CN105412665A - 一种治疗麻疹的药物及其制备方法 - Google Patents

一种治疗麻疹的药物及其制备方法 Download PDF

Info

Publication number
CN105412665A
CN105412665A CN201510950998.6A CN201510950998A CN105412665A CN 105412665 A CN105412665 A CN 105412665A CN 201510950998 A CN201510950998 A CN 201510950998A CN 105412665 A CN105412665 A CN 105412665A
Authority
CN
China
Prior art keywords
radix
grams
gram
dries
pick
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201510950998.6A
Other languages
English (en)
Inventor
徐士杰
Original Assignee
徐士杰
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 徐士杰 filed Critical 徐士杰
Priority to CN201510950998.6A priority Critical patent/CN105412665A/zh
Publication of CN105412665A publication Critical patent/CN105412665A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/19Acanthaceae (Acanthus family)
    • A61K36/195Strobilanthes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238Saposhnikovia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287Chrysanthemum, e.g. daisy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/30Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315Isatis, e.g. Dyer's woad
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/346Platycodon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • A61K36/428Trichosanthes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488Pueraria (kudzu)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534Mentha (mint)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538Schizonepeta
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605Morus (mulberry)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634Forsythia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/76Salicaceae (Willow family), e.g. poplar
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968Ophiopogon (Lilyturf)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969Polygonatum (Solomon's seal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

本发明公开了一种治疗麻疹的药物及其制备方法,其主要是由葛根、牛蒡子、前胡、山楂,升麻、薄荷、甘草、防风、荆芥、枳壳、木通、连翘等按一定重量配比制备而成,本发明药物具有升阳,发表,透疹,解毒的功能,用于治疗麻疹见效快,疗效好,无副作用。

