CN106492029A - 一种治疗丹痧的药物及其制备方法 - Google Patents

一种治疗丹痧的药物及其制备方法 Download PDF

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CN106492029A
CN106492029A CN201611106962.0A CN201611106962A CN106492029A CN 106492029 A CN106492029 A CN 106492029A CN 201611106962 A CN201611106962 A CN 201611106962A CN 106492029 A CN106492029 A CN 106492029A
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冉兆斌
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冉兆斌
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Abstract

本发明公开了一种治疗丹痧的药物及其制备方法,其主要是由生地黄、黄芩、牡丹皮、赤芍、竹叶、石膏、犀角、玄参、麦冬、玉竹、桑叶、薄荷等按一定重量配比制备而成,本发明药物具有清热下气,解肌清热,凉血解毒,除烦止渴的功能,用于治疗丹痧见效快,疗效好,无副作用。

Description

一种治疗丹痧的药物及其制备方法
技术领域
[0001] 本发明涉及一种治疗丹痧的药物及其制备方法,属中药领域。
背景技术
[0002] 丹痧也称烂喉痧、疫疹,属温病范畴,是一种急性呼吸道传染病。多见于2~8岁小 儿,常发生于冬春季节。临床以发热、咽喉肿痛,全身布有弥漫性猩红色皮疹为特征。由于 西药无法有效快速治疗丹痧,因此人们对有效治疗丹痧的中药药物存在极大的需求,至今 为止,还没有发现关于本发明的有关报道。
发明内容
[0003] 本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗丹痧 的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种更有效的治疗丹痧的中药组合药物。
[0005] 本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006] 本发明药物是选择生地黄、黄芩、牡丹皮、赤芍、竹叶、石膏、犀角、玄参、麦冬、玉 竹、桑叶、薄荷、芦根、白茅根、天花粉、桔梗、甘草、射干、牛蒡子、荆芥、蝉蜕、浮萍、淡豆豉、 葛根、连翘、金银花、知母、僵蚕、石斛、牛黄原料药进行组合制备的,将这些药物组合使得各 药物功效产生协同作用,从而能够有效治疗丹痧。其中选用生地黄是因为其性味甘,寒,归 心、肝、肾经,有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内热消渴, 吐血,衄血,发斑发疹。选用黄芩是因为其性味苦寒,入心肺、胆、大肠经,有泻实火,除湿热, 止血安胎的功能,治壮热烦渴,肺热咳嗽。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾 经,有清热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭, 癥瘕,痈疡,扑损。选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能, 治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选 用竹叶是因为其性味甘淡,寒,入心、肺、胆、胃经,有清热除烦,生津利尿的功能,治热病烦 喝,小儿惊癎,咳逆吐衄,面赤,小便短赤,□糜舌疮。