CN105362889A - 一种治疗耳鸣的药物及其制备方法 - Google Patents

一种治疗耳鸣的药物及其制备方法 Download PDF

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CN105362889A
CN105362889A CN201510936393.1A CN201510936393A CN105362889A CN 105362889 A CN105362889 A CN 105362889A CN 201510936393 A CN201510936393 A CN 201510936393A CN 105362889 A CN105362889 A CN 105362889A
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张朝兰
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张朝兰
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Abstract

本发明公开了一种治疗耳鸣的药物及其制备方法,其主要是由钩藤、熟地黄、路路通、柴胡、补骨脂、黄连、磁石、香附、苍耳子、甘草、当归、金银花、川芎、女贞子、分心木、肉桂、益智仁、透骨草、山茱萸、黑芝麻、珍珠母、桑椹、十大功劳叶、龙胆按一定重量配比制备而成。本发明药物具有补益肝肾,清肝泄热,理气解郁,祛风除湿的功能,用于治疗耳鸣见效快、疗效好,不复发。

Description

一种治疗耳鸣的药物及其制备方法
技术领域
[0001] 本发明涉及一种治疗耳鸣的药物及其制备方法,属中药领域。
背景技术
[0002] 耳鸣是一种听觉功能紊乱所致的常见症状,患者自觉耳内或头部有声音,但其环 境中并无相应的声源,而且愈是安静,感觉鸣音越大。中医则认为此病多与风热之邪侵袭, 肝火上扰清窍,痰火郁结耳窍,肾精亏损失养,脾胃虚弱失运等有关。由于西药治疗副作用 大,因此人们对有效治疗耳鸣的中药药物存在极大的需求,至今为止,还没有发现关于本发 明的有关报道。
发明内容
[0003] 本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗耳鸣 的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种有效治疗耳鸣的中药组合药物。
[0005] 本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006] 本发明药物是选择钩藤、黄芪、石菖蒲、熟地黄、路路通、柴胡、补骨脂、黄连、磁石、 香附、苍耳子、甘草、黑大豆、当归、金银花、川芎、女贞子、分心木、防风、肉桂、益智仁、透骨 草、山茱萸、黑芝麻、珍珠母、桑椹、十大功劳叶、龙胆原料药进行组合制备的,将这些原料药 物组合使得各药物功效产生协同作用,从而能够有效治疗耳鸣。其中,选用钩藤是因为其性 味苦,凉,入肝、心经,有清热平肝,熄风定惊的功能,治小儿惊癎瘈痕,大人血压偏高,头晕、 目眩,妇人子癎。选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿, 托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益的功能,治 内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用石菖蒲是因为其性味 辛苦,微温,入心、肝、脾经,有开窍,豁痰,理气,活血,散风,去湿的功能,治癫癎,痰厥,热病 神昏,健忘,气闭耳聋,心胸烦闷,胃痛,腹痛,风寒湿痹,痈疽肿毒,跌打损伤。选用熟地黄是 因为其性味甘,微温,入肝、肾经,有滋阴,补血的功能,治阴虚血少,腰膝痿弱,劳嗽骨蒸,遗 精,崩漏,月经不调,消渴,溲数,耳聋,目昏。选用路路通是因为其性味苦平,通行十二经, 有祛风通络,利尿除湿的功能,治水肿,胀满,经闭,乳少,手足拘挛。选用柴胡是因为其性 味苦,凉,入肝、胆经,有和解表里,疏肝,升阳的功能,治寒热往来,胸满胁痛,口苦耳聋,头 痛目眩,疟疾,下利脱肛,月经不调,子宫下垂。补骨脂是因为其性味辛,温,入肾经,有补肾 助阳的功能,治肾虚冷泻,遗尿,滑精,小便频数,阳痿,腰膝冷痛,虚寒喘嗽。选用黄连是因 为其性味苦,寒,入心、肝、胃、大肠经,有泻火,燥湿,解毒,杀虫的功能,治时行热毒、伤寒, 热盛心烦,痞满呕逆,菌痢,热泻腹痛,肺结核,吐、衄、下血,消渴,疳积,蛔虫病,百日咳,咽 喉肿痛,火眼,口疮,痈疽疮毒,湿疹,汤火烫伤。选用磁石是因为其性味辛咸,平,入肾、肝、 肺经,有潜阳纳气,镇惊安神的功能,治头目眩晕,耳鸣耳聋,虚喘,惊癎,怔忡。选用香附是 因为其性味辛微苦干,平,入肝、三焦经,有理气解郁,止痛调经的功能,治肝胃不和,气郁不 舒,胸腹胁肋胀痛,痰饮痞满,月经不调,崩漏带下。