Description

-种治疗麻疹的药物及其制备方法
技术领域
[0001] 本发明设及一种治疗麻疹的药物及其制备方法,属中药领域。
背景技术
[0002] 麻疹是儿童最常见的传染病之一,其传染性很强,在人口密集而未普种疫苗的地 区易发生流行,2~3年一次大流行。麻疹病毒属副黏液病毒,通过呼吸道分泌物飞沫传播。 临床上W发热、上呼吸道炎症、眼结膜炎及皮肤出现红色斑丘疹和颊黏膜上有麻疹黏膜斑, 疹退后遗留色素沉着伴慷教样脱屑为特征。常并发呼吸道疾病如中耳炎、喉-气管炎、肺炎 等严重并发症。由于西药无法有效治疗麻疹,因此人们对有效治疗麻疹的中药药物存在极 大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
[0003] 本发明人经过反复的研究和临床试验的反复验证,终于找到了有效治疗麻疹的药 物,从而完成了本发明。
[0004] 本发明的目的就是提供一种更有效的治疗麻疹的中药组合药物。
[0005] 本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006] 本发明药物是选择葛根、牛募子、前胡、山植,升麻、薄荷、甘草、防风、荆芥、积壳、 木通、连翅、竹叶、枯梗、桑叶、紫草、金银花、浮萍、赤巧、石膏、赠蚁、菊花、白茅根、牡丹皮、 沙柳、麦冬、玉竹、天花粉、杏仁、扁豆、黄琴、板蓝根、芦根进行组合制备的,将运些药物组合 使得各药物功效产生协同作用,从而能够有效治疗麻疹。其中,选用葛根是因为其性味甘 辛,平,入脾、胃经,有升阳解肌,透疹止泻,除烦止渴的功能,治伤寒,溫热,头痛,项强,烦热 消喝,泄泻,频疾,療诊不透,高血压,屯、绞痛,耳聋。选用牛募子是因为其性味辛苦,凉,入 肺、胃经,有疏散风热,宣肺透疹,消肿解毒的功能,治风热咳嗽,咽喉肿痛,斑疹不透,风疹 作痒,痴肿疮毒。选用前胡是因为其性味辛、苦,微寒,归肺经,有散风清热,降气化疲的功 能,治风热咳嗽,疲多,疲热喘满,咯疲黄稠。选用山植是因为其性味酸甘,微溫,入脾、胃、肝 经,有消食积,散疲血,驱缘虫的功能,治肉积,瘤瘤,疲饮,瘡满,吞酸,泻频,肠风,腰痛,痛 气,产后儿枕痛,恶露不尽,小儿乳食停滞。选用升麻是因为其性味甘辛微苦,凉,入肺、脾、 胃经,有升阳,发表,透疹,解毒的功能,治时气疫劳,头痛寒热,喉痛,日疮瘤,斑疹不透,中 气下陷,久泻久频,脱肛,妇女崩带,子宫下坠,痴肿疮毒。选用薄荷是因为其性味辛,凉,入 肺、肝经,有疏风,散热,辟秽,解毒的功能,治外感风热,头痛,目赤,咽喉肿痛,食滞气胀,口 疮,牙痛,疮巧,癒疹。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒, 调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便漉,劳倦发热,肺瘦咳嗽,屯、惇,惊痴,生用 治咽喉肿痛,消化性溃瘍,痴痘疮瘍,解药毒及食物中毒。选用防风是因为其性味辛甘,溫, 入膀脫、肺、脾经,有发表,桂风,胜湿,止痛的功能,治外感风寒,头痛,目眩,项强,风寒湿 搏,骨节酸痛,四肢李急,破伤风。选用荆芥是因为其性味辛,溫,入肺、肝经,有发表,桂风, 理血的功能,炒炭止血,治感冒发热,头痛,咽喉肿痛,中风口嗦,吐血,赃血,便血,崩漏,产 后血晕,痴肿,疮巧,療痛。选用积壳是因为其性味苦辛,凉,入肺、脾、大肠经,有破气,行疲, 消积的功能,治胸隔疲滞,胸瘡,胁胀,食积,噫气,呕逆,下频后重,脱肛,子宫脱垂。