CN106177857A - 一种治疗习惯性流产的药物及其制备方法 - Google Patents
一种治疗习惯性流产的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗习惯性流产的药物及其制备方法，其主要是由人参、白术、当归、白芍、川芎、山药、山茱萸、大黄、杜仲、香附、续断、砂仁、熟地黄按一定重量配比制备而成。本发明药物具有补肝肾，安胎，养血柔肝，健脾补肺，固肾益精，补元气，固脱生津，安神的功能，用于治疗习惯性流产见效快、疗效好，不复发。
Description
技术领域
本发明涉及一种治疗习惯性流产的药物及其制备方法，属中药领域。
技术背景
习惯性流产是指连续自然流产三次及三次以上者。近年常用复发性流产取代习惯性流产，改为2次及两次以上的自然流产。中医则认为习惯性流产与阴虚血热，脾肾两虚，气血两虚有关。由于西药治疗副作用大，因此人们对有效治疗习惯性流产的中药药物存在极大的需求，至今为止，还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证，终于找到了有效治疗习惯性流产的药物，从而完成了本发明。
本发明的目的就是提供一种有效治疗习惯性流产的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择人参、白术、当归、白芍、川芎、山药、山茱萸、大黄、杜仲、香附、续断、砂仁、熟地黄、桑寄生、甘草、生姜药物进行组合制备的，将这些药物组合使得各药物功效产生协同作用，从而能够有效治疗习惯性流产。其中选用人参是因为其性味甘微甘，温，入脾、肺经，有大补元气，固脱生津，安神的功能，治劳伤虚损，食少，倦怠，反胃吐食，大便滑泄，虚咳喘促，自汗暴脱，惊悸，健忘，眩晕头痛，阳萎，尿频，消渴，妇女崩漏，小儿慢惊及久虚不复，一切气血津液不足之症。选用白术是因为其性味苦甘，温，入脾、胃经，有补脾，益胃，燥湿，和中的功能，治脾胃气弱，不思饮食，倦怠少气，虚胀，泄泻，痰饮，水肿，黄疸，湿痹，小便不利，头晕，自汗，胎气不安。选用当归是因为其性味甘辛，温，入心、肝、脾经，有补血和血，调经止痛，润燥滑肠的功能，治月经不调，经闭腹痛，癥瘕结聚，崩漏，血虚头痛，眩晕，痿痹，肠燥难便，赤痢后重，痈疽疮疡，金疮，跌扑损伤。选用白芍是因为其性味苦酸，凉，入肝、脾经，有养血柔肝，缓中止痛，敛阴收汗的功能，治胸腹胁肋疼痛，泻痢腹痛，自汗盗汗，阴虚发热，月经不调，崩漏，带下。选用川芎是因为其性味辛，温，入肝、胆经，有行气开郁，祛风燥湿，活血止痛的功能，治风冷头痛旋晕，胁痛腹疼，寒痹筋挛，经闭，难产，产后瘀阻块痛，痈疽疮疡。选用山药是因为其性味甘，平，入肺、脾、肾经，有健脾，补肺，固肾，益精的功能，治脾虚泄泻，久痢，虚劳咳嗽，消渴，遗精、带下，小便频数。选用山茱萸是因为其性味酸，微温，入肝、肾经，有补肝肾，涩精气，固虚脱的功能，治腰膝酸痛，眩晕，耳鸣，阳痿，遗精，小便频数，肝虚寒热，虚汗不止，心摇脉散。选用大黄是因为其性味苦、寒，入胃、大肠、肝径，有泻热毒，破积滞，行瘀血的功能，治实热便秘，谵语发狂，食积痞满，痢疾初起，里急后重，瘀停经闭，癥瘕积聚，时行热疫，暴眼赤痛，吐血，衄血，阳黄，水肿，淋浊，溲赤，痈疡肿毒，疔疮，汤火伤。选用杜仲是因为其性味甘微辛，温，入肝、肾经，有补肝肾，强筋骨，安胎的功能，治腰脊酸疼，足膝痿弱，小便余沥，阴下湿痒，胎漏欲堕，高血压。选用杜仲是因为其性味甘微辛，温，入肝、肾经，有补肝肾，强筋骨，安胎的功能，治腰脊酸疼，足膝痿弱，小便余沥，阴下湿痒，胎漏欲堕，高血压。选用续断是因为其性味苦辛，微温，入肝、肾经，有补肝肾，续筋骨，调血脉的功能，治腰背酸痛，足膝无力，胎漏，崩漏，带下，遗精，跌打损伤，金疮，痔漏，痈疽疮肿。选用砂仁是因为其性味辛，温，入脾、胃经，有行气调中，和胃、醒脾的功能，治腹痛痞胀，胃呆食滞，噎隔呕吐，寒泻冷痢，妊娠胎动。