CN105435111A - 一种治疗银屑病的药物及其制备方法 - Google Patents

一种治疗银屑病的药物及其制备方法 Download PDF

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CN105435111A
CN105435111A CN201510985240.6A CN201510985240A CN105435111A CN 105435111 A CN105435111 A CN 105435111A CN 201510985240 A CN201510985240 A CN 201510985240A CN 105435111 A CN105435111 A CN 105435111A
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王莉
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王莉
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Abstract

本发明公开了一种治疗银屑病的药物及其制备方法,其主要是由乌梢蛇、白鲜皮、地肤子、丹参、马齿苋、生地黄、板蓝根、鸡血藤、玄参、薏苡仁、葛根、何首乌、茜草、白花蛇舌草、秦艽、赤芍、僵蚕、蝉蜕、黄芩、槐花、白茅根、牛膝、玉竹、麦冬、菊花、牛蒡子、乌梅、苦参按一定重量配比制备而成。本发明药物具有疏风清热,清热凉血,散瘀止痛,活血调经,泻实火,除湿热,解毒的功能,用于治疗银屑病见效快、疗效好,不复发。

Description

一种治疗银屑病的药物及其制备方法
技术领域
[0001] 本发明涉及一种治疗银肩病的药物及其制备方法,属中药领域。
背景技术
[0002] 银肩病又称牛皮癣,是一种慢性炎症性皮肤病,病程较长,有易复发倾向,有的病 例几乎终生不愈。该病发病以青壮年为主,对患者的身体健康和精神状况影响较大。中医则 认为银肩病与湿毒内蕴,血瘀络脉,湿热内蕴,血燥血亏有关。由于西药治疗副作用大,因此 人们对有效治疗银肩病的中药药物存在极大的需求,至今为止,还没有发现关于本发明的 有关报道。
发明内容
[0003] 本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗银肩 病的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种有效治疗银肩病的中药组合药物。
[0005] 本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006] 本发明药物是选择乌梢蛇、白鲜皮、地肤子、丹参、马齿苋、生地黄、板蓝根、鸡血 藤、玄参、薏该仁、葛根、何首乌、茜草、白花蛇舌草、秦充、赤苟、僵蚕、蝴銳、黄苳、槐花、白茅 根、牛膝、玉竹、麦冬、菊花、牛蒡子、乌梅、苦参、茺蔚子、郁金、知母进行组合制备的,将这些 药物组合使得各药物功效产生协同作用,从而能够有效治疗银肩病。其中,选用乌梢蛇是因 为其性味甘,平,归肝经,有祛风活络,镇痉,治风湿痹痛,四肢麻木,抽搐痉挛,皮肤瘙痒,麻 风。选用白鲜皮是因为其性味苦,咸,寒,入脾、胃经,有祛风,燥湿,清热,解毒的功能,治风 热疮毒,疥癣,皮肤痒疹,风湿痹痛,黄疸。选用地肤子是因为其性味甘苦,寒,入肾、膀胱经, 有利小便,清湿热的功能,治小便不利,淋病,带下,疝气,风疹,疮毒,疥癣,阴部湿痒。选用 丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞 痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。 选用马齿苋是因为其性味酸,寒,入大肠、肝、脾经,有清热解毒,散血消肿的功能,治热痢脓 血,热淋,血淋,带下,痈肿恶疮,丹毒,瘰疬。选用生地黄是因为其性味甘,寒,归心、肝、肾 经,有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内热消渴,吐血,衄 血,发斑发疹。