选用木 通是因为其性味苦,凉,入屯、、小肠、膀脫经,有泻火行水,通利血脉的功能,治小便赤涩,淋 浊,水肿,胸中烦热,喉搏咽痛,遍身拘痛,妇女经闭,乳汁不通。选用连翅是因为其性味苦, 凉,入屯、、肝、胆经,有清热,解毒,散结,消肿的功能,治溫热,丹毒,斑疹,痴瘍肿毒,療痛,小 便淋闭。选用竹叶是因为其性味甘淡,寒,入屯、、肺、胆、胃经,有清热除烦,生津利尿的功能, 治热病烦喝,小儿惊癖,咳逆吐赃,面赤,小便短赤,口糜舌疮。选用枯梗是因为其性味苦辛, 平,入肺、胃经,有开宣肺气,桂疲排脈的功能,治外感咳嗽,咽喉肿痛,肺痴吐脈,胸满胁痛, 频疾腹痛。选用桑叶是因为其性味苦甘,寒,入肺、肝经,有桂风清热,凉血明目的功能,治风 湿发热,头痛,目赤,口渴,肺热咳嗽,风搏,癒疹,下肢象皮肿。选用紫草是因为其性味苦苦, 寒,入屯、包络、肝经,有凉血,活血,清热解毒的功能,治溫热斑疹,湿热黄痘,紫齋,吐、赃、尿 血,淋浊,血频,热结便秘,烧伤,湿疹,丹毒,痴瘍。选用金银花是因为其性味甘,寒,入肺、胃 经,有清热,解毒的功能,治溫病发热,热毒血频,痴瘍,肿毒,療痛,持漏。选用浮萍是因为 其性味辛,寒,入肺经,有发汗,桂风,行水,清热,解毒的功能,治时行热病,斑疹不透,风热 癒疹,皮肤痊痒,水肿,癌闭,疮癖,丹毒,烫伤。选用赤巧是因为其性味苦,微寒,归肝经,有 清热凉血,散疲止痛的功能,治溫毒发狂,吐血赃血,目赤肿痛,肝郁胁痛,经闭痛经,癖瘤腹 痛,跌扑损伤,痴肿疮瘍。选用石膏是因为其性味辛甘,寒,入肺、胃经,生用有解肌清热,除 烦止渴的功能,治热病壮热不退,屯、烦神昏,檐语发狂,口渴咽干,肺热喘急,中暑自汗,胃火 头痛、牙痛,热毒塞盛,发斑发疹,口舌生疮,般敷生肌敛疮,外治痴痘疮瘍,溃不收回,汤火 烫伤。选用赠蚁是因为其性味甘咸,凉,入肺、肝经,有散风热,宣肺,定疫的功能,治外感风 热,咳嗽音哑,麻疹透发不杨,风疹痊痒,小儿惊癖,目赤,繫障,疗疮肿毒,破伤风。选用菊花 是因为其性味甘苦,凉,入肺、肝经,有疏风,清热,明目,解毒的功能,治头痛,眩晕,目赤,屯、 胸烦热,疗疮,肿毒。选用白茅根是因为其性味甘、寒,入肺、胃、小肠经,有凉血,止血,清热, 利尿的功能,治热病烦渴,吐血,赃血,肺热喘急,胃热吵逆,淋病,小便不利,水肿,黄痘。选 用牡丹皮是因为其性味辛苦,凉,入屯、、肝、肾经,有清热,凉血,和血,消疲的功能,治热入血 分,发斑,惊癖,吐、赃、便血,骨蒸劳热,经闭,瘤瘤,痴瘍,扑损。选用沙柳是因为其性味甘 溫,有解表桂风的功能,治麻疹初期,斑疹不透,皮肤痊痒,慢性风湿。选用麦冬是因为其性 味甘微苦,寒,入肺、胃、屯、经,有养阴润肺,清屯、除烦,益胃生津的功能,治肺燥干咳,吐血, 咯血,肺瘦,肺痴,虚劳烦热,清渴,热病津伤,咽干口燥,便秘。选用玉竹是因为其性味甘, 平,入肺,胃经,有养阴,润燥,除烦,止渴的功能,治热病阳伤,咳嗽,烦渴,虚劳发热,消谷易 饥,小便频数。选用天花粉是因为其性味甘苦酸,凉,入肺、胃经,有生津,止渴,降火,润燥, 排脈,消肿的功能,治热病口渴,消渴,黄痘,肺燥咳血,痴肿,持擾。选用杏仁是因为其性味 苦,溫,有毒,入肺、大肠经,有桂疲止咳,平喘,润肠的功能,治外感咳嗽,喘满,喉搏,肠燥便 秘。选用扁豆是因为其性味甘,平,入脾、胃经,有健脾和中,消暑化湿的功能,治暑湿吐泻, 脾虚呕逆,食少久泄,水停消渴,赤白带下,小儿巧积。选用黄琴是因为其性味苦寒,入屯、肺、 胆、大肠经,有泻实火,除湿热,止血安胎的功能,治壮热烦渴,肺热咳嗽。选用板蓝根是因为 其性味苦,寒,入肝、胃血分,有清热,解毒,凉血的功能,治流感,流脑,乙脑,肺炎,丹毒,热 毒发斑,神昏吐赃,咽肿,巧腮,火眼,疮疹。选用芦根是因为其性味甘,寒,入肺,胃经,有清 热,生津,除烦,止呕的功能,治热病烦渴,胃热呕吐,喧隔,反胃,肺瘦,肺痴,并解河豚鱼毒。
