗初期的中药制剂A和用于破伤风治疗恢复期的中药制剂B;所述中药制剂A,包括以下原料:小白花蛇1-3条、乌蛇60-200g、蝉蜕50-150g、白僵蚕20-80g、细辛30-100g、防风20-80g、半夏5-50g、天竹黄30-100g、钩藤50-180g、全蝎10-60g、天麻20-80g、胆南星10-40g、地肤子40-120g、木通20-50g、当归20-50g、川芎10-50g、紫苏叶20-60g、薄荷10-70g、荆芥10-50g、桔梗10-50g、甘草5-45g、羌活10-60g和蜂蜜80-150g;所述中药制剂B包括以下原料:桔梗10-50g、炒杏仁8-40g、黄芩15-50g、沙叁20-40g、枇杷叶10-30g、薄荷8-25g、荆芥8-25g、蝉蜕10-45g、菊花10-50g、川芎5-30g、白芷8-30g、桑叶10-50g、青皮5-30g、陈皮10-30g、半夏10-30g、黄连5-20g、防风10-30g、红花5-30g、当归10-30g、连翘10-30g、厚朴8-40g、枳壳5-30g、川军10-50g、木通5-30g、地肤子10-30g、滑石10-30g、麻仁30-80g、山楂10-50g、炒莱菔子10-30g、黄柏10-30g、竹叶5-30g、灯心草5-30g、知母5-30g、泽泻3-20g、白芍10-30g和麦冬8-30g。
优选地,所述中药制剂A包括以下原料:小白花蛇1-3条、乌蛇80-150g、蝉蜕80-120g、白僵蚕30-60g、细辛50-80g、防风30-60g、半夏10-30g、天竹黄40-80g、钩藤80-150g、全蝎15-45g、天麻30-60g、胆南星15-30g、地肤子50-100g、木通25-40g、当归25-40g、川芎15-35g、紫苏叶30-50g、薄荷20-50g、荆芥20-40g、桔梗20-40g、甘草10-30g、羌活15-50g和蜂蜜90-120g;所述中药制剂B包括以下原料:桔梗15-35g、炒杏仁15-35g、黄芩20-40g、沙叁25-35g、枇杷叶15-25g、薄荷10-22g、荆芥10-20g、蝉蜕15-35g、菊花20-40g、川芎10-25g、白芷10-25g、桑叶20-40g、青皮10-25g、陈皮15-25g、半夏15-25g、黄连8-18g、防风15-25g、红花10-20g、当归15-25g、连翘15-25g、厚朴10-30g、枳壳10-20g、川军20-40g、木通10-25g、地肤子15-25g、滑石15-25g、麻仁40-60g、山楂20-40g、炒莱菔子15-25g、黄柏15-25g、竹叶10-22g、灯心草10-25g、知母10-20g、泽泻8-15g、白芍15-25g和麦冬10-25g。
进一步优选地,所述中药制剂A包括以下原料:小白花蛇2条、乌蛇100g、蝉蜕100g、白僵蚕40g、细辛60g、防风40g、半夏20g、天竹黄60g、钩藤100g、全蝎20g、天麻50g、胆南星20g、地肤子80g、木通30g、当归30g、川芎25g、紫苏叶40g、薄荷30g、荆芥30g、桔梗30g、甘草20g、羌活25g和蜂蜜100g;所述中药制剂B包括以下原料:桔梗20g、炒杏仁18g、黄芩25g、沙叁30g、枇杷叶20g、薄荷14g、荆芥14g、蝉蜕25g、菊花30g、川芎20g、白芷16g、桑叶30g、青皮16g、陈皮20g、半夏20g、黄连10g、防风20g、红花14g、当归20g、连翘20g、厚朴20g、枳壳14g、川军30g、木通16g、地肤子20g、滑石20g、麻仁50g、山楂30g、炒莱菔子20g、黄柏20g、竹叶14g、灯心草16g、知母16g、泽泻13g、白芍20g和麦冬16g。
本发明还提供了上述中药制剂的制备方法,所述中药制剂A的制备包括以下步骤:
