CN103736037A - 一种治疗慢性疲劳综合症的药物及其制备方法 - Google Patents
一种治疗慢性疲劳综合症的药物及其制备方法 Download PDFInfo
- Publication number
- CN103736037A CN103736037A CN201410040774.7A CN201410040774A CN103736037A CN 103736037 A CN103736037 A CN 103736037A CN 201410040774 A CN201410040774 A CN 201410040774A CN 103736037 A CN103736037 A CN 103736037A
- Authority
- CN
- China
- Prior art keywords
- radix
- grams
- gram
- rhizoma
- clean
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 44
- 206010008874 Chronic fatigue syndrome Diseases 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 229940079593 drugs Drugs 0.000 title claims description 17
- 235000008434 ginseng Nutrition 0.000 claims abstract description 11
- 239000009636 Huang Qi Substances 0.000 claims abstract description 9
- 238000004140 cleaning Methods 0.000 claims description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances data:image/svg+xml;base64,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 data:image/svg+xml;base64,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 O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 34
- 238000005202 decontamination Methods 0.000 claims description 26
- 230000003588 decontaminative Effects 0.000 claims description 26
- 210000000582 Semen Anatomy 0.000 claims description 20
- 239000012535 impurity Substances 0.000 claims description 16
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 11
- 241000628997 Flos Species 0.000 claims description 10
- 240000004678 Panax pseudoginseng Species 0.000 claims description 10
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 10
- 238000009835 boiling Methods 0.000 claims description 10
- 235000005035 ginseng Nutrition 0.000 claims description 10
- 238000005520 cutting process Methods 0.000 claims description 6
- 235000015099 wheat brans Nutrition 0.000 claims description 6
- 210000003165 Abomasum Anatomy 0.000 claims description 4
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims description 4
- 240000003917 Bambusa tulda Species 0.000 claims description 4
- 235000017491 Bambusa tulda Nutrition 0.000 claims description 4
- 235000014676 Phragmites communis Nutrition 0.000 claims description 4
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims description 4
- 239000011425 bamboo Substances 0.000 claims description 4
- 210000003491 Skin Anatomy 0.000 claims description 3
- 238000009738 saturating Methods 0.000 claims description 3
- 240000000559 Albizia odoratissima Species 0.000 claims description 2
- 235000011438 Albizia odoratissima Nutrition 0.000 claims description 2
- 241000605447 Anemarrhena Species 0.000 claims description 2
- 235000014375 Curcuma Nutrition 0.000 claims description 2
- 240000002123 Curcuma aromatica Species 0.000 claims description 2
- 241000208966 Polygala Species 0.000 claims description 2
- 241000219780 Pueraria Species 0.000 claims description 2
- 241000545442 Radix Species 0.000 claims description 2
- 241000207929 Scutellaria Species 0.000 claims description 2
- 235000019504 cigarettes Nutrition 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- 239000004744 fabric Substances 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 230000003760 hair shine Effects 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- -1 remove stem and leaf Substances 0.000 claims description 2
- 230000001429 stepping Effects 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 210000004369 Blood Anatomy 0.000 abstract description 33
- 239000008280 blood Substances 0.000 abstract description 33
- 201000010099 disease Diseases 0.000 abstract description 10
- 230000001717 pathogenic Effects 0.000 abstract description 10
- 230000017531 blood circulation Effects 0.000 abstract description 6
- 230000001737 promoting Effects 0.000 abstract description 6
- 239000010839 body fluid Substances 0.000 abstract description 5
- 210000001124 Body Fluids Anatomy 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 241000382455 Angelica sinensis Species 0.000 abstract 1
- 241001131629 Lancea Species 0.000 abstract 1
- 240000004371 Panax ginseng Species 0.000 abstract 1
- 235000002789 Panax ginseng Nutrition 0.000 abstract 1
- 244000197580 Poria cocos Species 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 description 30
- 235000019634 flavors Nutrition 0.000 description 30
- 210000004185 Liver Anatomy 0.000 description 22
- 210000000952 Spleen Anatomy 0.000 description 17
- 210000002216 Heart Anatomy 0.000 description 16