选用板蓝根是因为其性味苦,寒,入肝、胃血分,有清热,解毒,凉血的功能,治 流感,流脑,乙脑,肺炎,丹毒,热毒发斑,神昏吐衄,咽肿,痄腮,火眼,疮疹。选用鸡血藤是因 为其性味苦甘,温,入心、脾二经,有活血、舒筋的功能,治腰膝酸痛,麻木瘫痪,月经不调。选 用玄参是因为其性味苦,咸,凉,入肺、肾经,有滋阴,降火,除烦,解毒的功能,治热病烦渴, 发斑,骨蒸劳热,夜寐不宁,自汗盗汗,津伤便秘,吐血衄血,咽喉肿痛,痈肿,瘰疬。选用薏苡 仁是因为其性味甘淡,凉,入脾、肺、肾经,有健脾,补肺,清热,利湿的功能,治泄泻,湿痹,筋 脉拘挛,屈伸不利,水肿,脚气,肺痿,肺痈,肠痈,淋浊,白带。选用葛根是因为其性味甘辛, 平,入脾、胃经,有升阳解肌,透疹止泻,除烦止渴的功能,治伤寒,温热,头痛,项强,烦热消 喝,泄泻,痢疾,癍诊不透,高血压,心绞痛,耳聋。选用何首乌是因为其性味苦甘涩,微温,入 肝、肾经,有补肝,益肾,养血,祛风的功能,治肝肾阴亏,发须早白,血虚头晕,腰膝软弱,筋 骨酸痛,遗精,崩带,久疟,久痢,慢性肝炎,痈肿,瘰疬,肠风,痔疾。选用茜草是因为其性味 苦,寒,有凉血止血,祛瘀通经的功能,治吐血,衄血,崩漏,外伤出血,瘀阻经闭,关节痹痛, 跌扑肿痛。选用白花蛇舌草是因为其性味苦甘,寒,入心、肝、脾三经,有清热,利湿,解毒的 功能,治肺热喘咳,扁桃体炎,咽喉炎,阑尾炎,痢疾,黄疸,盆腔炎,附件炎,痈肿疔疮,毒蛇 咬伤。选用秦艽是因为其性味苦辛,平,入肝、胃、胆经,有祛风除湿,和血舒筋,清热利尿的 功能,治风湿痹痛,筋骨拘挛,黄疸,便血,骨蒸潮热,小儿疳热,小便不利。选用赤芍是因为 其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛, 肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用僵蚕是因为其性味辛、咸,平,归 肝,肺经。祛风解痉,化痰散结。用于中风口眼歪斜,惊痫抽搐,头赐,喉痹,瘰疠结核,风疹丹 毒。选用蝉蜕是因为其性味甘咸,凉,入肺、肝经,有散风热,宣肺,定痉的功能,治外感风热, 咳嗽音哑,麻疹透发不畅,风疹瘙痒,小儿惊癎,目赤,翳障,疔疮肿毒,破伤风。选用黄芩是 因为其性味苦寒,入心肺、胆、大肠经,有泻实火,除湿热,止血安胎的功能,治壮热烦渴,肺 热咳嗽。选用槐花是因为其性味苦,凉,入肝、大肠经,有清热,凉血,止血的功能,治肠风便 血,痔血,尿血,血淋,崩漏,衄血,赤白痢下,风热目赤,痈疽疮毒,并用于预防中风。选用白 茅根是因为其性味甘、寒,入肺、胃、小肠经,有凉血,止血,清热,利尿的功能,治热病烦渴, 吐血,衄血,肺热喘急,胃热哕逆,淋病,小便不利,水肿,黄疸。选用牛膝是因为其性味甘苦 酸,平,入肝、肾经,生用散瘀血,消痈肿的功能,治淋病,尿血,经闭,癥瘕,难产,胞衣不下, 产后瘀血腹痛,喉痹,痈肿,跌打损伤,熟用补肝肾,强筋骨,治腰膝骨痛,四肢拘挛,痿痹。选 用玉竹是因为其性味甘,平,入肺,胃经,有养阴,润燥,除烦,止渴的功能,治热病阳伤,咳 嗽,烦渴,虚劳发热,消谷易饥,小便频数。选用麦冬是因为其性味甘微苦,寒,入肺、胃、心 经,有养阴润肺,清心、除烦,益胃生津的功能,治肺燥干咳,吐血,略血,肺痿,肺痈,虚劳烦 热,清渴,热病津伤,咽干口燥,便秘。选用菊花是因为其性味甘苦,凉,入肺,肝经,有疏风, 消热,明目,解毒的功能,治头痛,眩晕,目赤,心胸烦热,疔疮,肿毒。选用牛蒡子是因为其性 味辛苦,凉,入肺、胃经,有疏散风热,宣肺透疹,消肿解毒的功能,治风热咳嗽,咽喉肿痛,斑 疹不透,风疹作痒,痈肿疮毒。选用乌梅是因为其性味酸,温,入肝,脾,肺,大肠经,有收敛生 津,安蛔驱虫的功能,治久咳,虚热烦渴,久疟,痢疾,便血,尿血,血崩,蛔厥腹痛,呕吐,钩虫 病,牛皮癣,胬肉。选用苦参是因为其性味苦,寒,入肝、肾、大肠、小肠经,有清热,燥湿,杀虫 的功能,治热毒血痢,肠风下血,黄疸,赤白带下,小儿肺炎,疳积,急性扁桃体炎,痔漏,脱 肛,皮肤瘙痒,阴疮湿痒,瘰疬,烫伤。选用茺蔚子是因为其性味甘辛,凉,入心胞、肝经,有活 血调经,疏风清热的功能,治妇女月经不调,崩中带下,产后瘀血作痛,肝热头痛,目赤肿痛, 或生翳膜。选用郁金是因为其性味辛苦,凉,入心、肺、肝经,有行气解随,凉血破瘀的功能, 治胸腹胁肋诸痛,失心癫狂,热病神昏,吐血,衄血,尿血,血淋,妇女倒经,黄疸。选用知母是 因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺 热咳嗽,大便燥结,小便不利。
