CN105362822A - 一种治疗痤疮的药物及其制备方法 - Google Patents

一种治疗痤疮的药物及其制备方法 Download PDF

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CN105362822A
CN105362822A CN201510969538.8A CN201510969538A CN105362822A CN 105362822 A CN105362822 A CN 105362822A CN 201510969538 A CN201510969538 A CN 201510969538A CN 105362822 A CN105362822 A CN 105362822A
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徐士杰
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徐士杰
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Abstract

本发明公开了一种治疗痤疮的药物及其制备方法,其主要是由竹叶、甘草、地丁、石膏、赤芍、皂角刺、金银花、连翘、夏枯草、土茯苓、天南星,当归等按一定重量配比制备而成,本发明药物具有清热解毒,消肿排脓的功能,用于治疗痤疮见效快,疗效好,无副作用。

Description

一种治疗痤疮的药物及其制备方法
技术领域
[0001] 本发明涉及一种治疗痤疮的药物及其制备方法,属中药领域。 技术背景
[0002] 痤疮是毛囊皮脂腺单位的一种慢性炎症性皮肤病,主要好发于青少年,痤疮的发 生主要与皮脂分泌过多、毛囊皮脂腺导管堵塞、细菌感染和炎症反应等因素密切相关。临床 表现以好发于面部的粉刺、丘疹、脓疱、结节等多形性皮损为特点。由于西药无法有效快速 治疗痤疮,因此人们对有效治疗痤疮的中药药物存在极大的需求,至今为止,还没有发现关 于本发明的有关报道。
发明内容
[0003] 本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗痤疮 的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种更有效的治疗痤疮的中药组合药物。
[0005] 本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006] 本发明药物是选择竹叶、甘草、地丁、石膏、赤苟、阜角刺、金银花、连翘、夏枯草、土 茯苳、天南星,当归、枇杷叶、青蒿、白术、山大刀、荆芥、桑白皮、黄苳、柅子、黄连、生地黄、牡 丹皮、山楂、薏该仁、茵陈蒿、大黄、赤小豆、细辛、麻黄、泽泻、车前子、神曲、红花药物进行组 合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗痤疮。其中, 选用竹叶是因为其性味甘淡,寒,入心、肺、胆、胃经,有清热除烦,生津利尿的功能,治热病 烦喝,小儿惊癎,咳逆吐衄,面赤,小便短赤,口糜舌疮。选用甘草是因为其性味甘平,入脾、 胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦 发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。 选用地丁是因为其性味苦,寒,入心、肝经,有清热利湿,解毒消肿的功能,治疔疮,痈肿,瘰 疬,黄疸,痢疾,腹泻,目赤,喉痹,毒蛇咬伤。选用石膏是因为其性味辛甘,寒,入肺、胃经,生 用有解肌清热,除烦止渴的功能,治热病壮热不退,心烦神昏,谵语发狂,口渴咽干,肺热喘 急,中暑自汗,胃火头痛、牙痛,热毒壅盛,发斑发疹,口舌生疮,煅敷生肌敛疮,外治痈疽疮 疡,溃不收回,汤火烫伤。选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的 功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮 疡。选用皂角刺是因为其性味辛,温,有搜风,拔毒,消肿,排脓的功能,治痈肿,疮毒,疠风, 癣疮,胎衣不下。