- 235000009508 confectionery Nutrition 0.000 description 14
- 208000002193 Pain Diseases 0.000 description 13
- 206010037660 Pyrexia Diseases 0.000 description 13
- 230000036407 pain Effects 0.000 description 13
- 210000002784 Stomach Anatomy 0.000 description 12
- 210000004072 Lung Anatomy 0.000 description 11
- 210000001015 Abdomen Anatomy 0.000 description 9
- 208000006820 Arthralgia Diseases 0.000 description 8
- 206010007247 Carbuncle Diseases 0.000 description 8
- 206010011224 Cough Diseases 0.000 description 8
- 206010012735 Diarrhoea Diseases 0.000 description 7
- 206010019233 Headache Diseases 0.000 description 7
- 206010062717 Increased upper airway secretion Diseases 0.000 description 7
- 210000003734 Kidney Anatomy 0.000 description 7
- 206010027327 Menstrual disease Diseases 0.000 description 7
- 231100000869 headache Toxicity 0.000 description 7
- 230000035922 thirst Effects 0.000 description 7
- 208000001848 Dysentery Diseases 0.000 description 6
- 210000003205 Muscles Anatomy 0.000 description 6
- 206010033557 Palpitations Diseases 0.000 description 6
- 230000001914 calming Effects 0.000 description 6
- 230000001105 regulatory Effects 0.000 description 6
- 206010001928 Amenorrhoea Diseases 0.000 description 5
- 206010003549 Asthenia Diseases 0.000 description 5
- 206010022437 Insomnia Diseases 0.000 description 5
- 206010023126 Jaundice Diseases 0.000 description 5
- 206010027514 Metrorrhagia Diseases 0.000 description 5
- 206010030113 Oedema Diseases 0.000 description 5
- 231100000614 Poison Toxicity 0.000 description 5
- 206010042674 Swelling Diseases 0.000 description 5
- 206010068760 Ulcers Diseases 0.000 description 5
- 201000000736 amenorrhea Diseases 0.000 description 5
- 231100000540 amenorrhea Toxicity 0.000 description 5
- 230000002522 swelling Effects 0.000 description 5
- 231100000397 ulcer Toxicity 0.000 description 5
- 206010000087 Abdominal pain upper Diseases 0.000 description 4
- 206010010774 Constipation Diseases 0.000 description 4
- 208000002173 Dizziness Diseases 0.000 description 4
- 206010013990 Dysuria Diseases 0.000 description 4
- 208000001780 Epistaxis Diseases 0.000 description 4
- 210000000232 Gallbladder Anatomy 0.000 description 4
- 235000019789 appetite Nutrition 0.000 description 4
- 230000036528 appetite Effects 0.000 description 4
- 244000052769 pathogens Species 0.000 description 4
- 239000002574 poison Substances 0.000 description 4
- 230000002269 spontaneous Effects 0.000 description 4
- 210000000988 Bone and Bones Anatomy 0.000 description 3
- 210000000481 Breast Anatomy 0.000 description 3
- 206010011878 Deafness Diseases 0.000 description 3
- 241000668709 Dipterocarpus costatus Species 0.000 description 3
- 206010013954 Dysphoria Diseases 0.000 description 3
- 208000008454 Hyperhidrosis Diseases 0.000 description 3
- 206010022114 Injury Diseases 0.000 description 3
- 208000001431 Psychomotor Agitation Diseases 0.000 description 3
- 206010038743 Restlessness Diseases 0.000 description 3
- 206010043458 Thirst Diseases 0.000 description 3
- 230000002950 deficient Effects 0.000 description 3
- 201000008286 diarrhea Diseases 0.000 description 3
- 230000003203 everyday Effects 0.000 description 3
- 235000019525 fullness Nutrition 0.000 description 3
- 210000002429 large intestine Anatomy 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 210000004914 menses Anatomy 0.000 description 3
- 230000035807 sensation Effects 0.000 description 3
- 235000019615 sensations Nutrition 0.000 description 3
- 230000035900 sweating Effects 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 206010002383 Angina pectoris Diseases 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- 206010061428 Decreased appetite Diseases 0.000 description 2
- 206010015037 Epilepsy Diseases 0.000 description 2
- 206010018987 Haemorrhage Diseases 0.000 description 2
- 208000006750 Hematuria Diseases 0.000 description 2
- 210000001624 Hip Anatomy 0.000 description 2
- 206010021118 Hypotonia Diseases 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 206010072736 Rheumatic disease Diseases 0.000 description 2
- 231100000319 bleeding Toxicity 0.000 description 2
- 230000000740 bleeding Effects 0.000 description 2
- 230000002612 cardiopulmonary Effects 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- 230000001684 chronic Effects 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 231100000895 deafness Toxicity 0.000 description 2
