CN104398925A - 一种治疗皮肤病的药物及其制备方法 - Google Patents

一种治疗皮肤病的药物及其制备方法 Download PDF

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CN104398925A
CN104398925A CN201410611963.5A CN201410611963A CN104398925A CN 104398925 A CN104398925 A CN 104398925A CN 201410611963 A CN201410611963 A CN 201410611963A CN 104398925 A CN104398925 A CN 104398925A
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薛学明
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薛学明
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Abstract

本发明公开了一种治疗皮肤病的药物及其制备方法,它主要是由蝉蜕、野菊花、桑叶、白芷、泽泻、苦参、金银花、木通、刺蒺藜、甘草、当归按一定重量配比制备而成,本发明药物具有疏风清热,破血通经,解毒消肿的功能,用于治疗皮肤病见效快,疗效发,无毒副作用。

Description

一种治疗皮肤病的药物及其制备方法
技术领域
[0001] 本发明涉及一种用于治疗皮肤病的药物及其制备方法,属中药领域。 技术背景
[0002] 皮肤病是一种严重影响人民健康的常见病、多发病之一,皮肤病是由皮肤受到内 外因素的影响后,其形态、结构和功能均发生变化,产生病理过程,并相应的产生各种临床 先后表现。皮肤病的发病率很高,多比较轻,常不影响健康,但少数较重甚至可以危及生命。 目前,西药治疗皮肤病效果不佳,且长期服用西药有较多副作用,因此,人们对有效治疗皮 肤病的中药存在很大的需求。
发明内容
[0003] 本发明人依据中医理论的研究及临床反复的试验和验证,终于找到了有效治疗皮 肤病的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种能够有效治疗皮肤病的组合药物。
[0005] 本发明的另一个目的就是提供了该组合药物的制备方法。
[0006] 本发明药物是选用蝉蜕、菊花、桑叶、白芷、泽泻、苦参、金银花、木通、刺蒺藜、甘 草、当归、火麻仁、地肤子、荆芥、薄荷、生地黄、篇蓄、瞿麦、红豆、冬瓜皮、猪苓、土茯苓、郁李 仁、麻黄、防风、浮萍、白鲜皮、臭梧桐、威灵仙药物进行组合的,将这些药物组合使得各药物 功效产生协同作用,从而能够快速治疗皮肤病的复发。其中选用蝉蜕是因为其性味甘咸, 凉,入肺、肝经,有散风热,宣肺,定痉的功能,治外感风热,咳嗽音哑,麻疹透发不畅,风疹 瘙痒,小儿惊癎,目赤,翳障,疔疮肿毒,破伤风。选用菊花是因为其性味苦辛,凉,入肺、肝 经,有疏风清热,消肿解毒的功能,治风热感冒,头痛,眩晕。选用桑叶是因为其性味苦甘, 寒,入肺、肝经,有祛风清热,凉血明目的功能,治风湿发热,头痛,目赤,口渴,肺热咳嗽,风 痹,瘾疹,下肢象皮肿。选用白芷是因为其性味辛,温,入肺、脾、胃经,有祛风,燥湿,消肿, 止痛的功能,治头痛,眉棱骨痛,齿痛,鼻渊,寒湿腹痛,肠风痔漏,赤白带下,痈疽疮疡,皮肤 燥痒,疥癣。选用泽泻是因为其性味甘,寒,入膀胱经,有利水,渗湿,泄热的功能,治小便 不利,水肿肛满,呕吐,泻痢,痰饮,脚气,淋病,尿血。