选用金银花是因为其性味甘,寒,入肺、胃经,有清热,解毒的功能,治温病 发热,热毒血痢,痈疡,肿毒,瘰疬,痔漏。选用夏枯草是因为其性味苦辛,寒,入肝、胆经,有 清肝,散结的功能,治瘰疬,癭瘤,乳痈,乳癌,目珠夜痛,羞明流泪,头目眩晕,口眼歪斜,筋 骨疼痛,肺结核,急性黄疸型传染性肝炎,血崩,带下。选用连翘是因为其性味苦,凉,入心、 肝、胆经,有清热,解毒,散结,消肿的功能,治温热,丹毒,斑疹,痈疡肿毒,瘰疬,小便淋闭。 选用土茯苓是因为其性味甘淡,平,入肝、胃经,有解毒,除湿,利关节的功能,治梅毒,淋浊, 筋骨挛痛,脚气,疔疮,痈肿,瘰疬。选用天南星是因为其性味苦辛,温,有毒,入肺、肝、脾经, 有燥湿化痰,祛风定惊,消肿散结的功能,治中风痰壅,口眼喁斜,半身不遂,癫癎,惊风,破 伤风,风痰眩晕,喉痹,瘰疬,痈肿,跌扑折伤,蛇虫咬伤。选用当归是因为其性味甘辛,温,入 心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩 漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用枇杷叶是因 为其性味苦,凉,归肺、胃经,有清肺和胃,降气化痰,治肺热痰嗽,咳血,衄血,胃热呕哕。选 用青蒿是因为其性味苦,微辛,寒,归入肝、胆经,有清热,解暑,除蒸的功能,治温病,暑热, 骨蒸劳热,疥疮,瘙痒。选用白术是因为其性味苦甘,温,入脾、胃经,有补脾,益胃,燥湿,和 中的功能,治脾胃气弱,不思饮食,倦怠少气,虚胀,泄泻,痰饮,水肿,黄疸,湿痹,小便不利, 头晕,自汗,胎气不安。选用山大刀是因为其性味苦,凉,有清热解毒,祛风去湿的功能,治扁 桃体炎,白喉,疮疡肿毒,风湿疼痛,跌打损伤。选用荆芥是因为其性味辛,温,入肺、肝经,有 发表,祛风,理血的功能,炒炭止血,治感冒发热,头痛,咽喉肿痛,中风口噤,吐血,衄血,便 血,崩漏,产后血晕,痈肿,疮疥,瘰疬。选用桑白皮是因为其性味甘,寒,入肺、脾经,有泻肺 平喘,行水消肿的功能,治肺热喘咳,吐血,水肿,脚气,小便不利。选用黄芩是因为其性味苦 寒,入心肺、胆、大肠经,有泻实火,除湿热,止血安胎的功能,治壮热烦渴,肺热咳嗽。选用栀 子是因为其性味苦,寒,入心、肝、肺、胃经,有清热,泻火,凉血的功能,治热病虚烦不眠,黄 疸,淋病,消渴,目赤,咽痛,吐血,衄血,血痢,尿血,热毒疮疡,扭伤肿痛。选用黄连是因为其 性味苦,寒,入心、肝、胃、大肠经,有泻火,燥湿,解毒,杀虫的功能,治时行热毒、伤寒,热盛 心烦,痞满呕逆,菌痢,热泻腹痛,肺结核,吐、衄、下血,消渴,疳积,蛔虫病,百日咳,咽喉肿 痛,火眼,□疮,痈疽疮毒,湿疹,汤火烫伤。选用生地黄是因为其性味甘,寒,归心、肝、肾经, 有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内热消渴,吐血,衄血,发 斑发疹。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功 能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。选用山楂是因 为其性味酸甘,微温,入脾、胃、肝经,有消食积,散瘀血,驱绦虫的功能,治肉积,癥瘕,痰饮, 痞满,吞酸,泻痢,肠风,腰痛,疝气,产后儿枕痛,恶露不尽,小儿乳食停滞。选用薏苡仁是 因为其性味甘淡,凉,入脾、肺、肾经,有健脾,补肺,清热,利湿的功能,治泄泻,湿痹,筋脉拘 挛,屈伸不利,水肿,脚气,肺痿,肺痈,肠痈,淋浊,白带。选用茵陈蒿是因为其性味苦辛,凉, 入肝、脾、膀胱经,有清热利湿的功能,治湿热黄疸,小便不利,风痒疮疥。选用大黄是因为其 性味苦、寒,入胃、大肠、肝径,有泻热毒,破积滞,行瘀血的功能,治实热便秘,谵语发狂,食 积痞满,痢疾初起,里急后重,瘀停经闭,癥瘕积聚,时行热疫,暴眼赤痛,吐血,衄血,阳黄, 水肿,淋浊,溲赤,痈疡肿毒,疔疮,汤火伤。选用赤小豆是因为其性味甘酸,平,入心、小肠 经,有利水除湿,和血排脓,消肿解毒的功能,治水肿,脚气,黄疸,泻痢,便血,痈肿。选用细 辛是因为其性味辛,温,入肺、肾经,有祛风,散寒,行水,开窃的功能,治风冷头痛,鼻渊,止 痛,痰饮咳逆,风湿痹痛。