选用石膏是因为其性味辛甘,寒,入肺、 胃经,生用有解肌清热,除烦止渴的功能,治热病壮热不退,心烦神昏,谵语发狂,口渴咽干, 肺热喘急,中暑自汗,胃火头痛、牙痛,热毒壅盛,发斑发疹,口舌生疮,煅敷生肌敛疮,外治 痈疽疮疡,溃不收回,汤火烫伤。选用犀角是因为其性味酸咸,寒,入心、肝经,有清热,凉血, 定惊,解毒的功能,治伤寒温疫热入血分,惊狂,烦躁,谵妄,斑疹,发黄,吐血,衄血,下血,痈 疽肿毒。选用玄参是因为其性味苦,咸,凉,入肺、肾经,有滋阴,降火,除烦,解毒的功能,治 热病烦渴,发斑,骨蒸劳热,夜寐不宁,自汗盗汗,津伤便秘,吐血衄血,咽喉肿痛,痈肿,瘰 疬。选用麦冬是因为其性味甘微苦,寒,入肺、胃、心经,有养阴润肺,清心除烦,益胃生津的 功能,治肺燥干咳,吐血,咯血,肺痿,肺痈,虚劳烦热,清渴,热病津伤,咽干口燥,便秘。选用 玉竹是因为其性味甘,平,入肺,胃经,有养阴,润燥,除烦,止渴的功能,治热病阳伤,咳嗽, 烦渴,虚劳发热,消谷易饥,小便频数。选用桑叶是因为其性味苦甘,寒,入肺、肝经,有祛风 清热,凉血明目的功能,治风湿发热,头痛,目赤,口渴,肺热咳嗽,风痹,瘾疹,下肢象皮肿。 选用薄荷是因为其性味辛,凉,入肺、肝经,有疏风,散热,辟秽,解毒的功能,治外感风热,头 痛,目赤,咽喉肿痛,食滞气胀,口疮,牙痛,疮疥,瘾疹。选用芦根是因为其性味甘,寒,入肺, 胃经,有清热,生津,除烦,止呕的功能,治热病烦渴,胃热呕吐,噎膈,反胃,肺痿,肺痈,并解 河豚鱼毒。选用白茅根是因为其性味甘、寒,入肺、胃、小肠经,有凉血,止血,清热,利尿的功 能,治热病烦渴,吐血,衄血,肺热喘急,胃热哕逆,淋病,小便不利,水肿,黄疸。选用天花粉 是因为其性味甘苦酸,凉,入肺、胃经,有生津,止渴,降火,润燥,排脓,消肿的功能,治热病 口渴,消渴,黄疸,肺燥咳血,痈肿,痔痿。选用桔梗是因为其性味苦辛,平,入肺、胃经,有开 宣肺气,祛痰排脓的功能,治外感咳嗽,咽喉肿痛,肺痈吐脓,胸满胁痛,痢疾腹痛。选用甘草 是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃 虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽 疮疡,解药毒及食物中毒。选用射干是因为其性味苦,寒,有毒,入肺、肝经,有降火,解毒,散 血,消痰的功能,治喉痹咽痛,咳逆上气,痰涎壅盛,瘰疬结核,疟母,妇女经闭,痈肿疮毒。选 用牛蒡子是因为其性味辛苦,凉,入肺、胃经,有疏散风热,宣肺透疹,消肿解毒的功能,治风 热咳嗽,咽喉肿痛,斑疹不透,风疹作痒,痈肿疮毒。选用荆芥是因为其性味辛,温,入肺、肝 经,有发表,祛风,理血的功能,炒炭止血,治感冒发热,头痛,咽喉肿痛,中风口噤,吐血,衄 血,便血,崩漏,产后血晕,痈肿,疮疥,瘰疬。选用蝉蜕是因为其性味甘咸,凉,入肺、肝经,有 散风热,宣肺,定痉的功能,治外感风热,咳嗽音哑,麻疹透发不畅,风疹瘙痒,小儿惊癎,目 赤,翳障,疔疮肿毒,破伤风。选用浮萍是因为其性味辛,寒,入肺经,有发汗,祛风,行水,清 热,解毒的功能,治时行热病,斑疹不透,风热瘾疹,皮肤瘙痒,水肿,癃闭,疮癣,丹毒,烫伤。 选用淡豆豉是因为其性味苦,寒,入肺、胃经,有解表,除烦,宣郁,解毒的功能,治伤寒热病, 寒热,头痛,烦燥,胸闷。选用葛根是因为其性味甘辛,平,入脾、胃经,有升阳解肌,透疹止 泻,除烦止渴的功能,治伤寒,温热,头痛,项强,烦热消喝,泄泻,痢疾,癍诊不透,高血压,心 绞痛,耳聋。选用连翘是因为其性味苦,凉,入心、肝、胆经,有清热,解毒,散结,消肿的功能, 治温热,丹毒,斑疹,痈疡肿毒,瘰疬,小便淋闭。选用金银花是因为其性味甘,寒,入肺、胃 经,有清热,解毒的功能,治温病发热,热毒血痢,痈疡,肿毒,瘰疬,痔漏。选用知母是因为其 性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳 嗽,大便燥结,小便不利。选用僵蚕是因为其性味辛、咸,平,归肝,肺经。祛风解痉,化痰散 结。用于中风口眼歪斜,惊痫抽搐,头赐,喉痹,瘰疠结核,风疹丹毒。选用石斛是因为其性味 甘淡微咸,寒,入有、肺、肾经,有生津益胃,清热养阴的功能,治热病伤津,口干烦喝,病后虚 热,阴伤目暗。选用牛黄是因为其性味苦甘,凉,入心、肝经,有清心,化痰,利胆,镇惊的功 能,治热病神昏、谵语,癫癎发狂,小儿惊风抽摔,牙府,喉肿,□舌生疮,痈疽,疔毒。
