CN105381416A - 一种治疗上消化道出血的药物及其制备方法 - Google Patents

一种治疗上消化道出血的药物及其制备方法 Download PDF

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CN105381416A
CN105381416A CN201510984669.3A CN201510984669A CN105381416A CN 105381416 A CN105381416 A CN 105381416A CN 201510984669 A CN201510984669 A CN 201510984669A CN 105381416 A CN105381416 A CN 105381416A
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张永红
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张永红
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Abstract

本发明公开了一种治疗上消化道出血的药物及其制备方法,其主要是由海螵蛸、花蕊石、地榆、墨旱莲、大黄、甘草、茜草、牡丹皮、牡蛎、川楝子、白及、代赭石、白术、芡实、莲子、阿胶、川贝母、仙鹤草、瓦楞子、郁金、黄连、五倍子、牛膝、人参、白矾、石膏、麦冬、山药、薏苡仁按一定重量配比制备而成。本发明药物具有止血,健胃,降湿热,清肝火,补气血,益脾和胃的功能,用于治疗上消化道出血见效快、疗效好,不复发。

Description

-种治疗上消化道出血的药物及其制备方法
技术领域
[0001] 本发明设及一种治疗上消化道出血的药物及其制备方法,属中药领域。
背景技术
[0002] 上消化道出血是指屈氏初带W上的消化道,包括食管、胃、十二指肠或膜胆等病变 引起的出血,胃空肠吻合术后的空肠病变出血亦属运一范围。中医则认为上消化道出血与 肝火犯胃,气虚血溢,胃热塞盛有关。由于西药治疗副作用大,因此人们对有效治疗上消化 道出血的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
[0003] 本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗上消 化道出血的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种有效治疗上消化道出血的中药组合药物。
[0005] 本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006] 本发明药物是选择海螺峭、花蕊石、地愉、墨旱莲、大黄、甘草、茜草、牡丹皮、牡颇、 川棟子、白及、代髓石、白术、巧实、莲子、阿胶、川贝母、仙鹤草、瓦愣子、郁金、黄连、五倍子、 牛膝、人参、白抓、石膏、麦冬、山药、慧巧仁、山植、巧等、侧柏叶药物进行组合制备的,将运 些药物组合使得各药物功效产生协同作用,从而能够有效治疗上消化道出血。其中,选用海 螺峭是因为其性味咸,微溫,入肝、肾经,有除湿,制酸,止血,敛疮的功能,治胃痛吞酸,吐、 赃、呕血,便血,崩漏带下,血枯经闭,腹痛瘤瘤,虚追泻频,阴蚀烂疮。选用花蕊石是因其性 味酸,涩,平,无毒。有化疲,止血,主吐血,赃血,便血,崩漏,产妇血晕,死胎,胞衣不下,金 疮出血。选用地愉是因为其性味苦酸,寒,入肝、大肠经,有凉血止血,清热解毒的功能,治吐 血,赃血,血频,崩漏,肠风,持漏,痴肿,湿疹,金疮,烧伤。选用墨旱莲是因为其性味苦酸, 凉,入肝、肾经,有凉血,止血,补肾,益阴的功能,治吐血,咳血,赃血,尿血,便血,血频,刀伤 出血,须发早白,白喉,淋浊,滞下,阴部湿痒。选用大黄是因为其性味苦、寒,入胃、大肠、肝 径,有泻热毒,破积滞,行疲血的功能,治实热便秘,檐语发狂,食积瘡满,频疾初起,里急后 重,疲停经闭,瘤瘤积聚,时行热疫,暴眼赤痛,吐血,赃血,阳黄,水肿,淋浊,瘦赤,痴瘍肿 毒,疗疮,汤火伤。