选用熟地黄是因为其性味甘，微温，入肝、肾经，有滋阴，补血的功能，治阴虚血少，腰膝痿弱，劳嗽骨蒸，遗精，崩漏，月经不调，消渴，溲数，耳聋，目昏。选用桑寄生是因为其性味苦甘，平，入肝、肾经，有补肝肾，强筋骨，除风湿，通经络，益血，安胎的功能，治腰膝酸痛，筋骨痿弱，偏枯，脚气，风寒湿痹，胎漏血崩，产后乳汁不下。选用甘草是因为其性味甘平，入脾、胃、肺经，有和中缓急，润肺，解毒，调和诸药的功能，炙用治脾胃虚弱，食少，腹痛便溏，劳倦发热，肺痿咳嗽，心悸，惊痈，生用治咽喉肿痛，消化性溃疡，痈疽疮疡，解药毒及食物中毒。选用生姜是因为其性味辛，温，入肺、胃、脾经，有发表，散寒，止呕，开痰的功能，治感冒风寒，呕吐，痰饮，喘咳，胀满，泄泻，解半夏、天南星及鱼蟹、鸟兽肉毒。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的，各组分的用量在下述重量范围内都具有较好的疗效
人参3-7克，白术10-20克，当归10-20克，白芍3-7克，川芎10-20克，山药20-30克，山茱萸15-25克，大黄5-15克，杜仲10-20克，香附15-25克，续断10-20克，砂仁10-20克，熟地黄5-15克，桑寄生5-15克，甘草3-7克，生姜5-15克。
优选为
人参5克，白术15克，当归15克，白芍5克，川芎15克，山药25克，山茱萸20克，大黄10克，杜仲15克，香附20克，续断15克，砂仁15克，熟地黄10克，桑寄生10克，甘草5克，生姜10克。
本发明药物的制备方法如下
一、备料
1、人参：除去芦头，切段；
2、白术：拣净杂质，用水浸泡，泡后捞出，润透，切片，晒干；
3、当归：拣去杂质，洗净，闷润，稍晾，切片晒干；
4、白芍：拣去杂质，分开大小个，用水浸泡至八成透，捞出，晒晾，润至内外湿度均匀，切片，干燥；
5、川芎：拣去杂质，分开大、小个，用水浸泡，晒晾，闷润后切片，干燥；
6、山药：拣净杂质，用水浸泡至山药中心部软化为止，捞出稍晾，切片晒干或烘干；
7、山茱萸：洗净，除去果核及杂质，晒干；
8、大黄：拣净杂质，大小分档，闷润至内外湿度均匀，切片或切成小块、晒干；
9、杜仲：除去粗皮，洗净，润透，切成方块或丝条，晒干；
10、香附：拣去杂质，碾成碎粒，簸去细毛及细末；
11、续断：洗净泥沙，除去残留根头，润透后切片晒干，筛去屑；
12、砂仁：拣去杂质及果壳，捣碎；
13、熟地黄：取原药材，蒸至表面乌黑色，取出，晒至八成干时，切片，干燥；
14、桑寄生：用水洗净，润透，切段，晒干；
15、甘草：拣去杂质，洗净，用水浸泡至八成透时，捞出，润透，切片，晾干；
16、生姜：拣去杂质，洗净泥土，用时切片。
二、制备
1、将炮制后的人参、白术、当归、白芍、川芎、山药、山茱萸、大黄、杜仲、香附、续断、砂仁、熟地黄、桑寄生、甘草、生姜放入煎药容器内，第一次加水6倍量，浸泡100分钟后，武火煎煮沸腾，再用文火煎煮20分钟，过滤得第一次煎煮液，将第一次煎煮液倒入容器内；
2、将过滤的药渣加4倍量，武火煮沸，再用文火煎煮20分钟，过滤得第二次煎煮液；
3、将两次煎煮液混合搅拌均匀，分为2剂服用。
组方中杜仲有补肝肾，强筋骨，安胎的功能为君药；白芍养血柔肝，缓中止痛，敛阴收汗；山药有健脾，补肺，固肾，益精的功能，二者为臣药，三味药共同发挥补肝肾，安胎，养血柔肝，健脾补肺，固肾益精，缓中止痛的作用，治疗习惯性流产效力全面，且以补肝肾，安胎，养血柔肝，健脾补肺，固肾益精为主可治本，人参有大补元气，固脱生津，安神的功能为佐药，生姜有发表，散寒，止呕，开痰的功能为使药，与余下诸药是治标。
本发明药物具有补肝肾，安胎，养血柔肝，健脾补肺，固肾益精，补元气，固脱生津，安神的功能，用于治疗习惯性流产，疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果，这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告：