具体实施方式 [0007] 本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重 量范围内都具有较好的疗效 生地黄7-11克、黄芩4-8克、牡丹皮7-11克、赤芍7-11克、竹叶7-11克、石膏10-14克、犀 角2-4克、玄参10-14克,麦冬3-5克,玉竹3-5克,桑叶3-5克,薄荷4-5克、芦根25-35克、白茅 根10-14克,天花粉7-11克、桔梗7-11克、甘草1-5克、射干2-4克、牛蒡子5-7克、荆芥2-3克、 蝉蜕2-3克、浮萍8-10克、淡豆豉7-9克、葛根8-11克、连翘8-10克、金银花8-10克,知母8-10 克,僵蚕5-7克,石斛17-21克、牛黄0.1-0.2克。
[0008] 优选为 生地黄9克、黄芩6克、牡丹皮9克、赤芍9克、竹叶9克、石膏12克、犀角3克、玄参12克、麦 冬4克、玉竹4克、桑叶4克、薄荷4.5克、芦根30克、白茅根12克、天花粉9克、桔梗9克、甘草3 克、射干3克、牛蒡子6克、荆芥3克、蝴蜕3克、浮萍9克、淡豆豉8克、葛根9克、连翘9克、金银花 9克、知母9克、僵蚕6克、石斛19克、牛黄0.2克。
[0009] 本发明药物的制备方法如下 一、备料 1、 生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎肩; 2、 黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干; 3、 牡丹皮:拣去杂质,除去木心,洗净,润透,切片,瞭干; 4、 赤芍:取原药材,除去杂质,大小分档,洗净,润透,切片,干燥,筛去碎肩; 5、 竹叶:拣净杂质,除去梗叶,晾干; 6、 石膏:去净杂石,洗净泥土,打碎成小块; 7、 犀角:取犀角劈成瓣,置温水中浸泡,捞出,镑片,晒干; 8、 玄参:拣净杂质,除去芦头,洗净润透,切片,晾干; 9、 麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干; 10、 玉竹:除去杂质,洗净泥土,闷润至内外湿度均匀,切片,晒干; 11、 桑叶:拣去杂质,搓碎,鑛去梗,筛去泥肩; 12、 薄荷:拣净杂质,除去残根,先将叶抖下另放,然后将茎喷洒清水,润透后切段,晒 干,再与叶和匀; 13、 芦根:拣去杂质及根,切段,晒干; 14、 白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎肩; 15、 天花粉:拣去杂质,大小块分开,用水泡约六成透,捞出,闷润至内外湿度均匀,切 片,晒干,或用水洗净,捞出,晒至极干,捣成小块; 16、 桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干; 17、 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干; 18、 射干:拣去杂质,水洗净,稍浸泡,捞出,润透,切片,晒干,筛去须、肩; 19、 牛蒡子:拣去杂质,筛去泥肩; 20、 荆芥:拣净杂质,用水略泡,捞出切段,晒干; 21、 蝉蜕:拣去杂质,洗净晒干; 22、 浮萍:6-9月间捞取,晒干; 23、 淡ϋ妓:原品入药; 24、 葛根:拣去杂质,洗净,用水浸泡,捞出,润透,及时切片,晒干; 25、 连翘:拣净杂质,搓开,除去枝梗; 