- 201000004624 dermatitis Diseases 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 201000004792 malaria Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 231100000862 numbness Toxicity 0.000 description 2
- 230000025627 positive regulation of urine volume Effects 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 238000010791 quenching Methods 0.000 description 2
- 230000003014 reinforcing Effects 0.000 description 2
- 230000000552 rheumatic Effects 0.000 description 2
- 231100000486 side effect Toxicity 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 230000001225 therapeutic Effects 0.000 description 2
- 230000002588 toxic Effects 0.000 description 2
- 231100000820 toxicity test Toxicity 0.000 description 2
- 230000002936 tranquilizing Effects 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 206010000234 Abortion spontaneous Diseases 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 206010054196 Affect lability Diseases 0.000 description 1
- 206010002855 Anxiety Diseases 0.000 description 1
- 206010057666 Anxiety disease Diseases 0.000 description 1
- 208000006673 Asthma Diseases 0.000 description 1
- 208000009899 Burkitt Lymphoma Diseases 0.000 description 1
- 206010007882 Cellulitis Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010012218 Delirium Diseases 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 206010012373 Depressed level of consciousness Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 208000005679 Eczema Diseases 0.000 description 1
- 206010014599 Encephalitis Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010015958 Eye pain Diseases 0.000 description 1
- 206010016256 Fatigue Diseases 0.000 description 1
- 206010016286 Febrile disease Diseases 0.000 description 1
- 210000003754 Fetus Anatomy 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 208000001786 Gonorrhea Diseases 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 206010018836 Haematochezia Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000004044 Hypesthesia Diseases 0.000 description 1
- 206010020937 Hypoaesthesia Diseases 0.000 description 1
- 210000003026 Hypopharynx Anatomy 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 210000000936 Intestines Anatomy 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 210000003127 Knee Anatomy 0.000 description 1
- 206010024453 Ligament sprain Diseases 0.000 description 1
- 208000009856 Lung Disease Diseases 0.000 description 1
- 206010025182 Lymph node pain Diseases 0.000 description 1
- 206010026749 Mania Diseases 0.000 description 1
- 210000001616 Monocytes Anatomy 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 208000007443 Neurasthenia Diseases 0.000 description 1
- 206010029333 Neurosis Diseases 0.000 description 1
- 206010029410 Night sweats Diseases 0.000 description 1
- 206010059013 Nocturnal emission Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-N Picric acid Chemical compound data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='300px' height='300px' viewBox='0 0 300 300'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='300.0' height='300.0' x='0.0' y='0.0'> </rect>
<path class='bond-0 atom-0 atom-1' d='M 237.8,148.0 L 221.6,148.0' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-0 atom-0 atom-1' d='M 221.6,148.0 L 205.4,148.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-1 atom-2' d='M 205.4,148.0 L 180.7,190.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-1 atom-2' d='M 193.1,149.5 L 175.8,179.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-12 atom-1' d='M 180.7,105.2 L 205.4,148.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 180.7,190.8 L 188.5,204.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 188.5,204.4 L 196.3,217.9' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-2 atom-6' d='M 180.7,190.8 L 131.2,190.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-3 atom-4' d='M 194.0,253.3 L 191.7,257.3' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-3 atom-4' d='M 191.7,257.3 L 189.4,261.3' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-3 atom-5' d='M 230.6,238.6 L 234.5,238.6' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-3 atom-5' d='M 234.5,238.6 L 238.4,238.6' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-3 atom-5' d='M 230.6,228.7 L 234.5,228.7' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-3 atom-5' d='M 234.5,228.7 L 238.4,228.7' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-6 atom-7' d='M 131.2,190.8 L 106.5,148.