具体实施方式
[0007] 本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下 述重量范围内都具有较好的疗效: 葛根10-15克、牛募子10-15克、前胡10-15克、山植10-15克,升麻5-8克、薄荷5-8克、 甘草5-8克、防风5-8克、荆芥5-8克、积壳5-8克、木通5-8克、连翅5-8克、竹叶5-8克、 枯梗5-8克、桑叶10-15克、紫草10-15克、金银花10-15克、浮萍5-10克、赤巧4-6克、石 膏4-6克、赠蚁4-6克、菊花4-6克、白茅根6-8克、牡丹皮4-6克。沙柳5-15克,麦冬5-15 克,玉竹5-15克,天花粉5-15克,杏仁5-10克,扁豆5-10克,黄琴5-10克,板蓝根10-15 克,芦根15-20克。
[000引优选为: 葛根10克、牛募子10克、前胡10克、山植10克,升麻6克、薄荷6克、甘草6克、防风 6克、荆芥6克、积壳6克、木通6克、连翅6克、竹叶6克、枯梗6克、桑叶10克、紫草10克、 金银花10克、浮萍10克、赤巧6克、石膏6克、赠蚁6克、菊花6克、白茅根6克、牡丹皮6 克。沙柳10克,麦冬10克,玉竹10克,天花粉10克,杏仁10克,扁豆10克,黄琴10克,板 蓝根15克,芦根15克。
[0009] 本发明药物的制备方法如下 一、备料 1、 葛根:炼去杂质,洗净,用水浸泡,拱出,润透,及时切片,晒干; 2、 牛募子:炼去杂质,筛去泥屑; 3、 前胡:取原药材,除去杂质,洗净,润透,切薄片,干燥或低溫干燥,筛去碎屑; 4、 山植:炼净杂质,筛去核; 5、 升麻:炼去杂质,略泡洗净,拱出,润透,切片,晒干; 6、 薄荷:炼净杂质,除去残根,先将叶抖下另放,然后将茎喷洒清水,润透后切段,晒干, 再与叶和匀; 7、 甘草:炼去杂质,洗净,用水浸泡至八成透时,拱出,润透,切片,惊干; 8、 防风:除去残茎,用水浸泡,拱出,润透切片,晒干; 9、 荆芥:炼净杂质,用水略泡,拱出切段,晒干; 10、 积壳:除去飄、核,洗净,稍浸,拱出,润软,切片,惊干; 11、 木通:用水稍浸泡,闷润至透,切片,晒干; 12、 连翅:炼净杂质,磋开,除去枝梗; 13、 竹叶:炼净杂质,除去梗叶,惊干; 14、 枯梗:炼净杂质,除去芦头,洗净拱出,润透后切片,晒干; 15、 桑叶:炼去杂质,磋碎,鑛去梗,筛去泥屑; 16、 紫草:洗净,润透,切片,晒干; 17、 金银花:筛去泥沙,炼净杂质; 18、 浮萍:6-9月间拱取,晒干; 19、 赤巧:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑; 20、 石膏:去净杂石,洗净泥±,打碎成小块; 21、 赠蚁:炼去杂质,洗净晒干; 22、 菊花:炼净叶梗、花柄及泥屑杂质; 23、 白茅根:炼净杂质,洗净,微润,切段,晒干,鑛净碎屑; 24、 牡丹皮:炼去杂质,除去木屯、,洗净,润透,切片,惊干; 25、 沙柳:除去杂质,洗净,切段,晒干; 26、 