26、 金银花:筛去泥沙,拣净杂质; 27、 知母:拣净杂质,用水撞洗,捞出,润软,切片晒干; 28、 僵蚕:取原药材,除去残丝,杂质; 29、 石斛:取干燥的石斛,用水泡约至八成透,闷润,除去残根及黑枝,切段,撞去薄膜, 晒干; 30、 牛黄:研为极细粉末用; 二、制备 1、 将所述重量的生地黄、黄芩、牡丹皮、赤芍、竹叶、石膏、犀角、玄参、麦冬、玉竹、桑 叶、薄荷、芦根、白茅根、天花粉、桔梗、甘草、射干、牛蒡子、荆芥、蝴銳、浮萍、淡豆鼓、葛根、 连翘、金银花、知母、僵蚕、石斛放入煎药容器中,第一次加水8倍量,浸泡60分钟后,武火煎 煮沸腾,再用文火煎煮30分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内; 2、 将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟过滤,将第二次煎煮液倒 入容器内; 3、 将两次煎煮液混合加入牛黄粉搅拌均匀,即得混合药液,分成4剂服用。
[0010] 组方中生地黄有清热凉血,养阴生津的功能为君药;赤芍清热凉血,散瘀止痛,石 膏有解肌清热,除烦止渴的功能二者为臣药,三味药共同发挥解肌清热,凉血解毒,除烦止 渴的作用,治疗丹痧效力全面,且以清热解毒,除烦止渴为主,可治本;牛犀角清热,凉血,定 惊,解毒为佐药;桑叶祛风清热,凉血明目与下余诸药是治标。
[0011] 本发明药物具有解肌清热,凉血解毒,除烦止渴的功能,用于治疗丹痧,疗程短、见 效快、治愈后不复发、无毒副作用。
[0012] 以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发 明药物的动物毒性试验报告和临床疗效观察资料。
[0013] [试验例1]本发明药物的动物毒性试验报告: 取家兔30只,雌雄兼用,体重2.0-2.5kg,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给 药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良 毒副作用。
[0014] [试验例2]本发明药物的临床疗效观察 1、一般资料 收治丹痛门诊患者共40例。
[0015] 2、诊断标准 临床上该病潜伏期1-12天,前驱期一般不超过24小时。起病急骤,高热,畏寒,咽痛,吞 咽时加剧。伴头痛,呕吐,厌食,烦躁不安等症。咽及扁桃体有脓性分泌物,软腭充血,有细小 红疹或出血点。
[0016] 3、治疗方法 选用上述药剂,给患者服用,一日2次,每次服用1剂,每天早、晚各服1次,7天为一个疗 程,连续服用2个疗程。
[0017] 4、疗效评定标准 显效:丹痧症状消失,痊愈; 好转:丹痧症状明显好转,烦热、口渴症状已消除,体质逐步恢复; 无效:达不到好转标准者。
[0018] 5、治疗结果(见下表)
Figure CN106492029AD00081
在上述治疗中,用本发明药物治疗丹痧患者40例,结果显效38例,显效率为95%,好转1 例,好转率为2.5%,无效1例,总有效率为97.5%。

Claims (3)

1. 一种治疗丹痧的药物,其特征在于:它是由下列用量范围内的原料药制成: 生地黄7-11克、黄芩4-8克、牡丹皮7-11克、赤芍7-11克、竹叶7-11克、石膏10-14克、犀 角2-4克、玄参10-14克,麦冬3-5克,玉竹3-5克,桑叶3-5克,薄荷4-5克、芦根25-35克、白茅 根10-14克,天花粉7-11克、桔梗7-11克、甘草1-5克、射干2-4克、牛蒡子5-7克、荆芥2-3克、 蝉蜕2-3克、浮萍8-10克、淡豆豉7-9克、葛根8-11克、连翘8-10克、金银花8-10克,知母8-10 克,僵蚕5-7克,石斛17-21克、牛黄0.1-0.2克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 