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-6 atom-7' d='M 136.1,179.5 L 118.8,149.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 106.5,148.0 L 94.4,148.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 94.4,148.0 L 82.3,148.0' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-7 atom-11' d='M 106.5,148.0 L 131.2,105.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-8 atom-9' d='M 48.0,132.3 L 45.7,128.4' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-8 atom-9' d='M 45.7,128.4 L 43.5,124.4' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-8 atom-10' d='M 41.4,165.2 L 39.1,169.2' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-8 atom-10' d='M 39.1,169.2 L 36.8,173.2' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-8 atom-10' d='M 50.0,170.2 L 47.7,174.2' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-8 atom-10' d='M 47.7,174.2 L 45.4,178.1' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-11 atom-12' d='M 131.2,105.2 L 180.7,105.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-11 atom-12' d='M 138.7,115.1 L 173.3,115.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-12 atom-13' d='M 180.7,105.2 L 187.4,93.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-12 atom-13' d='M 187.4,93.6 L 194.0,82.1' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 230.6,62.4 L 234.5,62.4' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 234.5,62.4 L 238.4,62.4' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-13 atom-15' d='M 200.6,44.2 L 198.3,40.3' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-13 atom-15' d='M 198.3,40.3 L 196.1,36.3' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-13 atom-15' d='M 192.0,49.1 L 189.8,45.2' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-13 atom-15' d='M 189.8,45.2 L 187.5,41.3' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<text x='248.9' y='157.9' class='atom-0' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='262.6' y='157.9' class='atom-0' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >H</text>
<text x='199.5' y='243.5' class='atom-3' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='213.1' y='235.6' class='atom-3' style='font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >+</text>
<text x='174.8' y='286.4' class='atom-4' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='188.4' y='278.5' class='atom-4' style='font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >-</text>
<text x='248.9' y='243.5' class='atom-5' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='51.1' y='157.9' class='atom-8' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='64.8' y='150.0' class='atom-8' style='font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >+</text>
<text x='26.4' y='115.1' class='atom-9' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='40.1' y='107.2' class='atom-9' style='font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >-</text>
<text x='26.4' y='200.7' class='atom-10' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='199.5' y='72.3' class='atom-13' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='213.1' y='64.4' class='atom-13' style='font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >+</text>
<text x='248.9' y='72.3' class='atom-14' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='262.6' y='64.4' class='atom-14' style='font-size:13px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >-</text>
<text x='174.8' y='29.5' class='atom-15' style='font-size:19px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
</svg>
 data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='85px' height='85px' viewBox='0 0 85 85'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='85.0' height='85.0' x='0.0' y='0.0'> </rect>
<path class='bond-0 atom-0 atom-1' d='M 69.6,41.4 L 63.6,41.4' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-0 atom-0 atom-1' d='M 63.6,41.4 L 57.7,41.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-1 atom-2' d='M 57.7,41.4 L 50.7,53.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-1 atom-2' d='M 54.2,41.9 L 49.3,50.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-12 atom-1' d='M 50.7,29.3 L 57.7,41.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 50.7,53.6 L 53.6,58.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 53.6,58.6 L 56.5,63.6' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-2 atom-6' d='M 50.7,53.6 L 36.7,53.