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调 和诸药的功能,炙用治脾胃虚弱,食少,腹痛便漉,劳倦发热,肺瘦咳嗽,屯、惇,惊痴,生用治 咽喉肿痛,消化性溃瘍,痴痘疮瘍,解药毒及食物中毒。选用茜草是因为其性味苦,寒,有凉 血止血,桂疲通经的功能,治吐血,赃血,崩漏,外伤出血,疲阻经闭,关节搏痛,跌扑肿痛。选 用牡丹皮是因为其性味辛苦,凉,入屯、、肝、肾经,有清热,凉血,和血,消疲的功能,治热入血 分,发斑,惊癖,吐、赃、便血,骨蒸劳热,经闭,瘤瘤,痴瘍,扑损。选用牡颇是因为其性味咸 涩,凉,入肝、肾经,有敛阴,潜阳,止汗,涩精,化疲,软坚的功能,治惊癖,眩晕,自汗,盗汗, 遗精,淋浊,崩漏,带下,療痛,瘦瘤。选用川棟子是因为其性味苦,寒,有毒,入肝、胃、小肠 经,有降湿热,清肝火,止痛,杀虫的功能,治热厥屯、痛,胁痛,痛痛,虫积腹痛。选用白及是因 为其性味苦甘,凉,入肺经,有补肺,止血,消肿,生观,敛疮的功能,治肺伤咳血,赃血,金疮 出血,痴痘肿毒,溃瘍疼痛,汤火灼伤,手足薇裂。选用代髓石是因为其性味苦、甘,微寒,归 肝、胃、屯、经,有平肝潜阳,重镇降逆,凉血止血的功能,治头前眩晕,屯、惇,癒狂,惊痛,呕吐, 噫气,咳嗽气喘,吐血,鼻赃,崩漏,便血,尿血。选用白术是因为其性味苦甘,溫,入脾、胃经, 有补脾,益胃,燥湿,和中的功能,治脾胃气弱,不思饮食,倦怠少气,虚胀,泄泻,疲饮,水肿, 黄痘,湿搏,小便不利,头晕,自汗,胎气不安。选用巧实是因为其性味甘涩,平,入脾、肾经, 有固肾涩精,补脾止泄,治遗精,淋浊,带下,小便不禁,大便泄泻。选用莲子是因为其性味 甘涩,平,入屯、、脾、肾经,有养心益肾,补脾,涩肠的功能,治夜寐多梦,遗精,淋浊,久频,虚 泻,妇人崩漏带下。选用阿胶是因为其性味甘平,入肺、肝、肾经,有滋阴补血,安胎的功能, 治血虚,虚劳咳嗽,吐血、赃血、便血,妇女月经不调,崩中,治漏。选用川贝母是因为其性味 苦甘,凉,入肺经,有润肺散结,止嗽化疲的功能,治虚劳咳嗽,吐疲咯血,屯、胸郁结,肺瘦,肺 痴,瘦瘤,療痛,喉搏,乳痴。选用仙鹤草是因为其性味苦辛,平,入肺、肝、脾经,有止血,健胃 的功能,治咯血,吐血,尿血,便血,赤白频疾,崩漏带下,劳伤脱力,痴肿,跌打、创伤出血。选 用瓦愣子是因为其性味甘,咸,平,入肝、脾经,有化疲,软坚,散疲,消积的功能,治疲积,胃 痛,增杂,吐酸,瘤瘤,療痛,牙巧。选用郁金是因为其性味辛苦,凉,入屯、、肺、肝经,有行气解 随,凉血破疲的功能,治胸腹胁肋诸痛,失屯、癒狂,热病神昏,吐血,赃血,尿血,血淋,妇女倒 经,黄痘。选用黄连是因为其性味苦,寒,入屯、、肝、胃、大肠经,有泻火,燥湿,解毒,杀虫的功 能,治时行热毒、伤寒,热盛屯、烦,瘡满呕逆,菌频,热泻腹痛,肺结核,吐、赃、下血,消渴,巧 积,咖虫病,百日咳,咽喉肿痛,火眼,口疮,痴痘疮毒,湿疹,汤火烫伤。选用五倍子是因为其 性味酸,平。入肺,胃,大肠经。敛肺,涩肠,止血,解毒。治肺虚久咳,久频,久泻,脱肛,自 汗,盗汗,遗精,便血,赃血,崩漏,外伤出血,肿毒,疮巧,睫毛倒卷。选用川牛膝是因为其性 味平,味苦微苦,无毒,入肝、肾二经,有桂风,利湿,通经,活血的功能,治风湿腰膝疼痛,脚 瘦筋李,血淋,尿血,妇女经闭,瘤瘤。选用人参是因为其性味甘微甘,溫,入脾、肺经,有大补 元气,固脱生津,安神的功能,治劳伤虚损,食少,倦怠,反胃吐食,大便滑泄,虚咳喘促,自汗 暴脱,惊惇,健忘,眩晕头痛,阳萎,尿频,消渴,妇女崩漏,小儿慢惊及久虚不复,一切气血津 液不足之症。选用白抓是因为其性味酸涩,寒,有毒,入肺、脾、胃、大肠经,有消疲,燥湿,止 泻,解毒,杀虫的功能,治癒癖,喉搏,疲诞塞甚,肝炎,黄痘,黄肿,胃、十二指肠溃瘍,子宫脱 垂,白带,泻频,赃血,日舌生疮,疮持抓癖,7jC、火、虫伤。选用石膏是因为其性味辛甘,寒,入 肺、胃经,生用有解肌清热,除烦止渴的功能,治热病壮热不退,屯、烦神昏,檐语发狂,口渴咽 干,肺热喘急,中暑自汗,胃火头痛、牙痛,热毒塞盛,发斑发疹,口舌生疮,般敷生肌敛疮,外 治痴痘疮瘍,溃不收回,汤火烫伤。