取家兔30只，雌雄兼用，体重2.0—2.5kg，分两组，每组15只，其中一组为超剂量试验组，另一组为正常量试验组。超常量组为20ml/kg，正常量为10ml/kg，给药方式为灌胃法给药，每天两次，连服7天，每天观察给药反应，结果表明二组家兔活动、饮食正常，药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治习惯性流产门诊患者共33例。
2、诊断标准
典型症状为阴道少许出血，轻微下腹疼痛，妊娠物排除。
3、治疗方法
选用上述药剂，给患者服用，每次服用1剂，每天早、晚各服1次，10天为一个疗程，连续服用3个疗程。
4、疗效评定标准
显效：习惯性流产症状消失，体质恢复正常，已生育；
好转：患者阴道出血，下腹疼痛的现象减轻，习惯性流产症状明显好转，体质逐步恢复；
无效：达不到好转标准者。
5、治疗结果（见下表）
在上述治疗中，用本发明药物治疗习惯性流产患者33例，结果31人生育，显效31例，显效率为93.94%，无效2例，总有效率为93.94%。
Claims (3)
1.一种治疗习惯性流产的药物，其特征在于：它是由下列重量范围内的原料药制成：
人参3-7克，白术10-20克，当归10-20克，白芍3-7克，川芎10-20克，山药20-30克，山茱萸15-25克，大黄5-15克，杜仲10-20克，香附15-25克，续断10-20克，砂仁10-20克，熟地黄5-15克，桑寄生5-15克，甘草3-7克，生姜5-15克。
2.根据权利要求1所述的药物，其中各原料药的用量为：
人参5克，白术15克，当归15克，白芍5克，川芎15克，山药25克，山茱萸20克，大黄10克，杜仲15克，香附20克，续断15克，砂仁15克，熟地黄10克，桑寄生10克，甘草5克，生姜10克。
3.根据权利要求1或2所述药物的制备方法，它包括下列步骤：
（一）备料
（1）人参：除去芦头，切段；
（2）白术：拣净杂质，用水浸泡，泡后捞出，润透，切片，晒干；
（3）当归：拣去杂质，洗净，闷润，稍晾，切片晒干；
（4）白芍：拣去杂质，分开大小个，用水浸泡至八成透，捞出，晒晾，润至内外湿度均匀，切片，干燥；
（5）川芎：拣去杂质，分开大、小个，用水浸泡，晒晾，闷润后切片，干燥；
（6）山药：拣净杂质，用水浸泡至山药中心部软化为止，捞出稍晾，切片晒干或烘干；
（7）山茱萸：洗净，除去果核及杂质，晒干；
（8）大黄：拣净杂质，大小分档，闷润至内外湿度均匀，切片或切成小块、晒干；
（9）杜仲：除去粗皮，洗净，润透，切成方块或丝条，晒干；
（10）香附：拣去杂质，碾成碎粒，簸去细毛及细末；
（11）续断：洗净泥沙，除去残留根头，润透后切片晒干，筛去屑；
（12）砂仁：拣去杂质及果壳，捣碎；
（13）熟地黄：取原药材，蒸至表面乌黑色，取出，晒至八成干时，切片，干燥；
（14）桑寄生：用水洗净，润透，切段，晒干；
（15）甘草：拣去杂质，洗净，用水浸泡至八成透时，捞出，润透，切片，晾干；
（16）生姜：拣去杂质，洗净泥土，用时切片；
（二）制备
（1）将炮制后的人参、白术、当归、白芍、川芎、山药、山茱萸、大黄、杜仲、香附、续断、砂仁、熟地黄、桑寄生、甘草、生姜放入煎药容器内，加水6倍量，浸泡100分钟后，武火煎煮沸腾，再用文火煎煮20分钟，过滤得第一次煎煮液，将第一次煎煮液倒入容器内；
（2）将过滤的药渣加水4倍量，武火煮沸，再用文火煎煮20分钟，过滤得第二次煎煮液；
（3）将两次煎煮液混合搅拌均匀，分为2剂服用。
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Application publication date: 20161207 |