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-3 atom-4' d='M 55.8,69.1 L 53.8,72.4' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-3 atom-4' d='M 53.8,72.4 L 51.9,75.8' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-3 atom-5' d='M 62.3,67.1 L 66.0,67.1' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-3 atom-5' d='M 66.0,67.1 L 69.7,67.1' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-3 atom-5' d='M 62.3,64.3 L 66.0,64.3' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-3 atom-5' d='M 66.0,64.3 L 69.7,64.3' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-6 atom-7' d='M 36.7,53.6 L 29.7,41.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-6 atom-7' d='M 38.1,50.4 L 33.2,41.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 29.7,41.4 L 25.0,41.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 25.0,41.4 L 20.3,41.4' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-7 atom-11' d='M 29.7,41.4 L 36.7,29.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-8 atom-9' d='M 14.4,39.3 L 12.5,35.9' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-8 atom-9' d='M 12.5,35.9 L 10.6,32.6' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-8 atom-10' d='M 12.5,44.1 L 10.6,47.5' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-8 atom-10' d='M 10.6,47.5 L 8.6,50.8' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-8 atom-10' d='M 15.0,45.5 L 13.0,48.9' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-8 atom-10' d='M 13.0,48.9 L 11.1,52.2' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-11 atom-12' d='M 36.7,29.3 L 50.7,29.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-11 atom-12' d='M 38.8,32.1 L 48.6,32.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-12 atom-13' d='M 50.7,29.3 L 53.2,24.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-12 atom-13' d='M 53.2,24.9 L 55.8,20.5' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 62.3,17.2 L 66.0,17.2' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-14' d='M 66.0,17.2 L 69.7,17.2' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-13 atom-15' d='M 57.7,14.3 L 55.7,11.0' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-13 atom-15' d='M 55.7,11.0 L 53.8,7.6' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-13 atom-15' d='M 55.2,15.7 L 53.3,12.4' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-13 atom-15' d='M 53.3,12.4 L 51.4,9.0' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<text x='69.9' y='44.4' class='atom-0' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='74.0' y='44.4' class='atom-0' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >H</text>
<text x='55.9' y='68.7' class='atom-3' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='60.0' y='66.3' class='atom-3' style='font-size:3px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >+</text>
<text x='48.9' y='80.8' class='atom-4' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='53.0' y='78.4' class='atom-4' style='font-size:3px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >-</text>
<text x='69.9' y='68.7' class='atom-5' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='13.9' y='44.4' class='atom-8' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='18.0' y='42.0' class='atom-8' style='font-size:3px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >+</text>
<text x='6.9' y='32.3' class='atom-9' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='11.0' y='29.9' class='atom-9' style='font-size:3px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >-</text>
<text x='6.9' y='56.6' class='atom-10' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='55.9' y='20.2' class='atom-13' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='60.0' y='17.8' class='atom-13' style='font-size:3px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >+</text>
<text x='69.9' y='20.2' class='atom-14' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='74.0' y='17.8' class='atom-14' style='font-size:3px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >-</text>
<text x='48.9' y='8.0' class='atom-15' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
</svg>
 OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
- 206010036018 Pollakiuria Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000008425 Protein Deficiency Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000008128 Pulmonary Tuberculosis Diseases 0.000 description 1
- 210000004915 Pus Anatomy 0.000 description 1
- 206010037844 Rash Diseases 0.000 description 1