选用麦冬是因为其性味甘微苦,寒,入肺、胃、屯、经,有养 阴润肺,清屯、除烦,益胃生津的功能,治肺燥干咳,吐血,咯血,肺瘦,肺痴,虚劳烦热,清渴, 热病津伤,咽干口燥,便秘。选用山药是因为其性味甘,平,入肺、脾、肾经,有健脾,补肺,固 肾,益精的功能,治脾虚泄泻,久频,虚劳咳嗽,消渴,遗精、带下,小便频数。选用慧巧仁是 因为其性味甘淡,凉,入脾、肺、肾经,有健脾,补肺,清热,利湿的功能,治泄泻,湿搏,筋脉拘 李,屈伸不利,水肿,脚气,肺瘦,肺痴,肠痴,淋浊,白带。选用山植是因为其性味酸甘,微溫, 入脾、胃、肝经,有消食积,散疲血,驱缘虫的功能,治肉积,瘤瘤,疲饮,瘡满,吞酸,泻频,肠 风,腰痛,痛气,产后儿枕痛,恶露不尽,小儿乳食停滞。选用巧等是因为其性味甘淡,平,入 屯、、脾、肺经,有渗湿利水,益脾和胃,宁屯、安神的功能,治小便不利,水肿胀满,疲饮咳逆,呕 吵,泄泻,遗精,淋浊,惊惇,健忘。选用侧柏叶是因为其性味苦涩,寒,入屯、、肝、大肠经,有凉 血,止血,桂风湿,散肿毒的功能,治吐血,赃血,尿血,血频,肠风,崩漏,风湿搏痛,细菌性频 疾,高血压,咳嗽,丹毒,巧腮,烫伤。
具体实施方式
[0007]本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下 述重量范围内都具有较好的疗效: 海螺峭5-15克,花蕊石10-15克,地愉5-15克,墨旱莲10-20克,大黄5-15克,甘草 5-15克,茜草10-15克,牡丹皮5-15克,牡颇10-20克,川棟子5-10克,白及10-20克,代 髓石5-15克,白术5-15克,巧实10-20克,莲子10-15克,阿胶7-12克,川贝母5-15克,仙 鹤草10-20克,瓦愣子10-20克,郁金5-15克,黄连5-15克,五倍子5-10克,牛膝5-15克, 人参7-12克,白抓3-6克,石膏7-12克,麦冬5-15克,山药5-15克,慧巧仁10-15克,山植 10-20克,巧等5-15克,侧柏叶10-20克。
[000引优选为: 海螺峭10克,花蕊石15克,地愉10克,墨旱莲15克,大黄10克,甘草10克,茜草12 克,牡丹皮10克,牡颇15克,川棟子8克,白及15克,代髓石10克,白术10克,巧实15克, 莲子12克,阿胶9克,川贝母10克,仙鹤草15克,瓦愣子15克,郁金10克,黄连10克,五 倍子8克,牛膝10克,人参9克,白抓5克,石膏9克,麦冬10克,山药10克,慧巧仁12克, 山植15克,巧等10克,侧柏叶15克。
[0009]本发明药物的制备方法如下 一、备料 1、 海螺峭:刷洗干净,晒干,砸成小块; 2、 花蕊石:洗净,干燥,砸成碎块,研为细粉; 3、 地愉:炼去杂质,用水洗净,稍浸泡,润透,切成厚片,晒干; 4、 墨旱莲:炼净杂质,除去残根,洗净闷透,切段晒干; 5、 大黄:炼净杂质,大小分档,炯润至内外湿度均匀,切片或切成小块、晒干; 6、 甘草:炼去杂质,洗净,用水浸泡至八成透时,拱出,润透,切片,凉干; 7、 茜草:除去杂质,洗净,润透,切厚片或段,干燥,筛去碎屑; 8、 牡丹皮:炼去杂质,除去木屯、,洗净,润透,切片,惊干; 9、 牡颇:洗净,晒干,娠碎用; 10、 川棟子:炼去杂质,洗净,烘干,社碎或劈成两半; 11、 白及:炼去杂质,用水浸泡,拱出,惊至湿度适宜,切片,干燥; 12、 代髓石:取原药材,除去杂质,洗净,干燥,打成碎块; 13、 白术:炼净杂质,用水浸泡,泡后拱出,润透,切片,晒干; 14、 巧实:先将教皮放热锅内炒至烟起,再将净巧实倒入,拌炒至微黄色,取出,筛净教 皮,放凉; 15、 莲子:炼尽杂质,或砸碎、去皮、去屯、用; 16、 阿胶:捣碎用; 17、 川贝母:炼去杂质,用水浸泡,拱出,闷润,剥去屯、,晒干; 18、 仙鹤草:除去杂质残根,洗净,润透,切断,晒干; 19、 瓦愣子:洗净晒干,娠碎; 20、 郁金:用水浸泡,洗净,拱出晒惊,润透,切片,晒干; 21、 黄连:炼去杂质,洗净泥砂,润透,切片,阴干; 22、 五倍子:炼净、敲开、剔去其中杂质,研为细粉; 23、 牛膝:炼去杂质,洗净,润软,去芦,切段,晒干; 24、 人参:除去芦头,切段; 25、 白抓:炼净杂质,捣碎,研为细粉; 