选用苦参是因为其性味苦,寒,入肝、 肾、大肠、小肠经,有清热,燥湿,杀虫的功能,治热毒血痢,肠风下血,黄疸,赤白带下,小儿 肺炎,疳积,急性扁桃体炎,痔漏,脱肛,皮肤瘙痒,阴疮湿痒,瘰疬,烫伤。选用金银花是因 为其性味甘,寒,入肺、胃经,有清热,解毒的功能,治温病发热,热毒血痢,痈疡,肿毒,瘰疬, 痔漏。选用木通是因为其性味苦,凉,入心、小肠、膀胱经,有泻火行水,通利血脉的功能,治 小便赤涩,淋浊,水肿,胸中烦热,喉痹咽痛,遍身拘痛,妇女经闭,乳汁不通。选用刺蒺藜是 因为其性味苦辛,温,入肝、肺经,有散风,明目,下气,行血的功能,治头痛,身痒,目赤肿翳, 胸满,咳逆,癥瘕,乳难,痈疽,瘰疬。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓 急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心 悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用当归是因为其 性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹 痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。 选用火麻仁是因为其性味甘,平,入脾、胃、大肠经,有润燥,滑肠,通淋,活血的功能,治肠燥 便秘,消渴,热淋,风痹,痢疾,月经不调,疥疮,癣癫。选用地肤子是因为其性味甘苦,寒,入 肾、膀胱经,有利小便,清湿热的功能,治小便不利,淋病,带下,疝气,风疫,疮毒,疥癣,阴部 湿痒。选用荆芥是因为其性味辛,温,入肺、肝经,有发表,祛风,理血的功能,炒炭止血,治 感冒发热,头痛,咽喉肿痛,中风口噤,吐血,衄血,便血,崩漏,产后血晕,痈肿,疮疥,瘰疬。 选用薄荷是因为其性味辛,凉,入肺、肝经,有疏风,散热,辟秽,解毒的功能,治外感风热,头 痛,目赤,咽喉肿痛,食滞气胀,口疮,牙痛,疮挤,瘾疹。选用生地黄是因为其性味甘,寒,归 心、肝、肾经,有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内热消渴, 吐血,衄血,发斑发疹。选用篇蓄是因为其性味苦,寒,入膀胱经,有利尿,清热,杀虫的功能, 治热淋、癃闭,黄疸,阴蚀,白带,蛔虫,疳积,痔肿,湿疮。选用瞿麦是因为其性味苦,寒,入 心、肾、小肠、膀胱经,有清热利水,破血通经的功能,治小便不通,淋病,水肿,经闭,痈肿,目 赤障翳,浸淫疮毒。选用红豆是因为其性平,味苦,有小毒,有理气,通经的功能,治疝气,腹 痛,血滞经闭。选用冬瓜皮是因为其性味甘,凉,入脾、肺二经,有利水消种的功能,治水肿, 腹泻,痈肿。选用猪苓是因为其性味甘淡,平,入脾、肾、膀胱经,有利尿渗湿的功能,治小便 不利,水肿胀满,脚气,泄泻,淋、浊,带下。选用土茯苓是因为其性味甘淡,平,入肝、胃经, 有解毒,除湿,利关节的功能,治梅毒,淋浊,筋骨挛痛,脚气,疔疮,痈肿,瘰疬。选用郁李仁 是因为其性味辛苦甘,平,入脾、大小肠经,有润燥,滑肠,下气,利水的功能,治大肠气滞,燥 涩不通,小便不利,大腹水肿,四肢浮肿,脚气。选用麻黄是因为其性味辛苦,温,入肺、膀胱 经,有发汗,平喘,利水的功能,治伤寒表实,发热恶寒无汗、头痛鼻塞、骨节疼痛,咳嗽气喘, 风水浮肿,小便不利,风邪顽痹,皮肤不仁,风疹瘙痒。选用防风是因为其性味辛甘,温,入膀 胱、肺、脾经,有发表,祛风,胜湿,止痛的功能,治外感风寒,头痛,目眩,项强,风寒湿痹,骨 节酸痛,四肢挛急,破伤风。选用浮萍是因为其性味辛,寒,入肺经,有发汗,祛风,行水,清 热,解毒的功能,治时行热病,斑疹不透,风热瘾疹,皮肤瘙痒,水肿,癃闭,疮癣,丹毒,烫伤。 选用白鲜皮是因为其性味苦,咸,寒,入脾、胃经,有祛风,燥湿,清热,解毒的功能,治风热疮 毒,疥癣,皮肤痒疹,风湿痹痛,黄疸。选用臭梧桐是因为其性味苦带甘,有祛风湿,降血压的 功能,治风湿痹痛,半身不遂,高血压病,偏头痛,疟疾,痢疾,痔疮,痈疽疮疥。选用威灵仙是 因为其性味辛咸,温,有毒,入膀胱经,有祛风湿,通经络,消痰涎,散癖积的功能,治痛风、顽 痹、腰膝冷痛,脚气,疟疾,癥瘕积聚,破伤风,扁桃体炎,诸骨鲠咽。