- 206010057071 Rectal tenesmus Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 208000005687 Scabies Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 210000004706 Scrotum Anatomy 0.000 description 1
- 206010040872 Skin infection Diseases 0.000 description 1
- 206010040943 Skin ulcer Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 210000003802 Sputum Anatomy 0.000 description 1
- 210000002435 Tendons Anatomy 0.000 description 1
- 208000009189 Tinea Favosa Diseases 0.000 description 1
- 206010043866 Tinea capitis Diseases 0.000 description 1
- 206010044302 Tracheitis Diseases 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 206010046788 Uterine haemorrhage Diseases 0.000 description 1
- 206010046814 Uterine prolapse Diseases 0.000 description 1
- 208000001756 Virus Disease Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000003187 abdominal Effects 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000003213 activating Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000001166 anti-perspirant Effects 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 231100000406 dermatitis Toxicity 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 231100001003 eczema Toxicity 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000968 intestinal Effects 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 230000003211 malignant Effects 0.000 description 1
- 230000002175 menstrual Effects 0.000 description 1
- 230000003340 mental Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 230000003020 moisturizing Effects 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 201000006487 neurotic disease Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 244000045947 parasites Species 0.000 description 1
- 229940114148 picric acid Drugs 0.000 description 1
- 230000003389 potentiating Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002035 prolonged Effects 0.000 description 1
- 230000000306 recurrent Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 201000010874 syndrome Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 229950002929 trinitrophenol Drugs 0.000 description 1
Abstract
本发明公开了一种治疗慢性疲劳综合症的药物及其制备方法，它主要是由人参、黄芪、白术、当归、茯苓、白芍、柴胡、香附等药物按一定重量配比制备而成，本发明药物具有补血和血，滋阴降火，固脱生津的功效，用于治疗慢性疲劳综合症见效快，疗效好，治愈后不复发。
Description
一种治疗慢性疲劳综合症的药物及其制备方法
技术领域
[0001] 本发明涉及一种治疗慢性疲劳综合症的药物及其制备方法，属中药领域。
背景技术
[0002] 慢性疲劳综合症又称雅痞症、慢性伯基特淋巴瘤病毒症、慢性类单核白血球增多症等等，其症状包括发烧、喉咙痛、淋巴结肿大、极度疲劳、失去食欲、复发性上呼吸道感染、小肠不适、黄疽、焦虑、忧郁、烦躁及情绪不稳、睡眠中断、对光及热敏感、暂时失去记忆力、无法集中注意力、头痛、痉挛、肌肉与关节痛。目前，由于西药治疗慢性疲劳综合症效果不佳，且长期服用西药有较多副作用，因此，人们对有效治疗慢性疲劳综合症的中药存在极大的需求。
发明内容
[0003] 本发明人依据中医理论的研究及临床反复的试验和验证，终于找到了有效治疗慢性疲劳综合症的药物，从而完成了本发明。
[0004] 本发明的目的就是提供一种能够有效治疗慢性疲劳综合症的组合药物。
[0005] 本发明的另一个目的就是提供了该组合药物的制备方法。
[0006] 本发明药物是选择人参、黄芪、白术、当归、茯苓、白芍、柴胡、香附、郁金、甘草、黄精、远志、水菖蒲、酸枣仁、合欢皮、熟地黄、葛根、鸡血藤、花斑叶、龙胆草、黄芩、桅子、牡丹皮、大黄、生地黄、知母、黄柏、桃仁、红花、丹参药物进行组合的，将这些药物组合使得各药物功效产生协同作用，从而能够有效治疗慢性疲劳综合症的复发。其中选用人参是因为其性味甘微甘，温，入脾、肺经，有大补元气，固脱生津，安神的功能，治劳伤虚损，食少，倦怠，反胃吐食，大便滑泄，虚咳喘促，自汗暴脱，惊悸，健忘，眩晕头痛，阳萎，尿频，消渴，妇女崩漏，小儿慢惊及久虚不复，一切气血津液不足之症。选用黄芪是因为其性味甘，微温，入肺、脾经，生用有益卫固表，利水消肿，托毒，生肌的功能，治自汗，盗汗，血痹，浮肿，痈疽不溃或溃久敛；炙用有补中益的功能，治内伤劳倦，脾虚泄泻，脱肛，气虚血脱，崩带及一切气衰血虚之症。选用白术是因为其性味苦甘，温，入脾、胃经，有补脾，益胃，燥湿，和中的功能，治脾胃气弱，不思饮食，倦怠少气，虚胀，泄泻，痰饮，水肿，黄疸，湿痹，小便不利，头晕，自汗，胎气不安。选用当归是因为其性味甘辛，温，入心、肝、脾经，有补血和血，调经止痛，润燥滑肠的功能，治月经不调，经闭腹痛，癥瘕结聚，崩漏，血虚头痛，眩晕，痿痹，肠燥难便，赤痢后重，痈疽疮疡，金疮，跌扑损伤。茯苓:选用茯苓是因为其性味甘淡，平，入心、脾、肺经，有渗湿利水，益脾和 胃，宁心安神的功能，治小便不利水肿胀痛，痰饮咳逆，呕哕，泄泻，遗精，淋浊，惊悸，健忘。选用白芍是因为其性味苦酸，凉，入肝、脾经，有养血柔肝，缓中止痛，敛阴收汗的功能，治胸腹胁肋疼痛，泻痢腹痛，自汗盗汗，阴虚发热，月经不调，崩漏，带下。选用柴胡是因为其性味苦，凉，入肝、胆经，有和解表里，疏肝，升阳的功能，治寒热往来，胸满胁痛，口苦耳聋，头痛目眩，疟疾，下利脱肛，月经不调，子宫下垂。选用香附是因为其性味辛微苦干，平，入肝、三焦经，有理气解郁，止痛调经的功能，治肝胃不和，气郁不舒，胸腹胁肋胀痛，痰饮痞满，月经不调，崩漏带下。选用郁金是因为其性味辛苦，凉，入心、肺、肝经，有行气解随,凉血破瘀的功能,治胸腹胁肋诸痛,失心癫狂,热病神昏，吐血,衄血,尿血,血淋,妇女倒经，黄疸。选用甘草是因为其性味甘平，入脾、胃、肺经，有和中缓急，润肺，解毒，调和诸药的功能，炙用治脾胃虚弱，食少，腹痛便溏，劳倦发热，肺痿咳嗽，心悸，惊痈，生用治咽喉肿痛，消化性溃疡，痈疽疮疡，解药毒及食物中毒。选用黄精是因为其性味甘平，入脾、肺、肾经，有补中益气，润心肺，强筋骨的功能，治虚损寒热，肺痨咳血，病后体虚食少，筋骨软弱，风湿疼痛，风癞癣疾。选用远志是因为其性味苦辛，温，入心、肾经，有安神益智，祛痰，解郁的功能，治惊悸，健忘，梦遗，失眠，咳嗽多痰，痈疽疮肿。选用水菖蒲是因为其性味苦、辛，微温，入心、肺、胃经，有开窍化痰，辟秽杀虫的功能，治痰涎壅闭，神志不清，慢性气管炎，腹胀腹痛，食欲不振，肠炎，痢疾，风湿痹痛，外伤疥疮。选用酸枣仁是因为其性味甘，平，入心、脾、肝、胆经，有养肝，宁心，安神，敛汗的功能，治虚烦不眠，惊悸怔忡，烦渴，虚汗。选用合欢皮是因为其性味甘，平，入心、肝经，有解郁，和血，宁心，消痈肿的功能，治心神不安，忧郁失目民，肺痈，痈肿，瘰疬，筋骨折伤。选用熟地黄是因为其性味甘，微温，入肝、肾经，有滋阴，补血的功能，治阴虚血少，腰膝痿弱，劳嗽骨蒸，遗精，崩漏，月经不调，消渴，溲数，耳聋，目昏。选用葛根是因为其性味甘辛，平，入脾、胃经，有升阳解肌，透疹止泻，除烦止渴的功能，治伤寒，温热，头痛，项强，烦热消喝，泄泻，痢疾，癍诊不透，高血压，心绞痛，耳聋。选用鸡血藤是因为其性味苦甘，温，入心、脾二经，有活血、舒筋的功能，治腰膝酸痛，麻木瘫痪，月经不调。选用花斑叶是因为其有疏风散毒，消肿散瘀的功能，治湿疹，皮炎，风湿麻木。选用龙胆是因为其性味苦，寒，入肝、胆经，有泻肝实火，除下焦湿热的功能，治肝经热盛，惊癎狂躁，乙型脑炎，头痛，目赤，咽痛，黄疸，热痢，痈肿疮瘍，阴囊肿痛，阴部湿痒。选用黄芩是因为其性味苦寒，入心肺、胆、大肠经，有泻实火，除湿热，止血安胎的功能，治壮热烦渴，肺热咳嗽。选用桅子是因为其性味苦，寒，入心、肝、肺、胃经，有清热，泻火，凉血的功能，治热病虚烦不眠，黄疸,淋病，消渴，目赤,咽痛，吐血,衄血,血痢,尿血,热毒疮疡,扭伤肿痛。选用牡丹皮是因为其性味辛苦，凉，入心、肝、肾经，有清热，凉血，和血，消瘀的功能，治热入血分，发斑，惊癎，吐、衄、便血，骨蒸劳热，经闭，癥瘕，痈疡，扑损。选用大黄是因为其性味苦、寒，入胃、大肠、肝径，有泻热毒，破积滞，行瘀血的功能，治实热便秘，谵语发狂，食积痞满，痢疾初起，里急后重，瘀停经闭，癥瘕积聚，时行热疫，暴眼赤痛,吐血,衄血，阳黄,水肿,淋浊,溲赤,痈疡肿毒，疔疮，汤火伤。选用生地黄是因为其性味甘，寒，归心、肝、肾经，有清热凉血，养阴，生津的功能，治热病烦渴，阴虚内热，骨蒸劳热，内热消渴，吐血，衄血，发斑发疹。选用石菖蒲因为其性味辛，微温。选用知母是因为其性味苦，寒，入肺、胃、肾经，有滋阴降火，润燥滑肠的功能，治烦热消渴，骨蒸劳热，肺热咳嗽，大便燥结，小便不利。选用黄柏是因为其性味苦，寒，入肺、胃、肾经，有滋阴降火，润燥滑肠的功能，治烦热消渴，骨蒸劳热，肺热咳嗽，大便燥结，小便不利。桃仁是因为其性味苦甘，平，入心、肝、大肠经，有破血行瘀，润燥滑经的功能，治经闭，癥瘕,热病蓄血,血痹,疟疾,跌打损伤,瘀血肿痛,血燥便秘。选用红花是因为其性味辛，温，入心、肝经，有活血通经，去瘀止痛的功能，治经闭，癥瘕，难产，死胎，产后恶露不行，瘀血作痛，痈肿，跌扑损伤。选用丹参是因为其性味苦，微温，入心、肝经，有活血祛痰，安神宁心，排脓，止痛的功能，治心绞痛，月经不调，痛经，经闭，血崩带下，癥瘕，积聚，瘀血腹痛， 骨节疼痛，惊悸不眠，恶疮肿毒。具体实施方式
