CN105412622A - 一种治疗面瘫的药物及其制备方法 - Google Patents
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Abstract
本发明公开了一种治疗面瘫的药物及其制备方法,其主要是由牛蒡子、僵蚕、枳壳、天麻、甘草、白芷、防风、川芎、天南星、羌活、生地黄、当归、赤芍、蔓荆子、金银花、全蝎、钩藤、白附子、乌药、路路通、浙贝母、紫苏叶、牡丹皮、蝉蜕按一定重量配比制备而成。本发明药物具有祛风,镇痉,治口眼歪斜,惊痫抽搐,活血补血,通络的功能,用于治疗面瘫见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗面瘫的药物及其制备方法,属中药领域。
技术背景
面瘫是指以面部表情肌群运动功能障碍为主要特征的一种常见病。一般症状是口眼歪斜。它是一种常见病、多发病,它不受年龄限制。患者往往连最基本的抬眉、闭眼、鼓嘴等动作都无法完成。中医则认为面瘫与风寒邪毒,气滞血瘀,气血不足,经络阻痹有关。由于西药治疗副作用大,因此人们对有效治疗面瘫的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗面瘫的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗面瘫的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择牛蒡子、僵蚕、枳壳、天麻、甘草、白芷、防风、川芎、天南星、连翘、羌活、生地黄、当归、赤芍、蔓荆子、金银花、全蝎、钩藤、白附子、乌药、路路通、桂枝、浙贝母、紫苏叶、牡丹皮、蝉蜕、半夏、石菖蒲、菊花、秦艽原料药进行组合制备的,将这些原料药组合使得各药物功效产生协同作用,从而能够有效治疗面瘫。其中,选用牛蒡子是因为其性味辛苦,凉,入肺、胃经,有疏散风热,宣肺透疹,消肿解毒的功能,治风热咳嗽,咽喉肿痛,斑疹不透,风疹作痒,痈肿疮毒。选用僵蚕是因为其性味辛、咸,平,归肝,肺经。祛风解痉,化痰散结。用于中风口眼歪斜,惊痫抽搐,头赐,喉痹,瘰疠结核,风疹丹毒。选用枳壳是因为其性味苦辛、凉。入肺、脾、大肠经。破气,行痰,消积。治胸膈痰滞,胸痞,胁胀,食积,噫气,呕逆,下痢后重,脱肛,子宫脱垂。选用天麻是因为其性味甘,平,入肝经,有息风,定惊的功能,治眩晕眼黑,头风头痛,肢体麻木,半身不遂,语言蹇涩,小儿惊癎动风。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用白芷是因为其性味辛,温,入肺、脾、胃经,有祛风,燥湿,消肿,止痛的功能,治头痛,眉棱骨痛,齿痛,鼻渊,寒湿腹痛,肠风痔漏,赤白带下,痈疽疮疡,皮肤燥痒,疥癣。选用防风是因为其性味辛甘,温,入膀胱、肺、脾经,有发表,祛风,胜湿,止痛的功能,治外感风寒,头痛,目眩,项强,风寒湿痹,骨节酸痛,四肢挛急,破伤风。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用天南星是因为其性味苦辛,温,有毒,入肺、肝、脾经,有燥湿化痰,祛风定惊,消肿散结的功能,治中风痰壅,口眼斜,半身不遂,癫癎,惊风,破伤风,风痰眩晕,喉痹,瘰疬,痈肿,跌扑折伤,蛇虫咬伤。选用连翘是因为其性味苦,凉,入心、肝、胆经,有清热,解毒,散结,消肿,治温热,丹毒,斑疹,痈疡肿毒,瘰疬,小便淋闭。选用羌活是因为其性味辛苦,温,入膀胱、肾经,有散表寒,祛风湿,利关节的功能,治感冒风寒,头痛无汗,风寒湿痹,项强筋急,骨节酸疼,风水浮肿,痈疽疮毒。选用生地黄是因为其性味甘,寒,归心、肝、肾经,有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内热消渴,吐血,衄血,发斑发疹。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用蔓荆子是因为其性味苦辛,凉,入肝、胃,膀胱经,有疏散风热,清利头目的功能,治风热感冒,正、偏头痛,齿痛,目睛内痛。选用金银花是因为其性味甘,寒,入肺、胃经,有清热,解毒的功能,治温病发热,热毒血痢,痈疡,肿毒,瘰疬,痔漏。选用全蝎是因为其性味咸辛,平,有毒,入足厥阴经,有祛风,止痉,通络,解毒的功能,治惊风抽搐,癫癎,中风、半身不遂、口眼喎斜,偏头痛,风湿痹痛,破伤风,淋巴结结核,风疹疮肿。