[0007] 本发明选用苦参为君药,白芷、浮萍为臣药,生地黄为佐药,甘草为使药,共同组成 治疗皮肤病的中药方剂。
[0008] 本发明组合的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下 述重量范围内都具有较好疗效 蝉蜕 10-20克 菊花 10-20克 桑叶 10-20克 白芷 10-20克 泽泻 10-20克 苦参 15-25克 金银花 15-25克 木通 10-20克 刺蒺藜 5-15克 甘草 10-20克 当归 10-20克 火麻仁 15-25克 地肤子 20-30克 荆芥 10-20克 薄荷 10-20克 生地黄 20-30克 篇蓄 10-20克 瞿麦 10-20克 红豆 15-25克 冬瓜皮 10-20克 猪苓 10-20克 土茯苓 10-20克 郁李仁 10-20克 麻黄 10-20克 防风 10-20克 浮萍 10-20克 白鲜皮 10-20克 臭梧桐 10-20克 威灵仙 10-20克 优选用量为 蝉蜕 15克 菊花 15克 桑叶 15克 白芷 15克 泽泻 15克 苦参 20克 金银花 20克 木通 15克 刺蒺藜 10克 甘草 15克 当归 15克 火麻仁 20克 地肤子 25克 荆芥 15克 薄荷 15克 生地黄 25克 篇蓄 15克 瞿麦 15克 红豆 20克 冬瓜皮 15克 猪苓 15克 土茯苓 15克 郁李仁 15克 麻黄 15克 防风 15克 浮萍 15克 白鲜皮 15克 臭梧桐 15克 威灵仙 15克 本发明药物的制备方法如下 一、备料 1、 蝉蜕:拣去杂质,洗净晒干; 2、 菊花:拣净叶梗、花柄及泥屑杂质; 3、 桑叶:拣去杂质,搓碎,簾去梗,筛去泥屑; 4、 白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切片 干燥; 5、 泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切 片,晒干; 6、 苦参:拣净杂质,除去残茎,洗净泥土,用水浸泡,捞出,润透,切片,晒干; 7、 金银花:筛去泥沙,拣净杂质; 8、 木通:用水稍浸泡,闷润至透,切片,晒干; 9、 刺蒺藜:漂去泥沙,除净残留的硬刺; 10、 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晒干; 11、 当归:拣去杂质,洗净,闷润,稍晾,切片晒干; 12、 火麻仁:拣去杂质及残留外壳,取净仁; 13、 地肤子:取原药材,除去杂质,筛去碎屑; 14、 荆芥:拣净杂质,用水略泡,捞出切段,晒干; 15、 薄荷:拣净杂质,除去残根,先将叶抖下另放,然后将茎喷洒清水,润透后切段,晒 干,再与叶和勻; 16、 生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑; 17、 篇蓄:去净杂质及根,洗净,润软,切段晒干; 18、 瞿麦:拣净杂质,除去残根,洗净,焖润,切段,晒干; 19、 红見:秋末冬初米种子,晒干; 20、 冬瓜皮:取原药材,除去杂质及霉烂变质者,洗净,切块,干燥,筛去碎屑; 21、 猪苓:洗净泥砂,润软切片,晾干; 22、 土茯苓:用水浸漂,夏季每日换水1次,春、秋每2日换水1次,冬季可3日换水1次, 