[0007] 本发明组分的药物用量也是发明人经过大量摸索总结得出的，各组分的用量在下述重量范围内都具有较好疗效
人参 10-20克 黄芪 10-20克白术 10-20克
当归 10-20克 茯苓 10-20克白芍 10-20克
柴胡 5-15克 香附 15-25克郁金 5-15克
甘草 5-15克 黄精 15-25克远志 5-15克
水菖蒲 5-15克 酸枣仁 15-25克合欢皮 5-15克
熟地黄 5-15克 葛根 15-25克鸡血藤 5-15克
花斑叶 10-20克 龙胆草 10-20克黄芩 10-20克
桅子 10-20克 牡丹皮 10-20克大黄 10-20克
生地黄 5-15克 知母 15-25克黄柏 5-15克
桃仁 10-20克 红花 10-20克丹参 10-20克
优选用量为
人参 15克 黄芪 15克 白术 15克
当归 15克 茯苓 15克 白芍 15克
柴胡 10克 香附 20克 郁金 10克
甘草 10克 黄精 20克 远志 10克
水菖蒲 10克 酸枣仁 20克 合欢皮 10克
熟地黄 10克 葛根 20克 鸡血藤 10克
花斑叶 15克 龙胆草 15克 黄芩 15克
桅子 15克 牡丹皮 15克 大黄 15克
生地黄 10克 知母 20克 黄柏 10克
桃仁 15克 红花 15克 丹参 15克
本发明药物的制备方法如下 一、备料
1、人参:除去芦头，切段或以湿布包裹，润软后切片，晾干；
2、黄芪:拣净杂质，除去残留的根头和空心较大者，用水浸泡，捞出，润透后及时切片，晒干；
3、白术:先将麸皮撒于热锅内，候烟冒出时，将白术片倒入微炒至淡黄色，取出，筛去麸皮后放凉，每白术片100斤，用麸皮10斤；
4、当归:拣去杂质，洗净，闷润，稍晾，切片晒干；
5、茯苓:用水浸泡，洗净捞出，闷透后，切片，晒干；
6、白芍:拣去杂质，分开大小个，用水浸泡至八成透，捞出，晒晾，润至内外湿度均匀，切片，干燥；
7、柴胡:拣去杂质，去芦，用水洗净，稍浸泡捞出，润透，切片，晒干；
8、香附:拣去杂质，碾成碎粒，簸去细毛及细末；
9、郁金:用水浸泡，洗净，捞出晒晾，润透，切片，晒干；
10、甘草:拣去杂质，洗净， 用水浸泡至八成透时，捞出，润透，切片，凉干；11、黄精:洗净泥土，略润，切片，晒干；
12、远志:拣去杂质，切段，筛去灰屑；
13、水菖蒲:取原药材，除去芦衣、杂质，洗净，润透，切厚片，低温干燥；
14、酸枣仁:原药放入竹萝内，沉入清水缸中，使仁浮在水面，壳沉水底，将刺仁捞出，晒
干;
15、合欢皮:清水浸泡洗净，捞出，闷润后先划成相等大的长条，再切块或切丝，干燥；
16、熟地黄:取原药材，蒸至表面乌黑色，取出，晒至八成干时，切片，干燥；
17、葛根:拣去杂质，洗净，用水浸泡，捞出，润透，及时切片，晒干；
18、鸡血藤:用水润透，切片，或蒸软后乘热切片，晒干； 19、花斑叶:拣去杂质，洗净晒干；
20、龙胆:拣去杂质，除去残茎，洗净，润透后切段，晒干；
21、黄芩:拣去杂质，除去残茎，用凉水浸润或置开水中稍浸捞出，切片，晒干；
22、桅子:筛去灰屑，拣去杂质，碾碎过筛或剪去两端；
23、牡丹皮:拣去杂质，除去木心，洗净，润透，切片，晾干；
24、大黄:拣净杂质，大小分档，焖润至内外湿度均匀，切片或切成小块、晒干；
25、生地黄:取原药材，除去杂质，洗净，稍润，切厚片，干燥，筛去碎屑；
26、知母:拣净杂质，用水撞洗，捞出，润软，切片晒干；
27、黄柏:拣去杂质，用水洗净，捞出，润透，切片或切丝，晒干；
28、桃仁:除去硬壳杂质，置沸水锅中煮至外皮微皱，捞出，浸入凉水中，搓去种皮，晒干，簸净；
29、红花:拣净杂质，除去茎叶、蒂头，晒干；
30、丹参:拣净杂质，除去根茎，洗净，捞出，润透后切片，晾干。
[0008] 二、制备
1、将所述重量的人参、黄芪、白术、当归、茯苓、白芍、柴胡、香附、郁金、甘草、黄精、远志、水菖蒲、酸率仁、合欢皮、熟地黄、葛根、鸡血藤、花斑叶、龙胆草、黄岑、桅子、牡丹皮、大黄、生地黄、知母、黄柏、桃仁、红花、丹参药物加水煎煮2次，第一次加水6倍量，浸泡120分钟后，武火煎煮沸腾10分钟，再用文火煎煮25分钟，过滤得第一次煎煮液。
[0009] 2、将过滤的药渣加水4倍量，先用急火煮沸，再用文火煎煮20分钟，过滤得第二次煎煮液。
[0010] 3、将两次煎煮液进行混合搅拌均匀，分成4剂服用。
[0011] 本发明药物具有补血和血，大补元气，固脱生津的功效，治疗慢性疲劳综合症见效快、疗程短，不复发。
[0012] 以下通过试验例来进一步阐述本发明药物的有益效果，这些试验包括本发明药物的动物毒性试验报告和临床观察资料。
[0013][试验例I]本发明药物的动物毒性试验报告
取家兔30只，雌雄兼用，体重2.0-2.4kg，分两组，每组15只，其中一组为超剂量试验组，另一组为正常量试验组。超常量组为20ml/kg，正常量为10ml/kg，给药方式为灌胃法给药，每天2次，连服7天，每天观察给药反应，结果表明二组家兔活动、饮食正常，药物无不良毒副作用。[0014][试验例2]本发明药物的临床观察资料
1、一般资料
收治门诊患者169例。
[0015] 2、诊断标准
临床表现:慢性疲劳综合症这一概念最早是由美国全国疾病控制中心于1987年正式命名的。现在美国疾病控制中心采用的是1994年国际慢性疲劳综合征小组的会议上对慢性疲劳综合症的解释:
排除其它疾病的情况下疲劳持续6个月或者以上，并且至少具备以下症状中的四项:
(1)短期记忆力减退或者注意力不能集中；
(2)咽痛；
(3)淋巴结痛；
(4)肌肉酸痛；
(5)不伴有红肿的关节疼痛；
(6)新发头痛；
(7)睡眠后精力不能恢复；· (8)体力或脑力劳动后连续24小时身体不适。
[0016] 临床医生常常将其误诊为神经衰弱、更年期综合征、内分泌失调、神经官能症等，延误了治疗。
[0017] 3、治疗方法
选用上述药剂，给患者服用，每次服用I剂，每天早、晚各服I次，7天为一个疗程，连续服用5个疗程。
[0018] 4、疗效评定标准
显效:症状消失，体质恢复正常，观察一年无复发者；
好转:病情明显好转，症状逐渐消失；
无效:达不到好转标准者。
[0019] 5、治疗结果(见下表)
在上述的治疗中，用本发明药物治疗慢性疲劳综合症患者169例，结果显效161例，显效率为95.27%，好转5例，好转率为2.96%，无效3例，总有效率为98.23%。
Claims (3)
1.一种治疗慢性疲劳综合症的药物，其特征在于:它是由下列重量范围内的原料药制成: 人参10-20克黄芪10-20克白术10-20克 当归10-20克茯苓10-20克白芍10-20克 柴胡5-15克香附15-25克郁金5-15克 甘草5-15克黄精15-25克远志5-15克 水菖蒲5-15克酸枣仁15-25克合欢皮5-15克 熟地黄5-15克葛根15-25克鸡血藤5-15克 花斑叶10-20克龙胆草10-20克黄芩10-20克 桅子10-20克牡丹皮10-20克大黄10-20克 生地黄5-15克知母15-25克黄柏5-15克 桃仁10-20克红花10-20克丹参10-20克。
2.根据权利要求1所述的药物，其中各原料药的用量为: 人参15克黄芪15克白术15克 当归15克茯苓15克 郁金10克 甘草10克黄精20克远志10克 水菖蒲10克酸枣仁20克合欢皮10克 熟地黄10克葛根20克鸡血藤10克 花斑叶15克龙胆草15克黄芩15克 桅子15克牡丹皮15克大黄15克 生地黄10克知母20克黄柏10克 桃仁15克红花15克丹参15克。