选用钩藤是因为其性味苦,凉,入肝、心经,有清热平肝,熄风定惊的功能,治小儿惊癎瘈瘲,大人血压偏高,头晕、目眩,妇人子癎。选用白附子是因为其性味辛,温,归胃、肝经,有祛风痰,镇痉的功能,治中风、口眼歪斜,面神经麻痹,偏头痛,破伤风,淋巴结结核,痈肿。选用乌药是因为其性味辛,温,入脾、肺、肾、膀胱经,有顺气,开郁,散寒,止痛的功能,治气逆胸腹胀痛,宿食不满,反胃吐食,寒疝,脚气,小便频数。选用路路通是因为其性味苦平,通行十二经,有祛风通络,利尿除湿的功能,治水肿,胀满,经闭,乳少,手足拘挛。选用桂枝是因为其性味辛甘,温,入膀胱、心、肺经,有发汗解肌,温经通脉的功能,治风寒表证,肩背肢节酸疼,胸痹痰饮,经闭癥瘕。选用浙贝母是因为其性味苦,微寒,归肺、心经,有清热散结,化痰止咳的功能,治风热犯肺,痰火咳嗽,肺痈,乳痈,瘰疬,疮毒,心胸郁闷。选用紫苏叶是因为其性味辛,温,入肺、脾经,有发表,散寒,理气,和营的功能,治感冒风寒,恶寒发热,咳嗽,气喘,胸腹胀满,胎动不安,并能解鱼蟹毒。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。选用蝉蜕是因为其性味甘咸,凉,入肺、肝经,有散风热,宣肺,定痉的功能,治外感风热,咳嗽音哑,麻疹透发不畅,风疹瘙痒,小儿惊癎,目赤,翳障,疔疮肿毒,破伤风。选用半夏是因为其性味辛,温,有毒,入脾、胃经,有燥湿化痰,降逆止呕,清痞散结的功能,治湿痰冷饮呕吐,反胃,咳喘痰多,我膈胀满,痰厥头痛,头晕不眠,外消痈肿。选用石菖蒲是因为其性味辛苦,微温,入心、肝、脾经,有开窍,豁痰,理气,活血,散风,去湿的功能,治癫癎,痰厥,热病神昏,健忘,气闭耳聋,心胸烦闷,胃痛,腹痛,风寒湿痹,痈疽肿毒,跌打损伤。选用菊花是因为其性味甘苦,凉,入肺,肝经,有疏风,消热,明目,解毒的功能,治头痛,眩晕,目赤,心胸烦热,疔疮,肿毒。选用秦艽是因为其性味苦辛,平,入肝、胃、胆经,有祛风除湿,和血舒筋,清热利尿的功能,治风湿痹痛,筋骨拘挛,黄疸,便血,骨蒸潮热,小儿疳热,小便不利。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效
牛蒡子15-25克,僵蚕5-15克,枳壳10-15克,天麻10-20克,甘草4-7克,白芷10-15克,防风5-15克,川芎10-20克,天南星5-15克,连翘10-20克,羌活5-15克,生地黄10-20克,当归5-15克,赤芍5-15克,蔓荆子7-12克,金银花10-15克,全蝎4-8克,钩藤10-20克,白附子5-15克,乌药5-15克,路路通15-25克,桂枝5-15克,浙贝母5-15克,紫苏叶5-15克,牡丹皮7-12克,蝉蜕5-15克,半夏5-15克,石菖蒲5-15克,菊花5-15克,秦艽10-20克。
优选为
牛蒡子20克,僵蚕10克,枳壳12克,天麻15克,甘草6克,白芷12克,防风10克,川芎15克,天南星10克,连翘15克,羌活10克,生地黄15克,当归10克,赤芍10克,蔓荆子9克,金银花12克,全蝎6克,钩藤15克,白附子10克,乌药10克,路路通20克,桂枝10克,浙贝母10克,紫苏叶10克,牡丹皮9克,蝉蜕10克,半夏10克,石菖蒲10克,菊花10克,秦艽15克。
本发明药物的制备方法如下
一、备料
1、牛蒡子:拣去杂质,筛去泥屑;
2、僵蚕:取原药材,除去残丝,杂质;
3、枳壳:除去瓤、核,洗净,稍浸,捞出,润软,切片,晾干;
4、天麻:拣去杂质,大小分档,用水浸泡至七成透,捞出,稍晾,再润至内外温度均匀,切片,晒干;
5、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晾干;
6、白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切片干燥;
7、防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
8、川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
9、天南星:拣去杂质,洗净灰屑,晒干;
10、连翘:拣净杂质,搓开,除去枝梗;
11、羌活:拣去杂质,洗净,润透,切片,晾干;
12、生地黄:除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