(1)制剂I的制备:将除小白花蛇、胆南星和蜂蜜外的其他原料洗净干燥后粉碎并混合,加水进行第一次煎煮,煎煮后过滤得到制剂I与药渣;
(2)制剂II的制备:
①将步骤(1)得到的药渣加水进行第二次煎煮并过滤得到药液A1;
②将小白花蛇与胆南星研磨至粉末,得到粉末A;
③将步骤②制得的粉末A、步骤①制得药液A1与蜂蜜混合,得到制剂II;
所述中药制剂B的制备包括以下步骤:
S1:将原料洗净、干燥、粉碎并混合,加水进行第一次煎煮,过滤后得到药液A2和药渣;
S2:将步骤S1中的药渣加水进行第二次煎煮,过滤后得到药液B;
S3:将步骤S1得到的药液A2和步骤S2得到的药液B混合,得到中药制剂B。
进一步地,步骤(1)中所述第一次煎煮,水的加入量为除小白花蛇、胆南星和蜂蜜外的其他原料总重量的6-8倍;步骤S1中所述第一次煎煮,水的加入量为原料总重量的6-8倍;步骤①中所述第二次煎煮,水的加入量为除小白花蛇、胆南星和蜂蜜外的其他原料总重量的4-6倍;步骤S2中所述第二次煎煮,水的加入量为原料总重量的2-3倍;步骤(1)及步骤S1中所述第一次煎煮,煮沸时间为3-4h;步骤①及步骤S2中所述第二次煎煮,煮沸时间为1-2h。
进一步地,步骤(1)及步骤S1中所述粉碎,粉碎至粒径为50μm;步骤(1)、步骤①、步骤S1及步骤S2中所述过滤,使用200目的滤网。
本发明所取得的技术效果是:
1.本发明的两种中药制剂分别用于破伤风治疗的不同时期,前者以治疗为主,功效快速,后者以调理恢复为主,用药温和,二者相互结合使用能够提高中药制剂中药物的利用率,对发病期为前、中、后期的破伤风患者均有治疗效果。
2.当中药制剂A中乌蛇与蝉蜕的重量比为1:1,白僵蚕与全蝎的重量比为2:1,同时中药制剂B中薄荷、荆芥、红花与竹叶的重量比为1:1:1:1时,本发明中中药制剂的治疗效果较好,治愈率较高。
3.本发明的中药制剂无毒副作用、成本低且制备过程简单,同时避免了破伤风治疗过程进行伤口或手术处理给病人造成的痛苦。
具体实施方式
值得说明的是,本发明中使用的原料均为普通的市售中药药材,因此本发明对材料的来源不做具体限定。
实施例1
治疗破伤风的中药制剂,包括用于破伤风治疗初期的中药制剂A和用于破伤风治疗恢复期的中药制剂B。
中药制剂A包括以下原料:小白花蛇1条、乌蛇60g、蝉蜕50g、白僵蚕20g、细辛30g、防风20g、半夏5g、天竹黄30g、钩藤50g、全蝎10g、天麻20g、胆南星10g、地肤子40g、木通20g、当归20g、川芎10g、紫苏叶20g、薄荷10g、荆芥10g、桔梗10g、甘草5g、羌活10g和蜂蜜80g;中药制剂B包括以下原料:桔梗10g、炒杏仁8g、黄芩15g、沙叁20g、枇杷叶10g、薄荷8g、荆芥8g、蝉蜕10g、菊花10g、川芎5g、白芷8g、桑叶10g、青皮5g、陈皮10g、半夏10g、黄连5g、防风10g、红花5g、当归10g、连翘10g、厚朴8g、枳壳5g、川军10g、木通5g、地肤子10g、滑石10g、麻仁30g、山楂10g、炒莱菔子10g、黄柏10g、竹叶5g、灯心草5g、知母5g、泽泻3g、白芍10g和麦冬8g。
中药制剂A的制备包括以下步骤:
(1)制剂I的制备:将除小白花蛇、胆南星和蜂蜜外的各原料洗净干燥后粉碎至50μm并混合,加水进行第一次煎煮,水的加入量为除小白花蛇、胆南星和蜂蜜外的其他原料总重量的6倍,煮沸3h后使用200目的滤网过滤得到制剂I与药渣;
(2)制剂II的制备:
①将步骤(1)得到的药渣加水进行第二次煎煮,水的加入量为除小白花蛇、胆南星和蜂蜜外的其他原料总重量的4倍,煮沸1h后使用200目的滤网过滤得到药液A1;
②将小白花蛇1条与胆南星10g研磨至粉末,得到粉末A;
③将步骤②制得的粉末A、步骤①制得的药液A1与蜂蜜混合,得到制剂II。