3.根据权利要求1或2所述药物的制备方法，它包括下列步骤: (一)备料 (10人参:除去芦头，切段或以湿布包裹，润软后切片，晾干； (2)黄芪:拣净杂质，除去残留的根头和空心较大者，用水浸泡，捞出，润透后及时切片，晒干； (3)白术:先将麸皮撒于热锅内，候烟冒出时，将白术片倒入微炒至淡黄色，取出，筛去麸皮后放凉，每白术片100斤，用麸皮10斤； (4)当归:拣去杂质，洗净，闷润，稍晾，切片晒干； (5 )茯苓:用水浸泡，洗净捞出，闷透后，切片，晒干； (6)白芍:拣去杂质，分开大小个，用水浸泡至八成透，捞出，晒晾，润至内外湿度均匀，切片，干燥； (7)柴胡:拣去杂质，去芦，用水洗净，稍浸泡捞出，润透，切片，晒干； (8)香附:拣去杂质，碾成碎粒，簸去细毛及细末； (9)郁金:用水浸泡,洗净,捞出晒晾,润透,切片，晒干； (10)甘草:拣去杂质，洗净，用水浸泡至八成透时，捞出，润透，切片，凉干； (11)黄精:洗净泥土，略润，切片，晒干；(12)远志:拣去杂质，切段，筛去灰屑； (13)水菖蒲:取原药材，除去芦衣、杂质，洗净，润透，切厚片，低温干燥； (14)酸枣仁:原药放入竹萝内，沉入清水缸中，使仁浮在水面，壳沉水底，将刺仁捞出，晒干； (15)合欢皮:清水浸泡洗净，捞出，闷润后先划成相等大的长条，再切块或切丝，干燥； (16)熟地黄:取原药材，蒸至表面乌黑色，取出，晒至八成干时，切片，干燥； (17)葛根:拣去杂质，洗净，用水浸泡，捞出，润透，及时切片，晒干； (18)鸡血藤:用水润透，切片，或蒸软后乘热切片，晒干； (19)花斑叶:拣去杂质，洗净晒干； (20)龙胆:拣去杂质，除去残茎，洗净，润透后切段，晒干； (21)黄芩:拣去杂质，除去残茎，用凉水浸润或置开水中稍浸捞出，切片，晒干； (22)桅子:筛去灰屑，拣去杂质，碾碎过筛或剪去两端； (23)牡丹皮:拣去杂质，除去木心，洗净，润透，切片，晾干； (24)大黄:拣净杂质，大小分档，焖润至内外湿度均匀，切片或切成小块、晒干； (25)生地黄:取原药材，除去杂质，洗净，稍润，切厚片，干燥，筛去碎屑； (26)知母:拣净杂质，用水撞洗，捞出，润软，切片晒干；` (27)黄柏:拣去杂质，用水洗净，捞出，润透，切片或切丝，晒干； (28)桃仁:除去硬壳杂质，置沸水锅中煮至外皮微皱，捞出，浸入凉水中，搓去种皮，晒干，簸净； (29)红花:拣净杂质，除去茎叶、蒂头，晒干； (30)丹参:拣净杂质，除去根茎，洗净，捞出，润透后切片，晾干； (二)制备 (1)将所述重量的人参、黄芪、白术、当归、茯苓、白芍、柴胡、香附、郁金、甘草、黄精、远志、水菖蒲、酸率仁、合欢皮、熟地黄、葛根、鸡血藤、花斑叶、龙胆草、黄岑、桅子、牡丹皮、大黄、生地黄、知母、黄柏、桃仁、红花、丹参药物加水煎煮2次，第一次加水6倍量，浸泡120分钟后，武火煎煮沸腾10分钟，再用文火煎煮25分钟，过滤得第一次煎煮液； (2)将过滤的药渣加水4倍量，先用急火煮沸，再用文火煎煮20分钟，过滤得第二次煎煮液； (3 )将两次煎煮液进行混合搅拌均匀，分成4剂服用。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410040774.7A CN103736037A (zh) | 2014-01-28 | 2014-01-28 | 一种治疗慢性疲劳综合症的药物及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410040774.7A CN103736037A (zh) | 2014-01-28 | 2014-01-28 | 一种治疗慢性疲劳综合症的药物及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103736037A true CN103736037A (zh) | 2014-04-23 |
Family
ID=50493153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410040774.7A Pending CN103736037A (zh) | 2014-01-28 | 2014-01-28 | 一种治疗慢性疲劳综合症的药物及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103736037A (zh) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104082745A (zh) * | 2014-07-10 | 2014-10-08 | 山西大学 | 用于血瘀体质调理和提高免疫调节能力的药膳及制备方法 |
| CN105055954A (zh) * | 2015-08-19 | 2015-11-18 | 孙秀梅 | 一种用于治疗慢性疲劳综合征的中药制剂及制备方法 |
| CN105232659A (zh) * | 2015-11-10 | 2016-01-13 | 首都医科大学附属北京中医医院 | 一种疏肝健脾的中药组合物及其制备方法 |
| CN105233207A (zh) * | 2015-10-19 | 2016-01-13 | 南阳医学高等专科学校 | 一种缓压舒心健脑益智的中药组合物 |
| CN105833184A (zh) * | 2016-05-09 | 2016-08-10 | 三峡大学 | 一种中药组合物、其制备的发酵药液及制备方法与应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1395946A (zh) * | 2002-07-08 | 2003-02-12 | 李军 | 治疗疲劳的纯中药制剂 |
| CN1569107A (zh) * | 2004-05-08 | 2005-01-26 | 河北世济唐威药业有限公司 | 一种治疗慢性疲劳综合症的药物及其制作方法 |
| CN101757231A (zh) * | 2008-11-07 | 2010-06-30 | 唐超 | 一种治疗慢性疲劳综合症的中药丸剂 |
-
2014
- 2014-01-28 CN CN201410040774.7A patent/CN103736037A/zh active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1395946A (zh) * | 2002-07-08 | 2003-02-12 | 李军 | 治疗疲劳的纯中药制剂 |
| CN1569107A (zh) * | 2004-05-08 | 2005-01-26 | 河北世济唐威药业有限公司 | 一种治疗慢性疲劳综合症的药物及其制作方法 |
| CN101757231A (zh) * | 2008-11-07 | 2010-06-30 | 唐超 | 一种治疗慢性疲劳综合症的中药丸剂 |
Non-Patent Citations (1)
| Title |
|---|
| 战雅莲等: "《慢性疲劳综合征的自我调护》", 31 May 2008, article "37", pages: 111-112 * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104082745A (zh) * | 2014-07-10 | 2014-10-08 | 山西大学 | 用于血瘀体质调理和提高免疫调节能力的药膳及制备方法 |
| CN104082745B (zh) * | 2014-07-10 | 2016-06-29 | 山西大学 | 用于血瘀体质调理和提高免疫调节能力的药膳及制备方法 |
| CN105055954A (zh) * | 2015-08-19 | 2015-11-18 | 孙秀梅 | 一种用于治疗慢性疲劳综合征的中药制剂及制备方法 |
| CN105233207A (zh) * | 2015-10-19 | 2016-01-13 | 南阳医学高等专科学校 | 一种缓压舒心健脑益智的中药组合物 |
| CN105233207B (zh) * | 2015-10-19 | 2020-10-13 | 南阳医学高等专科学校 | 一种缓压舒心健脑益智的中药组合物 |
| CN105232659A (zh) * | 2015-11-10 | 2016-01-13 | 首都医科大学附属北京中医医院 | 一种疏肝健脾的中药组合物及其制备方法 |
| CN105232659B (zh) * | 2015-11-10 | 2018-09-11 | 首都医科大学附属北京中医医院 | 一种疏肝健脾的中药组合物及其制备方法 |
| CN105833184A (zh) * | 2016-05-09 | 2016-08-10 | 三峡大学 | 一种中药组合物、其制备的发酵药液及制备方法与应用 |
| CN105833184B (zh) * | 2016-05-09 | 2019-07-26 | 三峡大学 | 一种中药组合物、其制备的发酵药液及制备方法与应用 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103610978B (zh) | 一种治疗失眠的药物及其制备方法 | |
| CN103479896B (zh) | 一种治疗脑血栓的药物及其制备方法 | |
| CN102648946A (zh) | 熥敷热疗液及其制备方法 | |
| CN103736037A (zh) | 一种治疗慢性疲劳综合症的药物及其制备方法 | |
| CN103736036A (zh) | 一种治疗非酒精性脂肪性肝病的药物及其制备方法 | |
| CN103751682B (zh) | 一种治疗肺热咳嗽的药物及其制备方法 | |
| CN103656406B (zh) | 一种治疗肺结核的药物及其制备方法 | |
| CN103977306A (zh) | 一种治疗乙型肝炎的药物及其制备方法 | |
| CN104107362A (zh) | 一种治疗脾虚生湿型外阴湿疹的中药配方 | |
| CN105362889A (zh) | 一种治疗耳鸣的药物及其制备方法 | |
| CN103735934B (zh) | 一种治疗腰部疼痛的药物及其制备方法 | |
| CN102872351B (zh) | 一种治疗甲状腺炎的药物及其制备方法 | |
| CN102872443B (zh) | 一种治疗偏头痛的药物及其制备方法 | |
| CN103550694A (zh) | 一种治疗脱发的药物及其制备方法 | |
| CN103961616A (zh) | 一种治疗过敏性咳嗽的药物及其制备方法 | |
| CN103751730B (zh) | 一种治疗单纯性肥胖症的药物及其制备方法 | |
| CN105457001A (zh) | 一种治疗小儿多动症的药物及其制备方法 | |
| CN103735916B (zh) | 一种治疗肾病综合症的药物及其制备方法 | |
| CN103263555B (zh) | 一种治疗功能失调性子宫出血的药物及其制备方法 | |
| CN103263575B (zh) | 一种治疗头痛的药物及其制备方法 | |
| CN104056224A (zh) | 一种治疗习惯性流产的药物及其制备方法 | |
| CN103961566A (zh) | 一种治疗高血压的药物及其制备方法 | |
| CN103735833B (zh) | 一种治疗小儿脱发的药物及其制备方法 | |
| CN106668664A (zh) | 一种治疗原发性血小板增多症的药物及其制备方法 | |
| CN105412830A (zh) | 一种治疗急性黄疸型肝炎的药物及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140423 |