防止发臭,以泡透为止,捞出切片,及时干燥; 23、 郁李仁:筛去泥屑,淘净,拣净杂质和碎壳,晒干,用时捣碎; 24、 麻黄:拣去杂质,去尽木质茎及残根,用水洗净,微润后切段,干燥即得; 25、 防风:除去残茎,用水浸泡,捞出,润透切片,晒干 26、 浮萍:6-9月间捞取,晒干; 27、 白鲜皮:拣净杂质,除去粗皮,洗净,稍润,切片,晒干; 28、 臭梧桐:拣去杂草,用清水略浸,润透,切成1厘米长的小段,晒干; 29、 威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干。
[0009]二、制备 1、将所述重量的蝉蜕、菊花、桑叶、白芷、泽泻、苦参、金银花、木通、刺蒺藜、甘草、当归、 火麻仁、地肤子、荆芥、薄荷、生地黄、篇蓄、瞿麦、红豆、冬瓜皮、猪苓、土茯苓、郁李仁、麻黄、 防风、浮萍、白鲜皮、臭梧桐、威灵仙药物,加水6倍量,浸泡100分钟后,武火煎煮沸腾20分 钟,再用文火煎煮20分钟,过滤得煎煮液,将煎煮液倒入容器内。
[0010] 2、将过滤的药渣加水4倍量,煮沸,再用文火煎煮10分钟,过滤得第二次煎煮液。
[0011] 3、合并二次煎煮液即得,将药液分为4剂服用。
[0012] 本发明药物具有疏风清热,破血通经,解毒消肿的功能,用于治疗皮肤病,疗程短、 见效快、无毒副作用。
具体实施方式
[0013] 以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括了本 发明药物的动物毒性试验报告和临床观察资料。
[0014] [试验例1]本发明药物的动物毒性试验报告: 取家兔30只,雌雄兼用,体重2. 0-2. 4kg,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给 药,每天2次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良 毒副作用。
[0015] [试验例2]本发明药物治疗皮肤病的观察资料 1、一般资料 收治皮肤病患者共38例。
[0016] 2、诊断标准 临床表现 多发生在皮肤的外露部分,全身可见,局部出现不规则扁平肿块,瘙痒难忍,搔之易溃, 久溃不愈,皮损处可有瘙痒胀痛感。
[0017] 3、治疗方法 选用上述药剂,给患者服用,每日2次,每次服用1剂,每天早、晚各服1次,7天为一个 疗程,连续服用3个疗程。(孕妇禁服,身体虚弱者待身体食补强壮后再服用)。
[0018] 4、疗效评定标准 显效:皮肤病症状消失,观察半年无反弹者; 好转:皮肤病症状明显改善,体质逐步增强; 无效:皮肤病症状无改变,达不到好转标准者。
[0019] 5、治疗结果(见下表)
Figure CN104398925AD00081
在上述的治疗中,用本发明药物治疗皮肤病患者38例,结果显效35例,显效率为 92. 11%,好转2例,好转率为5. 26%,无效1例,总有效率为97. 37%。

Claims (3)

1. 一种治疗皮肤病的药物,其特征在于:它是由下列重量范围内的原料药制成: 蝉蜕10-20克 菊花10-20克 桑叶10-20克 白芷10-20克 泽泻10-20克 苦参15-25克 金银花15-25克木通10-20克刺蒺藜5-15克 甘草10-20克 当归10-20克 火麻仁15-25克 地肤子20-30克荆芥10-20克薄荷10-20克 生地黄20-30克篇蓄10-20克瞿麦10-20克 红豆15-25克 冬瓜皮10-20克 猪苓10-20克 土茯苓10-20克 郁李仁10-20克 麻黄10-20克 防风10-20克浮萍10-20克 白鲜皮10-20克 