麦冬:炼净杂质,用水浸泡,拱出,润透后抽去屯、,再洗净晒干; 27、 玉竹:除去杂质,洗净泥±,闷润至内外湿度均匀,切片,晒干; 28、 天花粉:炼去杂质,大小块分开,用水泡约六成透,拱出,闷润至内外湿度均匀,切 片,晒干,或用水洗净,拱出,晒至极干,捣成小块; 29、 杏仁:炼净杂质,置沸水中略煮,俟皮微皱起拱出,浸凉水中,脱去种皮,晒干,鑛 净; 30、 扁豆:炼净杂质,置沸水中稍煮,至种皮鼓起、松软为度,拱出,浸入冷水中,脱去皮, 晒干; 31、 黄琴:炼去杂质,除去残茎,用凉水浸润或置开水中稍浸拱出,切片,晒干; 32、 板蓝根:炼净杂质,洗净,润透,切片,晒干; 33、 芦根:炼去杂质及残茎,切段,晒干; 二、制备 1、将所述重量的葛根、牛募子、前胡、山植,升麻、薄荷、甘草、防风、荆芥、积壳、木通、连 翅、竹叶、枯梗、桑叶、紫草、金银花、浮萍、赤巧、石膏、赠蚁、菊花、白茅根、牡丹皮、沙柳、麦 冬、玉竹、天花粉、杏仁、扁豆、黄琴、板蓝根、芦根放入煎药容器内,第一次加水8倍量,浸泡 80分钟后,武火煎煮沸腾,再用文火煎煮30分钟,过滤得第一次煎煮液,将第一次煎煮液倒 入容器内。
[0010] 2、将过滤的药渣加水6倍量,先用武火煮沸,再用文火煎煮20分钟过滤,将第二次 煎煮液倒入容器内。
[0011] 3、将两次煎煮液混合揽拌均匀,分成4剂服用。
[0012] 组方中牛募子有疏散风热,宣肺透疹,消肿解毒的功能为君药;升麻升阳,发表, 透疹,解毒;葛根升阳解肌,透疹止泻的功能,二者为臣药,Ξ味药共同发挥升阳透疹,消肿 解毒的作用,治疗麻疹效力全面,且W疏风散热,消肿解毒为主,可治本,薄荷疏风,散热,辟 秽,解毒为佐药;甘草有和中缓急,润肺,解毒,调和诸药的功能为佐药,与下余诸药是治标。
[0013] 本发明药物具有升阳,发表,透疹,解毒的功能,用于治疗麻疹,疗程短、见效快、无 毒副作用。
[0014]
具体实施方式: W下通过试验例来进一步阐述本发明所述药物的有益效果,运些试验例包括本发明药 物的动物毒性试验报告和临床疗效观察资料。
[0015] [试验例1]本发明药物的动物毒性试验报告: 取家兔30只,雌雄兼用,体重2. 0-2.化g,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。服用药液超常量组为20ml/kg,正常量为lOml/kg,给药方式为 灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常, 药物无不良毒副作用。
[0016] [试验例2]本发明药物的临床疗效观察 1、一般资料 收治麻疹口诊患者共36例。
[0017] 2、诊断标准 临床表现为持续性发热,咽痛,畏光,流泪,眼结膜红肿,在口腔颊黏膜处见到麻疹黏膜 斑。发热4天左右全身皮肤出现红色斑丘疹。
[001引 3、治疗方法 选用上述药剂,给患者服用,每次每个患儿服用1/4~1/6剂,每天早、晚各服1次,7天 为一个疗程,连续服用2个疗程。
[0019] 4、疗效评定标准 显效:麻疹症状消失,痊愈,体质恢复正常; 好转:咽痛、畏光、流泪症状减轻麻疹明显好转,体质逐步恢复; 无效:达不到好转标准者。
[0020] 5、治疗结果(见下表)
Figure CN105412665AD00081
在上述治疗中,用本发明药物治疗麻疹患者36例,结果显效32例,显效率为88. 89%,好 转3例,好转率为8. 33%,无效1例,总有效率为97. 22%。