26、 石膏:去净杂石,洗净泥±,打碎成小块; 27、 麦冬:炼净杂质,用水浸泡,拱出,润透后抽去屯、,再洗净晒干; 28、 山药:炼净杂质,用水浸泡至山药中屯、部软化为止,拱出稍惊,切片晒干或烘干; 29、 慧巧仁:取原药材,除去残留皮壳、杂质; 30、 山植:炼净杂质,筛去核; 31、 侧柏叶:炼净杂质,揉碎去梗,筛净灰屑; 二、制备 1、 将炮制后的海螺峭、地愉、墨旱莲、大黄、甘草、茜草、牡丹皮、牡颇、川棟子、白及、代 髓石、白术、巧实、莲子、阿胶、川贝母、仙鹤草、瓦愣子、郁金、黄连、牛膝、人参、石膏、麦冬、 山药、慧巧仁、山植、巧等、侧柏叶放入煎药容器内,第一次加水8倍量,浸泡100分钟后,武 火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内, 2、 将过滤的药渣加6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液, 3、 将两次煎煮液混合揽拌均匀,分为4剂服用, 4、 将研为细粉末的花蕊石、五倍子、白帆用水调和制丸,分为四份,每次取一份与汤剂 同时服用。
[0010] 组方中仙鹤草有止血,健胃的功能为君药;茜草凉血止血,桂疲通经;川棟子有降 湿热,清肝火,止痛的功能,二者为臣药,Ξ味药共同发挥止血,健胃,凉血止血,桂疲通经, 降湿热,清肝火的作用,治疗上消化道出血效力全面,且W止血,健胃,降湿热,清肝火为主 可治本,阿胶有滋阴补血的功能为佐药,巧等有渗湿利水,益脾和胃的功能为使药,与余下 诸药是治标。
[0011] 本发明药物具有止血,健胃,降湿热,清肝火,补气血,益脾和胃的功能,用于治疗 上消化道出血,疗程短、见效快、治愈后不复发。
[0012] W下通过试验例来进一步阐述本发明所述药物的有益效果,运些试验例包括本发 明药物的动物毒性试验报告和临床疗效观察资料。
[0013] [试验例1]本发明药物的动物毒性试验报告: 取家兔30只,雌雄兼用,体重2. 0-2.化g,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。超常量组为20ml/kg,正常量为lOml/kg,给药方式为灌胃法给 药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不 良毒副作用。
[0014] [试验例2]本发明药物的临床疗效观察 1、一般资料 收治上消化道出血口诊患者共26例。
[001引2、诊断标准 典型症状为呕血和(或)黑粪,往往伴有血容量减少引起的急性周围循环衰竭,大出血 后均有失血性贫血,中度或大量出血病例,于24小时内发热,大量出血症状较明显,如头 晕、屯、惇、恶屯、、疲乏、嗜睡、脸色苍白、屯、率快、血压低等症状。
[001引3、治疗方法 选用上述药剂及丸剂,给患者服用,每次服用各1剂,每天早、晚各服1次,7天为一个疗 程,连续服用1个疗程。
[0017] 4、疗效评定标准 显效:上消化道出血症状消失,体质恢复正常,痊愈; 好转:患者呕血,便血,发热的症状减轻,上消化道出血症状明显好转,体质逐步恢复; 无效:达不到好转标准者。
[001引5、治疗结果(见下表)
Figure CN105381416AD00081
在上述治疗中,用本发明药物治疗上消化道出血患者26例,结果显效21例,显效率为 80. 76%,好转4例,好转率为15.38%,无效1例,总有效率为96.14%。

Claims (3)

1. 一种治疗上消化道出血的药物,其特征在于:它是由下列重量范围内的原料药制 成: 海螵蛸5-15克,花蕊石10-15克,地榆5-15克,墨旱莲10-20克,大黄5-15克,甘草 5-15克,茜草10-15克,牡丹皮5-15克,牡蛎10-20克,川楝子5-10克,白及10-20克,代 赭石5-15克,白术5-15克,芡实10-20克,莲子10-15克,阿胶7-12克,川贝母5-15克,仙 鹤草10-20克,瓦楞子10-20克,郁金5-15克,黄连5-15克,五倍子5-10克,牛膝5-15克, 人参7-12克,白矾3-6克,石膏7-12克,麦冬5-15克,山药5-15克,薏苡仁10-15克,山楂 