选用麻黄是因为其性味辛苦,温,入肺、膀胱经,有发汗,平喘,利水 的功能,治伤寒表实,发热恶寒无汗、头痛鼻塞、骨节疼痛,咳嗽气喘,风水浮肿,小便不利, 风邪顽痹,皮肤不仁,风疹瘙痒。选用泽泻是因为其性味甘,寒,入膀胱经,有利水,渗湿,泄 热的功能,治小便不利,水肿肛满,呕吐,泻痢,痰饮,脚气,淋病,尿血。选用车前子是因为其 性味甘,寒,入肾、膀胱经,有利水,清热,明目,祛痰的功能,治小便不通,淋池,带下,尿血, 暑湿泻痢,咳嗽多痰,湿痹,目赤障翳。选用神曲是因为其性味甘辛,温,入碑、胃经,有健脾 和胃,消食调中的功能,治饮食停滞,胸痞腹胀,呕吐泻痢,产后瘀血腹痛,小儿腹大坚积。选 用红花是因为其性味辛,温,入心、肝经,有活血通经,去瘀止痛的功能,治经闭,癥瘕,难产, 死胎,产后恶露不行,瘀血作痛,痈肿,跌扑损伤。
具体实施方式
[0007]本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下 述重量范围内都具有较好的疗效: 竹叶10-15克、甘草2-6克、地丁 10-20克、石膏15-25克、赤芍10-20克、皂角刺5-10 克、金银花10-15克、连翘10-15克、夏枯草10-15克、土茯苓10-15克、天南星5-10克、当 归8-12克、枇杷叶8-12克、青蒿10-15克、白术10-15克、山大刀15-25克、荆芥5-10克、 桑白皮8-12克、黄芩8-12克、柅子8-10克、黄连8-10克、生地黄10-15克、牡丹皮10-15 克、山楂20-30克、薏苡仁20-30克、茵陈蒿10-15克、大黄5-10克、赤小豆10-20克、细辛 4-6克,麻黄2-5克、泽泻6-8克、车前子8-10克、神曲10-15克、红花5-10克 优选为: 竹叶10克、甘草4克、地丁 15克、石膏20克、赤芍12克、皂角刺10克、金银花15克、 连翘12克、夏枯草12克、土茯苓15克、天南星10克、当归12克、枇杷叶12克、青蒿10克、 白术12克、山大刀20克、荆芥10克、桑白皮10克、黄芩10克、柅子10克、黄连10克、生 地黄15克、牡丹皮10克、山楂25克、薏苡仁25克、茵陈蒿12克、大黄10克、赤小豆20 克、细辛6克,麻黄3克、泽泻8克、车前子9克、神曲12克、红花8克 本发明药物的制备方法如下 一、备料 1、 竹叶:拣净杂质,除去梗叶,晾干; 2、 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干; 3、 地丁 :拣净杂质,用水洗去泥土,切段,晒干; 4、 石膏:去净杂石,洗净泥土,打碎成小块; 5、 赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎肩; 6、 皂角刺:拣去杂质,用水浸泡,润透后切片,晒干; 7、 金银花:筛去泥沙,拣净杂质; 8、 连翘:拣净杂质,搓开,除去枝梗; 9、 夏枯草:取原药材,除去枝梗、叶片及杂质,筛去灰肩; 10、 土茯苓:用水浸漂,夏季每日换水1次,春、秋每2日换水1次,冬季可3日换水1次, 防止发臭,以泡透为止,捞出切片,及时干燥; 11、 天南星:拣去杂质,洗净灰肩,晒干; 12、 当归:拣去杂质,洗净,闷润,稍晾,切片晒干; 13、 枇杷叶:刷去绒毛,用水洗净,稍润,切丝,晒干; 14、 青蒿:拣去杂质,除去残根,水淋使润,切段,晒干; 15、 白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干; 16、 山大刀:拣净杂质,干燥; 17、 荆芥:拣净杂质,用水略泡,捞出切段,晒干; 18、 桑白皮:刷去灰肩,洗净,润透后切丝,晒干; 19、 黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干; 20、 栀子:筛去灰肩,拣去杂质,碾碎过筛或剪去两端; 21、 黄连:拣去杂质,洗净泥砂,润透,切片,阴干; 22、 生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎肩; 23、 牡丹皮:拣去杂质,除去木心,洗净,润透,切片,瞭干; 24山楂:拣净杂质,筛去核; 25、 意该仁:取原药材,除去残留皮壳、杂质; 26、 茵陈蒿:过筛,拣去杂质,除去残根,碾碎,再过筛去净泥肩; 27、 大黄:拣净杂质,大小分档,闷润至内外湿度均匀,切片或切成小块、晒干; 