Claims (3)

1. 一种治疗麻疹的药物,其特征在于:它是由下列用量范围内的原料药制成: 葛根10-15克、牛蒡子10-15克、前胡10-15克、山楂10-15克,升麻5-8克、薄荷5-8 克、甘草5-8克、防风5-8克、荆芥5-8克、枳壳5-8克、木通5-8克、连翘5-8克、竹叶5-8 克、桔梗5-8克、桑叶10-15克、紫草10-15克、金银花10-15克、浮萍5-10克、赤芍4-6克、 石膏4-6克、蝉蜕4-6克、菊花4-6克、白茅根6-8克、牡丹皮4-6克、沙柳5-15克,麦冬5-15 克,玉竹5-15克,天花粉5-15克,杏仁5-10克,扁豆5-10克,黄芩5-10克,板蓝根10-15 克,芦根15-20克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 葛根10克、牛蒡子10克、前胡10克、山楂10克,升麻6克、薄荷6克、甘草6克、防风 6克、荆芥6克、枳壳6克、木通6克、连翘6克、竹叶6克、桔梗6克、桑叶10克、紫草10克、 金银花10克、浮萍10克、赤芍6克、石膏6克、蝉蜕6克、菊花6克、白茅根6克、牡丹皮6 克、沙柳10克,麦冬10克,玉竹10克,天花粉10克,杏仁10克,扁豆10克,黄芩10克,板 蓝根15克,芦根15克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (一)备料 (1) 葛根:拣去杂质,洗净,用水浸泡,捞出,润透,及时切片,晒干; (2) 牛蒡子:拣去杂质,筛去泥肩; (3) 前胡:取原药材,除去杂质,洗净,润透,切薄片,干燥或低温干燥,筛去碎肩; (4) 山楂:拣净杂质,筛去核; (5) 升麻:拣去杂质,略泡洗净,捞出,润透,切片,晒干; (6) 薄荷:拣净杂质,除去残根,先将叶抖下另放,然后将茎喷洒清水,润透后切段,晒 干,再与叶和匀; (7) 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干; (8) 防风:除去残茎,用水浸泡,捞出,润透切片,晒干; (9) 荆芥:拣净杂质,用水略泡,捞出切段,晒干; (10) 枳壳:除去瓤、核,冼净,稍浸,捞出,润软,切片,晾干; (11) 木通:用水稍浸泡,闷润至透,切片,晒干; (12) 连翘:拣净杂质,搓开,除去枝梗; (13) 竹叶:拣净杂质,除去梗叶,晾干; (14) 桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干; (15) 桑叶:拣去杂质,搓碎,鑛去梗,筛去泥肩; (16) 紫草:洗净,润透,切片,晒干; (17) 金银花:筛去泥沙,拣净杂质; (18) 浮萍:6-9月间捞取,晒干; (19) 赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎肩; (20) 石膏:去净杂石,洗净泥土,打碎成小块; (21) 蝉蜕:拣去杂质,洗净晒干; (22) 菊花:拣净叶梗、花柄及泥肩杂质; (23) 白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎肩; (24) 牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干; (25) 沙柳:除去杂质,洗净,切段,晒干; (26) 麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干; (27) 玉竹:除去杂质,洗净泥土,闷润至内外湿度均匀,切片,晒干; (28) 天花粉:拣去杂质,大小块分开,用水泡约六成透,捞出,闷润至内外湿度均匀,切 片,晒干,或用水洗净,捞出,晒至极干,捣成小块; (29) 杏仁:拣净杂质,置沸水中略煮,俟皮微皱起捞出,浸凉水中,脱去种皮,晒干,簸 净; (30) 扁豆:拣净杂质,置沸水中稍煮,至种皮鼓起、松软为度,捞出,浸入冷水中,脱去 皮,晒干; (31) 黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干; (32) 板蓝根:拣净杂质,洗净,润透,切片,晒干; (33) 芦根:拣去杂质及残茎,切段,晒干; (二)制备 (1) 将所述重量的葛根、牛蒡子、前胡、山楂,升麻、薄荷、甘草、防风、荆芥、枳壳、木通、 连翘、竹叶、桔梗、桑叶、紫草、金银花、浮萍、赤芍、石膏、蝉蜕、菊花、白茅根、牡丹皮、沙柳、 麦冬、玉竹、天花粉、杏仁、扁豆、黄苳、板蓝根、芦根放入煎药容器内,第一次加水8倍量,浸 泡180分钟后,武火煎煮沸腾,再用文火煎煮30分钟,过滤得第一次煎煮液,将第一次煎煮 液倒入容器内; (2) 将过滤的药渣加水6倍量,先用武火煮沸,再用文火煎煮20分钟过滤,将第二次煎 煮液倒入容器内; (3) 将两次煎煮液混合搅拌均匀,分成4剂服用。
CN201510950998.6A 2015-12-19 2015-12-19 一种治疗麻疹的药物及其制备方法 Pending CN105412665A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510950998.6A CN105412665A (zh) 2015-12-19 2015-12-19 一种治疗麻疹的药物及其制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510950998.6A CN105412665A (zh) 2015-12-19 2015-12-19 一种治疗麻疹的药物及其制备方法