生地黄9克、黄芩6克、牡丹皮9克、赤芍9克、竹叶9克、石膏12克、犀角3克、玄参12克、麦 冬4克、玉竹4克、桑叶4克、薄荷4.5克、芦根30克、白茅根12克、天花粉9克、桔梗9克、甘草3 克、射干3克、牛蒡子6克、荆芥3克、蝴蜕3克、浮萍9克、淡豆豉8克、葛根9克、连翘9克、金银花 9克、知母9克、僵蚕6克、石斛19克、牛黄0.2克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (一)备料 (1) 生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎肩; (2) 黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干; ⑶牡丹皮:拣去杂质,除去木心,洗净,润透,切片,瞭干; (4) 赤芍:取原药材,除去杂质,大小分档,洗净,润透,切片,干燥,筛去碎肩; (5) 竹叶:拣净杂质,除去梗叶,晾干; (6) 石膏:去净杂石,洗净泥土,打碎成小块; (7) 犀角:取犀角劈成瓣,置温水中浸泡,捞出,镑片,晒干; (8) 玄参:拣净杂质,除去芦头,洗净润透,切片,晾干; (9) 麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干; (10) 玉竹:除去杂质,洗净泥土,闷润至内外湿度均匀,切片,晒干; (11) 桑叶:拣去杂质,搓碎,鑛去梗,筛去泥肩; (12) 薄荷:拣净杂质,除去残根,先将叶抖下另放,然后将茎喷洒清水,润透后切段,晒 干,再与叶和匀; (13) 芦根:拣去杂质及根,切段,晒干; (14) 白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎肩; (15) 天花粉:拣去杂质,大小块分开,用水泡约六成透,捞出,闷润至内外湿度均匀,切 片,晒干,或用水洗净,捞出,晒至极干,捣成小块; (16) 桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干; (17) 甘草:拣去杂质,洗净,用水浸泡至Λ成透时,捞出,润透,切片,瞭干; (18) 射干:拣去杂质,水洗净,稍浸泡,捞出,润透,切片,晒干,筛去须、肩; (19) 牛蒡子:拣去杂质,筛去泥肩; (20) 荆芥:拣净杂质,用水略泡,捞出切段,晒干; (21) 蝉蜕:拣去杂质,洗净晒干; (22) 浮萍:6-9月间捞取,晒干; (23) 淡ϋ妓:原品入药; (24) 葛根:拣去杂质,洗净,用水浸泡,捞出,润透,及时切片,晒干; (25) 连翘:拣净杂质,搓开,除去枝梗; (26) 金银花:筛去泥沙,拣净杂质; (27) 知母:拣净杂质,用水撞洗,捞出,润软,切片晒干; (28) 僵蚕:取原药材,除去残丝,杂质; (29) 石斛:取干燥的石斛,用水泡约至八成透,闷润,除去残根及黑枝,切段,撞去薄膜, 晒干; (30) 牛黄:研为极细粉末用; (二)制备 (1) 将所述重量的生地黄、黄芩、牡丹皮、赤芍、竹叶、石膏、犀角、玄参、麦冬、玉竹、桑 叶、薄荷、芦根、白茅根、天花粉、桔梗、甘草、射干、牛蒡子、荆芥、蝴銳、浮萍、淡豆鼓、葛根、 连翘、金银花、知母、僵蚕、石斛放入煎药容器中,第一次加水8倍量,浸泡60分钟后,武火煎 煮沸腾,再用文火煎煮30分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内; (2) 将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟过滤,将第二次煎煮液倒 入容器内; (3) 将两次煎煮液混合加入牛黄粉搅拌均匀,即得混合药液,分成4剂服用。
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