10-20克,茯苓5-15克,侧柏叶10-20克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 海螵蛸10克,花蕊石15克,地榆10克,墨旱莲15克,大黄10克,甘草10克,茜草12 克,牡丹皮10克,牡蛎15克,川楝子8克,白及15克,代赭石10克,白术10克,芡实15克, 莲子12克,阿胶9克,川贝母10克,仙鹤草15克,瓦楞子15克,郁金10克,黄连10克,五 倍子8克,牛膝10克,人参9克,白矾5克,石膏9克,麦冬10克,山药10克,薏苡仁12克, 山楂15克,茯苓10克,侧柏叶15克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (一)备料 (1) 海螵蛸:刷洗干净,晒干,砸成小块; (2) 花蕊石:洗净,干燥,砸成碎块,研为细粉; (3) 地榆:拣去杂质,用水洗净,稍浸泡,润透,切成厚片,晒干; (4) 墨旱莲:拣净杂质,除去残根,洗净闷透,切段晒干; (5) 大黄:拣净杂质,大小分档,焖润至内外湿度均匀,切片或切成小块、晒干; (6) 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干; (7) 茜草:除去杂质,洗净,润透,切厚片或段,干燥,筛去碎肩; (8) 牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干; (9) 牡販:洗净,晒干,礙碎用; (10) 川楝子:拣去杂质,洗净,烘干,乳碎或劈成两半; (11) 白及:拣去杂质,用水浸泡,捞出,晾至湿度适宜,切片,干燥; (12) 代赭石:取原药材,除去杂质,洗净,干燥,打成碎块; (13) 白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干; (14) 芡实:先将麸皮放热锅内炒至烟起,再将净芡实倒入,拌炒至微黄色,取出,筛净麸 皮,放凉; (15) 莲子:拣尽杂质,或砸碎、去皮、去心用; (16) 阿胶:捣碎用; (17) 川贝母:拣去杂质,用水浸泡,捞出,闷润,剥去心,晒干; (18) 仙鹤草:除去杂质残根,洗净,润透,切断,晒干; (19) 瓦楞子:洗净晒干,碾碎; (20) 郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干; (21) 黄连:拣去杂质,洗净泥砂,润透,切片,阴干; (22) 五倍子:拣净、敲开、剔去其中杂质,研为细粉; (23) 牛膝:拣去杂质,洗净,润软,去芦,切段,晒干; (24) 人参:除去芦头,切段; (25) 白矾:拣净杂质,捣碎,研为细粉; (26) 石膏:去净杂石,洗净泥土,打碎成小块; (27) 麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干; (28) 山药:拣净杂质,用水浸泡至山药中心部软化为止,捞出稍晾,切片晒干或烘干; (29) 意该仁:取原药材,除去残留皮壳、杂质; (30) 山楂:拣净杂质,筛去核; (31) 侧柏叶:拣净杂质,揉碎去梗,筛净灰肩; (二)制备 (1) 将炮制后的海螵蛸、花蕊石、地榆、墨旱莲、大黄、甘草、茜草、牡丹皮、牡蛎、川楝子、 白及、代赭石、白术、芡实、莲子、阿胶、川贝母、仙鹤草、瓦楞子、郁金、黄连、五倍子、牛膝、人 参、白矾、石膏、麦冬、山药、薏苡仁、山楂、茯苓、侧柏叶放入煎药容器内,加水8倍量,浸泡 100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液 倒入容器内; (2) 将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮 液; (3) 将两次煎煮液混合搅拌均匀,分为4剂服用; (4) 将研为细粉末的花蕊石、五倍子、白帆用水调和制丸,分为四份,每次取一份与汤剂 同时服用。
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