Publications (1)

Publication Number Publication Date
CN105412665A true CN105412665A (zh) 2016-03-23

Family

ID=55491508

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201510950998.6A Pending CN105412665A (zh) 2015-12-19 2015-12-19 一种治疗麻疹的药物及其制备方法

Country Status (1)

Country Link
CN (1) CN105412665A (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106798853A (zh) * 2017-03-09 2017-06-06 李子义 一种治疗麻疹的药物及其制备方法
CN107397920A (zh) * 2016-05-21 2017-11-28 陈茹 一种治疗小儿麻疹的中药组合物及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103623260A (zh) * 2013-11-20 2014-03-12 曹庆礼 一种治疗小儿麻疹的中药组合物
CN104800678A (zh) * 2015-04-26 2015-07-29 燕子锋 一种治疗流行性感冒的药物及其制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103623260A (zh) * 2013-11-20 2014-03-12 曹庆礼 一种治疗小儿麻疹的中药组合物
CN104800678A (zh) * 2015-04-26 2015-07-29 燕子锋 一种治疗流行性感冒的药物及其制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
陈仲有: "中药治疗大龄儿童和成人麻疹20例", 《湖南中医药导报》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107397920A (zh) * 2016-05-21 2017-11-28 陈茹 一种治疗小儿麻疹的中药组合物及其制备方法
CN106798853A (zh) * 2017-03-09 2017-06-06 李子义 一种治疗麻疹的药物及其制备方法

Similar Documents

Publication Publication Date Title
CN102552855B (zh) 一种治疗胃胀的药物及其制备方法
CN103736072B (zh) 一种治疗过敏性鼻炎的药物及其制备方法
CN105362822A (zh) 一种治疗痤疮的药物及其制备方法
CN105412622A (zh) 一种治疗面瘫的药物及其制备方法
CN102805843A (zh) 一种治疗胃痛的药物及其制备方法
CN103830605A (zh) 一种治疗急性扁桃体炎的药物及其制备方法
CN105434952A (zh) 一种治疗丹痧的药物及其制备方法
CN104958626A (zh) 一种治疗结肠炎的药物及其制备方法
CN105412665A (zh) 一种治疗麻疹的药物及其制备方法
CN102772777B (zh) 一种治疗小儿肺炎的药物及其制备方法
CN102772693B (zh) 一种治疗复发性口腔溃疡的药物及其制备方法
CN103735921A (zh) 一种治疗尿道炎的药物及其制备方法
CN106421672A (zh) 一种治疗流行性腮腺炎的药物及其制备方法
CN103623279B (zh) 一种治疗小儿麻疹的药物及其制备方法
CN105521473A (zh) 一种治疗小儿麻痹后遗症的药物及其制备方法
CN102872405B (zh) 一种治疗黄疸的药物及其制备方法
CN104398925A (zh) 一种治疗皮肤病的药物及其制备方法
CN101607076B (zh) 一种治疗尿毒症的中药药物
CN103751658B (zh) 一种治疗湿热蕴结引起的乙型肝炎的药物及其制备方法
CN106474448A (zh) 一种治疗时行感冒的药物及其制备方法
CN105963586A (zh) 一种治疗肺脓肿的药物及其制备方法
CN103446522B (zh) 一种治疗吐酸的药物及其制备方法
CN105381416A (zh) 一种治疗上消化道出血的药物及其制备方法
CN105327327A (zh) 一种治疗急性胆囊炎的药物及其制备方法
CN106110056A (zh) 一种治疗睑腺炎的药物及其制备方法

Legal Events

Date Code Title Description
PB01 Publication
C06 Publication
SE01 Entry into force of request for substantive examination
C10 Entry into substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20160323

RJ01 Rejection of invention patent application after publication