选用苍耳子是因为其性味甘,温,有毒, 入肺、肝经,有散风,止痛,祛湿,杀虫的功能,治风寒头痛,鼻渊,齿痛,风寒湿痹,四脚挛痛, 疥癞,瘙痒。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药 的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿 痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用黑大豆是因为其性味苦甘,平,入脾、 肾经,有活血,利水,祛风,解毒的功能,治水肿胀满,风毒脚气,黄疸浮肿,风痹筋挛,产后风 痉、口噤,痈肿疮毒;解药毒。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血, 调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹, 肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用金银花是因为其性味甘,寒,入肺、胃 经,有清热,解毒的功能,治温病发热,热毒血痢,痈疡,肿毒,瘰疬,痔漏。选用川芎是因为其 性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹 疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用女贞子是因为其性味苦甘,平,入 肝、肾经,有补肝肾,强腰膝的功能,治阴虚内热,头晕,目花耳鸣,腰膝酸软,须发早白。选 用分心木是因为其性味苦湿,性平,入脾、肾二经,有固肾涩精的功能,治遗精滑泄,淋病,尿 血,遗溺,崩中,带下,泻痢。选用防风是因为其性味辛甘,温,入膀胱、肺、脾经,有发表,祛 风,胜湿,止痛的功能,治外感风寒,头痛,目眩,项强,风寒湿痹,骨节酸痛,四肢挛急,破伤 风。选用肉桂是因为其性味辛甘,热,入肾、脾、膀胱经,有补元阳,暖脾胃,除积冷,通血脉的 功能,治命门火衰,肢冷脉微,亡阳虚脱,腹痛泄泻,寒疝奔豚,腰膝冷痛,经闭癥瘕,阴疽,流 注,及虚阳浮越,上热下寒。选用益智仁是因为其性味辛,温,入脾、肾经,有温脾,暖肾,固 气,涩精的功能,治冷气腹痛,中寒吐泻,多唾,遗精,小便余沥,夜多小便。选用透骨草是因 为其性味辛温,归肺、肝、肾经,有祛风除湿,舒筋活血,散瘀消肿,解毒止痛的功能,治风湿 痹痛,筋骨挛缩,疮癣肿毒。选用山茱萸是因为其性味酸,微温,入肝、肾经,有补肝肾,涩精 气,固虚脱的功能,治腰膝酸痛,眩晕,耳鸣,阳痿,遗精,小便频数,肝虚寒热,虚汗不止,心 摇脉散。选用黑芝麻,异名胡麻仁,其性味甘,平,归肝、肾、大肠经,有补肝肾,益精血,润肠 燥的功能,治头昏眼花,耳鸣耳聋,须发早白,病后脱发,肠燥便秘。选用珍珠母是因为其性 味咸,凉,入心、肝两经,有平肝,潜阳,定惊,止血的功能,治头眩,耳鸣,心悸,失眠,癫狂,惊 癎,吐血,衄血,妇女血崩。选用桑椹是因为其性味甘,寒,入肝,肾经,有补肝,益肾,熄风,滋 液的功能,治肝肾阴亏,消渴,便秘,目暗,耳鸣,瘰疬,关节不利。选用十大功劳叶是因为其 性味苦,凉,入肺经,有清热补虚,止咳化痰的功能,治肺痨咳血,骨蒸潮热,头晕耳鸣,腰酸 腿软,心烦,目赤。选用龙胆是因为其性味苦,寒,入肝、胆经,有泻肝实火,除下焦湿热的功 能,治肝经热盛,惊癎狂躁,乙型脑炎,头痛,目赤,咽痛,黄疸,热痢,痈肿疮疡,阴囊肿痛,阴 部湿痒。
具体实施方式
[0007] 本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下 述重量范围内都具有较好的疗效: 钩藤8-15克,黄芪10-15克,石菖蒲10-15克,熟地黄8-12克,路路通8-12克,柴胡 12-18克,补骨脂12-18克,黄连10-15克,磁石10-15克,香附10-15克,苍耳子6-10克,甘 草15-25克,黑大豆8-12克,当归8-12克,金银花10克,川考10-15克,女贞子12-18克,分 心木12-18克,防风8-12克,肉桂12-18克,益智仁12-18克,透骨草8-12克,山茱萸8-15 克,黑芝麻12-18克,珍珠母12-18克,桑椹15-25克,十大功劳叶10-15克,龙胆8-15克。
[0008] 优选为: 钩藤10克,黄芪12克,石菖蒲12克,熟地黄10克,路路通10克,柴胡15克,补骨脂15 克,黄连12克,磁石12克,香附12克,苍耳子8克,甘草20克,黑大豆10克,当归10克,金 银花10克,川芎12克,女贞子15克,分心木15克,防风10克,肉桂15克,益智仁15克,透 骨草10克,山茱萸10克,黑芝麻15克,珍珠母15克,桑椹20克,十大功劳叶12克,龙胆10 克。