具体实施方式
[0007]本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下 述重量范围内都具有较好的疗效: 乌梢蛇10-20克,白鲜皮15-25克,地肤子15-25克,丹参10-20克,马齿苋10-20克,生地 黄10-20克,板蓝根5-15克,鸡血藤10-20克,玄参5-15克,薏苡仁15-25克,葛根10-20克,何 首乌10-15克,茜草10-20克,白花蛇舌草15-25克,秦艽10-20克,赤芍15-25克,僵蚕10-15 克,蝉蜕5-15克,黄芩10-20克,槐花10-20克,白茅根15-25克,牛膝5-10克,玉竹5-15克,麦 冬10-15克,菊花5-15克,牛蒡子10-15克,乌梅10-20克,苦参5-15克,茺蔚子10-20克,郁金 5-15克,知母5-15克。
[0008] 优选为: 乌梢蛇15克,白鲜皮20克,地肤子20克,丹参15克,马齿苋15克,生地黄15克,板蓝根10 克,鸡血藤15克,玄参10克,薏苡仁20克,葛根15克,何首乌12克,茜草15克,白花蛇舌草20 克,秦艽15克,赤芍20克,僵蚕12克,蝉蜕10克,黄芩15克,槐花15克,白茅根20克,牛膝10克, 玉竹10克,麦冬12克,菊花10克,牛蒡子12克,乌梅15克,苦参10克,茺蔚子15克,郁金10克, 知母10克。
[0009] 本发明药物的制备方法如下 一、备料 1、 乌梢蛇:取原药材,刷去灰肩,用时去头、鳞,切段; 2、 白鲜皮:拣净杂质,除去粗皮,洗净,稍润,切片,晒干; 3、 地肤子:取原药材,除去杂质,筛去碎肩; 4、 丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干; 5、 马齿苋:拣净杂质,除去残根,以水稍润,切段晒干; 6、 生地黄:除去杂质,洗净,稍润,切厚片,干燥,筛去碎肩; 7、 板蓝根:拣净杂质,洗净,润透,切片,晒干; 8、 鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干; 9、 玄参:拣净杂质,除去芦头,洗净润透,切片,晾干; 10、 意该仁:取原药材,除去残留皮壳、杂质; 11、 葛根:拣去杂质,洗净,用水浸泡,捞出,润透,及时切片,晒干; 12、 何首乌:拣去杂质,洗净,用水泡至八成透,捞出,润至内外湿度均匀,切片或切成方 块,晒干; 13、 茜草:除去杂质,洗净,润透,切厚片或段,干燥,筛去碎肩; 14、 白花蛇舌草:取原药材,除去杂质,抢水洗净,稍晾,切段,干燥,筛去灰肩; 15、 秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干; 16、 赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎肩; 17、 僵蚕:取原药材,除去残丝,杂质; 18、 蝉蜕:拣去杂质,洗净晒干; 19、 黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干; 20、 槐花:取原药材,除去梗、叶及杂质,筛去灰肩; 21、 白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎肩; 22、 牛膝:拣去杂质,洗净,润软,去芦,切段,晒干; 23、 玉竹:除去杂质,洗净泥土,闷润至内外湿度均匀,切片,晒干; 24、 麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干; 25、 菊花:拣净叶梗、花柄及泥肩杂质; 26、 牛蒡子:拣去杂质,筛去泥肩; 27、 乌梅:拣净杂质,筛去灰肩,洗净,晒干; 28、 苦参:拣净杂质,除去残茎,洗净泥土,用水浸泡,捞出,润透,切片,晒干; 29、 宪蔚子:果实成熟时割取全株,晒干,打下果实,拣去枝叶,筛净杂质; 30、 郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干; 31、 知母:拣净杂质,用水撞洗,捞出,润软,切片晒干; 二、制备 1、 将炮制好的乌梢蛇、白鲜皮、地肤子、丹参、马齿苋、生地黄、板蓝根、鸡血藤、玄参、薏 苡仁、葛根、何首乌、茜草、白花蛇舌草、秦充、赤苟、僵蚕、蝴虫兑、黄苳、槐花、白茅根、牛膝、玉 竹、麦冬、菊花、牛蒡子、乌梅、苦参、茺蔚子、郁金、知母放入煎药容器内,第一次加水8倍量, 浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮 液倒入容器内; 2、 将过滤的药渣加6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液; 3、 将两次煎煮液混合搅拌均匀,分为4剂服用。
[0010] 组方中赤芍有清热凉血,散瘀止痛的功能为君药;何首乌补肝,益肾,养血,祛风; 黄芩有泻实火,除湿热的功能,二者为臣药,三味药共同发挥清热凉血,散瘀止痛,补肝,益 肾,养血,祛风,泻实火,除湿热的作用,治疗银肩病效力全面,且以清热凉血,散瘀止痛,养 血,泻实火,除湿热为主可治本,菊花有疏风,消热,明目,解毒的功能为佐药,茺蔚子有活血 调经,疏风清热的功能为使药,与余下诸药是治标。
[0011] 本发明药物具有疏风清热,清热凉血,散瘀止痛,活血调经,泻实火,除湿热,解毒 的功能,用于治疗银肩病,疗程短、见效快、治愈后不复发。
[0012]
具体实施方式: 以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药 物的动物毒性试验报告和临床疗效观察资料。
[0013][试验例1]本发明药物的动物毒性试验报告: 取家兔30只,雌雄兼用,体重2.0-2.5kg,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。超常量组为20ml/kg,正常量为IOmVkg,给药方式为灌胃法给 药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良 毒副作用。
[0014][试验例2 ]本发明药物的临床疗效观察 1、一般资料 收治银肩病门诊患者共27例。
[0015] 2、诊断标准 典型症状为境界清楚、形状大小不一的红斑,周围有炎性红晕。稍有浸润增厚。表面覆 盖多层银白色鳞肩。鳞肩易于刮脱,刮净后淡红发亮的半透明薄膜,刮破薄膜可见小出血 点。皮损好发于头部、骶部和四肢伸侧面,部分患者自觉不同程度的瘙痒等症状。
[0016] 3、治疗方法 选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,10天为一个疗程,连续 服用3个疗程。
[0017] 4、疗效评定标准 显效:银肩病症状消失,体质恢复正常,痊愈; 好转:患者头部、躯干、骶部和四肢伸侧面皮损和瘙痒的症状减轻,银肩病症状明显好 转,体质逐步恢复; 无效:达不到好转标准者。
[0018] 5、治疗结果(见下表)
Figure CN105435111AD00081
在上述治疗中,用本发明药物治疗银肩病患者27例,结果显效22例,显效率为81.48%, 好转3例,好转率为11.11%,无效2例,总有效率为92.59%。

Claims (3)

1. 一种治疗银肩病的药物,其特征在于:它是由下列重量范围内的原料药制成: 乌梢蛇10-20克,白鲜皮15-25克,地肤子15-25克,丹参10-20克,马齿苋10-20克,生地 黄10-20克,板蓝根5-15克,鸡血藤10-20克,玄参5-15克,薏苡仁15-25克,葛根10-20克,何 首乌10-15克,茜草10-20克,白花蛇舌草15-25克,秦艽10-20克,赤芍15-25克,僵蚕10-15 克,蝉蜕5-15克,黄芩10-20克,槐花10-20克,白茅根15-25克,牛膝5-10克,玉竹5-15克,麦 冬10-15克,菊花5-15克,牛蒡子10-15克,乌梅10-20克,苦参5-15克,茺蔚子10-20克,郁金 5-15克,知母5-15克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 