28、 赤小豆:取原药材,除去杂质,用时捣碎; 29、 细辛:除净杂质,用水喷润,及时切段,晒干; 30、 麻黄:拣去杂质,去尽木质茎及残根,用水洗净,微润后切段,干燥; 31、 泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀, 切片,晒干; 32、 车前子:拣去杂质,筛去泥肩,空粒; 33、 神曲:取麸皮撒匀于热锅内,俟起烟,将神曲倒入,炒至黄色,取出,筛去麸皮,放 凉; 34、 红花:拣净杂质,除去茎叶、蒂头,晒干; 二、制备 1、将所述重量的竹叶、甘草、地丁、石膏、赤芍、皂角刺、金银花、连翘、夏枯草、土茯苓、 天南星,当归、枇杷叶、青蒿、白术、山大刀、荆芥、桑白皮、黄芩、柅子、黄连、生地黄、牡丹皮、 山楂、薏苡仁、茵陈蒿、大黄、赤小豆、细辛、麻黄、泽泻、车前子、神曲、红花放入煎药容器内, 第一次加水8倍量,浸泡150分钟后,武火煎煮沸腾,再用文火煎煮30分钟,过滤得第一次 煎煮液,将第一次煎煮液倒入容器内。
[0008] 2、将过滤的药渣加水6倍量,先用武火煮沸,再用文火煎煮20分钟过滤,将第二次 煎煮液倒入容器内。
[0009] 3、将两次煎煮液混合搅拌均匀,分成2剂服用。
[0010] 组方中皂角刺有拔毒,消肿,排脓的功能为君药;地丁清热利湿,解毒消肿,连翘有 清热,解毒,散结,消肿的功能二者为臣药,三味药共同发挥清热解毒,消肿排脓的作用,治 疗痤疮效力全面;且以清热解毒,拔毒,消肿,散结为主可治本;土茯苓解毒,除湿为佐药; 甘草有和中缓急,润肺,解毒,治痈疽疮疡,调和诸药的功能,与下余诸药是治标。
[0011] 本发明药物具有清热解毒,消肿排脓的功能,用于治疗痤疮,疗程短、见效快、治愈 后不复发、无毒副作用。
[0012]
具体实施方式: 以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药 物的动物毒性试验报告和临床疗效观察资料。
[0013] [试验例1]本发明药物的动物毒性试验报告: 取家兔30只,雌雄兼用,体重2. 0 - 2. 5kg,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。服用药液超常量组为20ml/kg,正常量为10ml/kg,给药方式为 灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常, 药物无不良毒副作用。
[0014][试验例2]本发明药物的临床疗效观察 1、一般资料 收治痤疮门诊患者共38例。
[0015] 2、诊断标准 根据青少年发病、皮损分布于颜面和胸背部、主要表现为白头、黑头粉刺、炎性丘疹、脓 疱等多形性皮损等特点,临床易于诊断,通常无需做其他检查。有时需要与酒渣鼻、颜面播 散性粟粒性狼疮、皮脂腺瘤等鉴别。
[0016] 3、治疗方法 选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续 服用3个疗程。
[0017] 4、疗效评定标准 显效:座疮症状消失,疫愈; 好转:面部的粉刺、丘疹、脓疱等皮损减轻,痤疮症状明显好转; 无效:达不到好转标准者。
[0018] 5、治疗结果(见下表)
Figure CN105362822AD00081
在上述治疗中,用本发明药物治疗痤疮患者38例,结果显效34例,显效率为89. 47%,好 转3例,好转率为7. 90%,无效1例,总有效率为97. 37%。

Claims (3)

1. 一种治疗痤疮的药物,其特征在于:它是由下列用量范围内的原料药制成: 竹叶10-15克、甘草2-6克、地丁 10-20克、石膏15-25克、赤芍10-20克、皂角刺5-10 克、金银花10-15克、连翘10-15克、夏枯草10-15克、土茯苓10-15克、天南星5-10克、当 归8-12克、枇杷叶8-12克、青蒿10-15克、白术10-15克、山大刀15-25克、荆芥5-10克、 桑白皮8-12克、黄芩8-12克、柅子8-10克、黄连8-10克、生地黄10-15克、牡丹皮10-15 克、山楂20-30克、薏苡仁20-30克、茵陈蒿10-15克、大黄5-10克、赤小豆10-20克、细辛 