[0009] 本发明药物的制备方法如下 一、备料 1、 钩藤:拣去老梗、杂质,洗净,晒干; 2、 黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡; 3、 石菖蒲:拣去杂质,洗净,稍浸泡,润透,切片,晒干,捞出,润透后切片晒干; 4、 熟地黄:取原药材蒸至表面乌黑色,取出,晒至八成干,切片,干燥; 5、 路路通:除去杂质,洗净,晒干; 6、 柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,晒干; 7、 补骨脂:簸尽杂质,洗净,晒干; 8、 黄连:拣去杂质,洗净泥砂,润透,切片,阴干; 9、 磁石:拣去杂质,砸碎,过筛; 10、 香附:拣去杂质,礙成碎粒,鑛去细毛及细末; 11、 苍耳子:拣尽杂质,去刺,筛去灰肩,微炒至黄色,取出放凉; 12、 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干; 13、 黑大ϋ:栋净杂质,晒干; 14、 当归:拣去杂质,洗净,闷润,稍晾,切片晒干; 15、 金银花:筛去泥沙,拣净杂质; 16、 川芎:拣去杂质,分开大、小个,用水浸泡,晒瞭,闷润后切片,干燥; 17、 女贞子:拣去杂质,洗净,晒干; 18、 分心木:秋、冬季采收成熟核果,击开核壳,采取核仁时,收果核内的木质隔膜,晒 干; 19、 防风:除去残茎,用水浸泡,捞出,润透切片,晒干; 20、 肉桂:拣净杂质,刮去粗皮,用时打碎,或刮去粗皮,用温开水浸润片刻,切片,晾 干; 21、 益智仁:取益智仁置锅内,炒至外壳焦黑,取出冷透,除去果壳,取仁捣碎用; 22、 透骨草:拣净杂质,切段; 23、 山朱英:洗净,除去果核及杂质,晒干; 24、 黑芝麻:取原药材,除去杂质,筛去碎肩; 25、 珍珠母:拣去杂质,敲成碎块,筛去灰肩; 26、 桑椹:用水洗净,拣去杂质,摘除长柄,晒干; 27、 十大功劳叶:秋季采收,拣净杂质,晒干; 28、龙胆:拣去杂质,除去残茎,洗净,润透后切段,晒干。
[0010] 二、制备 1、将所述重量的钩藤、黄芪、石菖蒲、熟地黄、路路通、柴胡、补骨脂、黄连、磁石、香附、 苍耳子、甘草、黑大豆、当归、金银花、川芎、女贞子、分心木、防风、肉桂、益智仁、透骨草、山 茱萸、黑芝麻、珍珠母、桑椹、十大功劳叶、龙胆放入煎药容器内,第一次加水8倍量,浸泡 100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液 倒入容器内。
[0011] 2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮 液。
[0012] 3、将两次煎煮液混合搅拌均匀即得,分为4剂服用。
[0013] 组方中山茱萸有补肝肾,涩精气,固虚脱的功能为君药;桑椹补肝,益肾,熄风,滋 液;益智仁有温脾,暖肾,固气,涩精的功能,二者为臣药,三味药共同发挥补肝,益肾,温脾, 固气,熄风,滋液的作用,治疗耳鸣效力全面,且以补肝,益肾为主可治本,龙胆有泻肝实火, 除下焦湿热的功能为佐药,甘草有和中缓急,润肺,解毒,调和诸药的功能为使药,与余下诸 药是治标。
[0014] 本发明药物具有补益肝肾,清肝泄热,理气解郁,祛风除湿的功能,用于治疗耳鸣, 疗程短、见效快、治愈后不复发。
[0015]
具体实施方式: 以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药 物的动物毒性试验报告和临床疗效观察资料。
[0016] [试验例1]本发明药物的动物毒性试验报告: 取家兔30只,雌雄兼用,体重2. 0 - 2. 5kg,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。服用药液超常量组为20ml/kg,正常量为10ml/kg,给药方式为 灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常, 药物无不良毒副作用。
[0017] [试验例2]本发明药物的临床疗效观察 1、一般资料 收治耳鸣门诊患者共32例。
[0018] 2、诊断标准 临床症状为耳鸣声或如蝉噪,或如钟鼓,或如水激,久则耳聋,面色黄白,倦怠乏力,神 疲纳少,大便易溏。
[0019] 3、治疗方法 选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续 服用3个疗程。
[0020] 4、疗效评定标准 显效:耳鸣症状消失,体质恢复正常,痊愈; 好转:患者头痛、耳塞现象减轻,耳鸣症状明显好转,体质逐步恢复; 无效:达不到好转标准者。
[0021] 5、治疗结果(见下表)
Figure CN105362889AD00081
在上述治疗中,用本发明药物治疗耳鸣患者32例,结果显效29例,显效率为90. 62%,好 转2例,好转率为6. 25%,无效1例,总有效率为96. 87%。