乌梢蛇15克,白鲜皮20克,地肤子20克,丹参15克,马齿苋15克,生地黄15克,板蓝根10 克,鸡血藤15克,玄参10克,薏苡仁20克,葛根15克,何首乌12克,茜草15克,白花蛇舌草20 克,秦艽15克,赤芍20克,僵蚕12克,蝉蜕10克,黄芩15克,槐花15克,白茅根20克,牛膝10克, 玉竹10克,麦冬12克,菊花10克,牛蒡子12克,乌梅15克,苦参10克,茺蔚子15克,郁金10克, 知母10克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (一)备料 (I) 乌梢蛇:取原药材,刷去灰肩,用时去头、鳞,切段; (2 )白鲜皮:拣净杂质,除去粗皮,洗净,稍润,切片,晒干; (3) 地肤子:取原药材,除去杂质,筛去碎肩; (4) 丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干; (5) 马齿苋:拣净杂质,除去残根,以水稍润,切段晒干; (6) 生地黄:除去杂质,洗净,稍润,切厚片,干燥,筛去碎肩; (7 )板蓝根:拣净杂质,洗净,润透,切片,晒干; (8) 鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干; (9) 玄参:拣净杂质,除去芦头,洗净润透,切片,晾干; (10) 意该仁:取原药材,除去残留皮壳、杂质; (II) 葛根:拣去杂质,洗净,用水浸泡,捞出,润透,及时切片,晒干; (12) 何首乌:拣去杂质,洗净,用水泡至八成透,捞出,润至内外湿度均匀,切片或切成 方块,晒干; (13) 茜草:除去杂质,洗净,润透,切厚片或段,干燥,筛去碎肩; (14) 白花蛇舌草:取原药材,除去杂质,抢水洗净,稍晾,切段,干燥,筛去灰肩; (15) 秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干; (16) 赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎肩; (17) 僵蚕:取原药材,除去残丝,杂质; (18) 蝉蜕:拣去杂质,洗净晒干; (19) 黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干; (20) 槐花:取原药材,除去梗、叶及杂质,筛去灰肩; (21) 白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎肩; (22 )牛膝:拣去杂质,洗净,润软,去芦,切段,晒干; (23)玉竹:除去杂质,洗净泥土,闷润至内外湿度均匀,切片,晒干; (24)麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干; (25)菊花:拣净叶梗、花柄及泥肩杂质; (26)牛蒡子:拣去杂质,筛去泥肩; (27)乌梅:拣净杂质,筛去灰肩,洗净,晒干; (28) 苦参:拣净杂质,除去残茎,洗净泥土,用水浸泡,捞出,润透,切片,晒干; (29)茺蔚子:果实成熟时割取全株,晒干,打下果实,拣去枝叶,筛净杂质; (30)郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干; (31)知母:拣净杂质,用水撞洗,捞出,润软,切片晒干; (二)制备 (1) 将炮制好的乌梢蛇、白鲜皮、地肤子、丹参、马齿苋、生地黄、板蓝根、鸡血藤、玄参、 薏苡仁、葛根、何首乌、茜草、白花蛇舌草、秦艽、赤芍、僵蚕、蝉蜕、黄芩、槐花、白茅根、牛膝、 玉竹、麦冬、菊花、牛蒡子、乌梅、苦参、茺蔚子、郁金、知母放入煎药容器内,加水8倍量,浸泡 100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒 入容器内; (2) 将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液; (3)将两次煎煮液混合搅拌均匀,分为4剂服用。
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