中药制剂B的制备包括以下步骤:
S1:将原料洗净、干燥、粉碎至粒径为50μm并混合,加水进行第一次煎煮,水的加入量为原料总重量的6倍,煮沸时间为3h,使用200目的滤网过滤后得到药液A2和药渣;
S2:将步骤S1中的药渣加水进行第二次煎煮,水的加入量为原料总重量的2倍,煮沸时间为1h,使用200目的滤网过滤后得到药液B;
S3:将步骤S1得到的药液A2和步骤S2得到的药液B混合,得到中药制剂B。
实施例2
治疗破伤风的中药制剂,包括用于破伤风治疗初期的中药制剂A和用于破伤风治疗恢复期的中药制剂B。
中药制剂A包括以下原料:小白花蛇3条、乌蛇200g、蝉蜕150g、白僵蚕80g、细辛100g、防风80g、半夏50g、天竹黄100g、钩藤180g、全蝎60g、天麻80g、胆南星40g、地肤子120g、木通50g、当归50g、川芎50g、紫苏叶60g、薄荷70g、荆芥50g、桔梗50g、甘草45g、羌活60g和蜂蜜150g;中药制剂B包括以下原料:桔梗50g、炒杏仁40g、黄芩50g、沙叁40g、枇杷叶30g、薄荷25g、荆芥25g、蝉蜕45g、菊花50g、川芎30g、白芷30g、桑叶50g、青皮30g、陈皮30g、半夏30g、黄连20g、防风30g、红花30g、当归30g、连翘30g、厚朴40g、枳壳30g、川军50g、木通30g、地肤子30g、滑石30g、麻仁80g、山楂50g、炒莱菔子30g、黄柏30g、竹叶30g、灯心草30g、知母30g、泽泻20g、白芍30g和麦冬30g。
中药制剂A的制备包括以下步骤:
(1)制剂I的制备:将除小白花蛇、胆南星和蜂蜜外的各原料洗净干燥后粉碎至50μm并混合,加水进行第一次煎煮,水的加入量为除小白花蛇、胆南星和蜂蜜外的其他原料总重量的8倍,煮沸4h后使用200目的滤网过滤得到制剂I与药渣;
(2)制剂II的制备:
①将步骤(1)得到的药渣加水进行第二次煎煮,水的加入量为除小白花蛇、胆南星和蜂蜜外的其他原料总重量的6倍,煮沸2h后使用200目的滤网过滤得到药液A1;
②将小白花蛇3条与胆南星40g研磨至粉末,得到粉末A;
③将步骤②制得的粉末A、步骤①制得的药液A1与蜂蜜混合,得到制剂II。
中药制剂B的制备包括以下步骤:
S1:将原料洗净、干燥、粉碎至粒径为50μm并混合,加水进行第一次煎煮,水的加入量为原料总重量的8倍,煮沸时间为4h,使用200目的滤网过滤后得到药液A2和药渣;
S2:将步骤S1中的药渣加水进行第二次煎煮,水的加入量为原料总重量的3倍,煮沸时间为2h,使用200目的滤网过滤后得到药液B;
S3:将步骤S1得到的药液A2和步骤S2得到的药液B混合,得到中药制剂B。
实施例3
治疗破伤风的中药制剂,包括用于破伤风治疗初期的中药制剂A和用于破伤风治疗恢复期的中药制剂B。
中药制剂A包括以下原料:小白花蛇2条、乌蛇100g、蝉蜕100g、白僵蚕40g、细辛60g、防风40g、半夏20g、天竹黄60g、钩藤100g、全蝎20g、天麻50g、胆南星20g、地肤子80g、木通30g、当归30g、川芎25g、紫苏叶40g、薄荷30g、荆芥30g、桔梗30g、甘草20g、羌活25g和蜂蜜100g;中药制剂B包括以下原料:桔梗20g、炒杏仁18g、黄芩25g、沙叁30g、枇杷叶20g、薄荷14g、荆芥14g、蝉蜕25g、菊花30g、川芎20g、白芷16g、桑叶30g、青皮16g、陈皮20g、半夏20g、黄连10g、防风20g、红花14g、当归20g、连翘20g、厚朴20g、枳壳14g、川军30g、木通16g、地肤子20g、滑石20g、麻仁50g、山楂30g、炒莱菔子20g、黄柏20g、竹叶14g、灯心草16g、知母16g、泽泻13g、白芍20g和麦冬16g。
中药制剂A的制备包括以下步骤:
(1)制剂I的制备:将除小白花蛇、胆南星和蜂蜜外的各原料洗净干燥后粉碎至50μm并混合,加水进行第一次煎煮,水的加入量为除小白花蛇、胆南星和蜂蜜外的其他原料总重量的7倍,煮沸3.5h后使用200目的滤网过滤得到制剂I与药渣;
(2)制剂II的制备:
①将步骤(1)得到的药渣加水进行第二次煎煮,水的加入量为除小白花蛇、胆南星和蜂蜜外的其他原料总重量的5倍,煮沸1.5h后使用200目的滤网过滤得到药液A1;
②将小白花蛇2条与胆南星20g研磨至粉末,得到粉末A;
③将步骤②制得的粉末A、步骤①制得的药液A1与蜂蜜混合,得到制剂II。
中药制剂B的制备包括以下步骤:
S1:将原料洗净、干燥、粉碎至粒径为50μm并混合,加水进行第一次煎煮,水的加入量为原料总重量的7倍,煮沸时间为3.5h,使用200目的滤网过滤后得到药液A2和药渣;
S2:将步骤S1中的药渣加水进行第二次煎煮,水的加入量为原料总重量的2.5倍,煮沸时间为1.5h,使用200目的滤网过滤后得到药液B;
S3:将步骤S1得到的药液A2和步骤S2得到的药液B混合,得到中药制剂B。
实施例4
治疗破伤风的中药制剂,包括用于破伤风治疗初期的中药制剂A和用于破伤风治疗恢复期的中药制剂B。
中药制剂A包括以下原料:小白花蛇1条、乌蛇80g、蝉蜕80g、白僵蚕30g、细辛50g、防风30g、半夏10g、天竹黄40g、钩藤80g、全蝎15g、天麻30g、胆南星15g、地肤子50g、木通25g、当归25g、川芎15g、紫苏叶30g、薄荷20g、荆芥20g、桔梗20g、甘草10g、羌活15g和蜂蜜90g;中药制剂B包括以下原料:桔梗15g、炒杏仁15g、黄芩20g、沙叁25g、枇杷叶15g、薄荷10g、荆芥10g、蝉蜕15g、菊花20g、川芎10g、白芷10g、桑叶20g、青皮10g、陈皮15g、半夏15g、黄连8g、防风15g、红花10g、当归15g、连翘15g、厚朴10g、枳壳10g、川军20g、木通10g、地肤子15g、滑石15g、麻仁40g、山楂20g、炒莱菔子15g、黄柏15g、竹叶10g、灯心草10g、知母10g、泽泻8g、白芍15g和麦冬10g。
中药制剂A的制备包括以下步骤:
(1)制剂I的制备:将除小白花蛇、胆南星和蜂蜜外的各原料洗净干燥后粉碎至50μm并混合,加水进行第一次煎煮,水的加入量为除小白花蛇、胆南星和蜂蜜外的其他原料总重量的6.5倍,煮沸3.2h后使用200目的滤网过滤得到制剂I与药渣;
(2)制剂II的制备:
①将步骤(1)得到的药渣加水进行第二次煎煮,水的加入量为除小白花蛇、胆南星和蜂蜜外的其他原料总重量的4.5倍,煮沸1.2h后使用200目的滤网过滤得到药液A1;
②将小白花蛇1条与胆南星15g研磨至粉末,得到粉末A;
③将步骤②制得的粉末A、步骤①制得的药液A1与蜂蜜混合,得到制剂II。
中药制剂B的制备包括以下步骤:
S1:将原料洗净、干燥、粉碎至粒径为50μm并混合,加水进行第一次煎煮,水的加入量为原料总重量的6倍,煮沸时间为3h,使用200目的滤网过滤后得到药液A2和药渣;
S2:将步骤S1中的药渣加水进行第二次煎煮,水的加入量为原料总重量的2倍,煮沸时间为1h,使用200目的滤网过滤后得到药液B;
S3:将步骤S1得到的药液A2和步骤S2得到的药液B混合,得到中药制剂B。
实施例5
治疗破伤风的中药制剂,包括用于破伤风治疗初期的中药制剂A和用于破伤风治疗恢复期的中药制剂B。