13、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
14、赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
15、蔓荆子:筛净灰屑,除去残存萼片,置锅内用武火炒至焦黄色,略喷清水,放凉;
16、金银花:筛去泥沙,拣净杂质;
17、全蝎:清水漂去盐质,晒干,或微火焙用;
18、钩藤:拣去老梗、杂质,洗净,晒干;
19、白附子:取原药材,除去杂质,洗净,干燥;
20、乌药:拣去杂质,分开大小条,用水泡透,根据季节注意换水,防止发臭,及时捞出切片,筛去灰屑;
21、路路通:除去杂质,洗净,晒干;
22、桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
23、浙贝母:除去杂质,大小分档,洗净,润透,切厚片,干燥,街去碎屑,或打碎;
24、紫苏叶:拣去杂质,晒干;
25、牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
26、蝉蜕:拣去杂质,洗净晒干;
27、半夏:拣去杂质,筛去灰屑;
28、石菖蒲:拣去杂质,洗净,稍浸泡,润透,切片,晒干;
29、菊花:拣净叶梗、花柄及泥屑杂质;
30、秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干。
二、制备
1、将炮制后的牛蒡子、僵蚕、枳壳、天麻、甘草、白芷、防风、川芎、天南星、连翘、羌活、生地黄、当归、赤芍、蔓荆子、金银花、全蝎、钩藤、白附子、乌药、路路通、桂枝、浙贝母、紫苏叶、牡丹皮、蝉蜕、半夏、石菖蒲、菊花、秦艽放入煎药容器内,第一次加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀即得,分为4剂服用。
组方中白附子有祛风,镇痉的功能,治中风、口眼歪斜,面神经麻痹的功能为君药;僵蚕祛风解痉,治中风口眼歪斜,惊痫抽搐;川芎有行气开郁,祛风燥湿,活血,治寒痹筋挛的功能,二者为臣药,三味药共同发挥祛风解痉,活血,通络,解毒,治风湿痹痛,口眼喎斜的作用,治疗面瘫效力全面,且以祛风解痉,活血,通络为主可治本,路路通有祛风通络,治手足拘挛的功能为佐药,甘草有和中缓急,润肺,解毒,调和诸药,治脾胃虚弱,解药毒及食物中毒的功能为使药,与余下诸药是治标。
本发明药物具有祛风,镇痉,治中风口眼歪斜,惊痫抽搐,活血,通络的功能,用于治疗面瘫,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。服用药液超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治面瘫门诊患者共26例。
2、诊断标准
典型症状为面神经受损时引起,出现病灶同侧全部面肌瘫痪,从上到下表现为不能皱额、皱眉、闭目、角膜反射消失,鼻唇沟变浅,不能露齿、鼓腮、吹口哨,口角下垂(或称口角歪向病灶对侧,即瘫痪面肌对侧)。多见于受寒、耳部或脑膜感染、神经纤维瘤引起的周围型面神经麻痹。此外还可出现舌前2/3味觉障碍,说话不清晰等。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,10天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:面瘫症状消失,体质恢复正常,痊愈;
好转:患者说话不清面颊动作不灵、嘴巴歪斜,面部肌肉松弛、面纹消失,味觉障碍的现象减轻,面瘫症状明显好转,体质逐步恢复;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗面瘫患者26例,结果显效18例,显效率为69.23%,好转6例,好转率为23.08%,无效2例,总有效率为92.31%。
Claims (3)
1.一种治疗面瘫的药物,其特征在于:它是由下列重量范围内的原料药制成:
牛蒡子15-25克,僵蚕5-15克,枳壳10-15克,天麻10-20克,甘草4-7克,白芷10-15克,防风5-15克,川芎10-20克,天南星5-15克,连翘10-20克,羌活5-15克,生地黄10-20克,当归5-15克,赤芍5-15克,蔓荆子7-12克,金银花10-15克,全蝎4-8克,钩藤10-20克,白附子5-15克,乌药5-15克,路路通15-25克,桂枝5-15克,浙贝母5-15克,紫苏叶5-15克,牡丹皮7-12克,蝉蜕5-15克,半夏5-15克,石菖蒲5-15克,菊花5-15克,秦艽10-20克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