4-6克,麻黄2-5克、泽泻6-8克、车前子8-10克、神曲10-15克、红花5-10克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 竹叶10克、甘草4克、地丁 15克、石膏20克、赤芍12克、皂角刺10克、金银花15克、 连翘12克、夏枯草12克、土茯苓15克、天南星10克、当归12克、枇杷叶12克、青蒿10克、 白术12克、山大刀20克、荆芥10克、桑白皮10克、黄芩10克、柅子10克、黄连10克、生 地黄15克、牡丹皮10克、山楂25克、薏苡仁25克、茵陈蒿12克、大黄10克、赤小豆20 克、细辛6克,麻黄3克、泽泻8克、车前子9克、神曲12克、红花8克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (1) 竹叶:拣净杂质,除去梗叶,晾干; (2) 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干; (3 )地丁 :拣净杂质,用水洗去泥土,切段,晒干; (4) 石膏:去净杂石,洗净泥土,打碎成小块; (5) 赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎肩; (6) 皂角刺:拣去杂质,用水浸泡,润透后切片,晒干; (7) 金银花:筛去泥沙,拣净杂质; (8) 连翘:拣净杂质,搓开,除去枝梗; (9) 夏枯草:取原药材,除去枝梗、叶片及杂质,筛去灰肩; (10) 土茯苓:用水浸漂,夏季每日换水1次,春、秋每2日换水1次,冬季可3日换水1 次,防止发臭,以泡透为止,捞出切片,及时干燥; (11) 天南星:拣去杂质,洗净灰肩,晒干; (12) 当归:拣去杂质,洗净,闷润,稍晾,切片晒干; (13) 枇杷叶:刷去绒毛,用水洗净,稍润,切丝,晒干; (14) 青蒿:拣去杂质,除去残根,水淋使润,切段,晒干; (15) 白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干; (16) 山大刀:拣净杂质,干燥; (17) 荆芥:拣净杂质,用水略泡,捞出切段,晒干; (18) 桑白皮:刷去灰肩,洗净,润透后切丝,晒干; (19) 黄芩:拣去杂质,除去残茎,用凉水浸润或置开水中稍浸捞出,切片,晒干; (20) 栀子:筛去灰肩,拣去杂质,碾碎过筛或剪去两端; (21) 黄连:拣去杂质,洗净泥砂,润透,切片,阴干; (22) 生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎肩; (23) 牡丹皮:拣去杂质,除去木心,洗净,润透,切片,瞭干; (24) 山楂:拣净杂质,筛去核; (25) 意该仁:取原药材,除去残留皮壳、杂质; (26) 茵陈蒿:过筛,拣去杂质,除去残根,碾碎,再过筛去净泥肩; (27) 大黄:拣净杂质,大小分档,闷润至内外湿度均匀,切片或切成小块、晒干; (28) 赤小豆:取原药材,除去杂质,用时捣碎; (29) 细辛:除净杂质,用水喷润,及时切段,晒干; (30) 麻黄:拣去杂质,去尽木质茎及残根,用水洗净,微润后切段,干燥; (31) 泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀, 切片,晒干; (32) 车前子:拣去杂质,筛去泥肩,空粒; (33) 神曲:取麸皮撒匀于热锅内,俟起烟,将神曲倒入,炒至黄色,取出,筛去麸皮,放 凉; (34) 红花:拣净杂质,除去茎叶、蒂头,晒干; (二)制备 (1) 将所述重量的竹叶、甘草、地丁、石膏、赤芍、皂角刺、金银花、连翘、夏枯草、土茯苓、 天南星,当归、枇杷叶、青蒿、白术、山大刀、荆芥、桑白皮、黄芩、柅子、黄连、生地黄、牡丹皮、 山楂、薏苡仁、茵陈蒿、大黄、赤小豆、细辛、麻黄、泽泻、车前子、神曲、红花放入煎药容器内, 第一次加水8倍量,浸泡150分钟后,武火煎煮沸腾,再用文火煎煮30分钟,过滤得第一次 煎煮液,将第一次煎煮液倒入容器内; (2) 将过滤的药渣加水6倍量,先用武火煮沸,再用文火煎煮20分钟过滤,将第二次煎 煮液倒入容器内; (3) 将两次煎煮液混合搅拌均匀,分成2剂服用。
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