中药制剂A包括以下原料:小白花蛇3条、乌蛇150g、蝉蜕120g、白僵蚕60g、细辛80g、防风60g、半夏30g、天竹黄80g、钩藤150g、全蝎45g、天麻60g、胆南星30g、地肤子100g、木通40g、当归40g、川芎35g、紫苏叶50g、薄荷50g、荆芥40g、桔梗40g、甘草30g、羌活50g和蜂蜜120g;中药制剂B包括以下原料:桔梗35g、炒杏仁35g、黄芩40g、沙叁35g、枇杷叶25g、薄荷22g、荆芥20g、蝉蜕35g、菊花40g、川芎25g、白芷25g、桑叶40g、青皮25g、陈皮25g、半夏25g、黄连18g、防风25g、红花20g、当归25g、连翘25g、厚朴30g、枳壳20g、川军40g、木通25g、地肤子25g、滑石25g、麻仁60g、山楂40g、炒莱菔子25g、黄柏25g、竹叶22g、灯心草25g、知母20g、泽泻15g、白芍25g和麦冬25g。
中药制剂A的制备包括以下步骤:
(1)制剂I的制备:将除小白花蛇、胆南星和蜂蜜外的各原料洗净干燥后粉碎至50μm并混合,加水进行第一次煎煮,水的加入量为除小白花蛇、胆南星和蜂蜜外的其他原料总重量的7.5倍,煮沸3.8h后使用200目的滤网过滤得到制剂I与药渣;
(2)制剂II的制备:
①将步骤(1)得到的药渣加水进行第二次煎煮,水的加入量为除小白花蛇、胆南星和蜂蜜外的其他原料总重量的5.5倍,煮沸1.8h后使用200目的滤网过滤得到药液A1;
②将小白花蛇3条与胆南星30g研磨至粉末,得到粉末A;
③将步骤②制得的粉末A、步骤①制得的药液A1与蜂蜜混合,得到制剂II。
中药制剂B的制备包括以下步骤:
S1:将原料洗净、干燥、粉碎至粒径为50μm并混合,加水进行第一次煎煮,水的加入量为原料总重量的8倍,煮沸时间为4h,使用200目的滤网过滤后得到药液A2和药渣;
S2:将步骤S1中的药渣加水进行第二次煎煮,水的加入量为原料总重量的3倍,煮沸时间为2h,使用200目的滤网过滤后得到药液B;
S3:将步骤S1得到的药液A2和步骤S2得到的药液B混合,得到中药制剂B。
对比例1
与实施例3的区别在于,中药制剂A包括以下原料:乌蛇30g、蝉蜕30g、白僵蚕10g、细辛20g、防风10g、半夏3g、天竹黄20g、钩藤30g、全蝎8g、天麻10g、胆南星8g、地肤子30g、木通10g、当归10g、川芎8g、紫苏叶10g、薄荷8g、荆芥8g、桔梗8g、甘草3g、羌活8g和蜂蜜60g;中药制剂B包括以下原料:桔梗8g、炒杏仁5g、黄芩10g、沙叁15g、枇杷叶8g、薄荷5g、荆芥5g、蝉蜕8g、菊花8g、川芎3g、白芷5g、桑叶8g、青皮3g、陈皮8g、半夏8g、黄连3g、防风8g、红花3g、当归8g、连翘8g、厚朴5g、枳壳3g、川军8g、木通3g、地肤子8g、滑石8g、麻仁20g、山楂8g、炒莱菔子8g、黄柏8g、竹叶3g、灯心草3g、知母3g、泽泻1g、白芍8g和麦冬5g。
对比例2
与实施例3的区别在于,中药制剂A包括以下原料:小白花蛇4条、乌蛇210g、蝉蜕160g、白僵蚕90g、细辛110g、防风90g、半夏60g、天竹黄110g、钩藤190g、全蝎70g、天麻90g、胆南星50g、地肤子130g、木通60g、当归60g、川芎60g、紫苏叶70g、薄荷80g、荆芥60g、桔梗60g、甘草50g、羌活70g和蜂蜜160g;中药制剂B包括以下原料:桔梗55g、炒杏仁45g、黄芩55g、沙叁45g、枇杷叶35g、薄荷30g、荆芥30g、蝉蜕50g、菊花55g、川芎35g、白芷35g、桑叶55g、青皮35g、陈皮35g、半夏35g、黄连25g、防风35g、红花35g、当归35g、连翘35g、厚朴45g、枳壳35g、川军55g、木通35g、地肤子35g、滑石35g、麻仁85g、山楂55g、炒莱菔子35g、黄柏35g、竹叶35g、灯心草35g、知母35g、泽泻25g、白芍35g和麦冬35g。
对比例3
与实施例3的区别在于,不含有中药制剂B。
对比例4
与实施例3的区别在于,不含有中药制剂A。