牛蒡子20克,僵蚕10克,枳壳12克,天麻15克,甘草6克,白芷12克,防风10克,川芎15克,天南星10克,连翘15克,羌活10克,生地黄15克,当归10克,赤芍10克,蔓荆子9克,金银花12克,全蝎6克,钩藤15克,白附子10克,乌药10克,路路通20克,桂枝10克,浙贝母10克,紫苏叶10克,牡丹皮9克,蝉蜕10克,半夏10克,石菖蒲10克,菊花10克,秦艽15克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)牛蒡子:拣去杂质,筛去泥屑;
(2)僵蚕:取原药材,除去残丝,杂质;
(3)枳壳:除去瓤、核,洗净,稍浸,捞出,润软,切片,晾干;
(4)天麻:拣去杂质,大小分档,用水浸泡至七成透,捞出,稍晾,再润至内外温度均匀,切片,晒干;
(5)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晾干;
(6)白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切片干燥;
(7)防风:除去残茎,用水浸泡,捞出,润透切片,晒干;
(8)川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
(9)天南星:拣去杂质,洗净灰屑,晒干;
(10)连翘:拣净杂质,搓开,除去枝梗;
(11)羌活:拣去杂质,洗净,润透,切片,晾干;
(12)生地黄:除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
(13)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(14)赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
(15)蔓荆子:筛净灰屑,除去残存萼片,置锅内用武火炒至焦黄色,略喷清水,放凉;
(16)金银花:筛去泥沙,拣净杂质;
(17)全蝎:清水漂去盐质,晒干,或微火焙用;
(18)钩藤:拣去老梗、杂质,洗净,晒干;
(19)白附子:取原药材,除去杂质,洗净,干燥;
(20)乌药:拣去杂质,分开大小条,用水泡透,根据季节注意换水,防止发臭,及时捞出切片,筛去灰屑;
(21)路路通:除去杂质,洗净,晒干;
(22)桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
(23)浙贝母:除去杂质,大小分档,洗净,润透,切厚片,干燥,街去碎屑,或打碎;
(24)紫苏叶:拣去杂质,晒干;
(25)牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
(26)蝉蜕:拣去杂质,洗净晒干;
(27)半夏:拣去杂质,筛去灰屑;
(28)石菖蒲:拣去杂质,洗净,稍浸泡,润透,切片,晒干;
(29)菊花:拣净叶梗、花柄及泥屑杂质;
(30)秦艽:拣去杂质,除去芦头,稍浸,润透切片,晒干;
(二)制备
(1)将炮制后的牛蒡子、僵蚕、枳壳、天麻、甘草、白芷、防风、川芎、天南星、连翘、羌活、生地黄、当归、赤芍、蔓荆子、金银花、全蝎、钩藤、白附子、乌药、路路通、桂枝、浙贝母、紫苏叶、牡丹皮、蝉蜕、半夏、石菖蒲、菊花、秦艽放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为4剂服用。
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CN106266356A (zh) * | 2016-11-11 | 2017-01-04 | 东莞市百替生物科技有限公司 | 一种治疗面神经瘫痪的中药制剂及制备方法 |
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CN107569613A (zh) * | 2017-10-26 | 2018-01-12 | 刘萍 | 一种治疗口眼歪斜的药物及其制备方法 |
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