臭梧桐10-20克威灵仙10-20克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 蝉蜕15克 菊花15克 桑叶15克 白芷15克泽泻15克苦参20克 金银花20克木通15克刺蒺藜10克 甘草15克 当归15克 火麻仁20克 地肤子25克荆芥15克薄荷15克 生地黄25克篇蓄15克瞿麦15克 红豆20克 冬瓜皮15克 猪苓15克 土茯苓15克郁李仁15克麻黄15克 防风15克浮萍15克白鲜皮15克 臭梧桐15克威灵仙15克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (一)备料 (1) 蝉蜕:拣去杂质,洗净晒干; (2) 菊花:拣净叶梗、花柄及泥屑杂质; (3) 桑叶:拣去杂质,搓碎,簾去梗,筛去泥屑; (4) 白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切 片干燥; (5) 泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀, 切片,晒干; (6) 苦参:拣净杂质,除去残茎,洗净泥土,用水浸泡,捞出,润透,切片,晒干; (7) 金银花:筛去泥沙,拣净杂质; (8) 木通:用水稍浸泡,闷润至透,切片,晒干; (9) 刺蒺藜:漂去泥沙,除净残留的硬刺; (10) 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晒干; (11) 当归:拣去杂质,洗净,闷润,稍晾,切片晒干; (12) 火麻仁:拣去杂质及残留外壳,取净仁; (13) 地肤子:取原药材,除去杂质,筛去碎屑; (14) 荆芥:拣净杂质,用水略泡,捞出切段,晒干; (15) 薄荷:拣净杂质,除去残根,先将叶抖下另放,然后将茎喷洒清水,润透后切段,晒 干,再与叶和勻; (16) 生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑; (17) 篇蓄:去净杂质及根,洗净,润软,切段晒干; (18) 瞿麦:拣净杂质,除去残根,洗净,焖润,切段,晒干; (19) 红見:秋末冬初米种子,晒干; (20) 冬瓜皮:取原药材,除去杂质及霉烂变质者,洗净,切块,干燥,筛去碎屑; (21) 猪苓:洗净泥砂,润软切片,晾干; (22) 土茯苓:用水浸漂,夏季每日换水1次,春、秋每2日换水1次,冬季可3日换水1 次,防止发臭,以泡透为止,捞出切片,及时干燥; (23) 郁李仁:筛去泥屑,淘净,拣净杂质和碎壳,晒干,用时捣碎; (24) 麻黄:拣去杂质,去尽木质茎及残根,用水洗净,微润后切段,干燥即得; (25) 防风:除去残茎,用水浸泡,捞出,润透切片,晒干 (26) 浮萍:6-9月间捞取,晒干; (27) 白鲜皮:拣净杂质,除去粗皮,洗净,稍润,切片,晒干; (28) 臭梧桐:拣去杂草,用清水略浸,润透,切成1厘米长的小段,晒干; (29) 威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干; (二)制备 (1) 将所述重量的蝉蜕、野菊花、桑叶、白芷、泽泻、苦参、金银花、木通、刺蒺藜、甘草、当 归、火麻仁、地肤子、荆芥、薄荷、生地黄、篇蓄、瞿麦、红豆、冬瓜皮、猪苓、土茯苓、郁李仁、麻 黄、防风、浮萍、白鲜皮、臭梧桐、威灵仙药物,加水6倍量,浸泡100分钟后,武火煎煮沸腾20 分钟,再用文火煎煮20分钟,过滤得煎煮液,将煎煮液倒入容器内; (2) 将过滤的药渣加水4倍量,煮沸,再用文火煎煮10分钟,过滤得第二次煎煮液; (3) 合并二次煎煮液即得。
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