对460只患有破伤风病毒的驴进行诊断,根据破伤风的严重程度分为前、中、后不同发病期,随机选取发病期不同的病驴分组,各组数量见表1。其中7组分别给与实施例1-5及对比例1-2中的中药制剂A,给药方式为:使用灌胃管将各实例中步骤(1)中的制剂I对病驴进行灌胃,连续三日,一日一次,每次300mL,再将各实例中步骤(2)中的制剂II对病驴进行灌胃,连续三日,一日一次,每次200mL。而后剔除治疗无效的病驴,对剩余的病驴分别给与实施例1-5及对比例1-2中的中药制剂B,给药方式为:将各实例中的制剂B对病驴进行灌胃,二日一次,共三次,每次500mL。剩余两组中的一组仅喂食对比例3中的中药制剂A,按照中药制剂A的给药方式喂食并剔除治疗无效的病驴后,对剩余的病驴按照原方法再次喂食对比例3中的中药制剂A;另外一组仅喂食对比例4中的中药制剂B,按照中药制剂B的给药方式并剔除治疗无效的病驴后,对剩余的病驴按照原方法再次喂食对比例4中的中药制剂B。观察并统计中药制剂对于破伤风的治疗效果,得到表1。
表1破伤风疗效统计表
由表1可知,实施例1-5中的中药制剂A对于前、中、后发病期的病驴的无效剔除率均低于对比例1-2,最终治愈率高于对比例1-2,其中,实施例2的无效剔除率相对而言最低,最终治愈率最高;实施例4中的最终治愈率相比于实施例1-2及实施例5较高。对比例3的无效剔除率与实施例3一致,治愈率等相比于实施例3较低,对比例4的无效剔除率较高,治愈率较低。由上述结果可知,中药药剂的组成及含量极大地影响着中药制剂的疗效,本发明中的两种中药制剂结合使用,相比于单独使用,对于患有破伤风的机体有着更好的治疗效果。
最后应当说明的是,以上内容仅用以说明本发明的技术方案,而非对本发明保护范围的限制,本领域的普通技术人员对本发明的技术方案进行的简单修改或者等同替换,均不脱离本发明技术方案的实质和范围。
Claims (10)
1.治疗破伤风的中药制剂,其特征在于:包括用于破伤风治疗初期的中药制剂A和用于破伤风治疗恢复期的中药制剂B;
所述中药制剂A包括以下原料:小白花蛇1-3条、乌蛇60-200g、蝉蜕50-150g、白僵蚕20-80g、细辛30-100g、防风20-80g、半夏5-50g、天竹黄30-100g、钩藤50-180g、全蝎10-60g、天麻20-80g、胆南星10-40g、地肤子40-120g、木通20-50g、当归20-50g、川芎10-50g、紫苏叶20-60g、薄荷10-70g、荆芥10-50g、桔梗10-50g、甘草5-45g、羌活10-60g和蜂蜜80-150g;
所述中药制剂B包括以下原料:桔梗10-50g、炒杏仁8-40g、黄芩15-50g、沙叁20-40g、枇杷叶10-30g、薄荷8-25g、荆芥8-25g、蝉蜕10-45g、菊花10-50g、川芎5-30g、白芷8-30g、桑叶10-50g、青皮5-30g、陈皮10-30g、半夏10-30g、黄连5-20g、防风10-30g、红花5-30g、当归10-30g、连翘10-30g、厚朴8-40g、枳壳5-30g、川军10-50g、木通5-30g、地肤子10-30g、滑石10-30g、麻仁30-80g、山楂10-50g、炒莱菔子10-30g、黄柏10-30g、竹叶5-30g、灯心草5-30g、知母5-30g、泽泻3-20g、白芍10-30g和麦冬8-30g。
2.根据权利要求1所述的中药制剂,其特征在于:
所述中药制剂A包括以下原料:小白花蛇1-3条、乌蛇80-150g、蝉蜕80-120g、白僵蚕30-60g、细辛50-80g、防风30-60g、半夏10-30g、天竹黄40-80g、钩藤80-150g、全蝎15-45g、天麻30-60g、胆南星15-30g、地肤子50-100g、木通25-40g、当归25-40g、川芎15-35g、紫苏叶30-50g、薄荷20-50g、荆芥20-40g、桔梗20-40g、甘草10-30g、羌活15-50g和蜂蜜90-120g;