Claims (3)

1. 一种治疗耳鸣的药物,其特征在于:它是由下列重量范围内的原料药制成: 钩藤8-15克,黄芪10-15克,石菖蒲10-15克,熟地黄8-12克,路路通8-12克,柴胡 12-18克,补骨脂12-18克,黄连10-15克,磁石10-15克,香附10-15克,苍耳子6-10克,甘 草15-25克,黑大豆8-12克,当归8-12克,金银花10克,川考10-15克,女贞子12-18克,分 心木12-18克,防风8-12克,肉桂12-18克,益智仁12-18克,透骨草8-12克,山茱萸8-15 克,黑芝麻12-18克,珍珠母12-18克,桑椹15-25克,十大功劳叶10-15克,龙胆8-15克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 钩藤10克,黄芪12克,石菖蒲12克,熟地黄10克,路路通10克,柴胡15克,补骨脂15 克,黄连12克,磁石12克,香附12克,苍耳子8克,甘草20克,黑大豆10克,当归10克,金 银花10克,川芎12克,女贞子15克,分心木15克,防风10克,肉桂15克,益智仁15克,透 骨草10克,山茱萸10克,黑芝麻15克,珍珠母15克,桑椹20克,十大功劳叶12克,龙胆10 克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (一)备料 (1) 钩藤:拣去老梗、杂质,洗净,晒干; (2) 黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后切片晒 干; (3) 石菖蒲:拣去杂质,洗净,稍浸泡,润透,切片,晒干; (4) 熟地黄:取原药材蒸至表面乌黑色,取出,晒至八成干,切片,干燥; (5) 路路通:除去杂质,洗净,晒干; (6) 柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,晒干; (7) 补骨脂:簸尽杂质,洗净,晒干; (8) 黄连:拣去杂质,洗净泥砂,润透,切片,阴干; (9) 磁石:拣去杂质,砸碎,过筛; (10) 香附:拣去杂质,礙成碎粒,鑛去细毛及细末; (11) 苍耳子:拣尽杂质,去刺,筛去灰肩,微炒至黄色,取出放凉; (12) 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干; (13) 黑大豆:拣净杂质,晒干; (14) 当归:拣去杂质,洗净,闷润,稍晾,切片晒干; (15) 金银花:筛去泥沙,拣净杂质; (16) 川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥; (17) 女贞子:拣去杂质,洗净,晒干; (18) 分心木:秋、冬季采收成熟核果,击开核壳,采取核仁时,收果核内的木质隔膜,晒 干; (19) 防风:除去残茎,用水浸泡,捞出,润透切片,晒干; (20) 肉桂:拣净杂质,刮去粗皮,用时打碎,或刮去粗皮,用温开水浸润片刻,切片,晾 干; (21) 益智仁:取益智仁置锅内,炒至外壳焦黑,取出冷透,除去果壳,取仁捣碎用; (22) 透骨草:拣净杂质,切段; (23) 山茱萸:洗净,除去果核及杂质,晒干; (24) 黑芝麻:取原药材,除去杂质,筛去碎肩; (25) 珍珠母:拣去杂质,敲成碎块,筛去灰肩; (26) 桑椹:用水洗净,拣去杂质,摘除长柄,晒干; (27) 十大功劳叶:秋季采收,拣净杂质,晒干; (28) 龙胆:拣去杂质,除去残茎,洗净,润透后切段,晒干; (二)制备 (1) 将所述重量的钩藤、黄芪、石菖蒲、熟地黄、路路通、柴胡、补骨脂、黄连、磁石、香附、 苍耳子、甘草、黑大豆、当归、金银花、川芎、女贞子、分心木、防风、肉桂、益智仁、透骨草、山 茱萸、黑芝麻、珍珠母、桑椹、十大功劳叶、龙胆放入煎药容器内,加水8倍量,浸泡100分钟 后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器 内; (2) 将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮 液; (3) 将两次煎煮液混合搅拌均匀即得,分为4剂服用。
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