所述中药制剂B包括以下原料:桔梗15-35g、炒杏仁15-35g、黄芩20-40g、沙叁25-35g、枇杷叶15-25g、薄荷10-22g、荆芥10-20g、蝉蜕15-35g、菊花20-40g、川芎10-25g、白芷10-25g、桑叶20-40g、青皮10-25g、陈皮15-25g、半夏15-25g、黄连8-18g、防风15-25g、红花10-20g、当归15-25g、连翘15-25g、厚朴10-30g、枳壳10-20g、川军20-40g、木通10-25g、地肤子15-25g、滑石15-25g、麻仁40-60g、山楂20-40g、炒莱菔子15-25g、黄柏15-25g、竹叶10-22g、灯心草10-25g、知母10-20g、泽泻8-15g、白芍15-25g和麦冬10-25g。
3.根据权利要求2所述的中药制剂,其特征在于:
所述中药制剂A包括以下原料:小白花蛇2条、乌蛇100g、蝉蜕100g、白僵蚕40g、细辛60g、防风40g、半夏20g、天竹黄60g、钩藤100g、全蝎20g、天麻50g、胆南星20g、地肤子80g、木通30g、当归30g、川芎25g、紫苏叶40g、薄荷30g、荆芥30g、桔梗30g、甘草20g、羌活25g和蜂蜜100g;
所述中药制剂B包括以下原料:桔梗20g、炒杏仁18g、黄芩25g、沙叁30g、枇杷叶20g、薄荷14g、荆芥14g、蝉蜕25g、菊花30g、川芎20g、白芷16g、桑叶30g、青皮16g、陈皮20g、半夏20g、黄连10g、防风20g、红花14g、当归20g、连翘20g、厚朴20g、枳壳14g、川军30g、木通16g、地肤子20g、滑石20g、麻仁50g、山楂30g、炒莱菔子20g、黄柏20g、竹叶14g、灯心草16g、知母16g、泽泻13g、白芍20g和麦冬16g。
4.根据权利要求1-3任意一项所述的中药制剂的制备方法,其特征在于:
所述中药制剂A的制备包括以下步骤:
(1)制剂I的制备:将除小白花蛇、胆南星和蜂蜜外的其他原料洗净干燥后粉碎并混合,加水进行第一次煎煮,煎煮后过滤得到制剂I与药渣;
(2)制剂II的制备:
①将步骤(1)得到的药渣加水进行第二次煎煮并过滤得到药液A1;
②将小白花蛇与胆南星研磨至粉末,得到粉末A;
③将步骤②制得的粉末A、步骤①制得药液A1与蜂蜜混合,得到制剂II;
所述中药制剂B的制备包括以下步骤:
S1:将原料洗净、干燥、粉碎并混合,加水进行第一次煎煮,过滤后得到药液A2和药渣;
S2:将步骤S1中的药渣加水进行第二次煎煮,过滤后得到药液B;
S3:将步骤S1得到的药液A2和步骤S2得到的药液B混合,得到中药制剂B。
5.根据权利要求4所述的制备方法,其特征在于:步骤(1)中所述第一次煎煮,水的加入量为除小白花蛇、胆南星和蜂蜜外的其他原料总重量的6-8倍;步骤S1中所述第一次煎煮,水的加入量为原料总重量的6-8倍。
6.根据权利要求4所述的制备方法,其特征在于:步骤①中所述第二次煎煮,水的加入量为除小白花蛇、胆南星和蜂蜜外的其他原料总重量的4-6倍。
7.根据权利要求4所述的制备方法,其特征在于:步骤S2中所述第二次煎煮,水的加入量为原料总重量的2-3倍。
8.根据权利要求4所述的制备方法,其特征在于:步骤(1)及步骤S1中所述第一次煎煮,煮沸时间为3-4h;步骤①及步骤S2中所述第二次煎煮,煮沸时间为1-2h。
9.根据权利要求4所述的制备方法,其特征在于:步骤(1)及步骤S1中所述粉碎,粉碎至粒径为50μm。
10.根据权利要求4所述的制备方法,其特征在于:步骤(1)、步骤①、步骤S1及步骤S2中所述过滤,使用200目的滤网。
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